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Aliases for MEF2C Gene

Aliases for MEF2C Gene

  • Myocyte Enhancer Factor 2C 2 3 5
  • MADS Box Transcription Enhancer Factor 2, Polypeptide C 3
  • Myocyte-Specific Enhancer Factor 2C 3
  • C5DELq14.3 3
  • DEL5q14.3 3

External Ids for MEF2C Gene

Previous GeneCards Identifiers for MEF2C Gene

  • GC05M087047
  • GC05M088304
  • GC05M088052
  • GC05M088100
  • GC05M088098
  • GC05M088051
  • GC05M083218
  • GC05M088013

Summaries for MEF2C Gene

Entrez Gene Summary for MEF2C Gene

  • This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

GeneCards Summary for MEF2C Gene

MEF2C (Myocyte Enhancer Factor 2C) is a Protein Coding gene. Diseases associated with MEF2C include Mental Retardation, Stereotypic Movements, Epilepsy, And/Or Cerebral Malformations and Arrhythmogenic Right Ventricular Dysplasia 5. Among its related pathways are Activated TLR4 signalling and Phospholipase-C Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is MEF2A.

UniProtKB/Swiss-Prot for MEF2C Gene

  • Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Gene Wiki entry for MEF2C Gene

Additional gene information for MEF2C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEF2C Gene

Genomics for MEF2C Gene

Regulatory Elements for MEF2C Gene

Enhancers for MEF2C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H088730 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +169.8 169787 8 PKNOX1 ZNF133 BMI1 BATF RAD21 TCF12 SCRT2 ZNF143 ATF7 ETV6 MEF2C ENSG00000250377 MEF2C-AS1
GH05H088659 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.4 +240.1 240051 9 PKNOX1 ARNT FEZF1 ZNF2 ETS1 GLIS2 ATF7 RUNX3 SP3 REST LINC00461 ENSG00000250555 ENSG00000250377 MEF2C GC05P088664 ENSG00000250705
GH05H088671 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.1 +229.3 229325 7 ATF1 ARNT ZNF133 SIN3A FEZF1 ZNF2 GLIS2 ELK1 KLF7 ZNF548 TMEM161B MEF2C MEF2C-AS1 MEF2C-AS2 MIR9-2
GH05H088878 3.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 2.4 +19.1 19120 12 PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF143 FOS SP3 REST MEF2C-AS1 ENSG00000250831 MEF2C PIR46355
GH05H088540 1.3 FANTOM5 5.1 +364.1 364084 0 MEF2C GC05M088536 ENSG00000250705
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MEF2C on UCSC Golden Path with GeneCards custom track

Genomic Location for MEF2C Gene

Chromosome:
5
Start:
88,717,117 bp from pter
End:
88,904,257 bp from pter
Size:
187,141 bases
Orientation:
Minus strand

Genomic View for MEF2C Gene

Genes around MEF2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEF2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEF2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEF2C Gene

Proteins for MEF2C Gene

  • Protein details for MEF2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06413-MEF2C_HUMAN
    Recommended name:
    Myocyte-specific enhancer factor 2C
    Protein Accession:
    Q06413
    Secondary Accessions:
    • C9JMZ0
    • D7F7N5
    • F8W7V7

    Protein attributes for MEF2C Gene

    Size:
    473 amino acids
    Molecular mass:
    51221 Da
    Quaternary structure:
    • Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation (By similarity). Interacts with HDAC7 and CARM1 (By similarity). Interacts with HDAC4 and HDAC9; the interaction with HDACs represses transcriptional activity (PubMed:10523670, PubMed:11535832). Interacts with LPIN1. Interacts with MYOCD. Interacts with AKAP13 (By similarity). Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (By similarity).

    Alternative splice isoforms for MEF2C Gene

neXtProt entry for MEF2C Gene

Post-translational modifications for MEF2C Gene

  • Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity).
  • Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity.
  • Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
  • Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MEF2C Gene

Domains & Families for MEF2C Gene

Gene Families for MEF2C Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MEF2C Gene

Suggested Antigen Peptide Sequences for MEF2C Gene

Graphical View of Domain Structure for InterPro Entry

Q06413

UniProtKB/Swiss-Prot:

MEF2C_HUMAN :
  • The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.
  • Belongs to the MEF2 family.
Domain:
  • The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.
Family:
  • Belongs to the MEF2 family.
genes like me logo Genes that share domains with MEF2C: view

