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Aliases for ARRB1 Gene

Aliases for ARRB1 Gene

  • Arrestin, Beta 1 2 3
  • Arrestin 2 2 3
  • ARR1 3 4
  • Beta-Arrestin-1 3
  • Arrestin Beta-1 4
  • ARB1 3

External Ids for ARRB1 Gene

Previous HGNC Symbols for ARRB1 Gene

  • ARR1

Previous GeneCards Identifiers for ARRB1 Gene

  • GC11M077303
  • GC11M076515
  • GC11M075199
  • GC11M074702
  • GC11M074654
  • GC11M074976
  • GC11M071275

Summaries for ARRB1 Gene

Entrez Gene Summary for ARRB1 Gene

  • Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

GeneCards Summary for ARRB1 Gene

ARRB1 (Arrestin, Beta 1) is a Protein Coding gene. Diseases associated with ARRB1 include whim syndrome. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. GO annotations related to this gene include transcription factor binding and ubiquitin protein ligase binding. An important paralog of this gene is ARRB2.

UniProtKB/Swiss-Prot for ARRB1 Gene

  • Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3.

Gene Wiki entry for ARRB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRB1 Gene

Genomics for ARRB1 Gene

Regulatory Elements for ARRB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARRB1 Gene

Start:
75,260,122 bp from pter
End:
75,351,831 bp from pter
Size:
91,710 bases
Orientation:
Minus strand

Genomic View for ARRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRB1 Gene

Proteins for ARRB1 Gene

  • Protein details for ARRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49407-ARRB1_HUMAN
    Recommended name:
    Beta-arrestin-1
    Protein Accession:
    P49407
    Secondary Accessions:
    • B6V9G8
    • O75625
    • O75630
    • Q2PP20
    • Q9BTK8

    Protein attributes for ARRB1 Gene

    Size:
    418 amino acids
    Molecular mass:
    47066 Da
    Quaternary structure:
    • Monomer. Homodimer. Homooligomer; the self-association is mediated by InsP6-binding. Heterooligomer with ARRB2; the association is mediated by InsP6-binding. Interacts with GPR143. Interacts with ADRB2 (phosphorylated). Interacts with CHRM2 (phosphorylated). Interacts with LHCGR. Interacts with CYTH2 and CASR. Interacts with AP2B1 (dephosphorylated at Tyr-737); phosphorylation of AP2B1 at Tyr-737 disrupts the interaction. Interacts (dephosphorylated at Ser-412) with CLTC. Interacts with CCR2 and ADRBK1. Interacts with CRR5. Interacts with PTAFR (phosphorylated on serine residues). Interacts with CLTC and MAP2K3. Interacts with CREB1. Interacts with TRAF6. Interacts with IGF1R and MDM2. Interacts with C5AR1. Interacts with PDE4D. Interacts with SRC (via the SH3 domain and the protein kinase domain); the interaction is independent of the phosphorylation state of SRC C-terminus. Interacts with TACR1. Interacts with RAF1. Interacts with CHUK, IKBKB and MAP3K14. Interacts with DVL1; the interaction is enhanced by phosphorylation of DVL1. Interacts with DVL2; the interaction is enhanced by phosphorylation of DVL2. Interacts with IGF1R. Associates with MAP kinase p38. Part of a MAPK signaling complex consisting of TACR1, ARRB1, SRC, MAPK1 (activated) and MAPK3 (activated). Part of a MAPK signaling complex consisting of F2RL1, ARRB1, RAF1, MAPK1 (activated) and MAPK3 (activated) (By similarity). Interacts with MAP2K4/MKK4. Interacts with HCK and CXCR1 (phosphorylated). Interacts with ACKR3 and ACKR4.

