LUM Gene(Protein Coding)

Lumican

GCID:: GC12M091102

GIFtS:: 52

Genes Participants

Aliases for LUM Gene

Lumican ² ³ ³ ⁵
Keratan Sulfate Proteoglycan Lumican ³ ⁴
Lumican Proteoglycan ² ³
KSPG Lumican ³ ⁴
SLRR2D ³ ⁴
LDC ³ ⁴

External Ids for LUM Gene

HGNC: 6724
Entrez Gene: 4060
Ensembl: ENSG00000139329
OMIM: 600616
UniProtKB: P51884

Previous HGNC Symbols for LUM Gene

Previous GeneCards Identifiers for LUM Gene

GC12M090819
GC12M091944
GC12M091430
GC12M089999
GC12M088565

Search aliases for LUM gene in PubMed and other databases

Summaries for LUM Gene

Entrez Gene Summary for LUM Gene

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for LUM Gene

LUM (Lumican) is a Protein Coding gene. Diseases associated with LUM include Cornea Plana and Degenerative Myopia. Among its related pathways are Defective CHST6 causes MCDC1 and Keratan sulfate/keratin metabolism. Gene Ontology (GO) annotations related to this gene include collagen binding and extracellular matrix structural constituent. An important paralog of this gene is FMOD.

Gene Wiki entry for LUM Gene

Additional gene information for LUM Gene

Search for LUM at DataMed
Search for LUM at HumanCyc

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUM Gene

Genomics for LUM Gene

GeneHancer (GH) Regulatory Elements for LUM Gene

Promoters and enhancers for LUM Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH12I091108	Promoter/Enhancer	2	EPDnew Ensembl ENCODE dbSUPER	550.8	+1.3	1303	3.9	CTCF ZNF654 L3MBTL2 TRIM22 MAX RAD21 SMC3 ZNF143 CHD2	LUM KERA GC12P091066
GH12I091175	Promoter/Enhancer	2	EPDnew Ensembl ENCODE dbSUPER	10.2	-68.0	-68028	9.7	CTCF ZSCAN4 CEBPB RAD21 NR2F2 JUND ZNF316 ZNF366 POLR2A ZNF512	DCN KERA LUM LOC105369897
GH12I091137	Enhancer	1.4	VISTA Ensembl ENCODE dbSUPER	11.4	-29.0	-28960	5.8	JUN CEBPB ZNF384 FEZF1 EP300 POLR2A STAT3 FOS RCOR1 FOXP2	LUM DCN KERA LOC105369897
GH12I090979	Enhancer	0.8	Ensembl ENCODE	12.1	+133.6	133614	0.4	CTCF ZNF654 TRIM22 REST RAD21 MAFF SMC3 CHD2	LUM CCER1 EPYC
GH12I091184	Enhancer	0.7	ENCODE dbSUPER	10.2	-74.0	-74024	2.1	HLF SCRT2 CREB1 ATF2	LUM DCN ENSG00000258148

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LUM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LUM gene promoter:

Regulatory Element Products

Genomic Locations for LUM Gene

chr12:91,102,629-91,111,831: (GRCh38/hg38)

Size:: 9,203 bases
Orientation:: Minus strand

chr12:91,496,406-91,505,608: (GRCh37/hg19)

Genomic View for LUM Gene

Genes around LUM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

12q21.33 by Ensembl
12q21.33 by Entrez Gene
12q21.33 by HGNC

LUM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for LUM Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LUM Gene

Proteins for LUM Gene

Protein details for LUM Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P51884-LUM_HUMAN

Recommended name:

Lumican

Protein Accession:

P51884

Secondary Accessions:
- B2R6R5
- Q96QM7
Protein attributes for LUM Gene
Size:

338 amino acids

Molecular mass:

38429 Da
Quaternary structure:
Binds to laminin.

neXtProt entry for LUM Gene

Protein Expression for LUM Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LUM Gene

Sulfated on tyrosine residue(s).
- P51884-LUM_HUMAN
Glycosylation at posLast=8888, isoforms=127, isoforms=160, and isoforms=252
- NX_P51884

Other Protein References for LUM Gene

ENSEMBL proteins:

