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Aliases for MAP2 Gene

Aliases for MAP2 Gene

  • Microtubule Associated Protein 2 2 3 5
  • MAP-2 3 4
  • Microtubule-Associated Protein 2 3
  • MAP2A 3
  • MAP2B 3
  • MAP2C 3

External Ids for MAP2 Gene

Previous GeneCards Identifiers for MAP2 Gene

  • GC02P208719
  • GC02P209169
  • GC02P210252
  • GC02P210491
  • GC02P210646
  • GC02P210114
  • GC02P209997
  • GC02P202133

Summaries for MAP2 Gene

Entrez Gene Summary for MAP2 Gene

  • This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

GeneCards Summary for MAP2 Gene

MAP2 (Microtubule Associated Protein 2) is a Protein Coding gene. Diseases associated with MAP2 include Central Neurocytoma and Pituicytoma. Among its related pathways are Taxane Pathway, Pharmacokinetics and TGF-Beta Pathway. GO annotations related to this gene include structural molecule activity and calmodulin binding. An important paralog of this gene is MAPT.

UniProtKB/Swiss-Prot for MAP2 Gene

  • The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Gene Wiki entry for MAP2 Gene

Additional gene information for MAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2 Gene

Genomics for MAP2 Gene

Regulatory Elements for MAP2 Gene

Enhancers for MAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H209382 0.8 ENCODE 34.7 -40.7 -40713 1 TBP PKNOX1 FOXA2 DNMT3B RARA FOS CEBPB ELF1 ZNF217 CEBPA MAP2 GC02M209345
GH02H209367 1.1 Ensembl ENCODE 23.6 -55.2 -55158 2 PKNOX1 NFIB BRCA1 RFX5 ZNF366 SCRT2 RCOR1 FOS HCFC1 USF2 MAP2 GC02M209345 GC02P209234
GH02H209472 1.2 Ensembl ENCODE 18.8 +49.4 49391 2 TBP PKNOX1 NFIB INSM2 FEZF1 ZNF2 RFX5 ZNF366 ZSCAN5C SCRT2 MAP2 GC02M209529
GH02H209423 0.9 ENCODE 23.1 +1.3 1258 3 RB1 ARNT RAD21 ZEB1 GLIS2 ZNF366 ZNF143 RUNX3 SMARCA5 SP5 MAP2 GC02M209529
GH02H209524 0.9 Ensembl ENCODE 21.2 +102.2 102206 3 FOXA2 JUN EBF1 ATF2 JUND PRDM6 ATF3 POLR2A IKZF1 ATF7 MAP2 GC02M209529
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP2 on UCSC Golden Path with GeneCards custom track

Promoters for MAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000129593 354 2000 RB1 ARNT RAD21 ZEB1 GLIS2 ZNF366 ZNF143 RUNX3 SMARCA5 SP5

Genomic Location for MAP2 Gene

Chromosome:
2
Start:
209,424,047 bp from pter
End:
209,734,118 bp from pter
Size:
310,072 bases
Orientation:
Plus strand

Genomic View for MAP2 Gene

Genes around MAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2 Gene

Proteins for MAP2 Gene

  • Protein details for MAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11137-MTAP2_HUMAN
    Recommended name:
    Microtubule-associated protein 2
    Protein Accession:
    P11137
    Secondary Accessions:
    • Q17S04
    • Q8IUX2
    • Q99975
    • Q99976

    Protein attributes for MAP2 Gene

    Size:
    1827 amino acids
    Molecular mass:
    199526 Da
    Quaternary structure:
    • Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.

    Alternative splice isoforms for MAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2 Gene

Post-translational modifications for MAP2 Gene

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP2 Gene

Domains & Families for MAP2 Gene

Gene Families for MAP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP2 Gene

Suggested Antigen Peptide Sequences for MAP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAP2: view

No data available for UniProtKB/Swiss-Prot for MAP2 Gene

Function for MAP2 Gene

Molecular function for MAP2 Gene

GENATLAS Biochemistry:
microtubule (beta) associated protein 2,expressed in the cytoplasm of neural tissue and predominantly nuclear in germ cells,with an alternatively spliced isoform expressing exon 13 (MAP2+13),expressed in fetal oligodendrocytes during process extension and myelination,minimally expressed in normal mature CNS,expressed again in generating oligodendrocytes in multiple slcerosis lesions
UniProtKB/Swiss-Prot Function:
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Phenotypes From GWAS Catalog for MAP2 Gene

Gene Ontology (GO) - Molecular Function for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding IPI 18341635
GO:0005198 structural molecule activity NAS 9588626
GO:0005515 protein binding IPI 15536091
GO:0005516 calmodulin binding IEA --
GO:0008017 microtubule binding IBA --
genes like me logo Genes that share ontologies with MAP2: view
genes like me logo Genes that share phenotypes with MAP2: view

Animal Models for MAP2 Gene

MGI Knock Outs for MAP2:

Animal Model Products

CRISPR Products

miRNA for MAP2 Gene

miRTarBase miRNAs that target MAP2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2 Gene

Localization for MAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2 Gene

Cytoplasm, cytoskeleton. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MAP2: view

