Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MCAM Gene

Aliases for MCAM Gene

  • Melanoma Cell Adhesion Molecule 2 3 4 5
  • S-Endo 1 Endothelial-Associated Antigen 3 4
  • Melanoma-Associated Antigen MUC18 3 4
  • Cell Surface Glycoprotein P1H12 3 4
  • Melanoma-Associated Antigen A32 3 4
  • Gicerin 2 3
  • MUC18 3 4
  • Melanoma Adhesion Molecule 3
  • CD146 Antigen 4
  • CD146 3

External Ids for MCAM Gene

Previous GeneCards Identifiers for MCAM Gene

  • GC11P121109
  • GC11M120690
  • GC11M119212
  • GC11M118716
  • GC11M118684
  • GC11M119179
  • GC11M115119

Summaries for MCAM Gene

GeneCards Summary for MCAM Gene

MCAM (Melanoma Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with MCAM include Melanoma and Epithelioid Cell Melanoma. Among its related pathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Adhesion. An important paralog of this gene is AGER.

UniProtKB/Swiss-Prot for MCAM Gene

  • Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene Wiki entry for MCAM Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCAM Gene

Genomics for MCAM Gene

Regulatory Elements for MCAM Gene

Enhancers for MCAM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MCAM on UCSC Golden Path with GeneCards custom track

Promoters for MCAM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MCAM on UCSC Golden Path with GeneCards custom track

Genomic Location for MCAM Gene

Chromosome:
11
Start:
119,308,524 bp from pter
End:
119,321,521 bp from pter
Size:
12,998 bases
Orientation:
Minus strand

Genomic View for MCAM Gene

Genes around MCAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCAM Gene

Proteins for MCAM Gene

  • Protein details for MCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43121-MUC18_HUMAN
    Recommended name:
    Cell surface glycoprotein MUC18
    Protein Accession:
    P43121
    Secondary Accessions:
    • O95812
    • Q59E86
    • Q6PHR3
    • Q6ZTR2

    Protein attributes for MCAM Gene

    Size:
    646 amino acids
    Molecular mass:
    71607 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD93162.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MCAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCAM Gene

Proteomics data for MCAM Gene at MOPED

Post-translational modifications for MCAM Gene

  • Glycosylation at Asn 56, Asn 418, Asn 449, Asn 467, Asn 508, Asn 518, Asn 527, and Asn 544
  • Modification sites at PhosphoSitePlus

Other Protein References for MCAM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MCAM (MCAM)
  • Abcam antibodies for CD146

No data available for DME Specific Peptides for MCAM Gene

Domains & Families for MCAM Gene

Suggested Antigen Peptide Sequences for MCAM Gene

Graphical View of Domain Structure for InterPro Entry

P43121

UniProtKB/Swiss-Prot:

MUC18_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with MCAM: view

Function for MCAM Gene

Molecular function for MCAM Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
genes like me logo Genes that share phenotypes with MCAM: view

Animal Models for MCAM Gene

MGI Knock Outs for MCAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for MCAM

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCAM Gene

Localization for MCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCAM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MCAM Gene COMPARTMENTS Subcellular localization image for MCAM gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 3
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with MCAM: view

Pathways & Interactions for MCAM Gene

genes like me logo Genes that share pathways with MCAM: view

Pathways by source for MCAM Gene

1 Cell Signaling Technology pathway for MCAM Gene

Gene Ontology (GO) - Biological Process for MCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 23878390
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with MCAM: view

No data available for SIGNOR curated interactions for MCAM Gene

Drugs & Compounds for MCAM Gene

(3) Drugs for MCAM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with MCAM: view

Transcripts for MCAM Gene

Unigene Clusters for MCAM Gene

Melanoma cell adhesion molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MCAM Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - -
SP13: - - -
SP14: - - - - - -
SP15:
SP16: - - - - -
SP17: - - - - - -
SP18:

ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for MCAM Gene

GeneLoc Exon Structure for
MCAM
ECgene alternative splicing isoforms for
MCAM

Expression for MCAM Gene

mRNA expression in normal human tissues for MCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MCAM Gene

This gene is overexpressed in Artery - Tibial (x10.7), Artery - Coronary (x6.6), and Artery - Aorta (x5.1).

