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Aliases for MAP3K1 Gene

Aliases for MAP3K1 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 1, E3 Ubiquitin Protein Ligase 2 3
  • MAPK/ERK Kinase Kinase 1 3 4
  • MEK Kinase 1 3 4
  • MAPKKK1 3 4
  • MEKK 1 3 4
  • MEKK1 3 4
  • MEKK 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 1 2
  • MAP/ERK Kinase Kinase 1 3
  • EC 2.7.11.25 4
  • SRXY6 3

External Ids for MAP3K1 Gene

Previous HGNC Symbols for MAP3K1 Gene

  • MEKK1

Previous GeneCards Identifiers for MAP3K1 Gene

  • GC05P056276
  • GC05P057669
  • GC05P056081
  • GC05P056126
  • GC05P056146
  • GC05P053082
  • GC05P056110

Summaries for MAP3K1 Gene

Entrez Gene Summary for MAP3K1 Gene

  • The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

GeneCards Summary for MAP3K1 Gene

MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with MAP3K1 include 46xy sex reversal 6 and swyer syndrome. Among its related pathways are MAPK signaling pathway and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K5.

UniProtKB/Swiss-Prot for MAP3K1 Gene

  • Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Gene Wiki entry for MAP3K1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K1 Gene

Genomics for MAP3K1 Gene

Regulatory Elements for MAP3K1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP3K1 Gene

Chromosome:
5
Start:
56,815,073 bp from pter
End:
56,896,152 bp from pter
Size:
81,080 bases
Orientation:
Plus strand

Genomic View for MAP3K1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP3K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K1 Gene

Proteins for MAP3K1 Gene

  • Protein details for MAP3K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13233-M3K1_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 1
    Protein Accession:
    Q13233

    Protein attributes for MAP3K1 Gene

    Size:
    1512 amino acids
    Molecular mass:
    164470 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with STK38.

neXtProt entry for MAP3K1 Gene

Proteomics data for MAP3K1 Gene at MOPED

Post-translational modifications for MAP3K1 Gene

Other Protein References for MAP3K1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for MAP3K1

No data available for DME Specific Peptides for MAP3K1 Gene

Domains & Families for MAP3K1 Gene

Suggested Antigen Peptide Sequences for MAP3K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13233

UniProtKB/Swiss-Prot:

M3K1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  • Contains 1 RING-type zinc finger.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Similarity:
  • Contains 1 RING-type zinc finger.
  • Contains 1 SWIM-type zinc finger.
genes like me logo Genes that share domains with MAP3K1: view

Function for MAP3K1 Gene

Molecular function for MAP3K1 Gene

GENATLAS Biochemistry:
mitogen-activated protein (MAP/ERK) kinase kinase kinase 1,stress activated protein kinase,exercizing an antiapoptotic function as activator of C-Jun amino-terminal kinase (JNK) in response to changes in the microtubule cytoskeleton and extra signal-regulated protein kinase (ERK),also involved in apoptosis as caspase-3 substrate and in the induction of apoptosis by genotoxins but not by microtubule altering drugs. Stimulating MADH2 mediated transcriptional activation in endothelial cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization
UniProtKB/Swiss-Prot Function:
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Enzyme Numbers (IUBMB) for MAP3K1 Gene

Gene Ontology (GO) - Molecular Function for MAP3K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 15001576
GO:0004706 JUN kinase kinase kinase activity IEA --
GO:0004709 MAP kinase kinase kinase activity NAS 9808624
GO:0005488 binding --
GO:0005515 protein binding IPI 9808624
genes like me logo Genes that share ontologies with MAP3K1: view
genes like me logo Genes that share phenotypes with MAP3K1: view

Animal Models for MAP3K1 Gene

MGI Knock Outs for MAP3K1:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP3K1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MAP3K1 Gene

Localization for MAP3K1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP3K1 Gene COMPARTMENTS Subcellular localization image for MAP3K1 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAP3K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAP3K1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K1 Gene

Pathways & Interactions for MAP3K1 Gene

SuperPathways for MAP3K1 Gene

genes like me logo Genes that share pathways with MAP3K1: view

PCR Array Products

SIGNOR curated interactions for MAP3K1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP3K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0003382 epithelial cell morphogenesis IEA --
GO:0006468 protein phosphorylation NAS 9808624
genes like me logo Genes that share ontologies with MAP3K1: view

Drugs & Compounds for MAP3K1 Gene

(33) Drugs for MAP3K1 Gene - From: HMDB, DGIdb, NovoSeek, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2505
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1812
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1792
Erlotinib Approved, Investigational Pharma EGFR inhibitor, EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 759

(18) Additional Compounds for MAP3K1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
12-O-Tetradecanoylphorbol 13-acetate
Ceramide
3102-57-6
dithiothreitol
EGCG
989-51-5
genes like me logo Genes that share compounds with MAP3K1: view

