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Aliases for MATK Gene

Aliases for MATK Gene

  • Megakaryocyte-Associated Tyrosine Kinase 2 3
  • Hematopoietic Consensus Tyrosine-Lacking Kinase 2 3 4
  • Tyrosine-Protein Kinase CTK 2 3 4
  • Protein Kinase HYL 2 3 4
  • CTK 3 4 6
  • HYL 3 4 6
  • Leukocyte Carboxyl-Terminal Src Kinase Related 2 3
  • Csk-Type Protein Tyrosine Kinase 2 3
  • Hydroxyaryl-Protein Kinase 2 3
  • Tyrosylprotein Kinase 2 3
  • Csk-Homologous Kinase 2 3
  • CSK Homologous Kinase 3 4
  • Tyrosine Kinase MATK 2 3
  • HYL Tyrosine Kinase 2 3
  • EC 2.7.10.2 4 63
  • CHK 3 4
  • Megakaryocyte-Associated Tyrosine-Protein Kinase 3
  • EC 2.7.10 63
  • HHYLTK 3
  • HYLTK 3
  • Lsk 3

External Ids for MATK Gene

Previous GeneCards Identifiers for MATK Gene

  • GC19M003870
  • GC19M003717
  • GC19M003728
  • GC19M003542

Summaries for MATK Gene

Entrez Gene Summary for MATK Gene

  • The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MATK Gene

MATK (Megakaryocyte-Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MATK include preretinal fibrosis and spondylolisthesis. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include protein tyrosine kinase activity and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is FER.

UniProtKB/Swiss-Prot for MATK Gene

  • Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Gene Wiki entry for MATK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MATK Gene

Genomics for MATK Gene

Regulatory Elements for MATK Gene

Transcription factor binding sites by QIAGEN in the MATK gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MATK Gene

Start:
3,777,969 bp from pter
End:
3,802,129 bp from pter
Size:
24,161 bases
Orientation:
Minus strand

Genomic View for MATK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MATK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MATK Gene

Proteins for MATK Gene

  • Protein details for MATK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42679-MATK_HUMAN
    Recommended name:
    Megakaryocyte-associated tyrosine-protein kinase
    Protein Accession:
    P42679
    Secondary Accessions:
    • B3KNZ9
    • Q9NST8

    Protein attributes for MATK Gene

    Size:
    507 amino acids
    Molecular mass:
    56469 Da
    Quaternary structure:
    • Interacts with KIT.

    Three dimensional structures from OCA and Proteopedia for MATK Gene

    Alternative splice isoforms for MATK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MATK Gene

Proteomics data for MATK Gene at MOPED

Selected DME Specific Peptides for MATK Gene

Post-translational modifications for MATK Gene

  • Ubiquitination at Lys116
  • Modification sites at PhosphoSitePlus

Domains for MATK Gene

Gene Families for MATK Gene

HGNC:
  • SH2D :SH2 domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P42679

UniProtKB/Swiss-Prot:

MATK_HUMAN :
  • P42679
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
genes like me logo Genes that share domains with MATK: view

Function for MATK Gene

Molecular function for MATK Gene

GENATLAS Biochemistry: megakaryocyte-associated tyrosine kinase
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Enzyme Numbers (IUBMB) for MATK Gene

Gene Ontology (GO) - Molecular Function for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS 7530249
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 12122014
genes like me logo Genes that share ontologies with MATK: view
genes like me logo Genes that share phenotypes with MATK: view

Animal Models for MATK Gene

MGI Knock Outs for MATK:

Animal Model Products

CRISPR Products

miRNA for MATK Gene

miRTarBase miRNAs that target MATK

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MATK

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MATK Gene

Localization for MATK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MATK Gene

Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MATK Gene COMPARTMENTS Subcellular localization image for MATK gene
Compartment Confidence
chloroplast 4
cytosol 4
nucleus 4
extracellular 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with MATK: view

Pathways for MATK Gene

genes like me logo Genes that share pathways with MATK: view

Gene Ontology (GO) - Biological Process for MATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002009 morphogenesis of an epithelium IBA --
GO:0006468 protein phosphorylation TAS 7530249
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007498 mesoderm development TAS 8288563
GO:0008283 cell proliferation TAS 8288563
genes like me logo Genes that share ontologies with MATK: view

Compounds for MATK Gene

(3) Novoseek inferred chemical compound relationships for MATK Gene

Compound -log(P) Hits PubMed IDs
tyrosine 63.5 50
phosphotyrosine 58.6 2
atp 0 1
genes like me logo Genes that share compounds with MATK: view

Transcripts for MATK Gene

Unigene Clusters for MATK Gene

Megakaryocyte-associated tyrosine kinase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MATK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MATK Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - - -
SP7: -
SP8: -
SP9: - -
SP10: - -
SP11:
SP12: - - - - -
SP13:

