Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAM11 Gene

Aliases for ADAM11 Gene

  • ADAM Metallopeptidase Domain 11 2 3 5
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 3 4
  • ADAM 11 3 4
  • MDC 3 4
  • Metalloproteinase-Like, Disintegrin-Like, Cysteine-Rich Protein 2
  • Disintegrin And Metalloproteinase Domain-Containing Protein 11 3
  • A Disintegrin And Metalloproteinase Domain 11 2

External Ids for ADAM11 Gene

Previous HGNC Symbols for ADAM11 Gene

  • MDC

Previous GeneCards Identifiers for ADAM11 Gene

  • GC17P042355
  • GC17P045013
  • GC17P042847
  • GC17P043313
  • GC17P043286
  • GC17P040192
  • GC17P038601

Summaries for ADAM11 Gene

Entrez Gene Summary for ADAM11 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for ADAM11 Gene

ADAM11 (ADAM Metallopeptidase Domain 11) is a Protein Coding gene. Among its related pathways are LGI-ADAM interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM22.

UniProtKB/Swiss-Prot for ADAM11 Gene

  • Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

Gene Wiki entry for ADAM11 Gene

Additional gene information for ADAM11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM11 Gene

Genomics for ADAM11 Gene

GeneHancer (GH) Regulatory Elements for ADAM11 Gene

Promoters and enhancers for ADAM11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I044758 Promoter 1.5 EPDnew Ensembl 550.8 +0.1 70 0.6 ZBTB10 KLF1 MAZ ZNF449 ZNF10 KLF17 ZBTB7A ZFP69B ZNF335 ZFHX2 ADAM11 GC17P044768 DBF4B
GH17I045143 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +388.9 388916 9.6 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 HEXIM1 ENSG00000276728 GC17M045149 ENSG00000262372 ASB16-AS1 UBTF TMUB2 ENSG00000224505 LINC02210 MAP3K14-AS1
GH17I045157 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 +401.4 401417 5.4 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ENSG00000224505 HEXIM2 ENSG00000262372 UBTF TMUB2 ASB16-AS1 MAP3K14-AS1 EFTUD2 ACBD4 PLCD3
GH17I044013 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.8 -744.3 -744331 1.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TMEM101 ASB16-AS1 UBTF HMGN1P29 DHX8 TMUB2 MEOX1 MPP2 LINC00910 NAGS
GH17I044781 Enhancer 0.9 Ensembl ENCODE dbSUPER 20.5 +23.2 23164 1.7 KLF1 IKZF1 GLIS1 ZNF341 REST GABPA ZNF18 ADAM11 DBF4B GJC1 HIGD1B CCDC103 EFTUD2 FAM187A GFAP MEIOC C1QL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAM11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAM11 gene promoter:

Genomic Locations for ADAM11 Gene

Genomic Locations for ADAM11 Gene
chr17:44,759,031-44,781,846
(GRCh38/hg38)
Size:
22,816 bases
Orientation:
Plus strand
chr17:42,836,399-42,859,214
(GRCh37/hg19)

Genomic View for ADAM11 Gene

Genes around ADAM11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM11 Gene

Proteins for ADAM11 Gene

  • Protein details for ADAM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75078-ADA11_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 11
    Protein Accession:
    O75078
    Secondary Accessions:
    • Q14808
    • Q14809
    • Q14810

    Protein attributes for ADAM11 Gene

    Size:
    769 amino acids
    Molecular mass:
    83418 Da
    Quaternary structure:
    • Can bind to LGI1 and LGI4.

    Alternative splice isoforms for ADAM11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM11 Gene

Post-translational modifications for ADAM11 Gene

Other Protein References for ADAM11 Gene

No data available for DME Specific Peptides for ADAM11 Gene

Domains & Families for ADAM11 Gene

Gene Families for ADAM11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

O75078

UniProtKB/Swiss-Prot:

ADA11_HUMAN :
  • A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.
Domain:
  • A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.
genes like me logo Genes that share domains with ADAM11: view

Function for ADAM11 Gene

Molecular function for ADAM11 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (inactive) domain 11,membrane anchored cell surface adhesion protein with two isoforms MDC-769,MDC-524,highly expressed in the brain,also expressed in somatic tissues
UniProtKB/Swiss-Prot Function:
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

Phenotypes From GWAS Catalog for ADAM11 Gene

Gene Ontology (GO) - Molecular Function for ADAM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 9693107
GO:0008237 metallopeptidase activity TAS,IEA 9693107
genes like me logo Genes that share ontologies with ADAM11: view
genes like me logo Genes that share phenotypes with ADAM11: view

