Aliases for EPCAM Gene
Aliases for EPCAM Gene
- Epithelial Cell Adhesion Molecule 2 3 5
- Tumor-Associated Calcium Signal Transducer 1 2 3 4
- Major Gastrointestinal Tumor-Associated Protein GA733-2 3 4
- Adenocarcinoma-Associated Antigen 3 4
- Cell Surface Glycoprotein Trop-1 3 4
- Epithelial Glycoprotein 314 3 4
- TACSTD1 3 4
- EGP314 3 4
- MIC18 3 4
- TROP1 3 4
- M4S1 3 4
- KSA 3 4
- Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein) 3
- Antigen Identified By Monoclonal Antibody AUA1 2
- Human Epithelial Glycoprotein-2 3
- Epithelial Cell Surface Antigen 4
External Ids for EPCAM Gene
- HGNC: 11529
- Entrez Gene: 4072
- Ensembl: ENSG00000119888
- OMIM: 185535
- UniProtKB: P16422
Previous HGNC Symbols for EPCAM Gene
- M4S1
- MIC18
- TACSTD1
Previous GeneCards Identifiers for EPCAM Gene
- GC02P047425
- GC02P047572
- GC02P047332
Summaries for EPCAM Gene
-
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
GeneCards Summary for EPCAM Gene
EPCAM (Epithelial Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with EPCAM include Diarrhea 5, With Tufting Enteropathy, Congenital and Colorectal Cancer, Hereditary Nonpolyposis, Type 8. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include protein complex binding. An important paralog of this gene is TACSTD2.
UniProtKB/Swiss-Prot for EPCAM Gene
-
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Additional gene information for EPCAM Gene
- Monarch Initiative
- Search for EPCAM at DataMed
- Search for EPCAM at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPCAM Gene
Genomics for EPCAM Gene
GeneHancer (GH) Regulatory Elements for EPCAM Gene
Regulatory Element Products
Genomic Locations for EPCAM Gene
- chr2:47,345,158-47,387,601
- (GRCh38/hg38)
- Size:
- 42,444 bases
- Orientation:
- Plus strand
- chr2:47,572,297-47,614,740
- (GRCh37/hg19)
Genomic View for EPCAM Gene
- Cytogenetic band:
-
- 2p21 by Ensembl
- 2p21 by Entrez Gene
- 2p21 by HGNC


RefSeq DNA sequence for EPCAM Gene
Proteins for EPCAM Gene
-
Protein details for EPCAM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16422-EPCAM_HUMAN
- Recommended name:
- Epithelial cell adhesion molecule
- Protein Accession:
- P16422
- P18180
- Q6FG26
- Q6FG49
- Q96C47
- Q9UCD0
Protein attributes for EPCAM Gene
- Size:
- 314 amino acids
- Molecular mass:
- 34932 Da
- Quaternary structure:
-
- Monomer. Interacts with phosphorylated CLDN7.
Protein Expression for EPCAM Gene
Post-translational modifications for EPCAM Gene
- Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
- Ubiquitination at Lys303
- Glycosylation at posLast=7474, posLast=111111, posLast=171171, and Asn198
Other Protein References for EPCAM Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for EPCAM (EpCAM/TROP1)
- Cell Signaling Technology (CST) Antibodies for EPCAM (EPCAM)
-
Custom Antibody ServicesOriGene Antibodies for EPCAM
- CF506657
- TA506660
- CF506660
- TA506695
- CF506695
- TA600533
- TA600534
- TA700533
- TA700534
- TA809211
- CF809211
- UM500096
- UM570096
- UM500097
- UM570097
- TA500055S
- AM06447SU-N
- AM10033FC-N
- AM10033FC-S
- AM10033PU-N
- AM10033PU-S
- AM26013PU-N
- AM33194PU-N
- AM33194PU-S
- AM33243AC-S
- AM33243PU-N
- AM33243PU-S
- AM33243PU-T
- AM33243RP-N
- AM50093PU-N
- AM50093PU-S
- AM50137PU-N
- AM50137PU-S
- AM50137PU-T
- AP06671PU-N
- BM2274
- BM2274F
- BM2274X
- BM2274XL
- DM2013
- DM2014A
- DM406
- DM406-05
- TA311989
- TA321475
- TA327673
- TA327674
- TA336940
- TA353166
- TA353794
- TA353806
- TA500054
- CF500054
- TA500055
- TA506657
- CF506656
- TA506656
- CF506652
- TA506652
- CF506650
- TA506650
