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Aliases for MAP2 Gene

Aliases for MAP2 Gene

  • Microtubule Associated Protein 2 2 3 5
  • MAP-2 3 4
  • MAP2A 3
  • MAP2B 3
  • MAP2C 3

External Ids for MAP2 Gene

Previous GeneCards Identifiers for MAP2 Gene

  • GC02P208719
  • GC02P209169
  • GC02P210252
  • GC02P210491
  • GC02P210646
  • GC02P210114
  • GC02P209997
  • GC02P202133

Summaries for MAP2 Gene

Entrez Gene Summary for MAP2 Gene

  • This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

GeneCards Summary for MAP2 Gene

MAP2 (Microtubule Associated Protein 2) is a Protein Coding gene. Diseases associated with MAP2 include Occlusion Precerebral Artery and Tuberculum Sellae Meningioma. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and SIDS Susceptibility Pathways. GO annotations related to this gene include structural molecule activity and calmodulin binding. An important paralog of this gene is MAP4.

UniProtKB/Swiss-Prot for MAP2 Gene

  • The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Gene Wiki entry for MAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2 Gene

Genomics for MAP2 Gene

Regulatory Elements for MAP2 Gene

Enhancers for MAP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP2 on UCSC Golden Path with GeneCards custom track

Promoters for MAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP2 Gene

Chromosome:
2
Start:
209,424,047 bp from pter
End:
209,734,118 bp from pter
Size:
310,072 bases
Orientation:
Plus strand

Genomic View for MAP2 Gene

Genes around MAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2 Gene

Proteins for MAP2 Gene

  • Protein details for MAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11137-MTAP2_HUMAN
    Recommended name:
    Microtubule-associated protein 2
    Protein Accession:
    P11137
    Secondary Accessions:
    • Q17S04
    • Q8IUX2
    • Q99975
    • Q99976

    Protein attributes for MAP2 Gene

    Size:
    1827 amino acids
    Molecular mass:
    199526 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2 Gene

Proteomics data for MAP2 Gene at MOPED

Post-translational modifications for MAP2 Gene

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2/MAP2c is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP2 Gene

Domains & Families for MAP2 Gene

Gene Families for MAP2 Gene

Suggested Antigen Peptide Sequences for MAP2 Gene

Graphical View of Domain Structure for InterPro Entry

P11137

UniProtKB/Swiss-Prot:

MTAP2_HUMAN :
  • Contains 3 Tau/MAP repeats.
Similarity:
  • Contains 3 Tau/MAP repeats.
genes like me logo Genes that share domains with MAP2: view

Function for MAP2 Gene

Molecular function for MAP2 Gene

GENATLAS Biochemistry:
microtubule (beta) associated protein 2,expressed in the cytoplasm of neural tissue and predominantly nuclear in germ cells,with an alternatively spliced isoform expressing exon 13 (MAP2+13),expressed in fetal oligodendrocytes during process extension and myelination,minimally expressed in normal mature CNS,expressed again in generating oligodendrocytes in multiple slcerosis lesions
UniProtKB/Swiss-Prot Function:
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Gene Ontology (GO) - Molecular Function for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding IPI 18341635
genes like me logo Genes that share ontologies with MAP2: view
genes like me logo Genes that share phenotypes with MAP2: view

Animal Models for MAP2 Gene

MGI Knock Outs for MAP2:

miRNA for MAP2 Gene

miRTarBase miRNAs that target MAP2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2 Gene

Localization for MAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP2 Gene COMPARTMENTS Subcellular localization image for MAP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MAP2: view

Pathways & Interactions for MAP2 Gene

genes like me logo Genes that share pathways with MAP2: view

Pathways by source for MAP2 Gene

1 Cell Signaling Technology pathway for MAP2 Gene
1 PharmGKB pathway for MAP2 Gene
1 Qiagen pathway for MAP2 Gene

SIGNOR curated interactions for MAP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021954 central nervous system neuron development IEA,IEP 20846339
genes like me logo Genes that share ontologies with MAP2: view

Drugs & Compounds for MAP2 Gene

(45) Drugs for MAP2 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Target Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
Estramustine Approved Pharma Target, antagonist 53
Paclitaxel Approved Pharma Target Tubulin and Bcl2 inhibitor, Taxanes 2655
Abraxane Approved October 2012 Pharma Taxanes 0
Taxol Approved August 1997 Pharma Agonist Promotes assembly and inhibits disassembly of microtubules 0

(36) Additional Compounds for MAP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAP2: view

Transcripts for MAP2 Gene

Unigene Clusters for MAP2 Gene

Microtubule-associated protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - -
SP14: - -
SP15:
SP16:

