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Aliases for LUM Gene

Aliases for LUM Gene

  • Lumican 2 3 5
  • Keratan Sulfate Proteoglycan Lumican 3 4
  • Lumican Proteoglycan 2 3
  • KSPG Lumican 3 4
  • SLRR2D 3 4
  • LDC 3 4

External Ids for LUM Gene

Previous HGNC Symbols for LUM Gene

  • LDC

Previous GeneCards Identifiers for LUM Gene

  • GC12M090819
  • GC12M091944
  • GC12M091430
  • GC12M089999
  • GC12M088565

Summaries for LUM Gene

Entrez Gene Summary for LUM Gene

  • This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for LUM Gene

LUM (Lumican) is a Protein Coding gene. Diseases associated with LUM include Cornea Plana and Posterior Amorphous Corneal Dystrophy. Among its related pathways are Glycosaminoglycan metabolism and Defective B3GAT3 causes JDSSDHD. GO annotations related to this gene include collagen binding and extracellular matrix structural constituent. An important paralog of this gene is ECM2.

Gene Wiki entry for LUM Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUM Gene

Genomics for LUM Gene

Regulatory Elements for LUM Gene

Enhancers for LUM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LUM on UCSC Golden Path with GeneCards custom track

Promoters for LUM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LUM on UCSC Golden Path with GeneCards custom track

Genomic Location for LUM Gene

91,102,629 bp from pter
91,111,831 bp from pter
9,203 bases
Minus strand

Genomic View for LUM Gene

Genes around LUM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LUM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LUM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LUM Gene

Proteins for LUM Gene

  • Protein details for LUM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R6R5
    • Q96QM7

    Protein attributes for LUM Gene

    338 amino acids
    Molecular mass:
    38429 Da
    Quaternary structure:
    • Binds to laminin.

neXtProt entry for LUM Gene

Proteomics data for LUM Gene at MOPED

Post-translational modifications for LUM Gene

  • Sulfated on tyrosine residue(s).
  • Glycosylation at Asn 88, Asn 127, Asn 160, and Asn 252
  • Modification sites at PhosphoSitePlus

Other Protein References for LUM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LUM Gene

Domains & Families for LUM Gene

Gene Families for LUM Gene

Suggested Antigen Peptide Sequences for LUM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LRRNT domain.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
  • Contains 11 LRR (leucine-rich) repeats.
  • Contains 1 LRRNT domain.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LUM: view

Function for LUM Gene

Molecular function for LUM Gene

GENATLAS Biochemistry:
lumican,keratan sulfate proteoglycan one of the three major constituents of the corneal stroma,playing a role in the regulation of collagen assembly into fibrils in various connective tissues,small-leucine-rich proteoglycans family
genes like me logo Genes that share phenotypes with LUM: view

Animal Models for LUM Gene

MGI Knock Outs for LUM:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LUM Gene

Localization for LUM Gene

Subcellular locations from UniProtKB/Swiss-Prot for LUM Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for LUM Gene COMPARTMENTS Subcellular localization image for LUM gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
golgi apparatus 4
cytoskeleton 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LUM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with LUM: view

Pathways & Interactions for LUM Gene

genes like me logo Genes that share pathways with LUM: view

Gene Ontology (GO) - Biological Process for LUM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception IEA --
GO:0014070 response to organic cyclic compound IEA --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030199 collagen fibril organization NAS 10892350
GO:0032914 positive regulation of transforming growth factor beta1 production IEA --
genes like me logo Genes that share ontologies with LUM: view

No data available for SIGNOR curated interactions for LUM Gene

Drugs & Compounds for LUM Gene

No Compound Related Data Available

Transcripts for LUM Gene

mRNA/cDNA for LUM Gene

Unigene Clusters for LUM Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LUM Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP2: - -
SP3: -

Relevant External Links for LUM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LUM Gene

mRNA expression in normal human tissues for LUM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LUM Gene

This gene is overexpressed in Lung (x4.4), Heart - Atrial Appendage (x4.1), and Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for LUM Gene

This gene is overexpressed in Breast (6.3) and Synovial fluid (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LUM Gene

SOURCE GeneReport for Unigene cluster for LUM Gene Hs.406475

mRNA Expression by UniProt/SwissProt for LUM Gene

Tissue specificity: Cornea and other tissues.
genes like me logo Genes that share expression patterns with LUM: view

Protein tissue co-expression partners for LUM Gene

- Elite partner

Primer Products

Orthologs for LUM Gene

This gene was present in the common ancestor of chordates.