- CF506649
- TA506649
- CF506644
- TA506644
- CF506643
- TA506643
- CF506641
- TA506641
- CF506639
- TA506639
- CF506637
- TA506637
- CF506629
- TA506629
- CF506628
- TA506628
- CF506627
- TA506627
- CF506626
- TA506626
- CF506624
- TA506624
- CF506619
- TA506619
- CF500171
- TA500171
- CF500056
- TA500056
- CF500055
- Novus Biologicals Antibodies for EPCAM
-
Abcam antibodies for EPCAM
-
Cloud-Clone Corp. Antibodies for EPCAM
- Invitrogen Antibodies for EPCAM
- GeneTex EPCAM antibody for EPCAM
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPCAM
Protein Products
- R&D Systems Proteins and Enzymes for EPCAM (EpCAM/TROP1)
- Search Origene for MassSpec and Protein Over-expression Lysates for EPCAM
- Origene Custom Protein Services for EPCAM
- ProSpec Recombinant Proteins for EPCAM
-
Cloud-Clone Corp. Proteins for EPCAM
- Search GeneTex for Proteins for EPCAM
-
Abcam proteins for EPCAM
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, Cell Selection and Detection Kits, and other biochemical assays for EPCAM (EpCAM/TROP1)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for EPCAM (EPCAM)
-
Cloud-Clone Corp. Assay Kits for EPCAM
No data available for DME Specific Peptides for EPCAM Gene
Domains & Families for EPCAM Gene
Gene Families for EPCAM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for EPCAM Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EPCAM Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P16422- Family:
-
- Belongs to the EPCAM family.
Function for EPCAM Gene
Molecular function for EPCAM Gene
- UniProtKB/Swiss-Prot Function:
- May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16054130 |
GO:0032403 | protein complex binding | IDA | 19136966 |
GO:0098641 | cadherin binding involved in cell-cell adhesion | IBA | -- |
Phenotypes for EPCAM Gene
- MGI mutant phenotypes for EPCAM:
-
inferred from 8 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- embryo phenotype
- hematopoietic system phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for EPCAM:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPCAM
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EPCAM gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPCAM gene
- Search ViGene Biosciences for EPCAM
CRISPR Products
-
OriGene CRISPR knockouts for EPCAM
- genomics-online: gRNA clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
- Applied Biological Materials CRISPR for EPCAM
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPCAM
- GenScript: Design CRISPR guide RNA sequences for EPCAM
miRNA Products
- Search ViGene Biosciences for EPCAM
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPCAM
- Browse OriGene Inhibitory RNA Products For EPCAM
- genomics-online: shRNA clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EPCAM gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EPCAM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPCAM
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EPCAM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for EPCAM (EpCAM/TROP1)
Cell Line Products
-
Horizon Cell Lines for EPCAM
-
ViGene Biosciences adenoviral particle packaged cDNA for EPCAM gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EPCAM gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPCAM gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , miRNA , Transcription Factor Targets and HOMER Transcription for EPCAM Gene
Localization for EPCAM Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPCAM Gene
- Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. {ECO:0000269 PubMed:16054130}.
