Aliases for ADAM11 Gene
- ADAM Metallopeptidase Domain 11 2 3 5
- Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 3 4
- ADAM 11 3 4
- MDC 3 4
- Metalloproteinase-Like, Disintegrin-Like, Cysteine-Rich Protein 2
- Disintegrin And Metalloproteinase Domain-Containing Protein 11 3
- A Disintegrin And Metalloproteinase Domain 11 2
External Ids for ADAM11 Gene
Previous HGNC Symbols for ADAM11 Gene
Previous GeneCards Identifiers for ADAM11 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for ADAM11 Gene
ADAM11 (ADAM Metallopeptidase Domain 11) is a Protein Coding gene. Among its related pathways are LGI-ADAM interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM22.
UniProtKB/Swiss-Prot for ADAM11 Gene
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.