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Aliases for ARR3 Gene

Aliases for ARR3 Gene

  • Arrestin 3 2 3
  • Arrestin 3 Retinal (X-Arrestin) 2 3 5
  • Retinal Cone Arrestin-3 3 4
  • Cone Arrestin 2 4
  • Arrestin 4 2 3
  • C-Arrestin 3 4
  • ARRX 3 4
  • CArr 3 4
  • Arrestin 3, Retinal (X-Arrestin) 2
  • Arrestin-C 3
  • X-Arrestin 4
  • CAR 4

External Ids for ARR3 Gene

Previous GeneCards Identifiers for ARR3 Gene

  • GC0XP065666
  • GC0XP066965
  • GC0XP067721
  • GC0XP068354
  • GC0XP069271
  • GC0XP069404
  • GC0XP069488
  • GC0XP063309

Summaries for ARR3 Gene

Entrez Gene Summary for ARR3 Gene

  • The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]

GeneCards Summary for ARR3 Gene

ARR3 (Arrestin 3) is a Protein Coding gene. Diseases associated with ARR3 include Leber Congenital Amaurosis and Retinitis Pigmentosa. Among its related pathways are Thromboxane A2 receptor signaling and Phototransduction. GO annotations related to this gene include phosphoprotein binding and opsin binding. An important paralog of this gene is ARRB1.

UniProtKB/Swiss-Prot for ARR3 Gene

  • May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

Gene Wiki entry for ARR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARR3 Gene

Genomics for ARR3 Gene

Regulatory Elements for ARR3 Gene

Enhancers for ARR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARR3 Gene

Chromosome:
X
Start:
70,263,503 bp from pter
End:
70,281,840 bp from pter
Size:
18,338 bases
Orientation:
Plus strand

Genomic View for ARR3 Gene

Genes around ARR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARR3 Gene

Proteins for ARR3 Gene

  • Protein details for ARR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36575-ARRC_HUMAN
    Recommended name:
    Arrestin-C
    Protein Accession:
    P36575
    Secondary Accessions:
    • B5B0B9
    • Q5JT23
    • Q5JT24
    • Q6IBF5
    • Q96EN2

    Protein attributes for ARR3 Gene

    Size:
    388 amino acids
    Molecular mass:
    42778 Da
    Quaternary structure:
    • Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4.

    Three dimensional structures from OCA and Proteopedia for ARR3 Gene

    Alternative splice isoforms for ARR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARR3 Gene

Post-translational modifications for ARR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARR3 Gene

No data available for DME Specific Peptides for ARR3 Gene

Domains & Families for ARR3 Gene

Gene Families for ARR3 Gene

Protein Domains for ARR3 Gene

Suggested Antigen Peptide Sequences for ARR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36575

UniProtKB/Swiss-Prot:

ARRC_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARR3: view

Function for ARR3 Gene

Molecular function for ARR3 Gene

GENATLAS Biochemistry:
X arrestin,expressed in the red-,green-,blue-sensitive cone photoreceptors modulator of cone phototransduction
UniProtKB/Swiss-Prot Function:
May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

Gene Ontology (GO) - Molecular Function for ARR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002046 opsin binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0019904 protein domain specific binding IEA --
GO:0051219 phosphoprotein binding IEA --
genes like me logo Genes that share ontologies with ARR3: view
genes like me logo Genes that share phenotypes with ARR3: view

Animal Models for ARR3 Gene

MGI Knock Outs for ARR3:

Animal Model Products

CRISPR Products

miRNA for ARR3 Gene

miRTarBase miRNAs that target ARR3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARR3 Gene

Localization for ARR3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARR3 Gene COMPARTMENTS Subcellular localization image for ARR3 gene
Compartment Confidence
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for ARR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0001917 photoreceptor inner segment IDA 23704327
GO:0005737 cytoplasm TAS 8224247
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with ARR3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARR3 Gene

Pathways & Interactions for ARR3 Gene

genes like me logo Genes that share pathways with ARR3: view

Pathways by source for ARR3 Gene

Gene Ontology (GO) - Biological Process for ARR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0006897 endocytosis IEA --
GO:0007165 signal transduction IEA --
GO:0007601 visual perception IEA --
genes like me logo Genes that share ontologies with ARR3: view

