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Aliases for MARK3 Gene

Aliases for MARK3 Gene

  • Microtubule Affinity Regulating Kinase 3 2 3 5
  • MAP/Microtubule Affinity-Regulating Kinase 3 2 3
  • Serine/Threonine-Protein Kinase P78 3 4
  • Cdc25C-Associated Protein Kinase 1 3 4
  • Ser/Thr Protein Kinase PAR-1 3 4
  • Protein Kinase STK10 3 4
  • ELKL Motif Kinase 2 3 4
  • EC 2.7.11.1 4 61
  • C-TAK1 3 4
  • Par-1a 3 4
  • CTAK1 3 4
  • EMK-2 3 4
  • EC 2.7.11 61
  • PAR1A 3
  • KP78 3
  • EMK2 4

External Ids for MARK3 Gene

Previous GeneCards Identifiers for MARK3 Gene

  • GC14P101243
  • GC14P097667
  • GC14P101841
  • GC14P102921
  • GC14P103851
  • GC14P084029

Summaries for MARK3 Gene

Entrez Gene Summary for MARK3 Gene

  • The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for MARK3 Gene

MARK3 (Microtubule Affinity Regulating Kinase 3) is a Protein Coding gene. Diseases associated with MARK3 include Brain Stem Astrocytic Neoplasm and Pilocytic Astrocytoma Of Cerebellum. Among its related pathways are MAPK-Erk Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK1.

UniProtKB/Swiss-Prot for MARK3 Gene

  • Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on Ser-216. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.

Gene Wiki entry for MARK3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARK3 Gene

Genomics for MARK3 Gene

Regulatory Elements for MARK3 Gene

Enhancers for MARK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G103416 1.8 FANTOM5 Ensembl ENCODE dbSUPER 46.2 +32.6 32603 2.7 ARID4B GLIS2 GATA2 FOS SP5 JUNB NCOA1 SREBF1 MEF2D SMARCA4 MARK3 TNFAIP2 RNU7-160P CKB EIF5 RPL10AP1 GC14P103445
GH14G103426 1.5 Ensembl ENCODE dbSUPER 42 +42.8 42823 2.5 PKNOX1 ATF1 ARNT YY1 ZNF766 GATA2 ELK1 KLF13 CAVIN1 JUNB MARK3 RNU7-160P ENSG00000269940 GC14P103445 RPL10AP1
GH14G103517 1.6 Ensembl ENCODE dbSUPER 31.9 +135.3 135305 6.4 HDGF ARNT AGO1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B SLC30A9 CBX5 MARK3 CKB CDC42BPB RNU7-160P BAG5 ENSG00000269940 XRCC3 APOPT1 GC14M103376 GC14P103445
GH14G103392 1.5 Ensembl ENCODE dbSUPER 33.5 +9.2 9237 3.6 FOXA2 PKNOX1 ARNT ARID4B FEZF1 TCF12 ZNF121 ZNF766 GATA2 ZNF143 MARK3 RPL10AP1
GH14G103512 1.3 Ensembl ENCODE dbSUPER 37.2 +127.7 127709 1.5 CTCF KLF1 KLF17 ZIC2 ZFHX2 GLIS2 SCRT2 ZNF600 MAFK EGR2 MARK3 CKB RNU7-160P GC14M103376 GC14P103445
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MARK3 on UCSC Golden Path with GeneCards custom track

Promoters for MARK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000073546 836 2801 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Location for MARK3 Gene

Chromosome:
14
Start:
103,385,364 bp from pter
End:
103,503,831 bp from pter
Size:
118,468 bases
Orientation:
Plus strand

Genomic View for MARK3 Gene

Genes around MARK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARK3 Gene

Proteins for MARK3 Gene

  • Protein details for MARK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27448-MARK3_HUMAN
    Recommended name:
    MAP/microtubule affinity-regulating kinase 3
    Protein Accession:
    P27448
    Secondary Accessions:
    • O60219
    • Q86TT8
    • Q8TB41
    • Q8WX83
    • Q96RG1
    • Q9UMY9
    • Q9UN34

    Protein attributes for MARK3 Gene

    Size:
    753 amino acids
    Molecular mass:
    84489 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MARK3 Gene

