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Aliases for MAFG Gene

Aliases for MAFG Gene

  • V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G 2 3 5
  • Basic Leucine Zipper Transcription Factor MafG 2 3
  • HMAF 3 4
  • V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog G 4
  • Transcription Factor MafG 2

External Ids for MAFG Gene

Previous GeneCards Identifiers for MAFG Gene

  • GC17M079241
  • GC17M9I0116
  • GC17M080415
  • GC17M9I0558
  • GC17M9I7469
  • GC17M077469
  • GC17M079877
  • GC17M075277

Summaries for MAFG Gene

Entrez Gene Summary for MAFG Gene

  • Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

GeneCards Summary for MAFG Gene

MAFG (V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G) is a Protein Coding gene. Diseases associated with MAFG include fibrosarcoma. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is MAFA.

UniProtKB/Swiss-Prot for MAFG Gene

  • Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).

Gene Wiki entry for MAFG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAFG Gene

Genomics for MAFG Gene

Regulatory Elements for MAFG Gene

Genomic Location for MAFG Gene

Chromosome:
17
Start:
81,918,269 bp from pter
End:
81,931,560 bp from pter
Size:
13,292 bases
Orientation:
Minus strand

Genomic View for MAFG Gene

Genes around MAFG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAFG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAFG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAFG Gene

Proteins for MAFG Gene

  • Protein details for MAFG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15525-MAFG_HUMAN
    Recommended name:
    Transcription factor MafG
    Protein Accession:
    O15525

    Protein attributes for MAFG Gene

    Size:
    162 amino acids
    Molecular mass:
    17850 Da
    Quaternary structure:
    • Homodimer or heterodimer. Homodimerization leads to transcriptional repression. Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3. Interacts with NFE2; the interaction results in transactivation activation. Interacts with CREBBP; the interaction leads to acetylation of the basic region of MAFG and stimulation of NFE2 transcriptional activity through increased DNA binding.

neXtProt entry for MAFG Gene

Proteomics data for MAFG Gene at MOPED

Post-translational modifications for MAFG Gene

  • Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
  • Sumoylation at Lys-14 is required for active transcriptional repression.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAFG Gene

Antibody Products

No data available for DME Specific Peptides for MAFG Gene

Domains & Families for MAFG Gene

Gene Families for MAFG Gene

Protein Domains for MAFG Gene

Suggested Antigen Peptide Sequences for MAFG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15525

UniProtKB/Swiss-Prot:

MAFG_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. Maf subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Maf subfamily.
genes like me logo Genes that share domains with MAFG: view

Function for MAFG Gene

Molecular function for MAFG Gene

GENATLAS Biochemistry:
small MAF protein G,dimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor,homolog to v-maf musinloaponeurotic fibrosarcoma (avian) oncogene
UniProtKB/Swiss-Prot Function:
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).

Gene Ontology (GO) - Molecular Function for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,NAS 9286713
GO:0005515 protein binding IPI 18692475
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with MAFG: view
genes like me logo Genes that share phenotypes with MAFG: view

Animal Models for MAFG Gene

MGI Knock Outs for MAFG:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAFG Gene

Localization for MAFG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAFG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAFG Gene COMPARTMENTS Subcellular localization image for MAFG gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for MAFG Gene

Pathways & Interactions for MAFG Gene

genes like me logo Genes that share pathways with MAFG: view

Pathways by source for MAFG Gene

Gene Ontology (GO) - Biological Process for MAFG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007596 blood coagulation TAS --
GO:0010628 positive regulation of gene expression IEA --
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with MAFG: view

No data available for SIGNOR curated interactions for MAFG Gene

Drugs & Compounds for MAFG Gene

(1) Drugs for MAFG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MAFG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAFG: view

Transcripts for MAFG Gene

Unigene Clusters for MAFG Gene

V-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAFG Gene

No ASD Table

Relevant External Links for MAFG Gene

GeneLoc Exon Structure for
MAFG
ECgene alternative splicing isoforms for
MAFG

Expression for MAFG Gene

mRNA expression in normal human tissues for MAFG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAFG Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for MAFG Gene

