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Aliases for ARRB2 Gene

Aliases for ARRB2 Gene

  • Arrestin Beta 2 2 3
  • Arrestin, Beta 2 2 3 5
  • Arrestin Beta-2 3 4
  • Arrestin 3 2 3
  • ARR2 3 4
  • ARB2 3 4
  • BARR2 3

External Ids for ARRB2 Gene

Previous HGNC Symbols for ARRB2 Gene

  • ARR2

Previous GeneCards Identifiers for ARRB2 Gene

  • GC17P005040
  • GC17P004959
  • GC17P004564
  • GC17P004820
  • GC17P004560
  • GC17P004613
  • GC17P004502

Summaries for ARRB2 Gene

Entrez Gene Summary for ARRB2 Gene

  • Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for ARRB2 Gene

ARRB2 (Arrestin Beta 2) is a Protein Coding gene. Diseases associated with ARRB2 include whim syndrome and epidemic typhus. Among its related pathways are Chemokine Signaling and Circadian entrainment. GO annotations related to this gene include receptor binding and ubiquitin protein ligase binding. An important paralog of this gene is ARR3.

UniProtKB/Swiss-Prot for ARRB2 Gene

  • Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires ADRBK1. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3.

Gene Wiki entry for ARRB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRB2 Gene

Genomics for ARRB2 Gene

Regulatory Elements for ARRB2 Gene

Enhancers for ARRB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARRB2 on UCSC Golden Path with GeneCards custom track

Promoters for ARRB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARRB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARRB2 Gene

Chromosome:
17
Start:
4,710,489 bp from pter
End:
4,721,500 bp from pter
Size:
11,012 bases
Orientation:
Plus strand

Genomic View for ARRB2 Gene

Genes around ARRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRB2 Gene

Proteins for ARRB2 Gene

  • Protein details for ARRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32121-ARRB2_HUMAN
    Recommended name:
    Beta-arrestin-2
    Protein Accession:
    P32121
    Secondary Accessions:
    • B4DLW0
    • B5B0C0
    • B7WPL3
    • D3DTK2
    • H0Y688
    • Q0Z8D3
    • Q2PP19
    • Q6ICT3
    • Q8N7Y2
    • Q9UEQ6

    Protein attributes for ARRB2 Gene

    Size:
    409 amino acids
    Molecular mass:
    46106 Da
    Quaternary structure:
    • Homooligomer; the self-association is mediated by InsP6-binding (Probable). Heterooligomer with ARRB1; the association is mediated by InsP6-binding. Interacts with ADRB2 AND CHRM2. Interacts with PDE4A. Interacts with PDE4D. Interacts with MAPK10, MAPK1 and MAPK3. Interacts with DRD2. Interacts with FSHR. Interacts with CLTC. Interacts with HTR2C. Interacts with CCR5. Interacts with CXCR4. Interacts with SRC. Interacts with DUSP16; the interaction is interrupted by stimulation of AGTR1 and activation of MAPK10. Interacts with CHUK; the interaction is enhanced stimulation of ADRB2. Interacts with RELA. Interacts with MDM2; the interaction is enhanced by activation of GPCRs. Interacts with SLC9A5. Interacts with TRAF6. Interacts with IGF1R. Interacts with ENG. Interacts with KIR2DL1, KIR2DL3 and KIR2DL4. Interacts with LDLR. Interacts with AP2B1. Interacts with C5AR1. Interacts with RAF1. Interacts with MAP2K1. Interacts with MAPK1. Interacts with MAPK10; the interaction enhances MAPK10 activation by MAP3K5. Interacts with MAP2K4; the interaction is enhanced by presence of MAP3K5 and MAPK10. Interacts with MAP3K5. Interacts with AKT1. Interacts with IKBKB and MAP3K14. Interacts with SMO (activated). Interacts with GSK3A and GSK3B. Associates with protein phosphatase 2A (PP2A) (By similarity). Interacts with DHX8; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with GAPDHS; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with H2AFX; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with KIF14; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with RCC1; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with CXCR4; the interaction is dependent on C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with GPR143. Interacts with HCK and CXCR1 (phosphorylated). Interacts with ACKR3 and ACKR4.

