Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LYZ Gene

Aliases for LYZ Gene

  • Lysozyme 2 3
  • 1,4-Beta-N-Acetylmuramidase C 3 4
  • EC 3.2.1.17 4 63
  • LZM 3 4
  • Lysozyme (Renal Amyloidosis) 2
  • Renal Amyloidosis 2
  • C-Type Lysozyme 3
  • Lysozyme C 3

External Ids for LYZ Gene

Previous GeneCards Identifiers for LYZ Gene

  • GC12M069521
  • GC12P069681
  • GC12P069458
  • GC12P068028
  • GC12P066791

Summaries for LYZ Gene

Entrez Gene Summary for LYZ Gene

  • This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

GeneCards Summary for LYZ Gene

LYZ (Lysozyme) is a Protein Coding gene. Diseases associated with LYZ include lyz-related familial visceral amyloidosis and familial renal amyloidosis due to lysozyme variant. Among its related pathways are Disease and RNA Polymerase I Promoter Opening. GO annotations related to this gene include identical protein binding and lysozyme activity. An important paralog of this gene is SPACA5B.

UniProtKB/Swiss-Prot for LYZ Gene

  • Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents

Gene Wiki entry for LYZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LYZ Gene

Genomics for LYZ Gene

Regulatory Elements for LYZ Gene

Genomic Location for LYZ Gene

Start:
69,348,341 bp from pter
End:
69,354,234 bp from pter
Size:
5,894 bases
Orientation:
Plus strand

Genomic View for LYZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LYZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LYZ Gene

Proteins for LYZ Gene

  • Protein details for LYZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61626-LYSC_HUMAN
    Recommended name:
    Lysozyme C
    Protein Accession:
    P61626
    Secondary Accessions:
    • P00695
    • Q13170
    • Q9UCF8

    Protein attributes for LYZ Gene

    Size:
    148 amino acids
    Molecular mass:
    16537 Da
    Quaternary structure:
    • Monomer
    Miscellaneous:
    • Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides
    SequenceCaution:
    • Sequence=CAA32175.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LYZ Gene

neXtProt entry for LYZ Gene

Proteomics data for LYZ Gene at MOPED

Post-translational modifications for LYZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LYZ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for LYZ Gene

Suggested Antigen Peptide Sequences for LYZ Gene

Graphical View of Domain Structure for InterPro Entry

P61626

UniProtKB/Swiss-Prot:

LYSC_HUMAN :
  • P61626
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LYZ: view

No data available for Gene Families for LYZ Gene

Function for LYZ Gene

Molecular function for LYZ Gene

GENATLAS Biochemistry: lysozyme,14.5kDa,released from azurophilic granules of neutrophils,oxygen independent phagocytosis of Gram- bacteria
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
UniProtKB/Swiss-Prot Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents

Enzyme Numbers (IUBMB) for LYZ Gene

Gene Ontology (GO) - Molecular Function for LYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity TAS 2829884
GO:0042802 identical protein binding IPI 23353684
genes like me logo Genes that share ontologies with LYZ: view

Phenotypes for LYZ Gene

GenomeRNAi human phenotypes for LYZ:
genes like me logo Genes that share phenotypes with LYZ: view

miRNA for LYZ Gene

miRTarBase miRNAs that target LYZ

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for LYZ Gene

Localization for LYZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for LYZ Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LYZ Gene COMPARTMENTS Subcellular localization image for LYZ gene
Compartment Confidence
extracellular 5
cytoskeleton 3
lysosome 3
plasma membrane 3
vacuole 3
cytosol 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 2829884
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LYZ: view

Pathways for LYZ Gene

genes like me logo Genes that share pathways with LYZ: view

Pathways by source for LYZ Gene

1 BioSystems pathway for LYZ Gene
2 Reactome pathways for LYZ Gene
1 KEGG pathway for LYZ Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for LYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0006954 inflammatory response TAS 366724
GO:0008152 metabolic process IEA --
GO:0016998 cell wall macromolecule catabolic process --
GO:0019835 cytolysis IEA --
genes like me logo Genes that share ontologies with LYZ: view

Compounds for LYZ Gene

(1) HMDB Compounds for LYZ Gene

Compound Synonyms Cas Number PubMed IDs
N-Acetyl-D-glucosamine
  • 2-(acetylamino)-2-deoxyhexose
7512-17-6

(15) Drugbank Compounds for LYZ Gene

(1) Novoseek inferred chemical compound relationships for LYZ Gene

Compound -log(P) Hits PubMed IDs
nacl 6.42 1
genes like me logo Genes that share compounds with LYZ: view

Transcripts for LYZ Gene

mRNA/cDNA for LYZ Gene

(10) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LYZ Gene

Lysozyme:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LYZ

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LYZ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for LYZ Gene

GeneLoc Exon Structure for
LYZ
ECgene alternative splicing isoforms for
LYZ

Expression for LYZ Gene

mRNA expression in normal human tissues for LYZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LYZ Gene

This gene is overexpressed in Whole Blood (27.8) and Minor Salivary Gland (14.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LYZ Gene

SOURCE GeneReport for Unigene cluster for LYZ Gene Hs.524579

genes like me logo Genes that share expressions with LYZ: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LYZ Gene

Orthologs for LYZ Gene

This gene was present in the common ancestor of animals.