    Three dimensional structures from OCA and Proteopedia for ARRB1 Gene

    Alternative splice isoforms for ARRB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARRB1 Gene

Proteomics data for ARRB1 Gene at MOPED

Post-translational modifications for ARRB1 Gene

  • Constitutively phosphorylated at Ser-412 in the cytoplasm. At the plasma membrane, is rapidly dephosphorylated, a process that is required for clathrin binding and ADRB2 endocytosis but not for ADRB2 binding and desensitization. Once internalized, is rephosphorylated.
  • The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occur GPCR-specific. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRB1 Gene

Antibody Products

  • R&D Systems Antibodies for ARRB1 (beta-Arrestin 1)
  • Cell Signaling Technology (CST) Antibodies for ARRB1 (ARRB1)

No data available for DME Specific Peptides for ARRB1 Gene

Domains for ARRB1 Gene

Protein Domains for ARRB1 Gene

Suggested Antigen Peptide Sequences for ARRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49407

UniProtKB/Swiss-Prot:

ARRB1_HUMAN :
  • P49407
Domain:
  • The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1 (By similarity). Binding to phosphorylated GPCRs induces a conformationanl change that exposes the motif to the surface.
  • The N-terminus binds InsP6 with low affinity.
  • The C-terminus binds InsP6 with high affinity.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRB1: view

No data available for Gene Families for ARRB1 Gene

Function for ARRB1 Gene

Molecular function for ARRB1 Gene

GENATLAS Biochemistry: beta-arrestin 1,Ca2+ binding protein of the retinal red outer segments,widely expressed,binding to P-rhodopsin and inhibiting further G protein activation desensitized receptor-arrestin complex and sequestered through clathrin coated pits,also regulator of beta-adrenergic receptor A and involved in synaptic transmission in photoreceptor cells
UniProtKB/Swiss-Prot Function: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3.

Gene Ontology (GO) - Molecular Function for ARRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 NOT histone acetyltransferase activity IDA 16325578
GO:0004857 enzyme inhibitor activity TAS 2163110
GO:0005096 GTPase activator activity IMP 15611106
GO:0005159 insulin-like growth factor receptor binding IPI 15878855
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ARRB1: view
genes like me logo Genes that share phenotypes with ARRB1: view

Animal Models for ARRB1 Gene

MGI Knock Outs for ARRB1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARRB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARRB1 Gene

Localization for ARRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARRB1 Gene

Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit. Cell projection, pseudopodium. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARRB1 Gene COMPARTMENTS Subcellular localization image for ARRB1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
golgi apparatus 4
lysosome 4
vacuole 4
endosome 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0000785 chromatin IDA 16325578
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16325578
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ARRB1: view

Pathways for ARRB1 Gene

genes like me logo Genes that share pathways with ARRB1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ARRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 23633677
GO:0002031 G-protein coupled receptor internalization IMP 10521508
GO:0002092 positive regulation of receptor internalization IMP 22457824
GO:0006366 transcription from RNA polymerase II promoter IMP 16325578
GO:0006892 post-Golgi vesicle-mediated transport TAS --
genes like me logo Genes that share ontologies with ARRB1: view

Compounds for ARRB1 Gene

(9) Novoseek inferred chemical compound relationships for ARRB1 Gene

Compound -log(P) Hits PubMed IDs
etorphine 56.8 1
serine 36.4 2
tyrosine 31.4 3
threonine 30.3 1
phosphoinositide 29.8 1
genes like me logo Genes that share compounds with ARRB1: view

Transcripts for ARRB1 Gene

Unigene Clusters for ARRB1 Gene

Arrestin, beta 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARRB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRB1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: -
SP5:
SP6: - -

Relevant External Links for ARRB1 Gene

GeneLoc Exon Structure for
ARRB1
ECgene alternative splicing isoforms for
ARRB1

Expression for ARRB1 Gene

mRNA expression in normal human tissues for ARRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARRB1 Gene

SOURCE GeneReport for Unigene cluster for ARRB1 Gene Hs.503284

genes like me logo Genes that share expressions with ARRB1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARRB1 Gene

