Aliases for MAOB Gene
External Ids for MAOB Gene
Previous GeneCards Identifiers for MAOB Gene
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAOB Gene
MAOB (Monoamine Oxidase B) is a Protein Coding gene. Diseases associated with MAOB include deep brain stimulation for parkinson's disease and substance abuse. Among its related pathways are Alpha-synuclein signaling and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein homodimerization activity and flavin adenine dinucleotide binding. An important paralog of this gene is MAOA.
UniProtKB/Swiss-Prot for MAOB Gene
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine
Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin. They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit disorder, and irregular sexual maturation.