- Plasma membrane (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS,IDA | -- |
GO:0005887 | integral component of plasma membrane | IBA | -- |
GO:0005923 | bicellular tight junction | IDA,IEA | 16054130 |
GO:0009986 | cell surface | IEA | -- |
GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for EPCAM Gene
Pathways by source for EPCAM Gene
2 Cell Signaling Technology pathways for EPCAM Gene
2 Reactome pathways for EPCAM Gene
2 R&D Systems pathways for EPCAM Gene
Interacting Proteins for EPCAM Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001657 | ureteric bud development | IEA | -- |
GO:0008284 | positive regulation of cell proliferation | IDA | 15195135 |
GO:0023019 | signal transduction involved in regulation of gene expression | IMP | 19136966 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 15195135 |
GO:0048863 | stem cell differentiation | IMP | 19785009 |
No data available for SIGNOR curated interactions for EPCAM Gene
Drugs & Compounds for EPCAM Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for EPCAM Gene
mRNA/cDNA for EPCAM Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (435) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EPCAM Gene
CRISPR Products
-
OriGene CRISPR knockouts for EPCAM
- genomics-online: gRNA clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
- Applied Biological Materials CRISPR for EPCAM
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPCAM
- GenScript: Design CRISPR guide RNA sequences for EPCAM
miRNA Products
- Search ViGene Biosciences for EPCAM
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPCAM
- Browse OriGene Inhibitory RNA Products For EPCAM
- genomics-online: shRNA clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EPCAM gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EPCAM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPCAM
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EPCAM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for EPCAM (EpCAM/TROP1)
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||
SP4: | - |
Expression for EPCAM Gene
mRNA differential expression in normal tissues according to GTEx for EPCAM Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPCAM Gene
NURSA nuclear receptor signaling pathways regulating expression of EPCAM Gene:
EPCAMSOURCE GeneReport for Unigene cluster for EPCAM Gene:
Hs.542050mRNA Expression by UniProt/SwissProt for EPCAM Gene:
P16422-EPCAM_HUMANEvidence on tissue expression from TISSUES for EPCAM Gene
- Intestine(4.8)
- Liver(4.5)
- Stomach(4.1)
- Pancreas(4)
- Lung(3.3)
- Kidney(2.9)
- Thyroid gland(2.8)
- Blood(2.4)
- Gall bladder(2.4)
- Bone marrow(2.2)
- Lymph node(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for EPCAM Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- endocrine
- immune
- nervous
- reproductive
- urinary
- biliary tract
- gallbladder
- intestine
- kidney
- large intestine
- liver
- pancreas
- small intestine
- stomach
- anus
- ovary
- rectum
- uterus
- blood
- red blood cell
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for EPCAM
-
OriGene qPCR primer pairs for EPCAM
- genomics-online: primer clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for EPCAM Gene
Orthologs for EPCAM Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | EPCAM 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | EPCAM 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | EPCAM 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Epcam 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Epcam 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | EPCAM 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | EPCAM 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | EPCAM 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | EPCAM 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | epcam 33 |
|
||
Str.6317 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | epcam 33 34 |
|
- Species where no ortholog for EPCAM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for EPCAM Gene
(1) SIMAP similar genes for EPCAM Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for EPCAM Gene
Variants for EPCAM Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1037569065 | uncertain-significance, Lynch syndrome | 47,369,303(+) | C/G | 5_prime_UTR_variant | |
rs1047546178 | uncertain-significance, Lynch syndrome | 47,369,182(+) | C/A/G | 5_prime_UTR_variant | |
rs1126497 | benign, likely-benign, Hereditary cancer-predisposing syndrome, not specified, Lynch syndrome, Lynch syndrome I, Hereditary nonpolyposis colon cancer | 47,373,967(+) | T/C | coding_sequence_variant, missense_variant | |
rs114241106 | benign, uncertain-significance, Hereditary cancer-predisposing syndrome, not specified, Lynch syndrome | 47,373,452(+) | T/A/C | intron_variant | |
rs115283528 | likely-benign, conflicting-interpretations-of-pathogenicity, not specified, Lynch syndrome | 47,379,942(+) | A/G | coding_sequence_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3583781 | CNV | loss | 25503493 |
nsv1004828 | CNV | gain | 25217958 |
nsv1009586 | CNV | gain | 25217958 |
nsv520660 | CNV | loss | 19592680 |
nsv999576 | CNV | gain | 25217958 |
Additional Variant Information for EPCAM Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPCAM Gene
Disorders for EPCAM Gene

(35) MalaCards diseases for EPCAM Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
diarrhea 5, with tufting enteropathy, congenital |
|
|
colorectal cancer, hereditary nonpolyposis, type 8 |
|
|
lynch syndrome |
|
|
lynch syndrome i |
|
|
gastrointestinal carcinoma |
|
UniProtKB/Swiss-Prot
EPCAM_HUMAN- Diarrhea 5, with tufting enteropathy, congenital (DIAR5) [MIM:613217]: An intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum. {ECO:0000269 PubMed:18572020}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Hereditary non-polyposis colorectal cancer 8 (HNPCC8) [MIM:613244]: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term suspected HNPCC or incomplete HNPCC can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. {ECO:0000269 PubMed:19098912}. Note=The disease is caused by mutations affecting the gene represented in this entry. HNPCC8 results from heterozygous deletion of 3-prime exons of EPCAM and intergenic regions directly upstream of MSH2, resulting in transcriptional read-through and epigenetic silencing of MSH2 in tissues expressing EPCAM.
