External Ids for MAP2 Gene
Previous GeneCards Identifiers for MAP2 Gene
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
GeneCards Summary for MAP2 Gene
MAP2 (Microtubule Associated Protein 2) is a Protein Coding gene. Diseases associated with MAP2 include Occlusion Precerebral Artery and Tuberculum Sellae Meningioma. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and SIDS Susceptibility Pathways. GO annotations related to this gene include structural molecule activity and calmodulin binding. An important paralog of this gene is MAP4.
UniProtKB/Swiss-Prot for MAP2 Gene
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.