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Aliases for ART4 Gene

Aliases for ART4 Gene

  • ADP-Ribosyltransferase 4 (Dombrock Blood Group) 2 3
  • DOK1 3 4 6
  • DO 3 4 6
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 4 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 4 3 4
  • ADP-Ribosyltransferase 4 (DO Blood Group) 2 3
  • Dombrock Blood Group Carrier Molecule 3 4
  • ARTC4 3 4
  • Mono(ADP-Ribosyl)Transferase 4 4
  • Ecto-ADP-Ribosyltransferase 4 3
  • Mono-ADP-Ribosyltransferase 4 3
  • ADP-Ribosyltransferase 4 2
  • Dombrock Blood Group 2
  • CD297 Antigen 4
  • EC 2.4.2.31 4
  • CD297 3

External Ids for ART4 Gene

Previous HGNC Symbols for ART4 Gene

  • DO

Previous GeneCards Identifiers for ART4 Gene

  • GC12M014874
  • GC12M014982
  • GC12M014751

Summaries for ART4 Gene

Entrez Gene Summary for ART4 Gene

  • This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ART4 Gene

ART4 (ADP-Ribosyltransferase 4 (Dombrock Blood Group)) is a Protein Coding gene. Diseases associated with ART4 include acute chest syndrome. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART1.

Gene Wiki entry for ART4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART4 Gene

Genomics for ART4 Gene

Genomic Location for ART4 Gene

Start:
14,825,569 bp from pter
End:
14,843,495 bp from pter
Size:
17,927 bases
Orientation:
Minus strand

Genomic View for ART4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ART4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART4 Gene

Proteins for ART4 Gene

  • Protein details for ART4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93070-NAR4_HUMAN
    Recommended name:
    Ecto-ADP-ribosyltransferase 4
    Protein Accession:
    Q93070
    Secondary Accessions:
    • Q9BZ50
    • Q9BZ51
    • Q9HB06

    Protein attributes for ART4 Gene

    Size:
    314 amino acids
    Molecular mass:
    35878 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ART4 Gene

Proteomics data for ART4 Gene at MOPED

Post-translational modifications for ART4 Gene

  • Glycosylation at Asn114, Asn178, Asn222, Asn257, and Asn274
  • Modification sites at PhosphoSitePlus

Other Protein References for ART4 Gene

No data available for DME Specific Peptides for ART4 Gene

Domains for ART4 Gene

Gene Families for ART4 Gene

HGNC:

Protein Domains for ART4 Gene

Graphical View of Domain Structure for InterPro Entry

Q93070

UniProtKB/Swiss-Prot:

NAR4_HUMAN :
  • Q93070
Family:
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART4: view

Function for ART4 Gene

Molecular function for ART4 Gene

GENATLAS Biochemistry: ADP-ribosyltransferase 4,expressed in testis
UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine

Enzyme Numbers (IUBMB) for ART4 Gene

Gene Ontology (GO) - Molecular Function for ART4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity NAS 9119374
genes like me logo Genes that share ontologies with ART4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ART4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ART4 Gene

Localization for ART4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART4 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ART4 Gene COMPARTMENTS Subcellular localization image for ART4 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ART4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane NAS 9119374
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ART4: view

Pathways for ART4 Gene

genes like me logo Genes that share pathways with ART4: view

Interacting Proteins for ART4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000228936%0d%0a9606.ENSP00000348708%0d%0a
Selected Interacting proteins: ENSP00000228936 for ART4 Gene via STRING

Symbol External ID(s) Details
UPF2

Gene Ontology (GO) - Biological Process for ART4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation NAS 9119374
GO:0006525 arginine metabolic process NAS 11001920
genes like me logo Genes that share ontologies with ART4: view

Compounds for ART4 Gene

(5) HMDB Compounds for ART4 Gene

Compound Synonyms Cas Number PubMed IDs
L-Arginine
  • (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate
74-79-3
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
Niacinamide
  • 3-Carbamoylpyridine
98-92-0
genes like me logo Genes that share compounds with ART4: view

Transcripts for ART4 Gene

mRNA/cDNA for ART4 Gene

Unigene Clusters for ART4 Gene

ADP-ribosyltransferase 4 (Dombrock blood group):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ART4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ART4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ART4 Gene

No ASD Table

Relevant External Links for ART4 Gene

GeneLoc Exon Structure for
ART4
ECgene alternative splicing isoforms for
ART4

Expression for ART4 Gene

mRNA expression in normal human tissues for ART4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART4 Gene

