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Aliases for MAP3K5 Gene

Aliases for MAP3K5 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 5 2 3 5
  • Apoptosis Signal-Regulating Kinase 1 3 4
  • MAPK/ERK Kinase Kinase 5 3 4
  • MEK Kinase 5 3 4
  • EC 2.7.11.25 4 56
  • MAPKKK5 3 4
  • MEKK 5 3 4
  • MEKK5 3 4
  • ASK-1 3 4
  • ASK1 3 4
  • Apoptosis Signal Regulating Kinase 1 2
  • MAP/ERK Kinase Kinase 5 3
  • EC 2.7.11 56

External Ids for MAP3K5 Gene

Previous HGNC Symbols for MAP3K5 Gene

  • MEKK5

Previous GeneCards Identifiers for MAP3K5 Gene

  • GC06M136725
  • GC06M136858
  • GC06M136919
  • GC06M134442
  • GC06M136878

Summaries for MAP3K5 Gene

Entrez Gene Summary for MAP3K5 Gene

  • Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K5 Gene

MAP3K5 (Mitogen-Activated Protein Kinase Kinase Kinase 5) is a Protein Coding gene. Diseases associated with MAP3K5 include Ischemia and Amphetamine Abuse. Among its related pathways are Apoptosis Modulation and Signaling and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K15.

UniProtKB/Swiss-Prot for MAP3K5 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

Tocris Summary for MAP3K5 Gene

  • Apoptosis signal-regulated kinase 1 (ASK1) is a serine/threonine kinase, MAP3K family member, which induces apoptosis through the activation of JNK and p38. ASK1 has been implicated in the pathology of neurodegenerative and oxidative stress-related diseases.

Gene Wiki entry for MAP3K5 Gene

Additional gene information for MAP3K5 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K5 Gene

Genomics for MAP3K5 Gene

GeneHancer (GH) Regulatory Elements for MAP3K5 Gene

Promoters and enhancers for MAP3K5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I136782 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.7 +5.2 5224 12.1 HDGF FOXA2 PKNOX1 CLOCK SMAD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B MAP3K5 BCLAF1 PEX7 MTFR2 IFNGR1 LOC101928429
GH06I136760 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.8 +28.4 28435 9.2 HDGF PKNOX1 SMAD1 YBX1 IRF4 GATA2 ATF7 RUNX3 JUNB ZNF592 BCLAF1 PEX7 MAP3K5 LOC101928461 RNA5SP219 LOC101928429
GH06I136643 Enhancer 1.4 FANTOM5 Ensembl ENCODE 12.1 +148.8 148754 1.1 HDGF FOXA2 SIN3A ZNF2 YY1 ZNF213 ARID2 ZNF143 RUNX3 SP3 MAP3K5 PEX7 RNA5SP219 LOC101928461 LOC101928429
GH06I137222 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 10.4 -430.7 -430723 3.5 PKNOX1 CLOCK ATF1 FOXA2 YY1 ZNF766 FOS ATF7 RUNX3 CAVIN1 IFNGR1 MAP3K5 GC06P137179 LOC105378017
GH06I136607 Enhancer 1.2 Ensembl ENCODE 11.9 +183.0 183023 4.1 HDGF PKNOX1 ATF1 FOXA2 ZNF2 ZNF121 ZNF766 ZNF143 FOS ATF7 RNA5SP219 MAP3K5 PEX7 LOC101928461 MAP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAP3K5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP3K5 gene promoter:

Genomic Locations for MAP3K5 Gene

Genomic Locations for MAP3K5 Gene
chr6:136,557,046-136,793,051
(GRCh38/hg38)
Size:
236,006 bases
Orientation:
Minus strand
chr6:136,878,185-137,113,656
(GRCh37/hg19)

Genomic View for MAP3K5 Gene

Genes around MAP3K5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K5 Gene

Proteins for MAP3K5 Gene

  • Protein details for MAP3K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99683-M3K5_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 5
    Protein Accession:
    Q99683
    Secondary Accessions:
    • A6NIA0
    • B4DGB2
    • Q5THN3
    • Q99461

