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Aliases for LY9 Gene

Aliases for LY9 Gene

  • Lymphocyte Antigen 9 2 3 4
  • Signaling Lymphocytic Activation Molecule 3 3 4
  • Cell Surface Molecule Ly-9 3 4
  • SLAM Family Member 3 3 4
  • SLAMF3 3 4
  • T-Lymphocyte Surface Antigen Ly-9 3
  • CD229 Antigen 4
  • CD229 3
  • Hly9 3
  • MLY9 3

External Ids for LY9 Gene

Previous GeneCards Identifiers for LY9 Gene

  • GC01P158558
  • GC01P156498
  • GC01P157543
  • GC01P157982
  • GC01P157579
  • GC01P159032
  • GC01P132122

Summaries for LY9 Gene

Entrez Gene Summary for LY9 Gene

  • LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed 16365421]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LY9 Gene

LY9 (Lymphocyte Antigen 9) is a Protein Coding gene. Diseases associated with LY9 include dysgammaglobulinemia. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF6.

UniProtKB/Swiss-Prot for LY9 Gene

  • May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction

Gene Wiki entry for LY9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LY9 Gene

Genomics for LY9 Gene

Genomic Location for LY9 Gene

Start:
160,796,074 bp from pter
End:
160,828,261 bp from pter
Size:
32,188 bases
Orientation:
Plus strand

Genomic View for LY9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LY9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LY9 Gene

Proteins for LY9 Gene

  • Protein details for LY9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBG7-LY9_HUMAN
    Recommended name:
    T-lymphocyte surface antigen Ly-9
    Protein Accession:
    Q9HBG7
    Secondary Accessions:
    • A8K7N3
    • Q14775
    • Q5VYI3
    • Q6P2J4
    • Q9H4N5
    • Q9NQ24

    Protein attributes for LY9 Gene

    Size:
    655 amino acids
    Molecular mass:
    72139 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH72360.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LY9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LY9 Gene

Proteomics data for LY9 Gene at MOPED

Post-translational modifications for LY9 Gene

  • Glycosylation at Asn68, Asn95, Asn120, Asn169, Asn173, Asn285, Asn413, and Asn424
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for LY9 Gene

Domains for LY9 Gene

Gene Families for LY9 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for LY9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBG7

UniProtKB/Swiss-Prot:

LY9_HUMAN :
  • Q9HBG7
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LY9: view

Function for LY9 Gene

Molecular function for LY9 Gene

GENATLAS Biochemistry: lymphocyte surface antigen,murine Ly-9,immunoglobulin superfamily,putatively involved in adhesion reaction between T lymphocyte and accessory cells
UniProtKB/Swiss-Prot Function: May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction

Gene Ontology (GO) - Molecular Function for LY9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LY9: view

Phenotypes for LY9 Gene

genes like me logo Genes that share phenotypes with LY9: view

Animal Models for LY9 Gene

MGI Knock Outs for LY9:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LY9 Gene

Localization for LY9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LY9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LY9 Gene COMPARTMENTS Subcellular localization image for LY9 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for LY9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LY9: view

Pathways for LY9 Gene

SuperPathways for LY9 Gene

No Data Available

Interacting Proteins for LY9 Gene

Selected Interacting proteins: Q9HBG7-LY9_HUMAN for LY9 Gene via I2D

Gene Ontology (GO) - Biological Process for LY9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with LY9: view

No data available for Pathways by source for LY9 Gene

Compounds for LY9 Gene

(1) Novoseek inferred chemical compound relationships for LY9 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 38.4 2
genes like me logo Genes that share compounds with LY9: view

Transcripts for LY9 Gene

Unigene Clusters for LY9 Gene

Lymphocyte antigen 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LY9

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LY9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LY9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: -
SP5: -
SP6: - -
SP7: - - - -
SP8: - -
SP9: - - - - -
SP10: - - -
SP11: - - - - -

ExUns: 15b ^ 16
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for LY9 Gene

GeneLoc Exon Structure for
LY9
ECgene alternative splicing isoforms for
LY9

Expression for LY9 Gene

mRNA expression in normal human tissues for LY9 Gene

mRNA differential expression in normal tissues according to GTEx for LY9 Gene

This gene is overexpressed in Whole Blood (17.1) and Spleen (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for LY9 Gene

SOURCE GeneReport for Unigene cluster for LY9 Gene Hs.403857

genes like me logo Genes that share expressions with LY9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LY9 Gene

Orthologs for LY9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LY9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LY9 35
  • 98.52 (n)
  • 97.25 (a)
LY9 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LY9 35
  • 76.45 (n)
  • 61.83 (a)
LY9 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LY9 35
  • 76.3 (n)
  • 60.48 (a)
LY9 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ly9 35
  • 71.22 (n)
  • 55.83 (a)
Ly9 16
Ly9 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LY9 36
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ly9 35
  • 70.98 (n)
  • 54.6 (a)
Species with no ortholog for LY9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LY9 Gene

ENSEMBL:
Gene Tree for LY9 (if available)
TreeFam:
Gene Tree for LY9 (if available)

Paralogs for LY9 Gene

Paralogs for LY9 Gene

genes like me logo Genes that share paralogs with LY9: view

Variants for LY9 Gene

Sequence variations from dbSNP and Humsavar for LY9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs65463 -- 160,803,291(-) aaaaa(A/T)ttttt intron-variant
rs474131 -- 160,823,652(+) GAGGT(A/G)TTTGA reference, synonymous-codon
rs474918 -- 160,801,407(-) aaaac(A/G)aataa intron-variant
rs475705 -- 160,807,923(-) ggtgt(C/T)tgctt intron-variant
rs479737 -- 160,817,774(+) TCTTC(C/T)GTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LY9 Gene

Variant ID Type Subtype PubMed ID
nsv831714 CNV Gain 17160897
esv2671152 CNV Deletion 23128226
nsv825087 CNV Loss 20364138
esv2662152 CNV Deletion 23128226
dgv84n67 CNV Loss 20364138

Relevant External Links for LY9 Gene

HapMap Linkage Disequilibrium report
LY9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LY9 Gene

Disorders for LY9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for LY9 Gene including...

Search for LY9 Gene in MalaCards »

(1) University of Copenhagen DISEASES for LY9 Gene

(1) Novoseek inferred disease relationships for LY9 Gene

Disease -log(P) Hits PubMed IDs
lymphoproliferative syndrome 91.1 1

Relevant External Links for LY9

Genetic Association Database (GAD)
LY9
Human Genome Epidemiology (HuGE) Navigator
LY9
genes like me logo Genes that share disorders with LY9: view

No data available for UniProtKB/Swiss-Prot for LY9 Gene

Publications for LY9 Gene

  1. Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9. (PMID: 8537117) Sandrin M.S. … McKenzie I.F. (Immunogenetics 1996) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Association of LY9 in UK and Canadian SLE families. (PMID: 18216865) Cunninghame Graham D.S. … Rioux J.D. (Genes Immun. 2008) 3 48
  4. Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. (PMID: 12242590) Tovar V. … Engel P. (Immunogenetics 2002) 3 23
  5. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. (PMID: 11689425) Morra M. … Terhorst C. (EMBO J. 2001) 3 23

Products for LY9 Gene

Sources for LY9 Gene

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