Function for MEF2C Gene

Molecular function for MEF2C Gene

GENATLAS Biochemistry:
myocyte-specific enhancer binding factor 2C,interacting with members of the MyoD family of transcriptional activator,also interacting with TWIST to inhibit myogenesis,negatively regulated by MITR in association with HDAC1,also expressed in brain,activated by PRKM7
UniProtKB/Swiss-Prot Function:
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Phenotypes From GWAS Catalog for MEF2C Gene

Gene Ontology (GO) - Molecular Function for MEF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA,IDA 8455629
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS 21610032
GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific IDA 8455629
genes like me logo Genes that share ontologies with MEF2C: view
genes like me logo Genes that share phenotypes with MEF2C: view

Human Phenotype Ontology for MEF2C Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MEF2C Gene

MGI Knock Outs for MEF2C:

Animal Model Products

CRISPR Products

Targeted motifs for MEF2C Gene
HOMER Transcription Factor Regulatory Elements motif MEF2C
  • Consensus sequence: DCYAAAAATAGM Submotif: canonical Cell Type: GM12878 GEO ID: GSE32465

Clone Products

  • Addgene plasmids for MEF2C
  • Applied Biological Materials Clones for MEF2C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for MEF2C Gene

Localization for MEF2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEF2C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEF2C gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 8455629
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 8455629
GO:0005829 cytosol ISS --
GO:0016607 nuclear speck IDA 18079734
genes like me logo Genes that share ontologies with MEF2C: view

Pathways & Interactions for MEF2C Gene

genes like me logo Genes that share pathways with MEF2C: view

Pathways by source for MEF2C Gene

SIGNOR curated interactions for MEF2C Gene

Gene Ontology (GO) - Biological Process for MEF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 18079734
GO:0000165 MAPK cascade IMP 11160896
GO:0001568 blood vessel development ISS --
GO:0001649 osteoblast differentiation ISS --
GO:0001764 neuron migration ISS --
genes like me logo Genes that share ontologies with MEF2C: view

Drugs & Compounds for MEF2C Gene

(4) Drugs for MEF2C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for MEF2C Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MEF2C: view

Transcripts for MEF2C Gene

Unigene Clusters for MEF2C Gene

Myocyte enhancer factor 2C:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for MEF2C
  • Applied Biological Materials Clones for MEF2C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MEF2C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for MEF2C Gene

GeneLoc Exon Structure for
MEF2C
ECgene alternative splicing isoforms for
MEF2C

Expression for MEF2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEF2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEF2C Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.0), Muscle - Skeletal (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.0), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for MEF2C Gene

This gene is overexpressed in Stomach (27.0), Peripheral blood mononuclear cells (18.9), Fetal Brain (13.7), and Blymphocyte (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MEF2C Gene



Protein tissue co-expression partners for MEF2C Gene

NURSA nuclear receptor signaling pathways regulating expression of MEF2C Gene:

MEF2C

SOURCE GeneReport for Unigene cluster for MEF2C Gene:

Hs.649965

mRNA Expression by UniProt/SwissProt for MEF2C Gene:

Q06413-MEF2C_HUMAN
Tissue specificity: Expressed in brain and skeletal muscle.

Evidence on tissue expression from TISSUES for MEF2C Gene

  • Nervous system(5)
  • Muscle(4.7)
  • Heart(3.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MEF2C Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • lip
  • nose
  • outer ear
  • skull
General:
  • skin
genes like me logo Genes that share expression patterns with MEF2C: view

Primer Products

Orthologs for MEF2C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MEF2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEF2C 33 34
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia MEF2C 33 34
  • 97.7 (n)
oppossum
(Monodelphis domestica)
Mammalia MEF2C 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEF2C 33 34
  • 93.04 (n)
mouse
(Mus musculus)
Mammalia Mef2c 33 16 34
  • 91.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MEF2C 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mef2c 33
  • 90.86 (n)
chicken
(Gallus gallus)
Aves MEF2C 33 34
  • 88.41 (n)
lizard
(Anolis carolinensis)
Reptilia MEF2C 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mef2c 33
  • 83.95 (n)
zebrafish
(Danio rerio)
Actinopterygii mef2cb 33 34
  • 75.35 (n)
mef2ca 34
  • 73 (a)
OneToMany
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007608 33
  • 53.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mef2 33 34
  • 52.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMP1 34
  • 19 (a)
ManyToMany
RLM1 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 96 (a)
OneToMany
Species where no ortholog for MEF2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEF2C Gene

