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Aliases for MARCKS Gene

Aliases for MARCKS Gene

  • Myristoylated Alanine-Rich Protein Kinase C Substrate 2 3
  • Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS, 80K-L) 2 3
  • Protein Kinase C Substrate, 80 KDa Protein, Light Chain 3 4
  • PRKCSL 3 4
  • PKCSL 3 4
  • MACS 3 4
  • Phosphomyristin 3
  • 80K-L Protein 4
  • 80K-L 3

External Ids for MARCKS Gene

Previous HGNC Symbols for MARCKS Gene

  • MACS

Previous GeneCards Identifiers for MARCKS Gene

  • GC06P114013
  • GC06P114201
  • GC06P114224
  • GC06P114285
  • GC06P111756
  • GC06P114179
  • GC06P114189

Summaries for MARCKS Gene

Entrez Gene Summary for MARCKS Gene

  • The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MARCKS Gene

MARCKS (Myristoylated Alanine-Rich Protein Kinase C Substrate) is a Protein Coding gene. Diseases associated with MARCKS include macrocephaly, alopecia, cutis laxa, and scoliosis. Among its related pathways are MicroRNAs in cancer and Metabolism. GO annotations related to this gene include calmodulin binding and protein kinase C binding.

UniProtKB/Swiss-Prot for MARCKS Gene

  • MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein

Gene Wiki entry for MARCKS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCKS Gene

Genomics for MARCKS Gene

Regulatory Elements for MARCKS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MARCKS Gene

Chromosome:
6
Start:
113,857,335 bp from pter
End:
113,863,475 bp from pter
Size:
6,141 bases
Orientation:
Plus strand

Genomic View for MARCKS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MARCKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCKS Gene

Proteins for MARCKS Gene

  • Protein details for MARCKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29966-MARCS_HUMAN
    Recommended name:
    Myristoylated alanine-rich C-kinase substrate
    Protein Accession:
    P29966
    Secondary Accessions:
    • E1P560
    • Q2LA83
    • Q5TDB7

    Protein attributes for MARCKS Gene

    Size:
    332 amino acids
    Molecular mass:
    31555 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MARCKS Gene

Proteomics data for MARCKS Gene at MOPED

Post-translational modifications for MARCKS Gene

  • Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCKS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MARCKS (MARCKS)

No data available for DME Specific Peptides for MARCKS Gene

Domains & Families for MARCKS Gene

Protein Domains for MARCKS Gene

Suggested Antigen Peptide Sequences for MARCKS Gene

Graphical View of Domain Structure for InterPro Entry

P29966

UniProtKB/Swiss-Prot:

MARCS_HUMAN :
  • Belongs to the MARCKS family.
Family:
  • Belongs to the MARCKS family.
genes like me logo Genes that share domains with MARCKS: view

No data available for Gene Families for MARCKS Gene

Function for MARCKS Gene

Molecular function for MARCKS Gene

UniProtKB/Swiss-Prot Function:
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein

Gene Ontology (GO) - Molecular Function for MARCKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IEA --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0051015 actin filament binding TAS 1560845
genes like me logo Genes that share ontologies with MARCKS: view
genes like me logo Genes that share phenotypes with MARCKS: view

Animal Models for MARCKS Gene

MGI Knock Outs for MARCKS:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARCKS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MARCKS Gene

Localization for MARCKS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCKS Gene

Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MARCKS Gene COMPARTMENTS Subcellular localization image for MARCKS gene
Compartment Confidence
extracellular 5
cytoskeleton 4
plasma membrane 4
cytosol 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MARCKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005813 centrosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with MARCKS: view

Pathways & Interactions for MARCKS Gene

genes like me logo Genes that share pathways with MARCKS: view

Pathways by source for MARCKS Gene

1 Cell Signaling Technology pathway for MARCKS Gene
1 BioSystems pathway for MARCKS Gene

Interacting Proteins for MARCKS Gene

Selected Interacting proteins: P29966-MARCS_HUMAN for MARCKS Gene via I2D

SIGNOR curated interactions for MARCKS Gene

Other effect:

Gene Ontology (GO) - Biological Process for MARCKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0050796 regulation of insulin secretion TAS --
genes like me logo Genes that share ontologies with MARCKS: view