Orthologs for ARRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARRB1 35
  • 99.04 (n)
  • 99.04 (a)
ARRB1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARRB1 35
  • 93.3 (n)
  • 99.04 (a)
ARRB1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARRB1 35
  • 92.29 (n)
  • 98.8 (a)
ARRB1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arrb1 35
  • 89.79 (n)
  • 98.56 (a)
Arrb1 16
Arrb1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARRB1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARRB1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arrb1 35
  • 90.27 (n)
  • 99.04 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486349 35
  • 82.16 (n)
  • 94.16 (a)
zebrafish
(Danio rerio)
Actinopterygii arrb1 35
  • 76.63 (n)
  • 90.67 (a)
arrb1 36
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta ARRK 35
  • 64.24 (n)
  • 65.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arr1 36
  • 45 (a)
ManyToMany
Arr2 36
  • 42 (a)
ManyToMany
CG32683 36
  • 18 (a)
ManyToMany
krz 35
  • 63.07 (n)
  • 66.58 (a)
krz 36
  • 55 (a)
ManyToMany
Arr2 37
  • 43 (a)
krz 37
  • 65 (a)
Arr1 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea arr-1 35
  • 58.86 (n)
  • 59.29 (a)
arr-1 36
  • 53 (a)
OneToMany
arr-1 37
  • 54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9163 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10346 36
  • 67 (a)
OneToMany
Species with no ortholog for ARRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRB1 Gene

ENSEMBL:
Gene Tree for ARRB1 (if available)
TreeFam:
Gene Tree for ARRB1 (if available)

Paralogs for ARRB1 Gene

Paralogs for ARRB1 Gene

genes like me logo Genes that share paralogs with ARRB1: view

Variants for ARRB1 Gene

Sequence variations from dbSNP and Humsavar for ARRB1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3139 -- 75,265,976(+) GTCCT(A/G)TTGGC utr-variant-3-prime
rs472112 -- 75,310,457(-) CCTCC(A/G)CTTCC intron-variant
rs473344 -- 75,308,694(-) tatct(G/T)ggctc intron-variant, upstream-variant-2KB
rs475476 -- 75,300,708(-) ATTAC(A/G)GGCGT intron-variant
rs475557 -- 75,300,672(-) TTGTA(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARRB1 Gene

Variant ID Type Subtype PubMed ID
nsv832211 CNV Loss 17160897
nsv522447 CNV Loss 19592680

Relevant External Links for ARRB1 Gene

HapMap Linkage Disequilibrium report
ARRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRB1 Gene

Disorders for ARRB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARRB1 Gene including...

Search for ARRB1 Gene in MalaCards »

(7) Novoseek inferred disease relationships for ARRB1 Gene

Disease -log(P) Hits PubMed IDs
heart failure 23.6 1
multiple sclerosis 9.83 2
mood disorders 0.557 1
autoimmunity 0 3
metastasis 0 2

Relevant External Links for ARRB1

Genetic Association Database (GAD)
ARRB1
Human Genome Epidemiology (HuGE) Navigator
ARRB1
genes like me logo Genes that share disorders with ARRB1: view

No data available for UniProtKB/Swiss-Prot for ARRB1 Gene

Publications for ARRB1 Gene

  1. Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing. (PMID: 8486659) Parruti G. … de Blasi A. (J. Biol. Chem. 1993) 2 3 4 23
  2. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. (PMID: 9924018) Luttrell L.M. … Lefkowitz R.J. (Science 1999) 3 4 23
  3. Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. (PMID: 14711824) Ahn S. … Lefkowitz R.J. (J. Biol. Chem. 2004) 3 4 23
  4. {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. (PMID: 15878855) Girnita L. … Larsson O. (J. Biol. Chem. 2005) 3 4 23
  5. beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. (PMID: 15611106) Barnes W.G. … Lefkowitz R.J. (J. Biol. Chem. 2005) 3 4 23

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