    Alternative splice isoforms for MARK3 Gene

neXtProt entry for MARK3 Gene

Selected DME Specific Peptides for MARK3 Gene

P27448:
  • SLQKLFREVRIMK
  • LTGREVA
  • TIGKGNFA
  • GARCRNSIASC
  • GPEVDVWS
  • VQWEMEVCKLPRLSLNGVRFKRISGTS
  • LVAHGRM
  • KIIDKTQL
  • YNGPPASPS
  • RRNTYVC
  • EYASGGE
  • FAKVKLA
  • RPSSDLNNST
  • WSLGVILY
  • IVHRDLKAENLLLDADMNIKI
  • NLKELRERVLRGKYR
  • VAIKIID
  • GEVFDYLV
  • DFGFSNEFT
  • WSLGVILYTLVSGSLPFDG
  • LNHPNIVKLFEVIETEKTLYL
  • GSPPYAAPE
  • LVLNPIKRG
  • DEQPHIGNYRL
  • REIRKVLDAN
  • NHPNIVKL
  • IVHRDLK

Post-translational modifications for MARK3 Gene

  • Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.
  • Ubiquitination at Lys317
  • Modification sites at PhosphoSitePlus

Domains & Families for MARK3 Gene

Gene Families for MARK3 Gene

Suggested Antigen Peptide Sequences for MARK3 Gene

Graphical View of Domain Structure for InterPro Entry

P27448

UniProtKB/Swiss-Prot:

MARK3_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with MARK3: view

Function for MARK3 Gene

Molecular function for MARK3 Gene

GENATLAS Biochemistry:
MAP/microtubule affinity-regulating kinase 3 deleted in pancreas carcinoma
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564.
UniProtKB/Swiss-Prot Function:
Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on Ser-216. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.

Enzyme Numbers (IUBMB) for MARK3 Gene

Gene Ontology (GO) - Molecular Function for MARK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,IEA 16980613
GO:0005515 protein binding IPI 12556533
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MARK3: view
genes like me logo Genes that share phenotypes with MARK3: view

Animal Models for MARK3 Gene

MGI Knock Outs for MARK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for MARK3

miRNA for MARK3 Gene

miRTarBase miRNAs that target MARK3

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MARK3 Gene

Localization for MARK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARK3 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARK3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MARK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA,IDA 21145462
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with MARK3: view

Pathways & Interactions for MARK3 Gene

SuperPathways for MARK3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Signaling by moderate kinase activity BRAF mutants
3 MAPK-Erk Pathway
4 Developmental Biology
5 Cytokine Signaling in Immune system
genes like me logo Genes that share pathways with MARK3: view

Pathways by source for MARK3 Gene

2 Sino Biological pathways for MARK3 Gene
1 GeneTex pathway for MARK3 Gene

SIGNOR curated interactions for MARK3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MARK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0030010 establishment of cell polarity IEA --
genes like me logo Genes that share ontologies with MARK3: view

Drugs & Compounds for MARK3 Gene

(2) Drugs for MARK3 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
7-hydroxystaurosporine Experimental Pharma inhibitor 22

(1) Additional Compounds for MARK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MARK3: view

Transcripts for MARK3 Gene

Unigene Clusters for MARK3 Gene

MAP/microtubule affinity-regulating kinase 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARK3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5: - - - - - - - - - - - - - - - -
SP6:
SP7: - -
SP8: -
SP9: -
SP10: - -
SP11: - -
SP12:
SP13:
SP14:

ExUns: 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d · 20e · 20f · 20g
SP1: -
SP2:
SP3:
SP4:
SP5: - - -
SP6:
SP7: - - -
SP8: - -
SP9:
SP10:
SP11: - - -
SP12: - - -
SP13:
SP14:

Relevant External Links for MARK3 Gene

GeneLoc Exon Structure for
MARK3
ECgene alternative splicing isoforms for
MARK3

Expression for MARK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MARK3 Gene

This gene is overexpressed in Lung (59.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MARK3 Gene



Protein tissue co-expression partners for MARK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MARK3 Gene:

MARK3

SOURCE GeneReport for Unigene cluster for MARK3 Gene:

Hs.35828

mRNA Expression by UniProt/SwissProt for MARK3 Gene:

P27448-MARK3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for MARK3 Gene

  • Blood(4.4)
  • Nervous system(4.4)
  • Pancreas(4.3)
  • Lung(3.3)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with MARK3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARK3 Gene