    Protein attributes for MAP3K5 Gene

    Size:
    1374 amino acids
    Molecular mass:
    154537 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef (PubMed:11298454). Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF (PubMed:15310755, PubMed:15701637, PubMed:17210579, PubMed:17389591). This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis. Interacts with SOCS1 which recognizes phosphorylation of Tyr-718 and induces MAP3K5/ASK1 degradation in endothelial cells. Interacts with the 14-3-3 family proteins such as YWHAB, YWHAE, YWHAQ, YWHAH, YWHAZ and SFN (PubMed:10411906, PubMed:15023544, PubMed:15094778). Interacts with ARRB2, BIRC2, DAB2IP, IGF1R, MAP3K6/ASK2, PGAM5, PIM1, PPP5C, SOCS1, STUB1, TRAF2, TRAF6 and TXN (PubMed:9564042,PubMed:9774977, PubMed:10688666, PubMed:11090355, PubMed:11689443, PubMed:12556535, PubMed:12813029, PubMed:15310755, PubMed:16038411, PubMed:16129676, PubMed:16407264, PubMed:17220297, PubMed:17724081, PubMed:18408005, PubMed:19590015, PubMed:19749799). Interacts with ERN1 in a TRAF2-dependent manner (PubMed:14749717). Interacts with calcineurin subunit PPP3R1 and with PPM1L (PubMed:17456047) (By similarity). Interacts (via N-terminus) with RAF1 and this interaction inhibits the proapoptotic function of MAP3K5 (PubMed:11427728). Interacts with DAB2IP (via N-terminus C2 domain); the interaction occurs in a TNF-alpha-dependent manner (PubMed:15310755). Interacts with DUSP13/DUSP13A; may positively regulate apoptosis (PubMed:20358250). Interacts with DAXX (PubMed:9743501). Interacts with RC3H2 (PubMed:24448648).

    Three dimensional structures from OCA and Proteopedia for MAP3K5 Gene

    Alternative splice isoforms for MAP3K5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K5 Gene

Selected DME Specific Peptides for MAP3K5 Gene

Q99683:
  • LGKKGNL
  • LFGFQDAVN
  • YGIVYAGRDLSNQVRIAIKEIPERD
  • KISDFGTSK
  • VPGGSLS
  • NLLLSYRD

Post-translational modifications for MAP3K5 Gene

  • Phosphorylated at Thr-838 through autophosphorylation and by MAP3K6/ASK2 which leads to activation. Thr-838 is dephosphorylated by PPP5C. Ser-83 and Ser-1033 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 and AKT2. Phosphorylated at Ser-966 which induces association of MAP3K5/ASK1 with the 14-3-3 family proteins and suppresses MAP3K5/ASK1 activity. Calcineurin (CN) dephosphorylates this site. Also dephosphorylated and activated by PGAM5.
  • Ubiquitinated. Tumor necrosis factor (TNF) induces TNFR2-dependent ubiquitination leading to proteasomal degradation.

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP3K5 (ASK1)
  • Abcam antibodies for MAP3K5

Domains & Families for MAP3K5 Gene

Gene Families for MAP3K5 Gene

Suggested Antigen Peptide Sequences for MAP3K5 Gene

Graphical View of Domain Structure for InterPro Entry

Q99683

UniProtKB/Swiss-Prot:

