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Aliases for MAGEB2 Gene

Aliases for MAGEB2 Gene

  • MAGE Family Member B2 2 3 5
  • DSS/AHC Critical Interval MAGE Superfamily 6 2 3
  • Cancer/Testis Antigen Family 3, Member 2 2 3
  • Melanoma-Associated Antigen B2 2 3
  • Melanoma Antigen Family B2 2 3
  • Cancer/Testis Antigen 3.2 3 4
  • MAGE XP-2 Antigen 3 4
  • MAGE-B2 Antigen 3 4
  • CT3.2 3 4
  • DAM6 3 4
  • DSS-AHC Critical Interval MAGE Superfamily 6 4
  • Melanoma Antigen Family B, 2 3
  • MAGE-XP-2 3

External Ids for MAGEB2 Gene

Previous GeneCards Identifiers for MAGEB2 Gene

  • GC0XP028733
  • GC0XP028917
  • GC0XP029435
  • GC0XP029595
  • GC0XP029993
  • GC0XP030143
  • GC0XP027970

Summaries for MAGEB2 Gene

Entrez Gene Summary for MAGEB2 Gene

  • This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB2 Gene

MAGEB2 (MAGE Family Member B2) is a Protein Coding gene. Diseases associated with MAGEB2 include Melanoma. An important paralog of this gene is MAGEB1.

UniProtKB/Swiss-Prot for MAGEB2 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Wiki entry for MAGEB2 Gene

Additional gene information for MAGEB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB2 Gene

Genomics for MAGEB2 Gene

Regulatory Elements for MAGEB2 Gene

Enhancers for MAGEB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH030246 0.8 ENCODE 12.4 +31.5 31501 0.2 PKNOX1 ATF1 NFRKB ZBTB40 ELK1 EGR1 ATF7 HCFC1 ZBTB2 ZBTB11 MAGEB2 MAGEB1 PLCE1P1
GH0XH030102 0.2 ENCODE 4.3 -112.3 -112335 1 FTLP2 MAGEB2 PIGFP3 LOC100420324
GH0XH030215 0.8 ENCODE 0.7 -0.1 -100 0.2 HDAC1 TBP PKNOX1 ATF1 ZBTB40 ELK1 ETV6 ATF7 CREM HCFC1 MAGEB2 GC0XP030209
GH0XH030219 0.4 ENCODE 0.7 +4.1 4137 0.9 FOXA2 POU5F1 MAGEB1 MAGEB4 MAGEB2 MAGEB3
GH0XH030228 0.2 ENCODE 0.4 +13.2 13161 0.2 MAGEB3 MAGEB2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGEB2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MAGEB2 Gene

Genomic Locations for MAGEB2 Gene
chrX:30,215,558-30,220,089
(GRCh38/hg38)
Size:
4,532 bases
Orientation:
Plus strand
chrX:30,233,675-30,238,206
(GRCh37/hg19)

Genomic View for MAGEB2 Gene

Genes around MAGEB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB2 Gene

Proteins for MAGEB2 Gene

  • Protein details for MAGEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15479-MAGB2_HUMAN
    Recommended name:
    Melanoma-associated antigen B2
    Protein Accession:
    O15479
    Secondary Accessions:
    • O75860

    Protein attributes for MAGEB2 Gene

    Size:
    319 amino acids
    Molecular mass:
    35277 Da
    Quaternary structure:
    • Interacts with TRIM28.

neXtProt entry for MAGEB2 Gene

Post-translational modifications for MAGEB2 Gene

  • Ubiquitination at posLast=114114
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB2 Gene

Domains & Families for MAGEB2 Gene

Gene Families for MAGEB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEB2: view

No data available for UniProtKB/Swiss-Prot for MAGEB2 Gene

Function for MAGEB2 Gene

Molecular function for MAGEB2 Gene

GENATLAS Biochemistry:
melanoma antigen,family B,member 2,expressed in placenta,testis,melanoma and lung carcinomas
UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Ontology (GO) - Molecular Function for MAGEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEB2: view
genes like me logo Genes that share phenotypes with MAGEB2: view

miRNA for MAGEB2 Gene

miRTarBase miRNAs that target MAGEB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB2 Gene

Localization for MAGEB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEB2 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEB2 Gene

Pathways & Interactions for MAGEB2 Gene

SuperPathways for MAGEB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEB2 Gene

Drugs & Compounds for MAGEB2 Gene

No Compound Related Data Available

Transcripts for MAGEB2 Gene

mRNA/cDNA for MAGEB2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(61) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB2 Gene

Melanoma antigen family B, 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB2 Gene

ExUns: 1 ^ 2a · 2b · 2c
SP1: -
SP2:

Relevant External Links for MAGEB2 Gene

GeneLoc Exon Structure for
MAGEB2
ECgene alternative splicing isoforms for
MAGEB2

Expression for MAGEB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEB2 Gene

This gene is overexpressed in Testis (x50.5).

Protein differential expression in normal tissues from HIPED for MAGEB2 Gene

This gene is overexpressed in Testis (31.6), Urine (20.0), and Ovary (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGEB2 Gene



Protein tissue co-expression partners for MAGEB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGEB2 Gene:

MAGEB2

SOURCE GeneReport for Unigene cluster for MAGEB2 Gene:

Hs.113824

mRNA Expression by UniProt/SwissProt for MAGEB2 Gene:

O15479-MAGB2_HUMAN
Tissue specificity: Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.
genes like me logo Genes that share expression patterns with MAGEB2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEB2 Gene

Orthologs for MAGEB2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEB2 33 34
  • 98.54 (n)
dog
(Canis familiaris)
Mammalia MAGEB4 33
  • 75.69 (n)
rat
(Rattus norvegicus)
Mammalia Mageb2 33
  • 70.31 (n)
mouse
(Mus musculus)
Mammalia Mageb4 33 16 34
  • 70.28 (n)
cow
(Bos Taurus)
Mammalia LOC788399 33
  • 69.26 (n)
-- 34
  • 49 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
MAGEB4 34
  • 44 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
MGC133764 34
  • 42 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
Species where no ortholog for MAGEB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB2 Gene

ENSEMBL:
Gene Tree for MAGEB2 (if available)
TreeFam:
Gene Tree for MAGEB2 (if available)

Paralogs for MAGEB2 Gene

Variants for MAGEB2 Gene

Sequence variations from dbSNP and Humsavar for MAGEB2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000097469 -- 30,214,656(+) AAGCA(A/G)GTCAG intron-variant, upstream-variant-2KB
rs1000125655 -- 30,215,760(+) AAAGC(C/G/T)GTCCG intron-variant, upstream-variant-2KB
rs1000302479 -- 30,215,326(+) GGGCT(A/G)AGGGA nc-transcript-variant, upstream-variant-2KB
rs1000734359 -- 30,217,052(+) CAGAA(A/G)TGTGA intron-variant, upstream-variant-2KB
rs1001000592 -- 30,216,748(+) GGAGC(A/G)GTGGC intron-variant, upstream-variant-2KB

Variation tolerance for MAGEB2 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 21.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB2 Gene

Disorders for MAGEB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEB2
genes like me logo Genes that share disorders with MAGEB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEB2 Gene

Publications for MAGEB2 Gene

  1. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PMID: 9441743) Lurquin C … Boon T (Genomics 1997) 2 3 4 22 60
  2. MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera. (PMID: 9538511) McCurdy DK … Gatti RA (Molecular genetics and metabolism 1998) 3 4 22 60
  3. A family of rapidly evolving genes from the sex reversal critical region in Xp21. (PMID: 8535061) Dabovic B … Camerino G (Mammalian genome : official journal of the International Mammalian Genome Society 1995) 3 4 22 60
  4. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4 60
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60

Products for MAGEB2 Gene

Sources for MAGEB2 Gene

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