    Alternative splice isoforms for ARRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARRB2 Gene

Proteomics data for ARRB2 Gene at MOPED

Post-translational modifications for ARRB2 Gene

  • Hydroxylation by PHD2 modulates the rate of internalization by slowing down recruitment to the plasma membrane and inhibiting subsequent co-internalization with class A receptors.
  • Phosphorylated at Thr-382 in the cytoplasm; probably dephosphorylated at the plasma membrane. The phosphorylation does not regulate internalization and recycling of ADRB2, interaction with clathrin or AP2B1.
  • The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occurr GPCR-specifc. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33. Stimulation of a class B GPCR promotes a sustained ubiquitination.
  • Ubiquitination at Lys 78
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ARRB2 (beta-Arrestin 2)
  • Cell Signaling Technology (CST) Antibodies for ARRB2 (ARRB2)

No data available for DME Specific Peptides for ARRB2 Gene

Domains & Families for ARRB2 Gene

Gene Families for ARRB2 Gene

Protein Domains for ARRB2 Gene

Suggested Antigen Peptide Sequences for ARRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32121

UniProtKB/Swiss-Prot:

ARRB2_HUMAN :
  • The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.
  • Belongs to the arrestin family.
Domain:
  • The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRB2: view

Function for ARRB2 Gene

Molecular function for ARRB2 Gene

GENATLAS Biochemistry:
beta-arrestin 2,Ca2+ binding protein of the retinal red outer segments,widely expressed,binding to P-rhodopsin and inhibiting further G protein activation desensitized receptor-arrestin complex and sequestered through clathrin coated pits,also regulator of beta-adrenergic receptor A and involved in synaptic transmission in photoreceptor cells
UniProtKB/Swiss-Prot Function:
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires ADRBK1. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3.

Gene Ontology (GO) - Molecular Function for ARRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 10644702
GO:0031691 alpha-1A adrenergic receptor binding IEA --
GO:0031692 alpha-1B adrenergic receptor binding IEA --
GO:0031748 D1 dopamine receptor binding IEA --
GO:0032947 protein complex scaffold IDA 19372219
genes like me logo Genes that share ontologies with ARRB2: view
genes like me logo Genes that share phenotypes with ARRB2: view

Animal Models for ARRB2 Gene

MGI Knock Outs for ARRB2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ARRB2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARRB2 Gene

Localization for ARRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARRB2 Gene

Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARRB2 Gene COMPARTMENTS Subcellular localization image for ARRB2 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
endosome 2
lysosome 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ARRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005905 coated pit IEA --
genes like me logo Genes that share ontologies with ARRB2: view

Pathways & Interactions for ARRB2 Gene

SuperPathways for ARRB2 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by Hedgehog
3 CDK-mediated phosphorylation and removal of Cdc6
4 Signaling by GPCR
5 Chemokine Signaling
genes like me logo Genes that share pathways with ARRB2: view

SIGNOR curated interactions for ARRB2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ARRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IEA,IMP 12582207
GO:0006897 endocytosis IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with ARRB2: view

Drugs & Compounds for ARRB2 Gene

(9) Drugs for ARRB2 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methamphetamine Approved, Illicit Pharma 210

(2) Additional Compounds for ARRB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARRB2: view

Transcripts for ARRB2 Gene

Unigene Clusters for ARRB2 Gene

Arrestin, beta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARRB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - -
SP2: -
SP3: - - -
SP4: - - - - - - - -
SP5: - -
SP6:
SP7: - -
SP8:

Relevant External Links for ARRB2 Gene

GeneLoc Exon Structure for
ARRB2
ECgene alternative splicing isoforms for
ARRB2

Expression for ARRB2 Gene

mRNA expression in normal human tissues for ARRB2 Gene

mRNA differential expression in normal tissues according to GTEx for ARRB2 Gene

This gene is overexpressed in Whole Blood (x27.6).