No data available for SIGNOR curated interactions for ARR3 Gene

Drugs & Compounds for ARR3 Gene

(3) Drugs for ARR3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ARR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARR3: view

Transcripts for ARR3 Gene

Unigene Clusters for ARR3 Gene

Arrestin 3, retinal (X-arrestin):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARR3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for ARR3 Gene

GeneLoc Exon Structure for
ARR3
ECgene alternative splicing isoforms for
ARR3

Expression for ARR3 Gene

mRNA expression in normal human tissues for ARR3 Gene

mRNA differential expression in normal tissues according to GTEx for ARR3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.8) and Colon - Transverse (x4.2).

Protein differential expression in normal tissues from HIPED for ARR3 Gene

This gene is overexpressed in Retina (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARR3 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARR3 Gene:

ARR3

SOURCE GeneReport for Unigene cluster for ARR3 Gene:

Hs.308

mRNA Expression by UniProt/SwissProt for ARR3 Gene:

P36575-ARRC_HUMAN
Tissue specificity: Inner and outer segments, and the inner plexiform regions of the retina.
genes like me logo Genes that share expression patterns with ARR3: view

Primer Products

No data available for Protein tissue co-expression partners for ARR3 Gene

Orthologs for ARR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARR3 34
  • 88.14 (n)
  • 84.54 (a)
ARR3 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARR3 34
  • 88.14 (n)
  • 86.34 (a)
ARR3 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arr3 34
  • 85.65 (n)
  • 83.69 (a)
Arr3 16
Arr3 35
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARR3 34
  • 99.66 (n)
  • 99.74 (a)
ARR3 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arr3 34
  • 85.47 (n)
  • 83.42 (a)
oppossum
(Monodelphis domestica)
Mammalia ARR3 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARR3 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARR3 34
  • 71.55 (n)
  • 70.16 (a)
ARR3 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARR3 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arr3a 34
  • 64.18 (n)
  • 60.74 (a)
arr3a 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Arr1 36
  • 41 (a)
Arr2 36
  • 37 (a)
Arr1 35
  • 41 (a)
ManyToMany
Arr2 35
  • 35 (a)
ManyToMany
CG32683 35
  • 15 (a)
ManyToMany
krz 35
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea arr-1 35
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10346 35
  • 46 (a)
OneToMany
Species where no ortholog for ARR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARR3 Gene

ENSEMBL:
Gene Tree for ARR3 (if available)
TreeFam:
Gene Tree for ARR3 (if available)

Paralogs for ARR3 Gene

Paralogs for ARR3 Gene

(6) SIMAP similar genes for ARR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARR3: view

Variants for ARR3 Gene

Sequence variations from dbSNP and Humsavar for ARR3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_025520 -

Structural Variations from Database of Genomic Variants (DGV) for ARR3 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
nsv525258 CNV gain 19592680

Variation tolerance for ARR3 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARR3 Gene

Disorders for ARR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARR3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leber congenital amaurosis
  • lca
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search ARR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARR3
genes like me logo Genes that share disorders with ARR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARR3 Gene

Publications for ARR3 Gene

  1. X-arrestin: a new retinal arrestin mapping to the X chromosome. (PMID: 8224247) Murakami A. … Inana G. (FEBS Lett. 1993) 2 3 4 22 65
  2. Isolation and characterization of the human X-arrestin gene. (PMID: 9931451) Sakuma H. … Inana G. (Gene 1998) 3 4 22 65
  3. Immunolocalization of X-arrestin in human cone photoreceptors. (PMID: 8612728) Sakuma H. … McLaren M.J. (FEBS Lett. 1996) 3 4 22 65
  4. Cone arrestin identified by targeting expression of a functional family. (PMID: 8308033) Craft C.M. … Wiechmann A.F. (J. Biol. Chem. 1994) 3 4 22 65
  5. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PMID: 17620599) Xiao K. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 22 65

Products for ARR3 Gene

Sources for ARR3 Gene

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