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Aliases for MB Gene

Aliases for MB Gene

  • Myoglobin 2 3 5
  • Myoglobgin 3
  • PVALB 3

External Ids for MB Gene

Previous GeneCards Identifiers for MB Gene

  • GC22M032646
  • GC22M034274
  • GC22M034327
  • GC22M036002
  • GC22M018967

Summaries for MB Gene

Entrez Gene Summary for MB Gene

  • This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MB Gene

MB (Myoglobin) is a Protein Coding gene. Diseases associated with MB include Acute Myocardial Infarction and Acute Kidney Tubular Necrosis. Among its related pathways are Glucose / Energy Metabolism and Effects of nitric oxide. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is CYGB.

UniProtKB/Swiss-Prot for MB Gene

  • Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Gene Wiki entry for MB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MB Gene

Genomics for MB Gene

Regulatory Elements for MB Gene

Enhancers for MB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MB on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MB gene promoter:

Genomic Location for MB Gene

35,606,764 bp from pter
35,637,951 bp from pter
31,188 bases
Minus strand

Genomic View for MB Gene

Genes around MB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MB Gene

Proteins for MB Gene

  • Protein details for MB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q52H51
    • Q5THY7

    Protein attributes for MB Gene

    154 amino acids
    Molecular mass:
    17184 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MB Gene

neXtProt entry for MB Gene

Proteomics data for MB Gene at MOPED

Post-translational modifications for MB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MB Gene

Domains & Families for MB Gene

Protein Domains for MB Gene

Suggested Antigen Peptide Sequences for MB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the globin family.
  • Belongs to the globin family.
genes like me logo Genes that share domains with MB: view

No data available for Gene Families for MB Gene

Function for MB Gene

Molecular function for MB Gene

GENATLAS Biochemistry:
myoglobin,17.5kDa,muscle oxygen-carrying hemoprotein,non covalently
UniProtKB/Swiss-Prot Function:
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Gene Ontology (GO) - Molecular Function for MB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005344 oxygen transporter activity IEA --
GO:0019825 oxygen binding IEA --
genes like me logo Genes that share ontologies with MB: view
genes like me logo Genes that share phenotypes with MB: view

Animal Models for MB Gene

MGI Knock Outs for MB:
  • Mb tm1Wlm
  • Mb tm1Jsc

Animal Model Products

miRNA for MB Gene

miRTarBase miRNAs that target MB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MB Gene

Localization for MB Gene

Subcellular locations from

Jensen Localization Image for MB Gene COMPARTMENTS Subcellular localization image for MB gene
Compartment Confidence
extracellular 5
cytosol 4
cytoskeleton 3
mitochondrion 3
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MB Gene

Pathways & Interactions for MB Gene

genes like me logo Genes that share pathways with MB: view

Pathways by source for MB Gene

1 Cell Signaling Technology pathway for MB Gene
1 BioSystems pathway for MB Gene

Interacting Proteins for MB Gene

Gene Ontology (GO) - Biological Process for MB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007507 heart development IEA --
GO:0015671 oxygen transport IEA --
GO:0031444 slow-twitch skeletal muscle fiber contraction IEA --
GO:0042542 response to hydrogen peroxide IEA --
genes like me logo Genes that share ontologies with MB: view

No data available for SIGNOR curated interactions for MB Gene

Drugs & Compounds for MB Gene

(71) Drugs for MB Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Methylimidazole Experimental Pharma Target 0
4-Methylimidazole Experimental Pharma Target 0
6,7-Dicarboxyl-1,2,3,4,5,8-Hexamethylhemin Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0
biliverdin Experimental Pharma Target 0

(67) Additional Compounds for MB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
genes like me logo Genes that share compounds with MB: view

Transcripts for MB Gene

Unigene Clusters for MB Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - -
SP6: - -
SP7: -

Relevant External Links for MB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MB Gene

mRNA expression in normal human tissues for MB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MB Gene

This gene is overexpressed in Muscle - Skeletal (x23.8), Heart - Left Ventricle (x17.4), and Heart - Atrial Appendage (x10.9).

Protein differential expression in normal tissues from HIPED for MB Gene

This gene is overexpressed in Tonsil (42.8), Heart (11.3), and Oral epithelium (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MB Gene

SOURCE GeneReport for Unigene cluster for MB Gene Hs.517586

genes like me logo Genes that share expression patterns with MB: view

Protein tissue co-expression partners for MB Gene

- Elite partner

No data available for mRNA Expression by UniProt/SwissProt for MB Gene

Orthologs for MB Gene

This gene was present in the common ancestor of chordates.

Orthologs for MB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MB 35
  • 86.15 (n)
  • 84.42 (a)
MB 36
  • 84 (a)
(Canis familiaris)
Mammalia MB 35
  • 88.53 (n)
  • 85.71 (a)
MB 36
  • 86 (a)
(Mus musculus)
Mammalia Mb 35
  • 83.77 (n)
  • 83.77 (a)
Mb 16
Mb 36
  • 84 (a)
(Pan troglodytes)
Mammalia MB 35
  • 98.92 (n)
  • 99.35 (a)
MB 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mb 35
  • 83.98 (n)
  • 83.12 (a)
(Ornithorhynchus anatinus)
Mammalia MB 36
  • 84 (a)
(Gallus gallus)
Aves MB 35
  • 74.24 (n)
  • 76.62 (a)
MB 36
  • 77 (a)
(Anolis carolinensis)
Reptilia MB 36
  • 71 (a)
(Danio rerio)
Actinopterygii mb 35
  • 54.55 (n)
  • 44.06 (a)
mb 36
  • 41 (a)
Species with no ortholog for MB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MB Gene

Gene Tree for MB (if available)
Gene Tree for MB (if available)

Paralogs for MB Gene

Paralogs for MB Gene

genes like me logo Genes that share paralogs with MB: view

Variants for MB Gene

Sequence variations from dbSNP and Humsavar for MB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_003180 -
VAR_003181 -
rs142225854 - 35,607,343(+) CCTTC(C/T)GGAAC reference, missense
VAR_003183 -
rs7292 -- 35,610,998(-) GCCAC(C/T)GTGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MB Gene

Variant ID Type Subtype PubMed ID
nsv834184 CNV Loss 17160897
nsv510806 CNV Loss 20534489

Variation tolerance for MB Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MB Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MB Gene

Disorders for MB Gene

MalaCards: The human disease database

(78) MalaCards diseases for MB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myocardial infarction
acute kidney tubular necrosis
  • acute renal failure with lesion of tubular necrosis
malignant hyperthermia
  • anesthesia related hyperthermia
compartment syndrome
  • compartmental syndrome, nos
- elite association - COSMIC cancer census association via MalaCards
Search MB in MalaCards View complete list of genes associated with diseases

Relevant External Links for MB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MB Gene

Publications for MB Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 67
  2. Expression and functional regulation of myoglobin in epithelial cancers. (PMID: 19541931) Flonta S.E. … Bardelli A. (Am. J. Pathol. 2009) 3 23
  3. Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle. (PMID: 17311997) Robach P. … Lundby C. (Blood 2007) 3 23
  4. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  5. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26

Products for MB Gene

Sources for MB Gene