This gene is overexpressed in Liver (8.6), Heart - Atrial Appendage (6.8), Artery - Coronary (6.0), Artery - Aorta (5.6), and Spleen (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ART4 Gene

SOURCE GeneReport for Unigene cluster for ART4 Gene Hs.591158

mRNA Expression by UniProt/SwissProt for ART4 Gene

Q93070-NAR4_HUMAN
Tissue specificity: Expressed in spleen and T-cells
genes like me logo Genes that share expressions with ART4: view

In Situ Assay Products

Orthologs for ART4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ART4 35
  • 99.68 (n)
  • 99.36 (a)
ART4 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ART4 35
  • 77.7 (n)
  • 66.56 (a)
ART4 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ART4 35
  • 79.38 (n)
  • 66.99 (a)
ART4 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Art4 35
  • 73.77 (n)
  • 64.26 (a)
Art4 16
Art4 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 32 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Art4 35
  • 73.9 (n)
  • 64.71 (a)
chicken
(Gallus gallus)
Aves ART4 35
  • 58.48 (n)
  • 50.86 (a)
ART4 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii art4 36
  • 29 (a)
ManyToMany
BX908804.1 36
  • 30 (a)
ManyToMany
CABZ01019904.1 36
  • 25 (a)
ManyToMany
CABZ01019905.1 36
  • 38 (a)
ManyToMany
CABZ01019905.2 36
  • 35 (a)
ManyToMany
CABZ01064699.1 36
  • 26 (a)
ManyToMany
CR846080.3 36
  • 33 (a)
ManyToMany
CR846080.4 36
  • 28 (a)
ManyToMany
CR846080.5 36
  • 35 (a)
ManyToMany
LOC100537553 35
  • 47.66 (n)
  • 41.12 (a)
si:ch211-163m16.7 36
  • 26 (a)
ManyToMany
si:ch211-51i16.1 36
  • 31 (a)
ManyToMany
si:ch211-51i16.3 36
  • 33 (a)
ManyToMany
si:ch73-379f5.5 36
  • 29 (a)
ManyToMany
Species with no ortholog for ART4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART4 Gene

ENSEMBL:
Gene Tree for ART4 (if available)
TreeFam:
Gene Tree for ART4 (if available)

Paralogs for ART4 Gene

Paralogs for ART4 Gene

Selected SIMAP similar genes for ART4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ART4: view

Variants for ART4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ART4 Gene

Q93070-NAR4_HUMAN
DO is responsible for the Dombrock blood group system [MIM:616060]. The molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)].

Sequence variations from dbSNP and Humsavar for ART4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11276 Benign, - 14,840,505(-) GAGGA(A/G)ACTGG missense, reference
rs1001096 -- 14,835,521(+) CCTTC(A/G)CTTAC intron-variant
rs1465355 -- 14,835,930(+) CATAA(A/G)AGATA intron-variant
rs1465356 -- 14,835,961(+) ACTGT(A/T)TTCAG intron-variant
rs1465357 -- 14,835,966(+) ATTCA(A/G)TAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ART4 Gene

Variant ID Type Subtype PubMed ID
nsv898817 CNV Gain 21882294
esv259518 OTHER Complex 20981092

Relevant External Links for ART4 Gene

HapMap Linkage Disequilibrium report
ART4
Human Gene Mutation Database (HGMD)
ART4
Locus Specific Mutation Databases (LSDB)
ART4

Disorders for ART4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ART4 Gene including...

Search for ART4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ART4 Gene

Relevant External Links for ART4

Genetic Association Database (GAD)
ART4
Human Genome Epidemiology (HuGE) Navigator
ART4
genes like me logo Genes that share disorders with ART4: view

No data available for UniProtKB/Swiss-Prot for ART4 Gene

Publications for ART4 Gene

  1. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. (PMID: 9119374) Koch-Nolte F. … Thiele H.-G. (Genomics 1997) 2 3 4
  2. Insights into the Holley- and Joseph- phenotypes. (PMID: 11896313) Rios M. … Reid M.E. (Transfusion 2002) 3 4
  3. Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors. (PMID: 11520417) Wu G.-G. … Zhao T.-M. (Vox Sang. 2001) 3 4
  4. Identification of the Dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family. (PMID: 11001920) Gubin A.N. … Miller J.L. (Blood 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ART4 Gene

Sources for ART4 Gene

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