M3K5_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K5: view

Function for MAP3K5 Gene

Molecular function for MAP3K5 Gene

GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 5
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by various stressors, including oxidative stress, endoplasmic reticulum stress, and calcium overload, as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) and lipopolysaccharide (LPS). Homophilic association of MAP3K5/ASK1 through the C-terminal coiled-coil domains and the heteromeric complex formation of MAP3K5/ASK1 with the reduced form of thioredoxin (TXN), constitutes an inactive form of the kinase (PubMed:17210579, PubMed:9564042). Upon ROS-induced dissociation of TXN from MAP3K5/ASK1, TRAF2 and TRAF6 are reciprocally recruited to MAP3K5/ASK1 and form the active MAP3K5/ASK1 signalosome, in which TRAF2 and TRAF6 appear to facilitate the active configuration of MAP3K5/ASK1 (PubMed:9774977, PubMed:10688666, PubMed:11920685). MAP3K5/ASK1 activity is also regulated through several phosphorylation and dephosphorylation events. Thr-838 is an activating phosphorylation site that is autophosphorylated and phosphorylated by MAP3K6/ASK2 and dephosphorylated by PPP5C (PubMed:11689443). Ser-83 and Ser-1033 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 and AKT2 (PubMed:11154276, PubMed:12697749, PubMed:15094778). Phosphorylation of Ser-966 induces association of MAP3K5/ASK1 with the 14-3-3 family proteins, which suppresses MAP3K5/ASK1 activity (PubMed:10411906, PubMed:14688258). Calcium/calmodulin-activated protein phosphatase calcineurin (PPP3CA) has been shown to directly dephosphorylate this site (PubMed:14749717). SOCS1 binds to ASK1 by recognizing phosphorylation of Tyr-718 and induces MAP3K5/ASK1 degradation in endothelial cells (PubMed:16407264). Also dephosphorylated and activated by PGAM5. Contains an N-terminal autoinhibitory domain. Once activated targeted for proteosomal degradation by RC3H2-mediated ubiquitination (PubMed:24448648).
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
UniProtKB/Swiss-Prot Induction:
By TNF. Inhibited by HIV-1 Nef.

Enzyme Numbers (IUBMB) for MAP3K5 Gene

Gene Ontology (GO) - Molecular Function for MAP3K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 17210579
GO:0004672 protein kinase activity IDA 11096076
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004709 MAP kinase kinase kinase activity TAS,IDA 17210579
genes like me logo Genes that share ontologies with MAP3K5: view
genes like me logo Genes that share phenotypes with MAP3K5: view

Animal Models for MAP3K5 Gene

MGI Knock Outs for MAP3K5:

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K5 Gene

Localization for MAP3K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K5 Gene

Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K5 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
plasma membrane 3
nucleus 3
mitochondrion 2
extracellular 1
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP3K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA,TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0043234 protein complex IMP 11096076
genes like me logo Genes that share ontologies with MAP3K5: view

Pathways & Interactions for MAP3K5 Gene

genes like me logo Genes that share pathways with MAP3K5: view

SIGNOR curated interactions for MAP3K5 Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAP3K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IDA 17210579
GO:0000186 activation of MAPKK activity IDA 11959862
GO:0000187 activation of MAPK activity IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with MAP3K5: view

Drugs & Compounds for MAP3K5 Gene

(24) Drugs for MAP3K5 Gene - From: PharmGKB, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydroxyurea Approved Pharma 230
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist 0
NQDI 1 Pharma ASK1, MAP3K5 inhibitor, ASK1 inhibitor 0
TC ASK 10 Pharma Potent and selective ASK1 inhibitor; orally bioavailable 0

(12) Additional Compounds for MAP3K5 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
MSC 2032964A
1124381-43-6

(3) Tocris Compounds for MAP3K5 Gene

Compound Action Cas Number
MSC 2032964A Potent and selective ASK1 inhibitor; orally bioavailable 1124381-43-6
NQDI 1 ASK1 inhibitor 175026-96-7
TC ASK 10 Potent and selective ASK1 inhibitor; orally bioavailable 1005775-56-3

(2) ApexBio Compounds for MAP3K5 Gene

Compound Action Cas Number
NQDI 1 ASK1, MAP3K5 inhibitor 175026-96-7
TC ASK 10 1005775-56-3
genes like me logo Genes that share compounds with MAP3K5: view

Drug Products

Transcripts for MAP3K5 Gene

Unigene Clusters for MAP3K5 Gene

Mitogen-activated protein kinase kinase kinase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K5 Gene

No ASD Table

Relevant External Links for MAP3K5 Gene

GeneLoc Exon Structure for
MAP3K5
ECgene alternative splicing isoforms for
MAP3K5

Expression for MAP3K5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K5 Gene

This gene is overexpressed in Adrenal Gland (x5.6).

