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Aliases for MIR21 Gene

Subcategory (RNA class) for MIR21 Gene


Quality Score for this RNA gene is


Aliases for MIR21 Gene

  • MicroRNA 21 2 3
  • MIRN21 3 6
  • Hsa-Mir-21 3
  • MiRNA21 3
  • MiR-21 3

External Ids for MIR21 Gene

Previous HGNC Symbols for MIR21 Gene

  • MIRN21

Previous GeneCards Identifiers for MIR21 Gene

  • GC17P055276
  • GC17P057918

Summaries for MIR21 Gene

Entrez Gene Summary for MIR21 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR21 Gene

MIR21 (MicroRNA 21) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR21 include chromosome 17p deletion and neuroendocrine tumor. Among its related pathways are Proteoglycans in cancer and MicroRNAs in cancer.

Gene Wiki entry for MIR21 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR21 Gene

Genomics for MIR21 Gene

Genomic Location for MIR21 Gene

59,841,266 bp from pter
59,841,337 bp from pter
72 bases
Plus strand

Genomic View for MIR21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR21 Gene

No data available for Regulatory Elements for MIR21 Gene

Proteins for MIR21 Gene

Post-translational modifications for MIR21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR21 Gene

Domains for MIR21 Gene

Gene Families for MIR21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR21: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR21 Gene

Function for MIR21 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR21 Gene

Localization for MIR21 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR21 Gene

Pathways for MIR21 Gene

genes like me logo Genes that share pathways with MIR21: view

Pathways by source for MIR21 Gene

Interacting Proteins for MIR21 Gene

Gene Ontology (GO) - Biological Process for MIR21 Gene


Transcripts for MIR21 Gene

mRNA/cDNA for MIR21 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR21 Gene

No ASD Table

Relevant External Links for MIR21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR21 Gene

mRNA expression in normal human tissues for MIR21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR21: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR21 Gene

Orthologs for MIR21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-21 36
  • 77 (a)
(Canis familiaris)
Mammalia cfa-mir-21 36
  • 77 (a)
(Monodelphis domestica)
Mammalia mdo-mir-21 36
  • 92 (a)
(Mus musculus)
Mammalia Mir21 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-21 36
  • 58 (a)
(Pan troglodytes)
Mammalia ptr-mir-21 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-21 36
  • 69 (a)
(Anolis carolinensis)
Reptilia aca-mir-21 36
  • 68 (a)
(Danio rerio)
Actinopterygii dre-mir-21-1 36
  • 39 (a)
Species with no ortholog for MIR21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR21 Gene

Gene Tree for MIR21 (if available)
Gene Tree for MIR21 (if available)

Paralogs for MIR21 Gene

No data available for Paralogs for MIR21 Gene

Variants for MIR21 Gene

Sequence variations from dbSNP and Humsavar for MIR21 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs574116856 -- 59,841,737(+) TAGTC(A/G)TGGTT downstream-variant-500B
rs571607618 -- 59,841,436(+) GTCTG(A/G)TGGCA downstream-variant-500B
rs570199250 -- 59,841,166(+) CTGGG(-/T)TTTTT upstream-variant-2KB
rs566692719 -- 59,841,125(+) ATAGA(A/G)TAGAA upstream-variant-2KB
rs561219368 -- 59,841,243(+) TCGTG(A/T)CATCT upstream-variant-2KB

Relevant External Links for MIR21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIR21 Gene

Disorders for MIR21 Gene

Relevant External Links for MIR21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR21: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR21 Gene

Publications for MIR21 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48
  3. MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. (PMID: 19106647) Habbe N. … Maitra A. (Cancer Biol. Ther. 2009) 3
  4. Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. (PMID: 19264808) Wickramasinghe N.S. … Klinge C.M. (Nucleic Acids Res. 2009) 3
  5. MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. (PMID: 19296468) Selaru F.M. … Meltzer S.J. (Hepatology 2009) 3

Products for MIR21 Gene

Sources for MIR21 Gene

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