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Aliases for MB Gene

Aliases for MB Gene

  • Myoglobin 2 3
  • Myoglobgin 3
  • PVALB 3

External Ids for MB Gene

Previous GeneCards Identifiers for MB Gene

  • GC22M032646
  • GC22M034274
  • GC22M034327
  • GC22M036002
  • GC22M018967

Summaries for MB Gene

Entrez Gene Summary for MB Gene

  • This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MB Gene

MB (Myoglobin) is a Protein Coding gene. Diseases associated with MB include anuria and malignant triton tumor. Among its related pathways are Effects of nitric oxide. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is CYGB.

UniProtKB/Swiss-Prot for MB Gene

  • Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles

Gene Wiki entry for MB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MB Gene

Genomics for MB Gene

Regulatory Elements for MB Gene

Transcription factor binding sites by QIAGEN in the MB gene promoter:

Genomic Location for MB Gene

Start:
35,606,764 bp from pter
End:
35,637,951 bp from pter
Size:
31,188 bases
Orientation:
Minus strand

Genomic View for MB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MB Gene

Proteins for MB Gene

  • Protein details for MB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02144-MYG_HUMAN
    Recommended name:
    Myoglobin
    Protein Accession:
    P02144
    Secondary Accessions:
    • Q52H51
    • Q5THY7

    Protein attributes for MB Gene

    Size:
    154 amino acids
    Molecular mass:
    17184 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MB Gene

neXtProt entry for MB Gene

Proteomics data for MB Gene at MOPED

Post-translational modifications for MB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MB Gene

Domains for MB Gene

Protein Domains for MB Gene

Suggested Antigen Peptide Sequences for MB Gene

Graphical View of Domain Structure for InterPro Entry

P02144

UniProtKB/Swiss-Prot:

MYG_HUMAN :
  • P02144
Family:
  • Belongs to the globin family.
genes like me logo Genes that share domains with MB: view

No data available for Gene Families for MB Gene

Function for MB Gene

Molecular function for MB Gene

GENATLAS Biochemistry: myoglobin,17.5kDa,muscle oxygen-carrying hemoprotein,non covalently
UniProtKB/Swiss-Prot Function: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles

Gene Ontology (GO) - Molecular Function for MB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005344 oxygen transporter activity IEA --
GO:0005506 iron ion binding IEA --
GO:0019825 oxygen binding IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with MB: view
genes like me logo Genes that share phenotypes with MB: view

Animal Models for MB Gene

MGI Knock Outs for MB:
  • Mb tm1Wlm
  • Mb tm1Jsc

miRNA for MB Gene

miRTarBase miRNAs that target MB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MB Gene

Localization for MB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MB Gene COMPARTMENTS Subcellular localization image for MB gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 3
extracellular 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MB Gene

Pathways for MB Gene

SuperPathways for MB Gene

Superpath Contained pathways
1 Effects of nitric oxide
genes like me logo Genes that share pathways with MB: view

Pathways by source for MB Gene

1 BioSystems pathway for MB Gene

Interacting Proteins for MB Gene

Gene Ontology (GO) - Biological Process for MB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0007507 heart development IEA --
GO:0009725 response to hormone IEA --
GO:0015671 oxygen transport IEA --
GO:0031444 slow-twitch skeletal muscle fiber contraction IEA --
genes like me logo Genes that share ontologies with MB: view

Compounds for MB Gene

(2) HMDB Compounds for MB Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
Oxygen
  • Oxygen
7782-44-7

(14) Drugbank Compounds for MB Gene

(124) Novoseek inferred chemical compound relationships for MB Gene

Compound -log(P) Hits PubMed IDs
creatinine 83.9 247
de-oxy 81.8 27
fe2+ 71.9 35
histidine 71.2 69
oxygen 66.1 154
genes like me logo Genes that share compounds with MB: view