Protein differential expression in normal tissues from HIPED for MAP3K5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP3K5 Gene



Protein tissue co-expression partners for MAP3K5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP3K5 Gene:

MAP3K5

SOURCE GeneReport for Unigene cluster for MAP3K5 Gene:

Hs.186486

mRNA Expression by UniProt/SwissProt for MAP3K5 Gene:

Q99683-M3K5_HUMAN
Tissue specificity: Abundantly expressed in heart and pancreas.

Evidence on tissue expression from TISSUES for MAP3K5 Gene

  • Nervous system(4.6)
  • Blood(4.4)
  • Eye(4.4)
  • Liver(4.4)
  • Lung(4.4)
  • Heart(2.7)
  • Adrenal gland(2.4)
  • Kidney(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with MAP3K5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K5 Gene

Orthologs for MAP3K5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K5 33 34
  • 99.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K5 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K5 33 34
  • 92.43 (n)
cow
(Bos Taurus)
Mammalia MAP3K5 33 34
  • 92.26 (n)
mouse
(Mus musculus)
Mammalia Map3k5 33 16 34
  • 86.78 (n)
rat
(Rattus norvegicus)
Mammalia Map3k5 33
  • 85.59 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP3K5 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K5 33 34
  • 81.29 (n)
lizard
(Anolis carolinensis)
Reptilia MAP3K5 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497692 33
  • 72.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30542 33
zebrafish
(Danio rerio)
Actinopterygii map3k5 33 34
  • 68.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pk92B 35 34
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea nsy-1 35 34
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 34
  • 22 (a)
OneToMany
Species where no ortholog for MAP3K5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP3K5 Gene

ENSEMBL:
Gene Tree for MAP3K5 (if available)
TreeFam:
Gene Tree for MAP3K5 (if available)

Paralogs for MAP3K5 Gene

Paralogs for MAP3K5 Gene

(12) SIMAP similar genes for MAP3K5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAP3K5: view

Variants for MAP3K5 Gene

Sequence variations from dbSNP and Humsavar for MAP3K5 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000020329 -- 136,578,430(-) A/G intron_variant
rs1000021841 -- 136,645,088(-) C/G intron_variant
rs1000031322 -- 136,623,824(-) C/T intron_variant
rs1000057609 -- 136,595,262(-) C/T intron_variant
rs1000070415 -- 136,688,770(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K5 Gene

Variant ID Type Subtype PubMed ID
dgv404e215 CNV deletion 23714750
dgv6149n100 CNV gain 25217958
esv3610929 CNV loss 21293372
nsv1140697 CNV deletion 24896259
nsv1140698 CNV deletion 24896259
nsv464064 CNV loss 19166990
nsv475107 CNV novel sequence insertion 20440878
nsv604725 CNV loss 21841781
nsv604733 CNV gain 21841781

Variation tolerance for MAP3K5 Gene

Residual Variation Intolerance Score: 2.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP3K5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K5 Gene

Disorders for MAP3K5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAP3K5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ischemia
  • acute coronary syndrome
amphetamine abuse
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAP3K5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAP3K5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K5 Gene

Publications for MAP3K5 Gene

  1. Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians. (PMID: 20185809) Bian L … Bogardus C (Diabetes 2010) 3 22 44 58
  2. Apoptosis signal-regulating kinase 1 in stress and immune response. (PMID: 17883330) Takeda K … Ichijo H (Annual review of pharmacology and toxicology 2008) 3 4 22 58
  3. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. (PMID: 17210579) Takeda K … Ichijo H (The Journal of biological chemistry 2007) 3 4 22 58
  4. Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon. (PMID: 17456047) Saito J … Tamura S (The Biochemical journal 2007) 3 4 22 58
  5. Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. (PMID: 17724081) Fujino G … Ichijo H (Molecular and cellular biology 2007) 3 4 22 58

Products for MAP3K5 Gene

Sources for MAP3K5 Gene

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