ENSP00000266718

REFSEQ proteins:

NP_002336.1

Antibody Products

R&D Systems Antibodies for LUM (Lumican)

OriGene Antibodies for LUM
Custom Antibody Services

Novus Biologicals Antibodies for LUM

Abcam antibodies for LUM
- Lumican

Cloud-Clone Corp. Antibodies for LUM

Invitrogen Antibodies for LUM

Search GeneTex for Antibodies for LUM

Santa Cruz Biotechnology (SCBT) Antibodies for LUM
- Lumican (B-9)

Sino Biological Antibodies for LUM

Protein Products

R&D Systems Proteins and Enzymes for LUM (Lumican)

OriGene Purified Proteins for LUM
Search Origene for MassSpec and Protein Over-expression Lysates for LUM
Origene Custom Protein Services for LUM

GenScript Custom Purified and Recombinant Proteins Services for LUM

Novus Biologicals proteins and lysates for LUM

Sino Biological Recombinant Proteins for LUM
Sino Biological Cell Lysates for LUM

ProSpec Recombinant Proteins for LUM

Cloud-Clone Corp. Proteins for LUM
- RPB496Hu01

antibodies-online: Search results for 19 available LUM Proteins ranked by validation data
Compare Top LUM Proteins

Search GeneTex for Proteins for LUM

ProSci Proteins for LUM
- lumican

Abcam proteins for LUM
- Lumican

Assay Products

OriGene ELISA Kits for LUM
- EA100737
Custom Assay Services

R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for LUM (Lumican)

GenScript Custom Assay Services for LUM

Cloud-Clone Corp. Assay Kits for LUM
- SEB496Hu

Abcam assays for LUM
- Lumican

Browse Sino Biological Assays

No data available for DME Specific Peptides for LUM Gene

Domains & Families for LUM Gene

Gene Families for LUM Gene

HGNC:

573 : Small leucine rich repeat proteoglycans

Human Protein Atlas (HPA):

Cancer-related genes
Plasma proteins
Predicted secreted proteins

Protein Domains for LUM Gene

InterPro:

Blocks:

ProtoNet:

P51884

Suggested Antigen Peptide Sequences for LUM Gene

GenScript: Design optimal peptide antigens:

Keratan sulfate proteoglycan lumican (LUM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51884

UniProtKB/Swiss-Prot:

LUM_HUMAN :

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Family:

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Function for LUM Gene

Molecular function for LUM Gene

GENATLAS Biochemistry:

lumican,keratan sulfate proteoglycan one of the three major constituents of the corneal stroma,playing a role in the regulation of collagen assembly into fibrils in various connective tissues,small-leucine-rich proteoglycans family

Phenotypes From GWAS Catalog for LUM Gene

Gene Ontology (GO) - Molecular Function for LUM Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	NAS	10892350
GO:0005515	protein binding	IPI	25304424
GO:0005518	collagen binding	IDA	10892350

Phenotypes for LUM Gene

MGI mutant phenotypes for LUM:

inferred from 3 alleles

GenomeRNAi human phenotypes for LUM:

Animal Models for LUM Gene

MGI Knock Outs for LUM:

Lum ^{tm1.1(KOMP)Vlcg}
Lum ^tm1Wwk
Lum ^tm1Chak

Applied Biological Materials Clones for LUM
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- LUM

Cell Line Products

GenScript Custom overexpressing Cell Line Services for LUM

ESI BIO PureStem Z11, Meso Progenitor for LUM

Horizon Cell Lines for LUM
- LUM knockout cell line

ViGene Biosciences adenoviral particle packaged cDNA for LUM gene
- VH880297
ViGene Biosciences lentiviral particle packaged cDNA for LUM gene
- LH880297
ViGene Biosciences ready-to-package AAV shRNAs for LUM gene
- SH880297

Cloud-Clone Corp. primary cells service

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LUM Gene

Localization for LUM Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUM Gene

Secreted, extracellular space, extracellular matrix.