Additional Disease Information for EPCAM
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for EPCAM Gene
Publications for EPCAM Gene
- Retroposition in a family of carcinoma-associated antigen genes. (PMID: 8382772) Linnenbach AJ … Huebner K (Molecular and cellular biology 1993) 2 3 4 22 58
- Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1. (PMID: 19098912) Ligtenberg MJ … Hoogerbrugge N (Nature genetics 2009) 3 4 22 58
- Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM. (PMID: 18508581) Munz M … Gires O (Frontiers in bioscience : a journal and virtual library 2008) 3 4 22 58
- Identification of EpCAM as the gene for congenital tufting enteropathy. (PMID: 18572020) Sivagnanam M … Hoffman HM (Gastroenterology 2008) 3 4 22 58
- The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. (PMID: 15922867) Münz M … Gires O (Cancer letters 2005) 3 4 22 58
Products for EPCAM Gene
- R&D Systems Antibodies for EPCAM (EpCAM/TROP1)
- R&D Systems Proteins and Enzymes for EPCAM (EpCAM/TROP1)
- R&D Systems Cell Selection and Detection Kits, ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for EPCAM (EpCAM/TROP1)
- R&D Systems cDNA Clones for EPCAM (EpCAM/TROP1)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for EPCAM
- CF506657
- TA506660
- CF506660
- TA506695
- CF506695
- TA600533
- TA600534
- TA700533
- TA700534
- TA809211
- CF809211
- UM500096
- UM570096
- UM500097
- UM570097
- TA500055S
- AM06447SU-N
- AM10033FC-N
- AM10033FC-S
- AM10033PU-N
- AM10033PU-S
- AM26013PU-N
- AM33194PU-N
- AM33194PU-S
- AM33243AC-S
- AM33243PU-N
- AM33243PU-S
- AM33243PU-T
- AM33243RP-N
- AM50093PU-N
- AM50093PU-S
- AM50137PU-N
- AM50137PU-S
- AM50137PU-T
- AP06671PU-N
- BM2274
- BM2274F
- BM2274X
- BM2274XL
- DM2013
- DM2014A
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- TA506641
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- CF506643
- TA506644
- CF506644
- TA506649
- CF506649
- TA506650
- CF506650
- TA506652
- CF506652
- TA506656
- CF506656
- TA506657
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for EPCAM in any vector
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- Cell Signaling Technology (CST) Antibodies for EPCAM (EPCAM)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for EPCAM (EPCAM)
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- Novus Biologicals Antibodies for EPCAM
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- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for EPCAM
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPCAM
- VectorBuilder custom plasmid, inducible vectors for EPCAM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPCAM
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 1111 available EPCAM Antibodies ranked by validation data
- Compare Top EPCAM Antibodies
- antibodies-online: Search results for available EPCAM related products ranked by validation data
- antibodies-online: Search results for 47 available EPCAM Proteins ranked by validation data
- Compare Top EPCAM Proteins
- GeneTex EPCAM antibody for EPCAM
- Search GeneTex for Proteins for EPCAM
- ViGene Biosciences adenoviral particle packaged cDNA for EPCAM gene
- ViGene Biosciences lentiviral particle packaged cDNA for EPCAM gene
- ViGene Biosciences ready-to-package AAV shRNAs for EPCAM gene
- Search ViGene Biosciences for EPCAM
- Santa Cruz Biotechnology (SCBT) Antibodies for EPCAM
- Search Santa Cruz Biotechnology (SCBT) for EPCAM siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EPCAM
- Horizon Cell Lines for EPCAM
- genomics-online: cdna clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
- orf clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
- genomics-online: gRNA clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
- genomics-online: primer clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
- genomics-online: shRNA clones - Search results for 156 available EPCAM gene related products
- Overview of 156 available EPCAM gene related products
Sources for EPCAM Gene
- (1) GeneCards
- (2) HGNC
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- (4) Swiss-Prot
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- (7) GeneLoc
- (8) Gene Wiki
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- (14) ProtoNet
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- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew