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Aliases for MCM3 Gene

Aliases for MCM3 Gene

  • Minichromosome Maintenance Complex Component 3 2 3
  • DNA Polymerase Alpha Holoenzyme-Associated Protein P1 3 4
  • RLF Subunit Beta 3 4
  • P1-MCM3 3 4
  • P102 3 4
  • MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 3 2
  • MCM3 Minichromosome Maintenance Deficient 3 3
  • Replication Licensing Factor, Beta Subunit 3
  • Minichromosome Maintenance Deficient 3 3
  • DNA Replication Licensing Factor MCM3 3
  • Cervical Cancer Proto-Oncogene 5 3
  • DNA Replication Factor MCM3 3
  • HRlf Beta Subunit 3
  • EC 3.6.4.12 4
  • HCC5 3
  • P1.H 3
  • RLFB 3

External Ids for MCM3 Gene

Previous GeneCards Identifiers for MCM3 Gene

  • GC06M052130
  • GC06M052175
  • GC06M051960
  • GC06M052128

Summaries for MCM3 Gene

Entrez Gene Summary for MCM3 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MCM3 Gene

MCM3 (Minichromosome Maintenance Complex Component 3) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include DNA helicase activity.

UniProtKB/Swiss-Prot for MCM3 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation

Gene Wiki entry for MCM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM3 Gene

Genomics for MCM3 Gene

Regulatory Elements for MCM3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MCM3 Gene

Start:
52,264,009 bp from pter
End:
52,284,881 bp from pter
Size:
20,873 bases
Orientation:
Minus strand

Genomic View for MCM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MCM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM3 Gene

Proteins for MCM3 Gene

  • Protein details for MCM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25205-MCM3_HUMAN
    Recommended name:
    DNA replication licensing factor MCM3
    Protein Accession:
    P25205
    Secondary Accessions:
    • B4DWW4
    • Q92660
    • Q9BTR3
    • Q9NUE7

    Protein attributes for MCM3 Gene

    Size:
    808 amino acids
    Molecular mass:
    90981 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Associated with the replication-specific DNA polymerase alpha. Interacts with MCMBP. Interacts with ANKRD17.
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex

    Alternative splice isoforms for MCM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM3 Gene

Proteomics data for MCM3 Gene at MOPED

Post-translational modifications for MCM3 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Ubiquitination at Lys35, Lys266, Lys293, Lys301, Lys351, Lys463, Lys579, Lys635, and Lys748
  • Modification sites at PhosphoSitePlus

Other Protein References for MCM3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MCM3 (MCM3)

No data available for DME Specific Peptides for MCM3 Gene

Domains for MCM3 Gene

Graphical View of Domain Structure for InterPro Entry

P25205

UniProtKB/Swiss-Prot:

MCM3_HUMAN :
  • P25205
Domain:
  • Contains 1 MCM domain.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM3: view

No data available for Gene Families for MCM3 Gene

Function for MCM3 Gene

Molecular function for MCM3 Gene

GENATLAS Biochemistry: cell division cycle,early S-phase-like-3,participating in the cell cycle control of genome duplication
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation

Enzyme Numbers (IUBMB) for MCM3 Gene

Gene Ontology (GO) - Molecular Function for MCM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003678 DNA helicase activity IEA --
GO:0005515 protein binding IPI 12364596
GO:0005524 ATP binding IEA --
GO:0016851 magnesium chelatase activity --
genes like me logo Genes that share ontologies with MCM3: view
genes like me logo Genes that share phenotypes with MCM3: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MCM3 Gene

Localization for MCM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCM3 Gene COMPARTMENTS Subcellular localization image for MCM3 gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for MCM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20531406
GO:0005654 nucleoplasm TAS --
GO:0005658 alpha DNA polymerase:primase complex TAS 1549468
GO:0005737 cytoplasm --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with MCM3: view

Pathways for MCM3 Gene

genes like me logo Genes that share pathways with MCM3: view

Pathways by source for MCM3 Gene

1 Qiagen pathway for MCM3 Gene
1 Cell Signaling Technology pathway for MCM3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MCM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006270 DNA replication initiation IEA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
genes like me logo Genes that share ontologies with MCM3: view

Compounds for MCM3 Gene

(1) Novoseek inferred chemical compound relationships for MCM3 Gene

Compound -log(P) Hits PubMed IDs
estrogen 0 2
genes like me logo Genes that share compounds with MCM3: view

Transcripts for MCM3 Gene

Unigene Clusters for MCM3 Gene

Minichromosome maintenance complex component 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MCM3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCM3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1: - - -
SP2:
SP3: -
SP4: - - - - - - - - - - - - -
SP5: - -
SP6:
SP7: - - - - - - - - -
SP8:
SP9: - - - -
SP10: - - -
SP11: - -
SP12:
SP13:

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MCM3 Gene

GeneLoc Exon Structure for
MCM3
ECgene alternative splicing isoforms for
MCM3

Expression for MCM3 Gene

mRNA expression in normal human tissues for MCM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCM3 Gene

SOURCE GeneReport for Unigene cluster for MCM3 Gene Hs.179565

genes like me logo Genes that share expressions with MCM3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MCM3 Gene

Orthologs for MCM3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM3 35
  • 99.73 (n)
  • 99.77 (a)
MCM3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MCM3 35
  • 89.48 (n)
  • 95.67 (a)
MCM3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MCM3 35
  • 92.08 (n)
  • 97.52 (a)
MCM3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm3 35
  • 88.32 (n)
  • 93.79 (a)
Mcm3 16
Mcm3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCM3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MCM3 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcm3 35
  • 87.78 (n)
  • 94.29 (a)
chicken
(Gallus gallus)
Aves MCM3 35
  • 77.1 (n)
  • 81.81 (a)
MCM3 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCM3 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mcm3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zmcm3 35
  • 73.06 (n)
  • 79.58 (a)
zebrafish
(Danio rerio)
Actinopterygii mcm3 35
  • 71.76 (n)
  • 76.27 (a)
mcm3 36
  • 75 (a)
OneToMany
mcm3 36
  • 75 (a)
OneToMany
mcm3l 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001135 35
  • 61.44 (n)
  • 66.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mcm3 35
  • 62 (n)
  • 64.71 (a)
Mcm3 36
  • 61 (a)
OneToOne
Mcm3 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea mcm-3 36
  • 45 (a)
OneToOne
mcm-3 37
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR355C 35
  • 56.02 (n)
  • 54.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM3 35
  • 54.69 (n)
  • 54.43 (a)
MCM3 36
  • 38 (a)
OneToOne
MCM3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22243g 35
  • 53.34 (n)
  • 52.64 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MCM3 35
  • 54.61 (n)
  • 52.05 (a)
corn
(Zea mays)
Liliopsida Zm.174 35
rice
(Oryza sativa)
Liliopsida Os.23359 35
Os05g0476200 35
  • 54.93 (n)
  • 51.87 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14537 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08009 35
  • 57.87 (n)
  • 53.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm3 35
  • 55.28 (n)
  • 54.73 (a)
Species with no ortholog for MCM3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM3 Gene

ENSEMBL:
Gene Tree for MCM3 (if available)
TreeFam:
Gene Tree for MCM3 (if available)

Paralogs for MCM3 Gene

Selected SIMAP similar genes for MCM3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MCM3 Gene

genes like me logo Genes that share paralogs with MCM3: view

No data available for Paralogs for MCM3 Gene

Variants for MCM3 Gene

Sequence variations from dbSNP and Humsavar for MCM3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1737748 -- 52,263,675(-) ATACC(C/T)GATAC downstream-variant-500B
rs1781010 -- 52,263,697(+) GAAGG(A/G)TAAGT downstream-variant-500B
rs1803760 -- 52,264,150(-) CTGAG(G/T)CACGT utr-variant-3-prime
rs2073036 -- 52,279,283(-) TTGCC(A/G)TATTC intron-variant
rs2076509 -- 52,267,243(-) CAGGC(A/G)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MCM3 Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV Gain 17160897

Relevant External Links for MCM3 Gene

HapMap Linkage Disequilibrium report
MCM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM3 Gene

Disorders for MCM3 Gene

(6) Novoseek inferred disease relationships for MCM3 Gene

Disease -log(P) Hits PubMed IDs
anaplastic astrocytoma 44.2 1
breast cancer 0 1
tumors 0 6
carcinoma 0 2
melanoma 0 1

Relevant External Links for MCM3

Genetic Association Database (GAD)
MCM3
Human Genome Epidemiology (HuGE) Navigator
MCM3
genes like me logo Genes that share disorders with MCM3: view

No data available for UniProtKB/Swiss-Prot for MCM3 Gene

Publications for MCM3 Gene

  1. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PMID: 15210935) Cortez D. … Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  2. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe A.M. … Frappier L. (Mol. Cell. Biol. 2007) 3 4 23
  3. Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. (PMID: 1549468) Thoemmes P. … Knippers R. (Nucleic Acids Res. 1992) 2 3 4
  4. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. (PMID: 7758114) Kubota Y. … Nojima H. (Cell 1995) 3 4
  5. Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease. (PMID: 10780780) Hofmann Y. … Onuchic L.F. (Eur. J. Hum. Genet. 2000) 3 23

Products for MCM3 Gene

Sources for MCM3 Gene

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