P51884-LUM_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
extracellular	5
lysosome	5
golgi apparatus	4
cytoskeleton	2
plasma membrane	1
cytosol	1

Gene Ontology (GO) - Cellular Components for LUM Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IDA,TAS	--
GO:0005578	proteinaceous extracellular matrix	TAS	7665616
GO:0005583	fibrillar collagen trimer	IDA	10734230
GO:0005615	extracellular space	IEA,IDA	20551380
GO:0005796	Golgi lumen	TAS	--

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LUM Gene

Pathways & Interactions for LUM Gene

SuperPathways for LUM Gene

More details on SuperPathways for LUM

	SuperPathway	Contained pathways
1	Defective CHST6 causes MCDC1	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) .01 Defective ST3GAL3 causes MCT12 and EIEE15 .01	Defective CHST6 causes MCDC1 -
2	Keratan sulfate/keratin metabolism	Keratan sulfate biosynthesis .85 Keratan sulfate/keratin metabolism .85	Keratan sulfate degradation .01
3	Glycosaminoglycan metabolism	Glycosaminoglycan metabolism .44	Metabolism of carbohydrates .42
4	Proteoglycans in cancer	Proteoglycans in cancer -
5	HIV Life Cycle	Disease .45

Pathways by source for LUM Gene

15 Reactome pathways for LUM Gene

1 KEGG pathway for LUM Gene

Proteoglycans in cancer

Interacting Proteins for LUM Gene

http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000266718%0d%0a9606.ENSP00000303351%0d%0a9606.ENSP00000360776%0d%0a9606.ENSP00000369055%0d%0a9606.ENSP00000296585%0d%0a9606.ENSP00000262915%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: ENSP00000266718 P51884-LUM_HUMAN for LUM Gene via STRING UniProtKB IID

Symbol	External ID(s)	Details
MMP14	ENSP00000308208 ²⁰ P50281 ⁴ ¹³⁷	STRING: ENSP00000308208 EBI-725780, EBI-992788 IID: # exp=2
ACAN	ENSP00000387356 ²⁰ P16112 ¹³⁷	STRING: ENSP00000387356 IID: # exp=1
ACTA2	ENSP00000224784 ²⁰ P62736 ¹³⁷	STRING: ENSP00000224784 IID: # pred=1
BMP1	ENSP00000305714 ²⁰ P13497 ¹³⁷	STRING: ENSP00000305714 IID: # pred=1
C1S	ENSP00000328173 ²⁰ P09871 ¹³⁷	STRING: ENSP00000328173 IID: # pred=1

Gene Ontology (GO) - Biological Process for LUM Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007409	NOT axonogenesis	IBA	--
GO:0007601	visual perception	TAS,IEA	--
GO:0014070	response to organic cyclic compound	IEA	--
GO:0018146	keratan sulfate biosynthetic process	TAS	--
GO:0030198	extracellular matrix organization	TAS	--

No data available for SIGNOR curated interactions for LUM Gene

Drugs & Compounds for LUM Gene

(1) Drugs for LUM Gene - From: DrugBank

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Copper	Approved, Investigational	MalaCards Medline Plus	Pharma	Target		202

Drug Products

Browse Tocris compounds for LUM

Browse compounds at ApexBio

Transcripts for LUM Gene

mRNA/cDNA for LUM Gene

(1) REFSEQ mRNAs :

NM_002345.3

(7) Additional mRNA sequences :

(1083) Selected AceView cDNA sequences:

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LUM Gene

Lumican:

Hs.406475

Representative Sequences:

BG114678

CRISPR Products

OriGene CRISPR knockouts for LUM
- KN202757

genomics-online: gRNA clones - Search results for available LUM gene related products

Applied Biological Materials CRISPR for LUM
Vectors and viruses for KO, Activation, Repression, and more
- LUM-CRISPR-CAS9-Knockout

Santa Cruz Biotechnology (SCBT) CRISPR for LUM

GenScript: Design CRISPR guide RNA sequences for LUM

miRNA Products

Search ViGene Biosciences for LUM

SwitchGear LUM 3' UTR sequence
Browse SwitchGear 3'UTR luciferase reporter plasmids

Browse OriGene miRNA Products For LUM

Inhibitory RNA Products

Origene RNAi, sirna, and shrna products in human, mouse, rat for LUM
Browse OriGene Inhibitory RNA Products For LUM

genomics-online: shRNA clones - Search results for available LUM gene related products