Orthologs for LYZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LYZ 35
  • 99.32 (n)
  • 100 (a)
LYZ 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
LYSB 36
  • 70 (a)
OneToMany
LYZ 35
  • 87.16 (n)
  • 81.08 (a)
LYZ 36
  • 81 (a)
OneToMany
LYZ1 36
  • 80 (a)
OneToMany
LYZ1 36
  • 70 (a)
OneToMany
LYZ2 36
  • 69 (a)
OneToMany
LYZ3 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LYZ 35
  • 83.78 (n)
  • 80.41 (a)
LYZ 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9530003J23Rik 36
  • 60 (a)
OneToMany
Lyz1 36
  • 76 (a)
OneToMany
Lyz2 35
  • 78.15 (n)
  • 76.35 (a)
Lyz2 36
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia LYZ 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lyz2 35
  • 76.35 (n)
  • 71.62 (a)
chicken
(Gallus gallus)
Aves LYZ 35
  • 60.92 (n)
  • 57.93 (a)
LYZ 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LYZ 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492798 35
  • 61.34 (n)
  • 58.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11159 36
  • 32 (a)
ManyToMany
CG16756 36
  • 35 (a)
ManyToMany
CG16799 36
  • 25 (a)
ManyToMany
CG30062 36
  • 29 (a)
ManyToMany
CG7798 36
  • 41 (a)
ManyToMany
CG8492 36
  • 4 (a)
ManyToMany
LysB 36
  • 40 (a)
ManyToMany
LysC 36
  • 39 (a)
ManyToMany
LysD 36
  • 40 (a)
ManyToMany
LysE 36
  • 41 (a)
ManyToMany
LysP 36
  • 38 (a)
ManyToMany
LysS 36
  • 39 (a)
ManyToMany
LysX 36
  • 37 (a)
ManyToMany
Species with no ortholog for LYZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LYZ Gene

ENSEMBL:
Gene Tree for LYZ (if available)
TreeFam:
Gene Tree for LYZ (if available)

Paralogs for LYZ Gene

Paralogs for LYZ Gene

Selected SIMAP similar genes for LYZ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LYZ: view

Variants for LYZ Gene

Sequence variations from dbSNP and Humsavar for LYZ Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1384 -- 69,354,054(+) GATTT(C/T)TTAAA utr-variant-3-prime
rs2553 -- 69,353,418(+) TTTTT(C/T)AGTTT utr-variant-3-prime
rs8612 -- 69,353,874(+) GAAAA(G/T)GTTAT utr-variant-3-prime
rs10049 -- 69,353,970(+) AACCA(C/T)TTTTT utr-variant-3-prime
rs483142 -- 69,347,451(+) AAAGT(A/G)TTGTG upstream-variant-2KB

Relevant External Links for LYZ Gene

HapMap Linkage Disequilibrium report
LYZ
Human Gene Mutation Database (HGMD)
LYZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LYZ Gene

Disorders for LYZ Gene

(1) OMIM Diseases for LYZ Gene (153450)

UniProtKB/Swiss-Prot

LYSC_HUMAN
  • Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. {ECO:0000269 PubMed:8464497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) Novoseek inferred disease relationships for LYZ Gene

Disease -log(P) Hits PubMed IDs
meningitis 19.7 2
necrosis 0 3
tumors 0 3

Relevant External Links for LYZ

Genetic Association Database (GAD)
LYZ
Human Genome Epidemiology (HuGE) Navigator
LYZ
genes like me logo Genes that share disorders with LYZ: view

Publications for LYZ Gene

  1. The human lysozyme gene. Sequence organization and chromosomal localization. (PMID: 2546758) Peters C.W.B. … Sippel A.E. (Eur. J. Biochem. 1989) 2 3 4
  2. Human lysozyme gene mutations cause hereditary systemic amyloidosis. (PMID: 8464497) Pepy M.B. … Hsuan J.J. (Nature 1993) 2 3 4
  3. Indication of possible post-translational formation of disulphide bonds in the beta-sheet domain of human lysozyme. (PMID: 8503881) Kanaya E. … Kikuchi M. (Biochem. J. 1993) 3 4
  4. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 48
  5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 48

Products for LYZ Gene

Sources for LYZ Gene

Back to Top

Content