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Aliases for BORCS8-MEF2B Gene

Aliases for BORCS8-MEF2B Gene

  • BORCS8-MEF2B Readthrough 2
  • MEF2BNB-MEF2B Readthrough 2 3
  • LOC729991-MEF2B Readthrough 3
  • LOC729991-MEF2B 3
  • MEF2BNB-MEF2B 3
  • MEF2B 3

External Ids for BORCS8-MEF2B Gene

Previous HGNC Symbols for BORCS8-MEF2B Gene

  • MEF2BNB-MEF2B

Summaries for BORCS8-MEF2B Gene

Entrez Gene Summary for BORCS8-MEF2B Gene

  • This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

GeneCards Summary for BORCS8-MEF2B Gene

BORCS8-MEF2B (BORCS8-MEF2B Readthrough) is a Protein Coding gene. Among its related pathways are Developmental Biology and DAG and IP3 signaling.

Gene Wiki entry for BORCS8-MEF2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BORCS8-MEF2B Gene

Genomics for BORCS8-MEF2B Gene

Genomic Location for BORCS8-MEF2B Gene

Chromosome:
19
Start:
19,145,567 bp from pter
End:
19,192,591 bp from pter
Size:
47,025 bases
Orientation:
Minus strand

Genomic View for BORCS8-MEF2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for BORCS8-MEF2B Gene

No data available for Regulatory Elements for BORCS8-MEF2B Gene

Proteins for BORCS8-MEF2B Gene

Post-translational modifications for BORCS8-MEF2B Gene

No Post-translational modifications

Other Protein References for BORCS8-MEF2B Gene

REFSEQ proteins:

No data available for DME Specific Peptides for BORCS8-MEF2B Gene

Domains & Families for BORCS8-MEF2B Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BORCS8-MEF2B Gene

Function for BORCS8-MEF2B Gene

Phenotypes for BORCS8-MEF2B Gene

GenomeRNAi human phenotypes for BORCS8-MEF2B:
genes like me logo Genes that share phenotypes with BORCS8-MEF2B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BORCS8-MEF2B Gene

Localization for BORCS8-MEF2B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BORCS8-MEF2B Gene

Pathways & Interactions for BORCS8-MEF2B Gene

genes like me logo Genes that share pathways with BORCS8-MEF2B: view

Interacting Proteins for BORCS8-MEF2B Gene

Gene Ontology (GO) - Biological Process for BORCS8-MEF2B Gene

None

No data available for SIGNOR curated interactions for BORCS8-MEF2B Gene

Drugs & Compounds for BORCS8-MEF2B Gene

No Compound Related Data Available

Transcripts for BORCS8-MEF2B Gene

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate BORCS8-MEF2B
    • Block miRNA regulation of BORCS8-MEF2B using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for BORCS8-MEF2B

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for BORCS8-MEF2B Gene

    No ASD Table

    Relevant External Links for BORCS8-MEF2B Gene

    GeneLoc Exon Structure for
    BORCS8-MEF2B
    ECgene alternative splicing isoforms for
    BORCS8-MEF2B