ViGene Biosciences ready-to-package AAV shRNAs for LUM gene
- SH880297

Search Santa Cruz Biotechnology (SCBT) for LUM siRNA/shRNA

Clone Products

OriGene clones in human for LUM
OriGene ORF clones in human for LUM
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: Next-day shipping of latest version cDNA ORF clones for LUM in any vector
- NM_002345.3

Sino Biological Human cDNA Clone for LUM

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat

Search Addgene for plasmids for LUM

genomics-online: cdna clones - Search results for available LUM gene related products
orf clones - Search results for available LUM gene related products

Applied Biological Materials Clones for LUM
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- LUM

Alternative Splicing Database (ASD) splice patterns (SP) for LUM Gene

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c
SP1:
SP2:							-		-
SP3:							-

Relevant External Links for LUM Gene

GeneLoc Exon Structure for: LUM
ECgene alternative splicing isoforms for: LUM

Expression for LUM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LUM Gene

mRNA expression in normal human tissues for LUM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Tendon & Ligament (Muscoskeletal System)
- Tenocytes Limb Tendons and Ligaments
- Early Tenocyte Cells Axial Tendon Primordia
- Tenocytes Axial Tendons and Ligamnets
- Early Tenocyte Cells Limb Tendon Primordia

mRNA differential expression in normal tissues according to GTEx for LUM Gene

This gene is overexpressed in Lung (x4.4), Heart - Atrial Appendage (x4.1), and Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for LUM Gene

This gene is overexpressed in Breast (6.3) and Synovial fluid (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LUM Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LUM Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for LUM Gene

Protein tissue co-expression partners for LUM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LUM Gene:

LUM

SOURCE GeneReport for Unigene cluster for LUM Gene:

Hs.406475

mRNA Expression by UniProt/SwissProt for LUM Gene:

P51884-LUM_HUMAN

Tissue specificity: Cornea and other tissues.

Evidence on tissue expression from TISSUES for LUM Gene

Lung(4.9)
Intestine(4.8)
Eye(4.7)
Liver(4.5)
Heart(4.3)
Bone marrow(4.2)
Pancreas(3.7)
Muscle(3.2)
Gall bladder(3.1)
Stomach(3.1)
Bone(2.9)
Lymph node(2.9)
Kidney(2.6)
Adrenal gland(2.5)
Nervous system(2.4)
Skin(2.3)
Blood(2.2)
Spleen(2.1)

Primer Products

OriGene qPCR primer pairs for LUM
- HP206051
OriGene qPCR primer pairs and template standards for LUM
- HK204470

genomics-online: primer clones - Search results for available LUM gene related products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LUM Gene

Orthologs for LUM Gene

This gene was present in the common ancestor of chordates.

Orthologs for LUM Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	LUM ³³ ³⁴	99.41 (n)		452119 XM_509260.4 XP_509260.3 12:91274089-91282297
dog (Canis familiaris)	Mammalia	LUM ³³ ³⁴	89.64 (n)		482599 XM_539716.4 XP_539716.1 15:31791505-31800707
cow (Bos Taurus)	Mammalia	LUM ³³ ³⁴	87.67 (n)		280847 NM_173934.1 NP_776359.1 5:21037443-21044658
mouse (Mus musculus)	Mammalia	Lum ³³ ¹⁶ ³⁴	82.45 (n)		17022 NM_008524.2 NP_032550.2 97565501 10:97565501-97572703
rat (Rattus norvegicus)	Mammalia	Lum ³³	82.05 (n)		81682 NM_031050.1 NP_112312.1
oppossum (Monodelphis domestica)	Mammalia	LUM ³⁴	75 (a)	OneToOne	8:67343547-67359684
platypus (Ornithorhynchus anatinus)	Mammalia	LUM ³⁴	74 (a)	OneToOne	Ultra443:10429566-10445165
chicken (Gallus gallus)	Aves	LUM ³³ ³⁴	69.94 (n)		417891 NM_001276357.1 NP_001263286.1 1:43860883-43872867
lizard (Anolis carolinensis)	Reptilia	LUM ³⁴	65 (a)	OneToOne	5:32342766-32353400
tropical clawed frog (Silurana tropicalis)	Amphibia	lum ³³	63.01 (n)		496415 NM_001011006.1 NP_001011006.1
tropical clawed frog (Silurana tropicalis)	Amphibia	Str.15551 ³³			CF378620.1
African clawed frog (Xenopus laevis)	Amphibia	MGC64527 ³³			BC054282.1
zebrafish (Danio rerio)	Actinopterygii	lum ³³ ³⁴	57.35 (n)		415149 NM_001002059.1 NP_001002059.1 4:15419792-15422476
sea squirt (Ciona savignyi)	Ascidiacea	-- ³⁴	28 (a)	OneToMany	reftig_7:2574955-2580350