ENSEMBL:
Gene Tree for MEF2C (if available)
TreeFam:
Gene Tree for MEF2C (if available)

Paralogs for MEF2C Gene

Variants for MEF2C Gene

Sequence variations from dbSNP and Humsavar for MEF2C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs267607233 Pathogenic 88,731,856(-) GGTCT(C/G)ACCTG reference, stop-gained
rs397514655 Pathogenic 88,804,743(-) CGTGC(A/T)GTGTG reference, missense
rs397514656 Pathogenic 88,804,776(-) ATTTG(C/G)GTTGA reference, missense
rs545185248 Pathogenic 88,823,787(+) TCCCC(A/G/T)TAGTC reference, missense
rs587783747 Pathogenic 88,751,881(-) CACAT(C/T)GACCT reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for MEF2C Gene

Variant ID Type Subtype PubMed ID
dgv3122n106 CNV deletion 24896259
esv1006875 CNV deletion 20482838
esv1049510 CNV deletion 17803354
esv1739252 CNV deletion 17803354
esv2657453 CNV deletion 23128226
esv2730446 CNV deletion 23290073
esv2730447 CNV deletion 23290073
esv3292385 CNV deletion 24192839
esv3566252 CNV deletion 23714750
esv3566253 CNV deletion 23714750
esv3570247 CNV loss 25503493
esv3570248 CNV loss 25503493
esv4948 CNV loss 18987735
esv4987 CNV loss 18987735
esv5444 CNV loss 19470904
esv8549 CNV loss 19470904
esv993574 CNV deletion 20482838
nsv1073903 CNV deletion 25765185
nsv1074316 CNV deletion 25765185
nsv1135954 CNV deletion 24896259
nsv329625 CNV deletion 16902084
nsv471022 CNV loss 18288195
nsv476727 CNV novel sequence insertion 20440878
nsv956483 CNV deletion 24416366
nsv956487 CNV deletion 24416366
nsv980696 CNV duplication 23825009

Variation tolerance for MEF2C Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEF2C Gene

Human Gene Mutation Database (HGMD)
MEF2C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEF2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEF2C Gene

Disorders for MEF2C Gene

MalaCards: The human disease database

(9) MalaCards diseases for MEF2C Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, stereotypic movements, epilepsy, and/or cerebral malformations
  • chromosome 5q14.3 deletion syndrome
arrhythmogenic right ventricular dysplasia 5
  • arrhythmogenic right ventricular cardiomyopathy 5
congenital muscular dystrophy due to lmna mutation
  • congenital muscular dystrophy lmna-related
rett syndrome
  • rett syndrome, preserved speech variant
cardiomyopathy, dilated, 1e
  • cardiomyopathy, dilated, 1s
- elite association - COSMIC cancer census association via MalaCards
Search MEF2C in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MEF2C_HUMAN
  • Mental retardation, autosomal dominant 20 (MRD20) [MIM:613443]: A disorder characterized by severe mental retardation, absent speech, hypotonia, poor eye contact and stereotypic movements. Dysmorphic features include high broad forehead with variable small chin, short nose with anteverted nares, large open mouth, upslanted palpebral fissures and prominent eyebrows. Some patients have seizures. {ECO:0000269 PubMed:19592390}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MEF2C

Genetic Association Database (GAD)
MEF2C
Human Genome Epidemiology (HuGE) Navigator
MEF2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEF2C
genes like me logo Genes that share disorders with MEF2C: view

No data available for Genatlas for MEF2C Gene

Publications for MEF2C Gene

  1. Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression. (PMID: 20513142) Zweier M … Rauch A (Human mutation 2010) 3 22 45 60
  2. MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations. (PMID: 19592390) Le Meur N … Bonneau D (Journal of medical genetics 2010) 3 4 22 60
  3. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F … Genetic Factors for Osteoporosis (GEFOS) Consortium (Nature genetics 2009) 3 22 45 60
  4. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D … Mitchell GF (BMC medical genetics 2007) 3 22 45 60
  5. Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity. (PMID: 16478538) Kang J … Yu H (BMC biochemistry 2006) 3 4 22 60

Products for MEF2C Gene

  • Addgene plasmids for MEF2C

Sources for MEF2C Gene

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