This gene is overexpressed in Heart (51.8) and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAFG Gene



SOURCE GeneReport for Unigene cluster for MAFG Gene Hs.252229

mRNA Expression by UniProt/SwissProt for MAFG Gene

O15525-MAFG_HUMAN
Tissue specificity: Highly expressed in skeletal muscle. Also expressed in heart and brain.
genes like me logo Genes that share expression patterns with MAFG: view

Protein tissue co-expression partners for MAFG Gene

Primer Products

In Situ Assay Products

Orthologs for MAFG Gene

This gene was present in the common ancestor of animals.

Orthologs for MAFG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAFG 36
  • 100 (a)
OneToOne
MAFG 35
  • 99.59 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia MAFG 36
  • 99 (a)
OneToOne
MAFG 35
  • 94.24 (n)
  • 98.77 (a)
dog
(Canis familiaris)
Mammalia MAFG 35
  • 95.27 (n)
  • 98.77 (a)
MAFG 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mafg 16
Mafg 35
  • 90.95 (n)
  • 98.77 (a)
Mafg 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAFG 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAFG 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mafg 35
  • 91.15 (n)
  • 98.77 (a)
chicken
(Gallus gallus)
Aves MAFG 35
  • 87.24 (n)
  • 93.83 (a)
MAFG 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAFG 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mafg 35
  • 74.07 (n)
  • 85.8 (a)
zebrafish
(Danio rerio)
Actinopterygii mafga 36
  • 68 (a)
OneToMany
mafgb 36
  • 85 (a)
OneToMany
mafgb 35
  • 84.57 (n)
  • 90.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta maf-S 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea maf-1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for MAFG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAFG Gene

ENSEMBL:
Gene Tree for MAFG (if available)
TreeFam:
Gene Tree for MAFG (if available)

Paralogs for MAFG Gene

Paralogs for MAFG Gene

(5) SIMAP similar genes for MAFG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAFG: view

Variants for MAFG Gene

Sequence variations from dbSNP and Humsavar for MAFG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1554458 -- 81,931,512(-) CAAAG(C/T)GCCTG utr-variant-5-prime
rs1879570 -- 81,921,985(+) ACCAG(A/C)GATTT utr-variant-3-prime
rs2376532 -- 81,923,503(-) TCCCC(C/G/T)GCCCC intron-variant, utr-variant-5-prime
rs3087708 -- 81,921,698(+) TTTTT(C/T)TTTTT utr-variant-3-prime
rs34031935 -- 81,920,271(+) TGTCT(A/C)TGAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAFG Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3342n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
esv33468 CNV Loss 17666407
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
nsv833571 CNV Loss 17160897

Variation tolerance for MAFG Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAFG Gene

HapMap Linkage Disequilibrium report
MAFG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAFG Gene

Disorders for MAFG Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAFG Gene - From: GeneCards

Disorder Aliases PubMed IDs
fibrosarcoma
  • fibrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search MAFG in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAFG

Genetic Association Database (GAD)
MAFG
Human Genome Epidemiology (HuGE) Navigator
MAFG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAFG
genes like me logo Genes that share disorders with MAFG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAFG Gene

Publications for MAFG Gene

  1. hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. (PMID: 9195958) Marini M.G. … Moi P. (J. Biol. Chem. 1997) 3 4 23 67
  2. Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. (PMID: 9763667) Iwata T. … Ito E. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements. (PMID: 16716189) Yamamoto T. … Yamamoto M. (Genes Cells 2006) 3 23
  4. c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction. (PMID: 12149651) Dhakshinamoorthy S. … Jaiswal A.K. (Oncogene 2002) 3 23
  5. Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)- mediated acetylation. (PMID: 11154691) Hung H.-L. … Blobel G.A. (J. Biol. Chem. 2001) 3 23

Products for MAFG Gene

Sources for MAFG Gene

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