Pathways & Interactions for MAP2 Gene

genes like me logo Genes that share pathways with MAP2: view

Pathways by source for MAP2 Gene

1 Cell Signaling Technology pathway for MAP2 Gene
1 PharmGKB pathway for MAP2 Gene
1 Qiagen pathway for MAP2 Gene

SIGNOR curated interactions for MAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0001578 microtubule bundle formation IEA --
GO:0007409 axonogenesis IEA --
GO:0016358 dendrite development IEA --
GO:0021954 central nervous system neuron development IEA,IEP 20846339
genes like me logo Genes that share ontologies with MAP2: view

Drugs & Compounds for MAP2 Gene

(50) Drugs for MAP2 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Target Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1993
Estramustine Approved Pharma Target, antagonist 55
Paclitaxel Approved, Vet_approved Pharma Target Tubulin and Bcl2 inhibitor, Taxanes 2948
Abraxane Approved October 2012 Pharma Taxanes 0
taxol Approved August 1997 Pharma Agonist 0

(31) Additional Compounds for MAP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAP2: view

Transcripts for MAP2 Gene

Unigene Clusters for MAP2 Gene

Microtubule-associated protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - -
SP14: - -
SP15:
SP16:

ExUns: 20b · 20c · 20d ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b · 25c · 25d
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MAP2 Gene

GeneLoc Exon Structure for
MAP2
ECgene alternative splicing isoforms for
MAP2

Expression for MAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.7), Brain - Frontal Cortex (BA9) (x5.5), Brain - Cortex (x5.3), Brain - Amygdala (x5.2), Brain - Hypothalamus (x4.4), Brain - Nucleus accumbens (basal ganglia) (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for MAP2 Gene

This gene is overexpressed in Brain (36.2), Frontal cortex (16.1), and Fetal Brain (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAP2 Gene:

MAP2

SOURCE GeneReport for Unigene cluster for MAP2 Gene:

Hs.368281

Evidence on tissue expression from TISSUES for MAP2 Gene

  • Nervous system(5)
  • Intestine(4.4)
  • Heart(4.3)
  • Pancreas(4.2)
  • Liver(4.1)
  • Eye(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with MAP2: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2 Gene

Orthologs for MAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP2 33 34
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia MAP2 33
  • 88.51 (n)
MAP-2 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map2 33 16 34
  • 86.8 (n)
dog
(Canis familiaris)
Mammalia MAP2 34 33
  • 86.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map2 33
  • 82.94 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP2 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP2 33 34
  • 68.5 (n)
lizard
(Anolis carolinensis)
Reptilia MAP2 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map2 33
  • 72.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia a730034c02-prov 33
zebrafish
(Danio rerio)
Actinopterygii map2 34
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tau 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptl-1 34
  • 14 (a)
OneToMany
Species where no ortholog for MAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2 Gene

ENSEMBL:
Gene Tree for MAP2 (if available)
TreeFam:
Gene Tree for MAP2 (if available)

Paralogs for MAP2 Gene

Paralogs for MAP2 Gene

genes like me logo Genes that share paralogs with MAP2: view

Variants for MAP2 Gene

Sequence variations from dbSNP and Humsavar for MAP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs146432517 A colorectal cancer sample 209,694,284(+) TTTGC(C/G/T)GATGT intron-variant, reference, missense
VAR_036014 A colorectal cancer sample
rs142338628 Uncertain significance 209,694,424(+) CACCT(G/T)CACTG intron-variant, reference, missense
rs1000003237 -- 209,425,778(+) TATGA(-/T)TTTTT intron-variant
rs1000005188 -- 209,576,215(+) GGAAG(C/T)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP2 Gene

Variant ID Type Subtype PubMed ID
esv1055449 CNV insertion 17803354
esv2608148 CNV deletion 19546169
esv2678028 CNV deletion 23128226
esv3594149 CNV gain 21293372
esv3594150 CNV loss 21293372
nsv1005298 CNV gain 25217958
nsv1131545 CNV deletion 24896259
nsv1132522 CNV duplication 24896259
nsv214706 CNV deletion 16902084
nsv3141 CNV insertion 18451855
nsv478034 CNV novel sequence insertion 20440878
nsv507065 OTHER sequence alteration 20534489
nsv834518 CNV loss 17160897
nsv834519 CNV loss 17160897

Variation tolerance for MAP2 Gene

Residual Variation Intolerance Score: 2.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP2 Gene

Human Gene Mutation Database (HGMD)
MAP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2 Gene

Disorders for MAP2 Gene

MalaCards: The human disease database

(33) MalaCards diseases for MAP2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
central neurocytoma
  • neurolipocytoma
pituicytoma
human monocytic ehrlichiosis
  • ehrlichiosis chafeensis
ganglioglioma
  • adult ganglioglioma
chiari malformation
  • arnold chiari malformation
- elite association - COSMIC cancer census association via MalaCards
Search MAP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAP2

Genetic Association Database (GAD)
MAP2
Human Genome Epidemiology (HuGE) Navigator
MAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP2
genes like me logo Genes that share disorders with MAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP2 Gene

Publications for MAP2 Gene

  1. Fyn phosphorylates human MAP-2c on tyrosine 67. (PMID: 15536091) Zamora-Leon SP … Shafit-Zagardo B (The Journal of biological chemistry 2005) 3 4 22 60
  2. Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. (PMID: 7479905) Kalcheva N … Shafit-Zagardo B (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 22 60
  3. Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2). (PMID: 8294038) Albala JS … Shafit-Zagardo B (Gene 1993) 3 4 22 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for MAP2 Gene

Sources for MAP2 Gene

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