Orthologs for MARK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MARK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MARK3 34 35
  • 99.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MARK3 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MARK3 34 35
  • 92.11 (n)
dog
(Canis familiaris)
Mammalia MARK3 34 35
  • 91.89 (n)
mouse
(Mus musculus)
Mammalia Mark3 34 16 35
  • 90.05 (n)
rat
(Rattus norvegicus)
Mammalia Mark3 34
  • 88.53 (n)
oppossum
(Monodelphis domestica)
Mammalia MARK3 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves MARK3 34 35
  • 83.96 (n)
lizard
(Anolis carolinensis)
Reptilia MARK3 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mark3 34
  • 80.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1967 34
zebrafish
(Danio rerio)
Actinopterygii MARK3 (2 of 3) 35
  • 87 (a)
OneToMany
MARK3 (3 of 3) 35
  • 85 (a)
OneToMany
zgc:153725 34
  • 75.46 (n)
mark3 35
  • 75 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta par-1 36 34 35
  • 57.2 (n)
KP78a 36
  • 56 (a)
CG15072 36
  • 45 (a)
KP78b 36
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea par-1 34 35
  • 57.02 (n)
kin-29 36
  • 39 (a)
B0511.4 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
Species where no ortholog for MARK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MARK3 Gene

ENSEMBL:
Gene Tree for MARK3 (if available)
TreeFam:
Gene Tree for MARK3 (if available)

Paralogs for MARK3 Gene

Pseudogenes.org Pseudogenes for MARK3 Gene

genes like me logo Genes that share paralogs with MARK3: view

Variants for MARK3 Gene

Sequence variations from dbSNP and Humsavar for MARK3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000029942 -- 103,405,136(+) GAGCT(C/T)GGTGT intron-variant, reference, missense, utr-variant-5-prime
rs1000031944 -- 103,424,952(+) TTTTA(-/T)TTTTT intron-variant
rs1000032848 -- 103,490,938(+) GAACC(C/T)AAACC intron-variant
rs1000058050 -- 103,484,128(+) GTGAC(A/G)TGCTG intron-variant
rs1000089339 -- 103,443,344(+) CTCAA(A/G)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARK3 Gene

Variant ID Type Subtype PubMed ID
dgv422e214 CNV gain 21293372
esv2676094 CNV deletion 23128226
esv3335724 CNV insertion 20981092
esv3409253 CNV insertion 20981092
esv3635592 CNV gain 21293372
esv3635594 CNV loss 21293372
esv3635595 CNV loss 21293372
nsv1044967 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv1113676 CNV deletion 24896259
nsv1134407 CNV deletion 24896259
nsv525874 CNV gain 19592680
nsv832883 CNV loss 17160897
nsv85420 CNV deletion 16902084
nsv85551 CNV deletion 16902084
nsv9168 CNV loss 18304495
nsv952258 CNV duplication 24416366
nsv976372 CNV duplication 23825009

Variation tolerance for MARK3 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARK3 Gene

Human Gene Mutation Database (HGMD)
MARK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MARK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARK3 Gene

Disorders for MARK3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MARK3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
brain stem astrocytic neoplasm
  • brainstem astrocytoma
pilocytic astrocytoma of cerebellum
  • cerebellar pilocytic astrocytoma
central hypoventilation syndrome, congenital
  • central hypoventilation syndrome, congenital, with or without hirschsprung disease
muenke syndrome
  • fgfr3-related craniosynostosis
- elite association - COSMIC cancer census association via MalaCards
Search MARK3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MARK3

Genetic Association Database (GAD)
MARK3
Human Genome Epidemiology (HuGE) Navigator
MARK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARK3
genes like me logo Genes that share disorders with MARK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARK3 Gene

Publications for MARK3 Gene

  1. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PMID: 16980613) Dequiedt F. … Kettmann R. (Mol. Cell. Biol. 2006) 3 4 22 64
  2. OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts. (PMID: 20534768) Paternoster L. … Tobias J.H. (J. Clin. Endocrinol. Metab. 2010) 3 46 64
  3. Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. (PMID: 21145462) Moravcevic K. … Lemmon M.A. (Cell 2010) 3 4 64
  4. Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women. (PMID: 20554715) Liu J.M. … Ning G. (J. Clin. Endocrinol. Metab. 2010) 3 46 64
  5. New sequence variants associated with bone mineral density. (PMID: 19079262) Styrkarsdottir U. … Stefansson K. (Nat. Genet. 2009) 3 46 64

Products for MARK3 Gene

Sources for MARK3 Gene

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