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Aliases for MAX Gene

Aliases for MAX Gene

  • MYC Associated Factor X 2 3
  • Class D Basic Helix-Loop-Helix Protein 4 3 4
  • BHLHd4 3 4
  • Myc-Associated Factor X 4
  • MAX Protein 2
  • Protein Max 3

External Ids for MAX Gene

Summaries for MAX Gene

Entrez Gene Summary for MAX Gene

  • The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for MAX Gene

MAX (MYC Associated Factor X) is a Protein Coding gene. Diseases associated with MAX include max-related susceptibility to pheochromocytoma and max-related hereditary paraganglioma-pheochromocytoma syndrome. Among its related pathways are MAPK signaling pathway and Pathways in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for MAX Gene

  • Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5-CAC[GA]TG-3. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity

Gene Wiki entry for MAX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAX Gene

Genomics for MAX Gene

Genomic Location for MAX Gene

Start:
65,006,101 bp from pter
End:
65,102,695 bp from pter
Size:
96,595 bases
Orientation:
Minus strand

Genomic View for MAX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAX Gene

Regulatory Elements for MAX Gene

Proteins for MAX Gene

  • Protein details for MAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61244-MAX_HUMAN
    Recommended name:
    Protein max
    Protein Accession:
    P61244
    Secondary Accessions:
    • A6NH73
    • A8K265
    • A8K4G4
    • A8K824
    • P25912
    • P52163
    • Q14803
    • Q96CY8

    Protein attributes for MAX Gene

    Size:
    160 amino acids
    Molecular mass:
    18275 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity.

    Three dimensional structures from OCA and Proteopedia for MAX Gene

    Alternative splice isoforms for MAX Gene

neXtProt entry for MAX Gene

Proteomics data for MAX Gene at MOPED

Post-translational modifications for MAX Gene

  • Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys66

No data available for DME Specific Peptides for MAX Gene

Domains for MAX Gene

Gene Families for MAX Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for MAX Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MAX_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • P61244
Family:
  • Belongs to the MAX family.:
    • P61244
genes like me logo Genes that share domains with MAX: view

Function for MAX Gene

Molecular function for MAX Gene

GENATLAS Biochemistry: Max protein,heterodimerizing with MYC,with high affinity for the DNA-binding site of MYC,binds to MAD and MNT
UniProtKB/Swiss-Prot Function: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5-CAC[GA]TG-3. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity

Gene Ontology (GO) - Molecular Function for MAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0003712 transcription cofactor activity TAS 8425218
GO:0003713 transcription coactivator activity TAS 2006410
GO:0005515 protein binding IPI 10597290
genes like me logo Genes that share ontologies with MAX: view
genes like me logo Genes that share phenotypes with MAX: view

Animal Models for MAX Gene

MGI Knock Outs for MAX:

miRNA for MAX Gene

miRTarBase miRNAs that target MAX
Targeting motifs for MAX Gene
HOMER Transcription Factor Regulatory Elements motif MAX
  • Consensus sequence: ACCACGTGGTCN Submotif: canonical Cell Type: K562 GeoId: GSE31477

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for MAX Gene

Localization for MAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAX Gene

Nucleus. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAX Gene COMPARTMENTS Subcellular localization image for MAX gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15358760
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016605 PML body IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with MAX: view

Pathways for MAX Gene

genes like me logo Genes that share pathways with MAX: view

Gene Ontology (GO) - Biological Process for MAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8425218
GO:0006461 protein complex assembly IEA --
GO:0009267 cellular response to starvation IEA --
GO:0010243 response to organonitrogen compound --
genes like me logo Genes that share ontologies with MAX: view

Compounds for MAX Gene

(3) Novoseek inferred chemical compound relationships for MAX Gene

Compound -log(P) Hits PubMed IDs
leucine 72.4 20
lysine 13.1 1
forskolin 6.59 1
genes like me logo Genes that share compounds with MAX: view

Transcripts for MAX Gene

Unigene Clusters for MAX Gene

MYC associated factor X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for MAX Gene

GeneLoc Exon Structure for
MAX
ECgene alternative splicing isoforms for
MAX

Expression for MAX Gene

mRNA expression in normal human tissues for MAX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAX Gene

SOURCE GeneReport for Unigene cluster for MAX Gene Hs.285354

mRNA Expression by UniProt/SwissProt for MAX Gene

P61244-MAX_HUMAN
Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle
genes like me logo Genes that share expressions with MAX: view

Orthologs for MAX Gene

This gene was present in the common ancestor of animals.