Orthologs for LUM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LUM 35
  • 87.67 (n)
  • 89.35 (a)
LUM 36
  • 88 (a)
(Canis familiaris)
Mammalia LUM 35
  • 89.64 (n)
  • 91.12 (a)
LUM 36
  • 91 (a)
(Mus musculus)
Mammalia Lum 35
  • 82.45 (n)
  • 86.69 (a)
Lum 16
Lum 36
  • 87 (a)
(Pan troglodytes)
Mammalia LUM 35
  • 99.41 (n)
  • 99.41 (a)
LUM 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lum 35
  • 82.05 (n)
  • 85.21 (a)
(Monodelphis domestica)
Mammalia LUM 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia LUM 36
  • 74 (a)
(Gallus gallus)
Aves LUM 35
  • 69.94 (n)
  • 70.24 (a)
LUM 36
  • 69 (a)
(Anolis carolinensis)
Reptilia LUM 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lum 35
  • 63.01 (n)
  • 64.39 (a)
Str.15551 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64527 35
(Danio rerio)
Actinopterygii lum 35
  • 57.35 (n)
  • 51.75 (a)
lum 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for LUM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LUM Gene

Gene Tree for LUM (if available)
Gene Tree for LUM (if available)

Paralogs for LUM Gene

Paralogs for LUM Gene

(8) SIMAP similar genes for LUM Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LUM: view

Variants for LUM Gene

Sequence variations from dbSNP and Humsavar for LUM Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs147975710 - 91,108,384(+) AAGGC(A/G)GTCTG reference, missense
rs1920716 -- 91,112,772(+) AATTA(G/T)TGATA upstream-variant-2KB
rs1920717 -- 91,113,551(+) TAACA(C/T)ATAAC upstream-variant-2KB
rs11478 -- 91,103,540(-) ACTGT(A/G)TTTGA utr-variant-3-prime
rs11756 -- 91,103,047(+) GAGTA(G/T)TTATC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LUM Gene

Variant ID Type Subtype PubMed ID
nsv899425 CNV Gain 21882294
nsv899428 CNV Gain 21882294
nsv899429 CNV Loss 21882294
dgv210n27 CNV Loss 19166990

Variation tolerance for LUM Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LUM Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUM Gene

Disorders for LUM Gene

MalaCards: The human disease database

(10) MalaCards diseases for LUM Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cornea plana
  • flat cornea
posterior amorphous corneal dystrophy
  • pacd
macular corneal dystrophy
  • fehr corneal dystrophy
corneal dystrophy, congenital stromal
  • congenital stromal corneal dystrophy
actinic keratosis
  • actinic keratosis
- elite association - COSMIC cancer census association via MalaCards
Search LUM in MalaCards View complete list of genes associated with diseases

Relevant External Links for LUM

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LUM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LUM Gene

Publications for LUM Gene

  1. Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22. (PMID: 7558030) Chakravarti S. … Hassell J.R. (Genomics 1995) 2 3 4 23 67
  2. Association of the lumican gene functional 3'-UTR polymorphism with high myopia. (PMID: 19643966) Lin H.J. … Tsai F.J. (Invest. Ophthalmol. Vis. Sci. 2010) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TNF-I+-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation. (PMID: 26351669) Pilling D. … Gomer R.H. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  5. Association between a lumican promoter polymorphism and high myopia in the Chinese population: a meta-analysis of case-control studies. (PMID: 24516061) Deng Z.J. … Qu J. (Ophthalmologica 2014) 3

Products for LUM Gene

Sources for LUM Gene