ExUns: 20b · 20c · 20d ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b · 25c · 25d
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MAP2 Gene

GeneLoc Exon Structure for
MAP2
ECgene alternative splicing isoforms for
MAP2

Expression for MAP2 Gene

mRNA expression in normal human tissues for MAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.7), Brain - Frontal Cortex (BA9) (x5.5), Brain - Cortex (x5.3), Brain - Amygdala (x5.2), Brain - Hypothalamus (x4.4), Brain - Nucleus accumbens (basal ganglia) (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for MAP2 Gene

This gene is overexpressed in Brain (36.2), Frontal cortex (16.1), and Fetal Brain (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP2 Gene



SOURCE GeneReport for Unigene cluster for MAP2 Gene Hs.368281

genes like me logo Genes that share expression patterns with MAP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MAP2 Gene

Orthologs for MAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP2 35
  • 88.51 (n)
  • 87.89 (a)
MAP-2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP2 35
  • 86.12 (n)
  • 86.24 (a)
MAP2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map2 35
  • 86.8 (n)
  • 92.72 (a)
Map2 16
Map2 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP2 35
  • 99.64 (n)
  • 99.45 (a)
MAP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map2 35
  • 82.94 (n)
  • 80.42 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP2 35
  • 68.5 (n)
  • 64.69 (a)
MAP2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP2 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map2 35
  • 72.82 (n)
  • 75.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia a730034c02-prov 35
zebrafish
(Danio rerio)
Actinopterygii map2 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tau 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptl-1 36
  • 14 (a)
OneToMany
Species with no ortholog for MAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2 Gene

ENSEMBL:
Gene Tree for MAP2 (if available)
TreeFam:
Gene Tree for MAP2 (if available)

Paralogs for MAP2 Gene

Paralogs for MAP2 Gene

genes like me logo Genes that share paralogs with MAP2: view

Variants for MAP2 Gene

Sequence variations from dbSNP and Humsavar for MAP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2271251 - 209,653,415(-) TGTCA(C/G)CTGAG reference, missense
rs741006 - 209,693,438(-) TATCC(C/T)TTTGC intron-variant, reference, missense
VAR_036014 A colorectal cancer sample
VAR_036015 A colorectal cancer sample
rs6749066 - 209,692,706(+) GAAGG(A/G)AAAGG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAP2 Gene

Variant ID Type Subtype PubMed ID
nsv834518 CNV Loss 17160897
nsv834519 CNV Loss 17160897
esv1055449 CNV Insertion 17803354
nsv214706 CNV Loss 16902084
esv2678028 CNV Deletion 23128226
nsv3141 CNV Insertion 18451855
esv2608148 CNV Deletion 19546169
nsv875765 CNV Loss 21882294
nsv507065 CNV Insertion 20534489

Variation tolerance for MAP2 Gene

Residual Variation Intolerance Score: 2.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP2 Gene

Human Gene Mutation Database (HGMD)
MAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2 Gene

Disorders for MAP2 Gene

MalaCards: The human disease database

(31) MalaCards diseases for MAP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
occlusion precerebral artery
  • occlusion and stenosis of multiple and bilateral precerebral arteries
sella turcica neoplasm
  • tumor of sella turcica
tuberculum sellae meningioma
  • meningioma of the tuberculum sellae
central neurocytoma
  • neurolipocytoma
ischemia
- elite association - COSMIC cancer census association via MalaCards
Search MAP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAP2

Genetic Association Database (GAD)
MAP2
Human Genome Epidemiology (HuGE) Navigator
MAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP2
genes like me logo Genes that share disorders with MAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP2 Gene

Publications for MAP2 Gene

  1. Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. (PMID: 7479905) Kalcheva N. … Shafit-Zagardo B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 23 67
  2. Estramustine-phosphate binds to a tubulin binding domain on microtubule-associated proteins MAP-2 and tau. (PMID: 1599956) Moraga D. … Maccioni R.B. (Biochim. Biophys. Acta 1992) 23 25 26
  3. Evidence that estramustine binds MAP-1A to inhibit type IV collagenase secretion. (PMID: 1647395) Stearns M.E. … Sousa O. (J. Cell. Sci. 1991) 23 25 26
  4. Stoichiometry of estramustine phosphate binding to MAP2 measured by the disassembly of chick brain MAP2:tubulin microtubules. (PMID: 2125244) Burns R.G. (Cell Motil. Cytoskeleton 1990) 23 25 26
  5. Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1. (PMID: 19880519) Maddodi N. … Setaluri V. (J. Biol. Chem. 2010) 3 23

Products for MAP2 Gene

Sources for MAP2 Gene

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