Animal Models for ADAM11 Gene

MGI Knock Outs for ADAM11:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM11 Gene

Localization for ADAM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM11 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM11 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with ADAM11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAM11 Gene

Pathways & Interactions for ADAM11 Gene

genes like me logo Genes that share pathways with ADAM11: view

Pathways by source for ADAM11 Gene

2 Reactome pathways for ADAM11 Gene

Interacting Proteins for ADAM11 Gene

Gene Ontology (GO) - Biological Process for ADAM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007229 integrin-mediated signaling pathway IEA,TAS 8252040
genes like me logo Genes that share ontologies with ADAM11: view

No data available for SIGNOR curated interactions for ADAM11 Gene

Drugs & Compounds for ADAM11 Gene

(1) Additional Compounds for ADAM11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM11: view

Transcripts for ADAM11 Gene

Unigene Clusters for ADAM11 Gene

ADAM metallopeptidase domain 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM11 Gene

No ASD Table

Relevant External Links for ADAM11 Gene

GeneLoc Exon Structure for
ADAM11
ECgene alternative splicing isoforms for
ADAM11

Expression for ADAM11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM11 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM11 Gene

This gene is overexpressed in Brain - Cerebellum (x11.2), Brain - Cerebellar Hemisphere (x9.0), Brain - Cortex (x6.6), Brain - Frontal Cortex (BA9) (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for ADAM11 Gene

This gene is overexpressed in Frontal cortex (62.6) and Fetal Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAM11 Gene



Protein tissue co-expression partners for ADAM11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAM11 Gene:

ADAM11

SOURCE GeneReport for Unigene cluster for ADAM11 Gene:

Hs.6088

mRNA Expression by UniProt/SwissProt for ADAM11 Gene:

O75078-ADA11_HUMAN
Tissue specificity: Expressed predominantly in brain. Slightly detected or not at all in other tissues.

Evidence on tissue expression from TISSUES for ADAM11 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ADAM11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM11 Gene

Orthologs for ADAM11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM11 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia ADAM11 33 34
  • 90.34 (n)
cow
(Bos Taurus)
Mammalia ADAM11 33 34
  • 90.28 (n)
rat
(Rattus norvegicus)
Mammalia Adam11 33
  • 89.88 (n)
mouse
(Mus musculus)
Mammalia Adam11 33 16 34
  • 89.19 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAM11 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ADAM11 33 34
  • 75.86 (n)
lizard
(Anolis carolinensis)
Reptilia ADAM11 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam11 33
  • 66.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia MDC11a 33
zebrafish
(Danio rerio)
Actinopterygii adam11 33 34
  • 62.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta mmd 35 33 34
  • 47.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000974 33
  • 46.41 (n)
worm
(Caenorhabditis elegans)
Secernentea adm-1 35
  • 28 (a)
unc-71 34
  • 19 (a)
OneToMany
Species where no ortholog for ADAM11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM11 Gene

ENSEMBL:
Gene Tree for ADAM11 (if available)
TreeFam:
Gene Tree for ADAM11 (if available)

Paralogs for ADAM11 Gene

Paralogs for ADAM11 Gene

(9) SIMAP similar genes for ADAM11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ADAM11: view

Variants for ADAM11 Gene

Sequence variations from dbSNP and Humsavar for ADAM11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_062669 A pancreatic ductal adenocarcinoma sample p.Ser693Arg
rs1000181008 -- 44,761,246(+) A/G intron_variant
rs1000341692 -- 44,759,555(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000429598 -- 44,773,745(+) G/C intron_variant
rs1000609448 -- 44,780,391(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM11 Gene

Variant ID Type Subtype PubMed ID
esv3554459 CNV deletion 23714750
esv3893016 CNV loss 25118596
nsv1067206 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv833456 CNV gain+loss 17160897

Variation tolerance for ADAM11 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM11 Gene

Disorders for ADAM11 Gene

Additional Disease Information for ADAM11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADAM11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM11 Gene

Publications for ADAM11 Gene

  1. A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers. (PMID: 8252040) Emi M … Nakamura Y (Nature genetics 1993) 2 3 4 22 58
  2. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PMID: 9693107) Sagane K … Tanaka I (The Biochemical journal 1998) 3 4 22 58
  3. Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing. (PMID: 7956356) Katagiri T … Nakamura Y (Cytogenetics and cell genetics 1995) 3 4 22 58
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4 58
  5. ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students. (PMID: 11545539) Shea SH … Li TK (Behavior genetics 2001) 3 44 58

Products for ADAM11 Gene

Sources for ADAM11 Gene

Content
Loading form....