Drugs & Compounds for MARCKS Gene

(24) Drugs for MARCKS Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbachol Approved Pharma Full agonist, Agonist 3
Lithium Approved Pharma 206
Norepinephrine Approved Pharma 206
Valproic Acid Approved, Investigational Pharma HDAC1 inhibitor, Histone deacetylase (HDAC)inhibitors 302
Zinc Approved Pharma 1404

(22) Additional Compounds for MARCKS Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,2-Diacylglycerol
12-O-Tetradecanoylphorbol 13-acetate
Bisindolylmaleimide
CATECHOLAMINE
Cytochalasin D
genes like me logo Genes that share compounds with MARCKS: view

Transcripts for MARCKS Gene

mRNA/cDNA for MARCKS Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(585) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARCKS Gene

Myristoylated alanine-rich protein kinase C substrate:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MARCKS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCKS Gene

No ASD Table

Relevant External Links for MARCKS Gene

GeneLoc Exon Structure for
MARCKS
ECgene alternative splicing isoforms for
MARCKS

Expression for MARCKS Gene

mRNA expression in normal human tissues for MARCKS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MARCKS Gene

This gene is overexpressed in Cerebral cortex (11.3), Lavage (10.1), Frontal cortex (7.5), Fetal Brain (7.2), and Brain (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MARCKS Gene



SOURCE GeneReport for Unigene cluster for MARCKS Gene Hs.519909

genes like me logo Genes that share expression patterns with MARCKS: view

Protein tissue co-expression partners for MARCKS Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MARCKS Gene

Orthologs for MARCKS Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCKS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MARCKS 35
  • 83.59 (n)
  • 80.25 (a)
chimpanzee
(Pan troglodytes)
Mammalia MARCKS 35
  • 99.4 (n)
  • 99.1 (a)
mouse
(Mus musculus)
Mammalia Marcks 16
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8766 35
African clawed frog
(Xenopus laevis)
Amphibia marcks-prov 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10160 35
Species with no ortholog for MARCKS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MARCKS Gene

ENSEMBL:
Gene Tree for MARCKS (if available)
TreeFam:
Gene Tree for MARCKS (if available)

Paralogs for MARCKS Gene

No data available for Paralogs for MARCKS Gene

Variants for MARCKS Gene

Sequence variations from dbSNP and Humsavar for MARCKS Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10585 -- 113,861,195(+) GATTT(A/T)AAAAA utr-variant-3-prime
rs12223 -- 113,862,707(+) TGCCA(A/G)ATCTT utr-variant-3-prime
rs12307 -- 113,860,932(+) TGTCA(A/G)TCTAT utr-variant-3-prime
rs352082 -- 113,859,470(-) CCCCC(C/G)AAAAC intron-variant
rs352083 -- 113,861,962(-) TCTAC(A/G)TAATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MARCKS Gene

Variant ID Type Subtype PubMed ID
nsv482098 CNV Loss 20164927

Variation tolerance for MARCKS Gene

Gene Damage Index Score: 2.40; 42.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MARCKS Gene

HapMap Linkage Disequilibrium report
MARCKS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCKS Gene

Disorders for MARCKS Gene

MalaCards: The human disease database

(1) MalaCards diseases for MARCKS Gene - From: OMIM

Disorder Aliases PubMed IDs
macrocephaly, alopecia, cutis laxa, and scoliosis
  • mac
- elite association

Relevant External Links for MARCKS

Human Genome Epidemiology (HuGE) Navigator
MARCKS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MARCKS
genes like me logo Genes that share disorders with MARCKS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCKS Gene

Publications for MARCKS Gene

  1. Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation. (PMID: 19852062) Michel S. … BlAoker H. (Mol. Carcinog. 2010) 23 67
  2. Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway. (PMID: 20047593) Techasen A. … Yongvanit P. (Cancer Sci. 2010) 23 67
  3. Interaction of the MARCKS peptide with PIP2 in phospholipid monolayers. (PMID: 19362071) Dietrich U. … KAos J.A. (Biochim. Biophys. Acta 2009) 23 67
  4. Actin modulation of a MARCKS phosphorylation site located outside the effector domain. (PMID: 19366616) Toledo A. … Arruti C. (Biochem. Biophys. Res. Commun. 2009) 23 67
  5. Dominant role of lipid rafts L-type calcium channel in activity-dependent potentiation of large dense-core vesicle exocytosis. (PMID: 19457106) Park Y. … Kim K.T. (J. Neurochem. 2009) 23 67

Products for MARCKS Gene

Sources for MARCKS Gene

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