Transcripts for MAP3K1 Gene

Unigene Clusters for MAP3K1 Gene

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP3K1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2:

Relevant External Links for MAP3K1 Gene

GeneLoc Exon Structure for
MAP3K1
ECgene alternative splicing isoforms for
MAP3K1

Expression for MAP3K1 Gene

mRNA expression in normal human tissues for MAP3K1 Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K1 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for MAP3K1 Gene

This gene is overexpressed in Liver, secretome (27.6), Pancreatic juice (17.1), and Blymphocyte (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP3K1 Gene



SOURCE GeneReport for Unigene cluster for MAP3K1 Gene Hs.653654

genes like me logo Genes that share expression patterns with MAP3K1: view

Protein tissue co-expression partners for MAP3K1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAP3K1 Gene

Orthologs for MAP3K1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP3K1 35
  • 92.25 (n)
  • 93.82 (a)
MAP3K1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K1 35
  • 92.47 (n)
  • 93.89 (a)
MAP3K1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k1 35
  • 85.52 (n)
  • 90.52 (a)
Map3k1 16
Map3k1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP3K1 35
  • 99.51 (n)
  • 99.34 (a)
MAP3K1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912399 35
  • 86.22 (n)
  • 90.37 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP3K1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K1 35
  • 79.32 (n)
  • 83.29 (a)
MAP3K1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k1 35
  • 73.77 (n)
  • 78.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12302 35
zebrafish
(Danio rerio)
Actinopterygii map3k1 35
  • 67.37 (n)
  • 74.27 (a)
map3k1 36
  • 68 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCK1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for MAP3K1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K1 Gene

ENSEMBL:
Gene Tree for MAP3K1 (if available)
TreeFam:
Gene Tree for MAP3K1 (if available)

Paralogs for MAP3K1 Gene

Paralogs for MAP3K1 Gene

(11) SIMAP similar genes for MAP3K1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAP3K1: view

Variants for MAP3K1 Gene

Sequence variations from dbSNP and Humsavar for MAP3K1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_040680 -
VAR_040681 -
VAR_051636 -
VAR_051637 -
VAR_065504 46,XY sex reversal 6 (SRXY6)

Structural Variations from Database of Genomic Variants (DGV) for MAP3K1 Gene

Variant ID Type Subtype PubMed ID
nsv830308 CNV Gain 17160897
esv23998 CNV Loss 19812545
esv2730198 CNV Deletion 23290073
esv2730199 CNV Deletion 23290073
esv2375620 CNV Deletion 18987734
nsv329292 CNV Loss 16902084
esv1000409 CNV Deletion 20482838
esv1751401 CNV Deletion 17803354
nsv329673 CNV Loss 16902084

Variation tolerance for MAP3K1 Gene

Residual Variation Intolerance Score: 6.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.61; 96.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K1 Gene

HapMap Linkage Disequilibrium report
MAP3K1
Human Gene Mutation Database (HGMD)
MAP3K1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K1 Gene

Disorders for MAP3K1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MAP3K1 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
46xy sex reversal 6
  • srxy6
swyer syndrome
  • pure gonadal dysgenesis 46,xy
46,xy partial gonadal dysgenesis
  • 46,xy pgd
46,xy disorder of sex development and 46,xy complete gonadal dysgenesis
  • xy disorder of sex development and xy complete gonadal dysgenesis
duodenum adenocarcinoma
  • duodenal adenocarcinoma
- elite association

UniProtKB/Swiss-Prot

M3K1_HUMAN
  • 46,XY sex reversal 6 (SRXY6) [MIM:613762]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. {ECO:0000269 PubMed:21129722}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MAP3K1

Genetic Association Database (GAD)
MAP3K1
Human Genome Epidemiology (HuGE) Navigator
MAP3K1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K1
genes like me logo Genes that share disorders with MAP3K1: view

No data available for Genatlas for MAP3K1 Gene

Publications for MAP3K1 Gene

  1. Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan. (PMID: 20159036) Craig E.A. … Camenisch T.D. (Cell. Signal. 2010) 23 67
  2. MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. (PMID: 19710465) Enzler T. … Gallagher E. (J. Immunol. 2009) 23 67
  3. Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells. (PMID: 19513748) Su F. … Chen X. (J. Cancer Res. Clin. Oncol. 2009) 23 67
  4. Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. (PMID: 18160487) Ramnath R.D. … Bhatia M. (Am. J. Physiol., Cell Physiol. 2008) 23 67
  5. Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation. (PMID: 18784253) Siu Y.T. … Jin D.Y. (Mol. Biol. Cell 2008) 23 67

Products for MAP3K1 Gene

Sources for MAP3K1 Gene

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