Protein differential expression in normal tissues from HIPED for ARRB2 Gene

This gene is overexpressed in Lavage (18.5), Peripheral blood mononuclear cells (10.4), and Monocytes (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARRB2 Gene



SOURCE GeneReport for Unigene cluster for ARRB2 Gene Hs.435811

genes like me logo Genes that share expression patterns with ARRB2: view

Protein tissue co-expression partners for ARRB2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARRB2 Gene

Orthologs for ARRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARRB2 35
  • 92.3 (n)
  • 95.95 (a)
ARRB2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARRB2 35
  • 91.44 (n)
  • 96.08 (a)
ARRB2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arrb2 35
  • 88.97 (n)
  • 95.24 (a)
Arrb2 16
Arrb2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARRB2 35
  • 99.45 (n)
  • 99.52 (a)
ARRB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arrb2 35
  • 90.95 (n)
  • 96.33 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARRB2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arrb2 35
  • 76.46 (n)
  • 86.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398046 35
zebrafish
(Danio rerio)
Actinopterygii arrb2b 35
  • 78.46 (n)
  • 84.77 (a)
zgc64007 35
arrb2a 36
  • 81 (a)
OneToMany
arrb2b 36
  • 84 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11852 35
fruit fly
(Drosophila melanogaster)
Insecta Arr1 37
  • 43 (a)
Arr2 37
  • 43 (a)
krz 37
  • 56 (a)
Arr1 36
  • 42 (a)
ManyToMany
Arr2 36
  • 42 (a)
ManyToMany
CG32683 36
  • 18 (a)
ManyToMany
krz 36
  • 52 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea arr-1 37
  • 52 (a)
arr-1 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10346 36
  • 65 (a)
OneToMany
Species with no ortholog for ARRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRB2 Gene

ENSEMBL:
Gene Tree for ARRB2 (if available)
TreeFam:
Gene Tree for ARRB2 (if available)

Paralogs for ARRB2 Gene

Paralogs for ARRB2 Gene

genes like me logo Genes that share paralogs with ARRB2: view

Variants for ARRB2 Gene

Sequence variations from dbSNP and Humsavar for ARRB2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs14540 -- 4,721,402(-) AGAGA(A/G)AGTGA nc-transcript-variant, utr-variant-3-prime
rs1045280 -- 4,719,343(+) CTCAG(C/T)GACAA intron-variant, nc-transcript-variant, reference, synonymous-codon
rs2271167 -- 4,719,585(+) TGTAC(A/G)GCAGG intron-variant
rs2036656 -- 4,718,776(+) GCCAT(C/G)TCCAC intron-variant
rs2036657 -- 4,721,864(+) GAGTC(A/G)CGTTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ARRB2 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
esv2328716 CNV Deletion 18987734
esv995819 CNV Deletion 20482838
esv2715557 CNV Deletion 23290073
nsv111849 CNV Loss 16902084

Variation tolerance for ARRB2 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARRB2 Gene

HapMap Linkage Disequilibrium report
ARRB2
Human Gene Mutation Database (HGMD)
ARRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRB2 Gene

Disorders for ARRB2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ARRB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
whim syndrome
  • warts, hypogammaglobulinemia, infections, and myelokathexis
epidemic typhus
  • sylvatic typhus
basilar artery occlusion
hereditary choroidal atrophy
  • hereditary choroidal dystrophy
partial central choroid dystrophy
  • choroidal dystrophy, central areolar
- elite association - COSMIC cancer census association via MalaCards
Search ARRB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARRB2

Genetic Association Database (GAD)
ARRB2
Human Genome Epidemiology (HuGE) Navigator
ARRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARRB2
genes like me logo Genes that share disorders with ARRB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARRB2 Gene

Publications for ARRB2 Gene

  1. Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PMID: 7695743) Calabrese G. … De Blasi A. (Genomics 1994) 2 3 23 67
  2. Overexpression of beta-arrestin 2 in peripheral blood mononuclear cells of patients with cryptococcal meningitis. (PMID: 20035620) Xia R. … Wen H. (J. Interferon Cytokine Res. 2010) 3 23
  3. A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. (PMID: 19782076) Li X. … Baillie G.S. (FEBS Lett. 2009) 3 23
  4. Imaging ligand-dependent activation of CXCR7. (PMID: 19794961) Luker K.E. … Luker G.D. (Neoplasia 2009) 3 23
  5. Regulation of GPR54 signaling by GRK2 and {beta}-arrestin. (PMID: 19846537) Pampillo M. … Babwah A.V. (Mol. Endocrinol. 2009) 3 23

Products for ARRB2 Gene

Sources for ARRB2 Gene

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