Aliases for LUM Gene
Aliases for LUM Gene
External Ids for LUM Gene
- HGNC: 6724
- Entrez Gene: 4060
- Ensembl: ENSG00000139329
- OMIM: 600616
- UniProtKB: P51884
Previous HGNC Symbols for LUM Gene
- LDC
Previous GeneCards Identifiers for LUM Gene
- GC12M090819
- GC12M091944
- GC12M091430
- GC12M089999
- GC12M088565
Summaries for LUM Gene
-
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
GeneCards Summary for LUM Gene
LUM (Lumican) is a Protein Coding gene. Diseases associated with LUM include Cornea Plana and Degenerative Myopia. Among its related pathways are Defective CHST6 causes MCDC1 and Keratan sulfate/keratin metabolism. Gene Ontology (GO) annotations related to this gene include collagen binding and extracellular matrix structural constituent. An important paralog of this gene is FMOD.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LUM Gene
Genomics for LUM Gene
GeneHancer (GH) Regulatory Elements for LUM Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12I091108 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE dbSUPER | 550.8 | +1.3 | 1303 | 3.9 | CTCF ZNF654 L3MBTL2 TRIM22 MAX RAD21 SMC3 ZNF143 CHD2 | LUM KERA GC12P091066 | |
GH12I091175 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE dbSUPER | 10.2 | -68.0 | -68028 | 9.7 | CTCF ZSCAN4 CEBPB RAD21 NR2F2 JUND ZNF316 ZNF366 POLR2A ZNF512 | DCN KERA LUM LOC105369897 | |
GH12I091137 | Enhancer | 1.4 | VISTA Ensembl ENCODE dbSUPER | 11.4 | -29.0 | -28960 | 5.8 | JUN CEBPB ZNF384 FEZF1 EP300 POLR2A STAT3 FOS RCOR1 FOXP2 | LUM DCN KERA LOC105369897 | |
GH12I090979 | Enhancer | 0.8 | Ensembl ENCODE | 12.1 | +133.6 | 133614 | 0.4 | CTCF ZNF654 TRIM22 REST RAD21 MAFF SMC3 CHD2 | LUM CCER1 EPYC | |
GH12I091184 | Enhancer | 0.7 | ENCODE dbSUPER | 10.2 | -74.0 | -74024 | 2.1 | HLF SCRT2 CREB1 ATF2 | LUM DCN ENSG00000258148 |
- Top Transcription factor binding sites by QIAGEN in the LUM gene promoter:
Regulatory Element Products
Genomic Locations for LUM Gene
- chr12:91,102,629-91,111,831
- (GRCh38/hg38)
- Size:
- 9,203 bases
- Orientation:
- Minus strand
- chr12:91,496,406-91,505,608
- (GRCh37/hg19)
Genomic View for LUM Gene
- Cytogenetic band:
-
- 12q21.33 by Ensembl
- 12q21.33 by Entrez Gene
- 12q21.33 by HGNC


RefSeq DNA sequence for LUM Gene
Proteins for LUM Gene
-
Protein details for LUM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51884-LUM_HUMAN
- Recommended name:
- Lumican
- Protein Accession:
- P51884
- B2R6R5
- Q96QM7
Protein attributes for LUM Gene
- Size:
- 338 amino acids
- Molecular mass:
- 38429 Da
- Quaternary structure:
-
- Binds to laminin.
Protein Expression for LUM Gene
Post-translational modifications for LUM Gene
- Sulfated on tyrosine residue(s).
- Glycosylation at posLast=8888, isoforms=127, isoforms=160, and isoforms=252
Other Protein References for LUM Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for LUM (Lumican)
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-
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-
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- 2 IF/ICC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 25 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 13 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
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-
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Protein Products
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-
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-
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-
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-
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Assay Products
-
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- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for LUM (Lumican)
-
Cloud-Clone Corp. Assay Kits for LUM
-
Abcam assays for LUM
No data available for DME Specific Peptides for LUM Gene
Domains & Families for LUM Gene
Gene Families for LUM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for LUM Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LUM Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P51884UniProtKB/Swiss-Prot:
LUM_HUMAN :- Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
- Family:
-
- Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Function for LUM Gene
Molecular function for LUM Gene
- GENATLAS Biochemistry:
- lumican,keratan sulfate proteoglycan one of the three major constituents of the corneal stroma,playing a role in the regulation of collagen assembly into fibrils in various connective tissues,small-leucine-rich proteoglycans family
Phenotypes From GWAS Catalog for LUM Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005201 | extracellular matrix structural constituent | NAS | 10892350 |
GO:0005515 | protein binding | IPI | 25304424 |
GO:0005518 | collagen binding | IDA | 10892350 |
Phenotypes for LUM Gene
- MGI mutant phenotypes for LUM:
-
inferred from 3 alleles
- homeostasis/metabolism phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for LUM:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for LUM gene
-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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-
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-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LUM Gene
Localization for LUM Gene
Subcellular locations from UniProtKB/Swiss-Prot for LUM Gene
- Secreted, extracellular space, extracellular matrix.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IDA,TAS | -- |
GO:0005578 | proteinaceous extracellular matrix | TAS | 7665616 |
GO:0005583 | fibrillar collagen trimer | IDA | 10734230 |
GO:0005615 | extracellular space | IEA,IDA | 20551380 |
GO:0005796 | Golgi lumen | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LUM Gene
