Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAOB Gene

Aliases for MAOB Gene

  • Monoamine Oxidase B 2 3
  • Monoamine Oxidase Type B 3 4
  • EC 1.4.3.4 4 63
  • MAO-B 3 4
  • Amine Oxidase [Flavin-Containing] B 3
  • Adrenalin Oxidase 3
  • Tyramine Oxidase 3
  • MAO, Platelet 3
  • MAO, Brain 3
  • EC 1.4.3 63

External Ids for MAOB Gene

Previous GeneCards Identifiers for MAOB Gene

  • GC0XM041637
  • GC0XM041886
  • GC0XM042452
  • GC0XM042671
  • GC0XM043383
  • GC0XM043510
  • GC0XM043625
  • GC0XM041355

Summaries for MAOB Gene

Entrez Gene Summary for MAOB Gene

  • The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAOB Gene

MAOB (Monoamine Oxidase B) is a Protein Coding gene. Diseases associated with MAOB include deep brain stimulation for parkinson's disease and substance abuse. Among its related pathways are Alpha-synuclein signaling and Metabolism. GO annotations related to this gene include protein homodimerization activity and flavin adenine dinucleotide binding. An important paralog of this gene is MAOA.

UniProtKB/Swiss-Prot for MAOB Gene

  • Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

Tocris Summary for MAOB Gene

  • Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin. They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit disorder, and irregular sexual maturation.

Gene Wiki entry for MAOB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAOB Gene

Genomics for MAOB Gene

Regulatory Elements for MAOB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAOB Gene

Start:
43,766,610 bp from pter
End:
43,882,475 bp from pter
Size:
115,866 bases
Orientation:
Minus strand

Genomic View for MAOB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAOB Gene

Proteins for MAOB Gene

  • Protein details for MAOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27338-AOFB_HUMAN
    Recommended name:
    Amine oxidase [flavin-containing] B
    Protein Accession:
    P27338
    Secondary Accessions:
    • B2R6R3
    • B7Z5H3
    • D3DWC3
    • Q7Z6S2

    Protein attributes for MAOB Gene

    Size:
    520 amino acids
    Molecular mass:
    58763 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAOB Gene

    Alternative splice isoforms for MAOB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAOB Gene

Proteomics data for MAOB Gene at MOPED

Post-translational modifications for MAOB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAOB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for MAOB Gene

Protein Domains for MAOB Gene

Graphical View of Domain Structure for InterPro Entry

P27338

UniProtKB/Swiss-Prot:

AOFB_HUMAN :
  • P27338
Family:
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with MAOB: view

No data available for Gene Families for MAOB Gene

Function for MAOB Gene

Molecular function for MAOB Gene

GENATLAS Biochemistry:
monoamine oxidase B
UniProtKB/Swiss-Prot CatalyticActivity:
RCH(2)NHR + H(2)O + O(2) = RCHO + RNH(2) + H(2)O(2)
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

Enzyme Numbers (IUBMB) for MAOB Gene

Gene Ontology (GO) - Molecular Function for MAOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008131 primary amine oxidase activity TAS --
GO:0009055 electron carrier activity TAS 8602220
GO:0016491 oxidoreductase activity --
GO:0042803 protein homodimerization activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with MAOB: view
genes like me logo Genes that share phenotypes with MAOB: view

Animal Models for MAOB Gene

MGI Knock Outs for MAOB:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAOB

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MAOB Gene

Localization for MAOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAOB Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAOB Gene COMPARTMENTS Subcellular localization image for MAOB gene
Compartment Confidence
mitochondrion 5
nucleus 2
peroxisome 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MAOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005740 mitochondrial envelope TAS 7063850
GO:0005741 mitochondrial outer membrane TAS 24252804
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAOB: view

Pathways for MAOB Gene

genes like me logo Genes that share pathways with MAOB: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MAOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0009636 response to toxic substance IEA --
GO:0010044 response to aluminum ion IEA --
GO:0010269 response to selenium ion IEA --
GO:0014063 negative regulation of serotonin secretion IEA --
genes like me logo Genes that share ontologies with MAOB: view

Compounds for MAOB Gene

Compound Products

(5) Tocris Compounds for MAOB Gene

Compound Action Cas Number
(R)-(-)-Deprenyl hydrochloride MAO-B inhibitor [14611-52-0]
Bifemelane hydrochloride MAO-A and MAO-B inhibitor [62232-46-6]
Lazabemide hydrochloride Selective MAO-B inhibitor [103878-83-7]
Moclobemide Reversible MAO-A inhibitor [71320-77-9]
Rasagiline mesylate Selective, irreversible MAO-B inhibitor [161735-79-1]

(5) ApexBio Compounds for MAOB Gene

Compound Action Cas Number
Paeonol MAO inhibitor;multi-functional phenolic compound [552-41-0]
Procarbazine HCl Antineoplastic chemotherapy drug [366-70-1]
Rasagiline Mesylate Irreversible MAO-B inhibitor [161735-79-1]
Safinamide Mesylate "MAO-B inhibitor,potent,selective and reversible" [202825-46-5]
Sennoside A Irritant laxative;mild MAO inhibitor [81-27-6]