Protein differential expression in normal tissues from HIPED for MCAM Gene

This gene is overexpressed in Adipocyte (16.2), Seminal vesicle (7.3), and Nasopharynx (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MCAM Gene



SOURCE GeneReport for Unigene cluster for MCAM Gene Hs.599039

mRNA Expression by UniProt/SwissProt for MCAM Gene

P43121-MUC18_HUMAN
Tissue specificity: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.
genes like me logo Genes that share expression patterns with MCAM: view

Protein tissue co-expression partners for MCAM Gene

- Elite partner

Primer Products

Orthologs for MCAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCAM Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MCAM 35
  • 85.57 (n)
  • 83.66 (a)
MCAM 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mcam 35
  • 80.75 (n)
  • 76.47 (a)
Mcam 16
Mcam 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MCAM 35
  • 99.33 (n)
  • 98.92 (a)
MCAM 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcam 35
  • 81.27 (n)
  • 75.54 (a)
cow
(Bos Taurus)
Mammalia MCAM 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCAM 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves MCAM 35
  • 56.67 (n)
  • 43.65 (a)
MCAM 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCAM 36
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcam 35
  • 49.06 (n)
  • 38.77 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101884730 35
  • 50.45 (n)
  • 38.31 (a)
MCAM (2 of 3) 36
  • 35 (a)
OneToMany
MCAM (3 of 3) 36
  • 36 (a)
OneToMany
mcamb 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for MCAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCAM Gene

ENSEMBL:
Gene Tree for MCAM (if available)
TreeFam:
Gene Tree for MCAM (if available)

Paralogs for MCAM Gene

Paralogs for MCAM Gene

genes like me logo Genes that share paralogs with MCAM: view

Variants for MCAM Gene

Sequence variations from dbSNP and Humsavar for MCAM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_049915 -
rs1131437 -- 119,311,945(-) GACAG(A/G)CCAGG reference, missense
rs1131438 -- 119,310,443(-) TAAGA(C/G)CGAAC reference, missense
rs1131467 -- 119,308,968(-) AAGAT(A/G)CGTGC utr-variant-3-prime
rs1893267 -- 119,308,934(-) GTTTT(C/T)GAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MCAM Gene

Variant ID Type Subtype PubMed ID
nsv898417 CNV Loss 21882294
nsv898418 CNV Loss 21882294

Variation tolerance for MCAM Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MCAM Gene

Disorders for MCAM Gene

MalaCards: The human disease database

(4) MalaCards diseases for MCAM Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
epithelioid cell melanoma
  • epithelioid melanoma
uterine sarcoma
  • uterine corpus sarcoma
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search MCAM in MalaCards View complete list of genes associated with diseases

Relevant External Links for MCAM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MCAM
genes like me logo Genes that share disorders with MCAM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCAM Gene

Publications for MCAM Gene

  1. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. (PMID: 2602381) Lehmann J.M. … Johnson J.P. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3 4 67
  2. Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. (PMID: 10702685) Kuske M.D. … Johnson J.P. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines. (PMID: 19123925) Zabouo G. … Chabannon C. (Breast Cancer Res. 2009) 3 23
  4. Inhibition of CD146 gene expression via RNA interference reduces in vitro perineural invasion on ACC-M cell. (PMID: 19200179) Chen W. … Sun M.Y. (J. Oral Pathol. Med. 2009) 3 23
  5. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. (PMID: 19221091) Bidlingmaier S. … Liu B. (Cancer Res. 2009) 3 23

Products for MCAM Gene

Sources for MCAM Gene

Content