Pathways & Interactions for LUM Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Defective CHST6 causes MCDC1 | ||
2 | Keratan sulfate/keratin metabolism | ||
3 | Glycosaminoglycan metabolism | ||
4 | Proteoglycans in cancer | ||
5 | HIV Life Cycle |
.45
|
Pathways by source for LUM Gene
1 KEGG pathway for LUM Gene
Interacting Proteins for LUM Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007409 | NOT axonogenesis | IBA | -- |
GO:0007601 | visual perception | TAS,IEA | -- |
GO:0014070 | response to organic cyclic compound | IEA | -- |
GO:0018146 | keratan sulfate biosynthetic process | TAS | -- |
GO:0030198 | extracellular matrix organization | TAS | -- |
No data available for SIGNOR curated interactions for LUM Gene
Drugs & Compounds for LUM Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Target | 202 |
Transcripts for LUM Gene
mRNA/cDNA for LUM Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (1083) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for LUM
- genomics-online: gRNA clones - Search results for available LUM gene related products
- Applied Biological Materials CRISPR for LUM
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LUM
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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- Applied Biological Materials Clones for LUM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||
SP2: | - | - | |||||||||||||||
SP3: | - |
Expression for LUM Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tendon & Ligament (Muscoskeletal System)
- Tenocytes Limb Tendons and Ligaments
- Early Tenocyte Cells Axial Tendon Primordia
- Tenocytes Axial Tendons and Ligamnets
- Early Tenocyte Cells Limb Tendon Primordia
mRNA differential expression in normal tissues according to GTEx for LUM Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LUM Gene
NURSA nuclear receptor signaling pathways regulating expression of LUM Gene:
LUMSOURCE GeneReport for Unigene cluster for LUM Gene:
Hs.406475mRNA Expression by UniProt/SwissProt for LUM Gene:
P51884-LUM_HUMANEvidence on tissue expression from TISSUES for LUM Gene
- Lung(4.9)
- Intestine(4.8)
- Eye(4.7)
- Liver(4.5)
- Heart(4.3)
- Bone marrow(4.2)
- Pancreas(3.7)
- Muscle(3.2)
- Gall bladder(3.1)
- Stomach(3.1)
- Bone(2.9)
- Lymph node(2.9)
- Kidney(2.6)
- Adrenal gland(2.5)
- Nervous system(2.4)
- Skin(2.3)
- Blood(2.2)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for LUM
-
OriGene qPCR primer pairs and template standards for LUM
- genomics-online: primer clones - Search results for available LUM gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LUM Gene
Orthologs for LUM Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LUM 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | LUM 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | LUM 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Lum 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Lum 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | LUM 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | LUM 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | LUM 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | LUM 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | lum 33 |
|
||
Str.15551 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | MGC64527 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | lum 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for LUM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for LUM Gene
Variants for LUM Gene
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000372689 | -- | 91,112,781(-) | C/T | upstream_transcript_variant | |
rs1000905803 | -- | 91,103,437(-) | T/C | downstream_transcript_variant | |
rs1001019883 | -- | 91,103,138(-) | G/C | downstream_transcript_variant | |
rs1001137864 | -- | 91,109,763(-) | T/C | intron_variant | |
rs1001312923 | -- | 91,110,173(-) | G/A | intron_variant |
Additional Variant Information for LUM Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LUM Gene
Disorders for LUM Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
cornea plana |
|
|
degenerative myopia |
|
|
corneal dystrophy, posterior amorphous |
|
|
actinic keratosis |
|
|
la crosse encephalitis |
|
|
Additional Disease Information for LUM
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for LUM Gene
Publications for LUM Gene
- Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22. (PMID: 7558030) Chakravarti S … Hassell JR (Genomics 1995) 2 3 4 22 58
- Association of the lumican gene functional 3'-UTR polymorphism with high myopia. (PMID: 19643966) Lin HJ … Tsai FJ (Investigative ophthalmology & visual science 2010) 3 22 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- The association between lumican gene polymorphisms and high myopia. (PMID: 20010793) Lin HJ … Tsai FJ (Eye (London, England) 2010) 3 44 58
- High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes. (PMID: 19060265) Wang P … Zhang Q (Investigative ophthalmology & visual science 2009) 3 44 58
Products for LUM Gene
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for 83 available LUM Antibodies ranked by validation data
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- Recommended
- 46 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IF/ICC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 25 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 13 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for 38 available LUM Elisa Kits ranked by validation data
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- Search GeneTex for Antibodies for LUM
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- ViGene Biosciences adenoviral particle packaged cDNA for LUM gene
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Sources for LUM Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
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