ExUns: 17 ^ 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MATK Gene

GeneLoc Exon Structure for
MATK
ECgene alternative splicing isoforms for
MATK

Expression for MATK Gene

mRNA expression in normal human tissues for MATK Gene

mRNA differential expression in normal tissues according to GTEx for MATK Gene

This gene is overexpressed in Whole Blood (8.0), Brain - Cortex (5.6), Brain - Frontal Cortex (BA9) (5.0), Brain - Hippocampus (4.6), and Brain - Anterior cingulate cortex (BA24) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MATK Gene

SOURCE GeneReport for Unigene cluster for MATK Gene Hs.631845

mRNA Expression by UniProt/SwissProt for MATK Gene

P42679-MATK_HUMAN
Tissue specificity: Expressed in various myeloid cell lines, detected in brain and lung
genes like me logo Genes that share expressions with MATK: view

In Situ Assay Products

Orthologs for MATK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MATK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC455592 35
  • 98.34 (n)
  • 98.34 (a)
MATK 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MATK 35
  • 88.64 (n)
  • 93.6 (a)
MATK 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MATK 35
  • 88.77 (n)
  • 94.42 (a)
MATK 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Matk 35
  • 83.56 (n)
  • 87.72 (a)
Matk 16
Matk 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MATK 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MATK 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Matk 35
  • 83.91 (n)
  • 89.48 (a)
chicken
(Gallus gallus)
Aves MATK 35
  • 76.24 (n)
  • 76.02 (a)
MATK 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia matk 35
  • 62.12 (n)
  • 65.23 (a)
zebrafish
(Danio rerio)
Actinopterygii matk 35
  • 62.44 (n)
  • 63.35 (a)
matk 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Csk 36
  • 19 (a)
OneToMany
Csk 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea csk-1 36
  • 36 (a)
OneToMany
T25B9.5 37
  • 31 (a)
Y52D5A.2 37
  • 30 (a)
Y69E1A.3 37
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5205 36
  • 42 (a)
OneToMany
Species with no ortholog for MATK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MATK Gene

ENSEMBL:
Gene Tree for MATK (if available)
TreeFam:
Gene Tree for MATK (if available)

Paralogs for MATK Gene

Paralogs for MATK Gene

Pseudogenes.org Pseudogenes for MATK Gene

genes like me logo Genes that share paralogs with MATK: view

Variants for MATK Gene

Sequence variations from dbSNP and Humsavar for MATK Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2052059 -- 3,796,851(+) ATTGT(A/G)GGTGG intron-variant
rs2066766 -- 3,779,504(-) GGGGG(-/G)CCCAC intron-variant
rs2066767 -- 3,784,079(-) AGTGA(-/C)CCCCC intron-variant
rs2066768 -- 3,779,673(-) TGGGG(A/C)CCGTG intron-variant
rs2066769 -- 3,779,508(-) GGGAG(-/C)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MATK Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3660n71 CNV Loss 21882294
dgv3662n71 CNV Loss 21882294
nsv509718 CNV Insertion 20534489
nsv910770 CNV Loss 21882294
dgv3663n71 CNV Loss 21882294
nsv910775 CNV Loss 21882294
nsv910777 CNV Loss 21882294
esv1011184 CNV Deletion 20482838
nsv833715 CNV Loss 17160897
esv2662849 CNV Deletion 23128226
dgv3664n71 CNV Loss 21882294
nsv910780 CNV Loss 21882294

Relevant External Links for MATK Gene

HapMap Linkage Disequilibrium report
MATK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MATK Gene

Disorders for MATK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MATK Gene including...

Search for MATK Gene in MalaCards »

(5) University of Copenhagen DISEASES for MATK Gene

(3) Novoseek inferred disease relationships for MATK Gene

Disease -log(P) Hits PubMed IDs
breast cancer 22.1 18
tumors 0 3
cancer 0 3

Relevant External Links for MATK

Tumor Gene Database (TGDB):
MATK
genes like me logo Genes that share disorders with MATK: view

No data available for UniProtKB/Swiss-Prot for MATK Gene

Publications for MATK Gene

  1. Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. (PMID: 7530249) Avraham S. … Avraham H. (J. Biol. Chem. 1995) 2 3 4 23
  2. Identification and characterization of a novel tyrosine kinase from megakaryocytes. (PMID: 8288563) Bennett B.D. … Avraham H. (J. Biol. Chem. 1994) 2 3 4 23
  3. Characterization of mouse non-receptor tyrosine kinase gene, HYL. (PMID: 7936664) Hamaguchi I. … Suda T. (Oncogene 1994) 3 4 23
  4. Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase). (PMID: 8134117) Sakano S. … Suda T. (Oncogene 1994) 3 4 23
  5. Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. (PMID: 9038210) Price D.J. … Avraham H. (J. Biol. Chem. 1997) 3 4 23

Products for MATK Gene

  • Addgene plasmids for MATK

Sources for MATK Gene

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