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Aliases for MATK Gene

Aliases for MATK Gene

  • Megakaryocyte-Associated Tyrosine Kinase 2 3 5
  • Hematopoietic Consensus Tyrosine-Lacking Kinase 2 3 4
  • Tyrosine-Protein Kinase CTK 2 3 4
  • Protein Kinase HYL 2 3 4
  • Leukocyte Carboxyl-Terminal Src Kinase Related 2 3
  • Csk-Type Protein Tyrosine Kinase 2 3
  • Hydroxyaryl-Protein Kinase 2 3
  • Tyrosylprotein Kinase 2 3
  • Csk-Homologous Kinase 2 3
  • CSK Homologous Kinase 3 4
  • Tyrosine Kinase MATK 2 3
  • HYL Tyrosine Kinase 2 3
  • EC 2.7.10.2 4 63
  • CHK 3 4
  • CTK 3 4
  • HYL 3 4
  • EC 2.7.10 63
  • HHYLTK 3
  • HYLTK 3
  • LSK 3

External Ids for MATK Gene

Previous GeneCards Identifiers for MATK Gene

  • GC19M003870
  • GC19M003717
  • GC19M003728
  • GC19M003542

Summaries for MATK Gene

Entrez Gene Summary for MATK Gene

  • The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MATK Gene

MATK (Megakaryocyte-Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MATK include preretinal fibrosis and regular astigmatism. Among its related pathways are Signaling by GPCR and Neurotrophic factor-mediated Trk receptor signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TXK.

UniProtKB/Swiss-Prot for MATK Gene

  • Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Gene Wiki entry for MATK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MATK Gene

Genomics for MATK Gene

Regulatory Elements for MATK Gene

Transcription factor binding sites by QIAGEN in the MATK gene promoter:

Genomic Location for MATK Gene

Chromosome:
19
Start:
3,777,969 bp from pter
End:
3,802,129 bp from pter
Size:
24,161 bases
Orientation:
Minus strand

Genomic View for MATK Gene

Genes around MATK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MATK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MATK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MATK Gene

Proteins for MATK Gene

  • Protein details for MATK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42679-MATK_HUMAN
    Recommended name:
    Megakaryocyte-associated tyrosine-protein kinase
    Protein Accession:
    P42679
    Secondary Accessions:
    • B3KNZ9
    • Q9NST8

    Protein attributes for MATK Gene

    Size:
    507 amino acids
    Molecular mass:
    56469 Da
    Quaternary structure:
    • Interacts with KIT.

    Three dimensional structures from OCA and Proteopedia for MATK Gene

    Alternative splice isoforms for MATK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MATK Gene

Proteomics data for MATK Gene at MOPED

Selected DME Specific Peptides for MATK Gene

Post-translational modifications for MATK Gene

  • Ubiquitination at Lys 116
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MATK (CTK)

Domains & Families for MATK Gene

Gene Families for MATK Gene

Graphical View of Domain Structure for InterPro Entry

P42679

UniProtKB/Swiss-Prot:

MATK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
genes like me logo Genes that share domains with MATK: view

Function for MATK Gene

Molecular function for MATK Gene

GENATLAS Biochemistry:
megakaryocyte-associated tyrosine kinase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Enzyme Numbers (IUBMB) for MATK Gene

Gene Ontology (GO) - Molecular Function for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,TAS 7530249
genes like me logo Genes that share ontologies with MATK: view
genes like me logo Genes that share phenotypes with MATK: view

Animal Models for MATK Gene

MGI Knock Outs for MATK:

Animal Model Products

miRNA for MATK Gene

miRTarBase miRNAs that target MATK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MATK Gene

Localization for MATK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MATK Gene

Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MATK Gene COMPARTMENTS Subcellular localization image for MATK gene
Compartment Confidence
cytosol 5
nucleus 4
chloroplast 3
plasma membrane 3
extracellular 1
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MATK Gene

Pathways & Interactions for MATK Gene

genes like me logo Genes that share pathways with MATK: view

Gene Ontology (GO) - Biological Process for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,TAS 7530249
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0008284 positive regulation of cell proliferation TAS 8999872
GO:0030154 cell differentiation IBA --
GO:0038083 peptidyl-tyrosine autophosphorylation IBA --
genes like me logo Genes that share ontologies with MATK: view

No data available for SIGNOR curated interactions for MATK Gene

Drugs & Compounds for MATK Gene

(2) Drugs for MATK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MATK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MATK: view

Transcripts for MATK Gene

Unigene Clusters for MATK Gene

Megakaryocyte-associated tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MATK Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - - -
SP7: -
SP8: -
SP9: - -
SP10: - -
SP11:
SP12: - - - - -
SP13:

