Aliases for STS Gene
External Ids for STS Gene
Previous HGNC Symbols for STS Gene
Previous GeneCards Identifiers for STS Gene
This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]
GeneCards Summary for STS Gene
STS (Steroid Sulfatase (Microsomal), Isozyme S) is a Protein Coding gene. Diseases associated with STS include Ichthyosis, X-Linked and Ichthyosis Vulgaris. Among its related pathways are Estrone metabolism and Sphingolipid metabolism. GO annotations related to this gene include sulfuric ester hydrolase activity and steryl-sulfatase activity. An important paralog of this gene is ARSJ.
UniProtKB/Swiss-Prot for STS Gene
Conversion of sulfated steroid precursors to estrogens during pregnancy.