Transcripts for MB Gene

Unigene Clusters for MB Gene

Myoglobin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5:
SP6: - -
SP7: -

Relevant External Links for MB Gene

GeneLoc Exon Structure for
MB
ECgene alternative splicing isoforms for
MB

Expression for MB Gene

mRNA expression in normal human tissues for MB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MB Gene

This gene is overexpressed in Muscle - Skeletal (23.8), Heart - Left Ventricle (17.4), and Heart - Atrial Appendage (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MB Gene

SOURCE GeneReport for Unigene cluster for MB Gene Hs.517586

genes like me logo Genes that share expressions with MB: view

No data available for mRNA Expression by UniProt/SwissProt for MB Gene

Orthologs for MB Gene

This gene was present in the common ancestor of chordates.

Orthologs for MB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MB 35
  • 98.92 (n)
  • 99.35 (a)
MB 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MB 35
  • 86.15 (n)
  • 84.42 (a)
MB 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MB 35
  • 88.53 (n)
  • 85.71 (a)
MB 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mb 35
  • 83.77 (n)
  • 83.77 (a)
Mb 16
Mb 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MB 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mb 35
  • 83.98 (n)
  • 83.12 (a)
chicken
(Gallus gallus)
Aves MB 35
  • 74.24 (n)
  • 76.62 (a)
MB 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MB 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mb 35
  • 54.55 (n)
  • 44.06 (a)
mb 36
  • 41 (a)
OneToOne
Species with no ortholog for MB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MB Gene

ENSEMBL:
Gene Tree for MB (if available)
TreeFam:
Gene Tree for MB (if available)

Paralogs for MB Gene

Paralogs for MB Gene

genes like me logo Genes that share paralogs with MB: view

Variants for MB Gene

Sequence variations from dbSNP and Humsavar for MB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs7292 -- 35,610,998(-) GCCAC(C/T)GTGCT reference, synonymous-codon
rs7293 -- 35,611,028(-) AAGGC(A/G)TCTGA synonymous-codon, reference
rs762911 -- 35,612,648(-) CAAAA(G/T)GGCGT intron-variant
rs916230 -- 35,613,184(-) ACCTC(G/T)GACCA intron-variant
rs1056680 -- 35,607,006(-) ACCGA(A/G)CTTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MB Gene

Variant ID Type Subtype PubMed ID
nsv834184 CNV Loss 17160897
nsv510806 CNV Loss 20534489

Relevant External Links for MB Gene

HapMap Linkage Disequilibrium report
MB
Human Gene Mutation Database (HGMD)
MB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MB Gene

Disorders for MB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (18) Diseases for MB Gene including...

Search for MB Gene in MalaCards »

(96) Novoseek inferred disease relationships for MB Gene

Disease -log(P) Hits PubMed IDs
rhabdomyolysis 85.7 77
acute myocardial infarction 76 137
rhabdomyolysis exertional acute 70.1 2
renal failure acute 70 42
rhabdomyosarcoma 68.3 9

Relevant External Links for MB

Genetic Association Database (GAD)
MB
Human Genome Epidemiology (HuGE) Navigator
MB
genes like me logo Genes that share disorders with MB: view

No data available for UniProtKB/Swiss-Prot for MB Gene

Publications for MB Gene

  1. Cloning of the human myoglobin gene. (PMID: 2989088) Akaboshi E. (Gene 1985) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  3. The myoglobin of primates. I. Hylobates agilis (gibbon). (PMID: 11452891) Romero-Herrera A.E. … Lehmann H. (Biochim. Biophys. Acta 1971) 3 4
  4. Serum myoglobin/carbonic anhydrase III ratio in the diagnosis of perioperative myocardial infarction during coronary bypass surgery. (PMID: 12745799) Vuotikka P. … Peuhkurinen K. (Scand. Cardiovasc. J. 2003) 3 23
  5. Organization of the human myoglobin gene. (PMID: 6571704) Weller P. … Blanchetot A. (EMBO J. 1984) 3 4

Products for MB Gene

Sources for MB Gene

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