    Expression for BORCS8-MEF2B Gene

    No Expression Related Data Available

    Primer Products

    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat

    In Situ Assay Products

    No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BORCS8-MEF2B Gene

    Orthologs for BORCS8-MEF2B Gene

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BORCS8-MEF2B Gene

    Organism Taxonomy Gene Similarity Type Details
    mouse
    (Mus musculus)
    Mammalia Mef2b 16
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.2586 35
    corn
    (Zea mays)
    Liliopsida Zm.1104 35
    Species with no ortholog for BORCS8-MEF2B:
    • A. gosspyii yeast (Ashbya gossypii)
    • Actinobacteria (Mycobacterium tuberculosis)
    • African clawed frog (Xenopus laevis)
    • African malaria mosquito (Anopheles gambiae)
    • Alicante grape (Vitis vinifera)
    • alpha proteobacteria (Wolbachia pipientis)
    • amoeba (Dictyostelium discoideum)
    • Archea (Pyrococcus horikoshii)
    • baker's yeast (Saccharomyces cerevisiae)
    • barley (Hordeum vulgare)
    • beta proteobacteria (Neisseria meningitidis)
    • bread mold (Neurospora crassa)
    • chicken (Gallus gallus)
    • chimpanzee (Pan troglodytes)
    • Chromalveolata (Phytophthora infestans)
    • common water flea (Daphnia pulex)
    • cow (Bos Taurus)
    • dog (Canis familiaris)
    • E. coli (Escherichia coli)
    • filamentous fungi (Aspergillus nidulans)
    • Firmicute bacteria (Streptococcus pneumoniae)
    • fission yeast (Schizosaccharomyces pombe)
    • fruit fly (Drosophila melanogaster)
    • green algae (Chlamydomonas reinhardtii)
    • honey bee (Apis mellifera)
    • K. lactis yeast (Kluyveromyces lactis)
    • lizard (Anolis carolinensis)
    • loblloly pine (Pinus taeda)
    • malaria parasite (Plasmodium falciparum)
    • medicago trunc (Medicago Truncatula)
    • moss (Physcomitrella patens)
    • oppossum (Monodelphis domestica)
    • orangutan (Pongo pygmaeus)
    • pig (Sus scrofa)
    • platypus (Ornithorhynchus anatinus)
    • rat (Rattus norvegicus)
    • rice (Oryza sativa)
    • rice blast fungus (Magnaporthe grisea)
    • schistosome parasite (Schistosoma mansoni)
    • sea anemone (Nematostella vectensis)
    • sea squirt (Ciona intestinalis)
    • sea squirt (Ciona savignyi)
    • sea urchin (Strongylocentrotus purpuratus)
    • sorghum (Sorghum bicolor)
    • soybean (Glycine max)
    • stem rust fungus (Puccinia graminis)
    • sugarcane (Saccharum officinarum)
    • thale cress (Arabidopsis thaliana)
    • tomato (Lycopersicon esculentum)
    • toxoplasmosis (Toxoplasma gondii)
    • Trichoplax (Trichoplax adhaerens)
    • tropical clawed frog (Silurana tropicalis)
    • wheat (Triticum aestivum)
    • worm (Caenorhabditis elegans)
    • zebrafish (Danio rerio)

    No data available for Evolution for BORCS8-MEF2B Gene

    Paralogs for BORCS8-MEF2B Gene

    No data available for Paralogs for BORCS8-MEF2B Gene

    Variants for BORCS8-MEF2B Gene

    Sequence variations from dbSNP and Humsavar for BORCS8-MEF2B Gene

    SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
    rs1134953 -- 19,176,082(-) gcctc(A/G)ctcta intron-variant
    rs2283624 -- 19,172,371(+) TCTGG(G/T)GGGCA intron-variant
    rs2283625 -- 19,172,395(+) CATGG(G/T)CTGTC intron-variant
    rs2314035 -- 19,174,111(+) AGGAG(C/T)AGGTC intron-variant
    rs3178791 -- 19,175,413(-) gtgac(A/G)gagcg intron-variant

    Variation tolerance for BORCS8-MEF2B Gene

    Residual Variation Intolerance Score: 28.78% of all genes are more intolerant (likely to be disease-causing)
    Gene Damage Index Score: 0.28; 6.22% of all genes are more intolerant (likely to be disease-causing)

    Relevant External Links for BORCS8-MEF2B Gene

    HapMap Linkage Disequilibrium report
    BORCS8-MEF2B

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BORCS8-MEF2B Gene

    Disorders for BORCS8-MEF2B Gene

    Relevant External Links for BORCS8-MEF2B

    Atlas of Genetics and Cytogenetics in Oncology and Haematology:
    BORCS8-MEF2B
    genes like me logo Genes that share disorders with BORCS8-MEF2B: view

    No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BORCS8-MEF2B Gene

    Publications for BORCS8-MEF2B Gene

    1. Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. (PMID: 15567413) Han A. … Chen L. (J. Mol. Biol. 2005) 23 67
    2. Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma. (PMID: 16127744) Toiyama Y. … Kusunoki M. (World J. Gastroenterol. 2005) 23 67
    3. The MADS domain containing transcription factor cMef2a is expressed in heart and skeletal muscle during embryonic chick development. (PMID: 10370120) Buchberger A. … Arnold H.H. (Dev. Genes Evol. 1999) 23 67
    4. Expression of MEF2 genes during human cardiac development. (PMID: 10458488) Iida K. … Morisaki T. (Tohoku J. Exp. Med. 1999) 23 67
    5. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression. (PMID: 9430690) Katoh Y. … Periasamy M. (J. Biol. Chem. 1998) 23 67

    Products for BORCS8-MEF2B Gene

    Sources for BORCS8-MEF2B Gene

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