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Aliases for MIR21 Gene

Subcategory (RNA class) for MIR21 Gene


Quality Score for this RNA gene is


Aliases for MIR21 Gene

  • MicroRNA 21 2 3 5
  • Hsa-Mir-21 3
  • MiRNA21 3
  • MiR-21 3
  • MIRN21 3

External Ids for MIR21 Gene

Previous HGNC Symbols for MIR21 Gene

  • MIRN21

Previous GeneCards Identifiers for MIR21 Gene

  • GC17P055276
  • GC17P057918

Summaries for MIR21 Gene

Entrez Gene Summary for MIR21 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR21 Gene

MIR21 (MicroRNA 21) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR21 include Chromosome 17P Deletion. Among its related pathways are Proteoglycans in cancer and MicroRNAs in cardiomyocyte hypertrophy.

Gene Wiki entry for MIR21 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR21 Gene

Genomics for MIR21 Gene

Genomic Location for MIR21 Gene

59,841,266 bp from pter
59,841,337 bp from pter
72 bases
Plus strand

Genomic View for MIR21 Gene

Genes around MIR21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR21 Gene

No data available for Regulatory Elements for MIR21 Gene

Proteins for MIR21 Gene

Post-translational modifications for MIR21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR21 Gene

Domains & Families for MIR21 Gene

Gene Families for MIR21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR21: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR21 Gene

Function for MIR21 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR21 Gene

Localization for MIR21 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR21 Gene

Pathways & Interactions for MIR21 Gene

genes like me logo Genes that share pathways with MIR21: view

Pathways by source for MIR21 Gene

Interacting Proteins for MIR21 Gene

Gene Ontology (GO) - Biological Process for MIR21 Gene


No data available for SIGNOR curated interactions for MIR21 Gene

Drugs & Compounds for MIR21 Gene

No Compound Related Data Available

Transcripts for MIR21 Gene

mRNA/cDNA for MIR21 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR21 Gene

No ASD Table

Relevant External Links for MIR21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR21 Gene

mRNA expression in normal human tissues for MIR21 Gene

genes like me logo Genes that share expression patterns with MIR21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR21 Gene

Orthologs for MIR21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-21 36
  • 77 (a)
(Canis familiaris)
Mammalia cfa-mir-21 36
  • 77 (a)
(Monodelphis domestica)
Mammalia mdo-mir-21 36
  • 92 (a)
(Mus musculus)
Mammalia Mir21 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-21 36
  • 58 (a)
(Pan troglodytes)
Mammalia ptr-mir-21 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-21 36
  • 69 (a)
(Anolis carolinensis)
Reptilia aca-mir-21 36
  • 68 (a)
(Danio rerio)
Actinopterygii dre-mir-21-1 36
  • 39 (a)
Species with no ortholog for MIR21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR21 Gene

Gene Tree for MIR21 (if available)
Gene Tree for MIR21 (if available)

Paralogs for MIR21 Gene

No data available for Paralogs for MIR21 Gene

Variants for MIR21 Gene

Sequence variations from dbSNP and Humsavar for MIR21 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs13137 -- 59,841,670(-) GTTAA(A/T)CTATC downstream-variant-500B
rs1292037 -- 59,841,547(-) CCACA(A/G)TGCAG downstream-variant-500B
rs9892710 -- 59,841,806(+) AATAC(A/G)AATTG downstream-variant-500B
rs34573816 -- 59,841,096(+) TTTAG(-/G)AGCAT upstream-variant-2KB
rs35378558 -- 59,841,820(+) ATTTG(-/G)TACCA downstream-variant-500B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for MIR21 Gene

Disorders for MIR21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR21 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chromosome 17p deletion
  • 17p deletion
- elite association - COSMIC cancer census association via MalaCards
Search MIR21 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIR21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR21 Gene

Publications for MIR21 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48 67
  2. The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma. (PMID: 26302751) Amr K.S. … Kamel R.R. (Gene 2016) 3
  3. Altered microRNA expression in inflamed and non-inflamed terminal ileal mucosa of adult patients with active Crohn's disease. (PMID: 24910152) Guo Z. … Li J. (J. Gastroenterol. Hepatol. 2015) 3
  4. Exosomal miR-21 derived from arsenite-transformed human bronchial epithelial cells promotes cell proliferation associated with arsenite carcinogenesis. (PMID: 24912785) Xu Y. … Liu Q. (Arch. Toxicol. 2015) 3
  5. Endothelial progenitors promote hepatocarcinoma intrahepatic metastasis through monocyte chemotactic protein-1 induction of microRNA-21. (PMID: 24939570) Shih Y.T. … Chiu J.J. (Gut 2015) 3

Products for MIR21 Gene

Sources for MIR21 Gene