ExUns: 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MATK Gene

GeneLoc Exon Structure for
MATK
ECgene alternative splicing isoforms for
MATK

Expression for MATK Gene

mRNA expression in normal human tissues for MATK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MATK Gene

This gene is overexpressed in Whole Blood (x8.0), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.0), Brain - Hippocampus (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for MATK Gene

This gene is overexpressed in NK cells (39.0), Peripheral blood mononuclear cells (16.0), and CD8 Tcells (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MATK Gene



SOURCE GeneReport for Unigene cluster for MATK Gene Hs.631845

mRNA Expression by UniProt/SwissProt for MATK Gene

P42679-MATK_HUMAN
Tissue specificity: Expressed in various myeloid cell lines, detected in brain and lung.
genes like me logo Genes that share expression patterns with MATK: view

Protein tissue co-expression partners for MATK Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MATK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MATK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MATK 35
  • 88.64 (n)
  • 93.6 (a)
MATK 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MATK 35
  • 88.77 (n)
  • 94.42 (a)
MATK 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Matk 35
  • 83.56 (n)
  • 87.72 (a)
Matk 16
Matk 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC455592 35
  • 98.34 (n)
  • 98.34 (a)
MATK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Matk 35
  • 83.91 (n)
  • 89.48 (a)
oppossum
(Monodelphis domestica)
Mammalia MATK 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MATK 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MATK 35
  • 76.24 (n)
  • 76.02 (a)
MATK 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia matk 35
  • 62.12 (n)
  • 65.23 (a)
zebrafish
(Danio rerio)
Actinopterygii matk 35
  • 62.44 (n)
  • 63.35 (a)
matk 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Csk 37
  • 48 (a)
Csk 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T25B9.5 37
  • 31 (a)
Y52D5A.2 37
  • 30 (a)
Y69E1A.3 37
  • 31 (a)
csk-1 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5205 36
  • 42 (a)
OneToMany
Species with no ortholog for MATK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MATK Gene

ENSEMBL:
Gene Tree for MATK (if available)
TreeFam:
Gene Tree for MATK (if available)

Paralogs for MATK Gene

Paralogs for MATK Gene

Pseudogenes.org Pseudogenes for MATK Gene

genes like me logo Genes that share paralogs with MATK: view

Variants for MATK Gene

Sequence variations from dbSNP and Humsavar for MATK Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_041679 An ovarian mucinous carcinoma sample
rs35351680 - 3,778,221(-) AGGAC(A/G)CCGAC reference, missense
VAR_041681 A colorectal adenocarcinoma sample
rs2052059 -- 3,796,851(+) ATTGT(A/G)GGTGG intron-variant
rs2066766 -- 3,779,504(-) GGGGG(-/G)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MATK Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3660n71 CNV Loss 21882294
dgv3662n71 CNV Loss 21882294
nsv509718 CNV Insertion 20534489
nsv910770 CNV Loss 21882294
dgv3663n71 CNV Loss 21882294
nsv910775 CNV Loss 21882294
nsv910777 CNV Loss 21882294
esv1011184 CNV Deletion 20482838
nsv833715 CNV Loss 17160897
esv2662849 CNV Deletion 23128226
dgv3664n71 CNV Loss 21882294
nsv910780 CNV Loss 21882294

Variation tolerance for MATK Gene

Residual Variation Intolerance Score: 5.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MATK Gene

HapMap Linkage Disequilibrium report
MATK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MATK Gene

Disorders for MATK Gene

MalaCards: The human disease database

(2) MalaCards diseases for MATK Gene - From: DISEASES

Disorder Aliases PubMed IDs
preretinal fibrosis
  • cellophane maculopathy
regular astigmatism
- elite association - COSMIC cancer census association via MalaCards
Search MATK in MalaCards View complete list of genes associated with diseases

Relevant External Links for MATK

Tumor Gene Database (TGDB):
MATK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MATK
genes like me logo Genes that share disorders with MATK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MATK Gene

Publications for MATK Gene

  1. Identification and characterization of a novel tyrosine kinase from megakaryocytes. (PMID: 8288563) Bennett B.D. … Avraham H. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. (PMID: 7530249) Avraham S. … Avraham H. (J. Biol. Chem. 1995) 2 3 23
  3. Decreased CHK protein levels are associated with Src activation in colon cancer cells. (PMID: 17934522) Zhu S. … Fujita D.J. (Oncogene 2008) 3 23
  4. Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma. (PMID: 18292939) Zagozdzon R. … Avraham H.K. (Int. J. Oncol. 2008) 3 23
  5. Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. (PMID: 17492661) Belot M.P. … Machelon V. (J. Cell. Biochem. 2007) 3 23

Products for MATK Gene

Sources for MATK Gene

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