(37) HMDB Compounds for MAOB Gene

Compound Synonyms Cas Number PubMed IDs
1-Methylhistamine
  • 1-Methyl-1H-imidazole-4-ethanamine
501-75-7
1-Phenylethylamine
  • a-phenylethylamine
98-84-0
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
13023-73-9
3,4-Dihydroxyphenylacetaldehyde
  • Protocatechuatealdehyde
5707-55-1
3-Methoxy-4-hydroxyphenylglycolaldehyde
  • a,4-dihydroxy-3-methoxy-Benzeneacetaldehyde
17592-23-3

(129) Novoseek inferred chemical compound relationships for MAOB Gene

Compound -log(P) Hits PubMed IDs
selegiline 96.3 147
rasagiline 95.5 89
lazabemide 93.2 30
propargylamine 88.9 8
safinamide 88.5 19
genes like me logo Genes that share compounds with MAOB: view

Transcripts for MAOB Gene

Unigene Clusters for MAOB Gene

Monoamine oxidase B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAOB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAOB Gene

No ASD Table

Relevant External Links for MAOB Gene

GeneLoc Exon Structure for
MAOB
ECgene alternative splicing isoforms for
MAOB

Expression for MAOB Gene

mRNA expression in normal human tissues for MAOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MAOB Gene

This gene is overexpressed in Spinal cord (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAOB Gene

SOURCE GeneReport for Unigene cluster for MAOB Gene Hs.654473

genes like me logo Genes that share expressions with MAOB: view

Expression partners for MAOB Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAOB Gene

Orthologs for MAOB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAOB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAOB 35
  • 90.64 (n)
  • 91.35 (a)
MAOB 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAOB 35
  • 91.79 (n)
  • 95 (a)
MAOB 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Maob 35
  • 87.58 (n)
  • 89 (a)
Maob 16
Maob 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAOB 35
  • 99.29 (n)
  • 99.62 (a)
MAOB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Maob 35
  • 86.64 (n)
  • 88.44 (a)
oppossum
(Monodelphis domestica)
Mammalia MAOB 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAOB 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAOB 35
  • 74.57 (n)
  • 75.34 (a)
MAOB 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAOB 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494267 35
  • 72.96 (n)
  • 75.14 (a)
zebrafish
(Danio rerio)
Actinopterygii mao 35
  • 68.53 (n)
  • 69.88 (a)
mao 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11797 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05933 35
  • 42.47 (n)
  • 29.51 (a)
Species with no ortholog for MAOB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAOB Gene

ENSEMBL:
Gene Tree for MAOB (if available)
TreeFam:
Gene Tree for MAOB (if available)

Paralogs for MAOB Gene

Paralogs for MAOB Gene

Selected SIMAP similar genes for MAOB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAOB: view

Variants for MAOB Gene

Sequence variations from dbSNP and Humsavar for MAOB Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6324 -- 43,767,568(-) TTGCC(C/T)TCCGT reference, synonymous-codon
rs17462 -- 43,767,249(-) TCACC(A/G)GTTTC utr-variant-3-prime
rs736944 -- 43,815,788(+) ATATT(C/T)CCCTT intron-variant
rs1014876 -- 43,808,101(-) GTGCA(C/T)CTTGA intron-variant
rs1040398 -- 43,766,184(-) TTAAA(C/T)GGTAT downstream-variant-500B

Relevant External Links for MAOB Gene

HapMap Linkage Disequilibrium report
MAOB
Human Gene Mutation Database (HGMD)
MAOB
Locus Specific Mutation Databases (LSDB)
MAOB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAOB Gene

Disorders for MAOB Gene

(3) University of Copenhagen DISEASES for MAOB Gene

(56) Novoseek inferred disease relationships for MAOB Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 86.8 132
parkinsonism 67.3 21
neurodegenerative diseases 62.8 13
alzheimers disease 51.1 26
neurodegeneration 47.9 7

Genatlas disease for MAOB Gene

monoamine oxidase deficiency

Relevant External Links for MAOB

Genetic Association Database (GAD)
MAOB
Human Genome Epidemiology (HuGE) Navigator
MAOB
genes like me logo Genes that share disorders with MAOB: view

No data available for OMIM and UniProtKB/Swiss-Prot for MAOB Gene

Publications for MAOB Gene

  1. Human monoamine oxidase A and B genes exhibit identical exon-intron organization. (PMID: 2023912) Grimsby J. … Shih J.C. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  2. Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines. (PMID: 8316221) Wu H.F. … Shih J.C. (Mol. Pharmacol. 1993) 3 4 23
  3. The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical. (PMID: 8515265) Chen K. … Shih J.C. (J. Neurochem. 1993) 3 4 23
  4. Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. (PMID: 8665924) Cesura A.M. … Da Prada M. (Eur. J. Biochem. 1996) 3 4 23
  5. High-level expression of human liver monoamine oxidase B in Pichia pastoris. (PMID: 11049757) Newton-Vinson P. … Edmondson D.E. (Protein Expr. Purif. 2000) 3 4 23

Products for MAOB Gene

Sources for MAOB Gene

Back to Top

Content