Orthologs for MAX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAX 36
  • 100 (n)
  • 100 (a)
MAX 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAX 36
  • 98.12 (n)
  • 99.37 (a)
MAX 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAX 36
  • 98.33 (n)
  • 100 (a)
MAX 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Max 36
  • 96.04 (n)
  • 99.37 (a)
Max 16
Max 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAX 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAX 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Max 36
  • 95.83 (n)
  • 98.75 (a)
chicken
(Gallus gallus)
Aves MAX 36
  • 84.17 (n)
  • 94.96 (a)
MAX 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia max-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia max 36
  • 81.36 (n)
  • 93.7 (a)
Str.4058 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11119 36
zebrafish
(Danio rerio)
Actinopterygii max 36
  • 79.58 (n)
  • 85 (a)
max 37
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Max 37
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mxl-1 37
  • 35 (a)
OneToMany
mxl-3 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2903 37
  • 57 (a)
OneToOne
Species with no ortholog for MAX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAX Gene

ENSEMBL:
Gene Tree for MAX (if available)
TreeFam:
Gene Tree for MAX (if available)

Paralogs for MAX Gene

Pseudogenes.org Pseudogenes for MAX Gene

genes like me logo Genes that share paralogs with MAX: view

No data available for Paralogs for MAX Gene

Variants for MAX Gene

Sequence variations from dbSNP and Humsavar for MAX Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs762809 -- 65,076,566(-) ACCAT(C/T)TCTGC intron-variant, reference, synonymous-codon, utr-variant-3-prime, nc-transcript-variant
rs762810 -- 65,077,649(-) TTGGG(G/T)CTCAG intron-variant
rs942626 -- 65,083,364(-) ACTTC(A/G)TCTGA downstream-variant-500B, intron-variant
rs942627 -- 65,083,307(-) TTCTA(C/T)TTAGA downstream-variant-500B, intron-variant
rs942628 -- 65,072,745(-) CTCAG(C/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAX Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv832816 CNV Gain 17160897
esv2506970 CNV Deletion 19546169
esv2748787 CNV Deletion 23290073
esv2665422 CNV Deletion 23128226
esv2748788 CNV Deletion 23290073
esv2673460 CNV Deletion 23128226
esv2748789 CNV Deletion 23290073

Relevant External Links for MAX Gene

HapMap Linkage Disequilibrium report
MAX
Human Gene Mutation Database (HGMD)
MAX

Disorders for MAX Gene

(1) OMIM Diseases for MAX Gene (154950)

(4) Novoseek inferred disease relationships for MAX Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia 26.8 1
pheochromocytoma 11.8 2
tumors 8.83 7
cancer 0 1

Relevant External Links for MAX

Genetic Association Database (GAD)
MAX
Human Genome Epidemiology (HuGE) Navigator
MAX
Tumor Gene Database (TGDB):
MAX
genes like me logo Genes that share disorders with MAX: view

No data available for UniProtKB/Swiss-Prot for MAX Gene

Publications for MAX Gene

  1. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. (PMID: 2006410) Blackwood E.M. … Eisenman R.N. (Science 1991) 3 4 23
  2. The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. (PMID: 9115440) Brownlie P. … Suck D. (Structure 1997) 3 4 23
  3. Max is acetylated by p300 at several nuclear localization residues. (PMID: 17217336) Faiola F. … Martinez E. (Biochem. J. 2007) 3 4 23
  4. The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression. (PMID: 17471507) Zhang Y. … DeWille J. (J. Cell. Biochem. 2007) 3 23
  5. Small-molecule perturbation of competing interactions between c-Myc and Max. (PMID: 19114306) Follis A.V. … Metallo S.J. (Bioorg. Med. Chem. Lett. 2009) 3 23

Products for MAX Gene

Sources for MAX Gene

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