Species where no ortholog for LUM was found in the sources mined by GeneCards:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
fruit fly (Drosophila melanogaster)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)
worm (Caenorhabditis elegans)

Evolution for LUM Gene

ENSEMBL:: Gene Tree for LUM (if available)
TreeFam:: Gene Tree for LUM (if available)

Paralogs for LUM Gene

FMOD ⁵
OMD ⁵
PRELP ⁵
KERA ⁵
DCN ⁵
ASPN ⁵
BGN ⁵
ECM2 ⁵
PODN ⁵
PODNL1 ⁵
FLRT2 ⁵
FLRT1 ⁵
FLRT3 ⁵

(8) SIMAP similar genes for LUM Gene using alignment to 1 proteins:

LUM_HUMAN

Variants for LUM Gene

Sequence variations from dbSNP and Humsavar for LUM Gene

SNP ID	Clin	Chr 12 pos	Variation	Type
rs1000372689	--	91,112,781(-)	C/T	upstream_transcript_variant
rs1000905803	--	91,103,437(-)	T/C	downstream_transcript_variant
rs1001019883	--	91,103,138(-)	G/C	downstream_transcript_variant
rs1001137864	--	91,109,763(-)	T/C	intron_variant
rs1001312923	--	91,110,173(-)	G/A	intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LUM Gene

Variant ID	Type	Subtype	PubMed ID
dgv210n27	CNV	loss	19166990
dgv2784n54	CNV	loss	21841781
nsv559751	CNV	loss	21841781

Variation tolerance for LUM Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 1.08; 22.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LUM Gene

Human Gene Mutation Database (HGMD): LUM
SNPedia medical, phenotypic, and genealogical associations of SNPs for: LUM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUM Gene

Disorders for LUM Gene

(8) MalaCards diseases for LUM Gene - From: HGMD, DISEASES, and GeneCards

Disorder	Aliases	PubMed IDs
cornea plana	flat cornea
degenerative myopia	degenerative progressive high myopia
corneal dystrophy, posterior amorphous	pacd
actinic keratosis	seborrheic keratosis
la crosse encephalitis	california encephalitis

- elite association - COSMIC cancer census association via MalaCards

Search LUM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LUM

Genetic Association Database: (GAD)
Human Genome Epidemiology Navigator: (HuGE)
: ATLAS of Genetics and Cytogenetics in Oncology and Haematology

Search disorders for LUM gene in PubMed and other databases

No data available for UniProtKB/Swiss-Prot and Genatlas for LUM Gene

Publications for LUM Gene

Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22. (PMID: 7558030) Chakravarti S … Hassell JR (Genomics 1995) ² ³ ⁴ ²² ⁵⁸
Association of the lumican gene functional 3'-UTR polymorphism with high myopia. (PMID: 19643966) Lin HJ … Tsai FJ (Investigative ophthalmology & visual science 2010) ³ ²² ⁴⁴ ⁵⁸
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) ³ ⁴⁴ ⁵⁸
The association between lumican gene polymorphisms and high myopia. (PMID: 20010793) Lin HJ … Tsai FJ (Eye (London, England) 2010) ³ ⁴⁴ ⁵⁸
High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes. (PMID: 19060265) Wang P … Zhang Q (Investigative ophthalmology & visual science 2009) ³ ⁴⁴ ⁵⁸