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Aliases for LTK Gene

Aliases for LTK Gene

  • Leukocyte Receptor Tyrosine Kinase 2 3
  • TYK1 3 4 6
  • Protein Tyrosine Kinase 1 3 4
  • EC 2.7.10.1 4 63
  • Leukocyte Tyrosine Kinase Receptor 3
  • Leukocyte Tyrosine Kinase 2

External Ids for LTK Gene

Summaries for LTK Gene

Entrez Gene Summary for LTK Gene

  • The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for LTK Gene

LTK (Leukocyte Receptor Tyrosine Kinase) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is ALK.

UniProtKB/Swiss-Prot for LTK Gene

  • Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.

Gene Wiki entry for LTK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTK Gene

Genomics for LTK Gene

Genomic Location for LTK Gene

Start:
41,503,638 bp from pter
End:
41,513,887 bp from pter
Size:
10,250 bases
Orientation:
Minus strand

Genomic View for LTK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTK Gene

Regulatory Elements for LTK Gene

Proteins for LTK Gene

  • Protein details for LTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29376-LTK_HUMAN
    Recommended name:
    Leukocyte tyrosine kinase receptor
    Protein Accession:
    P29376
    Secondary Accessions:
    • A6NNJ8
    • B4DL89
    • E9PFX4

    Protein attributes for LTK Gene

    Size:
    864 amino acids
    Molecular mass:
    91681 Da
    Quaternary structure:
    • Homodimer when bound to ligand (Probable). Part of a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2.
    Miscellaneous:
    • Transgenic mice expressing human LTK show specific activation (tyrosine phosphorylation, kinase activity, membrane localization and homooligomerization) in heart combined with cardiac hypertrophy, cardiomyocyte degeneration

    Alternative splice isoforms for LTK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LTK Gene

Proteomics data for LTK Gene at MOPED

Selected DME Specific Peptides for LTK Gene

Post-translational modifications for LTK Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn257, Asn380, and Asn412

Other Protein References for LTK Gene

Domains for LTK Gene

Suggested Antigen Peptide Sequences for LTK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P29376

UniProtKB/Swiss-Prot:

LTK_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P29376
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.:
    • P29376
genes like me logo Genes that share domains with LTK: view

Function for LTK Gene

Molecular function for LTK Gene

GENATLAS Biochemistry: tyrosine kinase,receptor type,leukocyte
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.

Enzyme Numbers (IUBMB) for LTK Gene

Gene Ontology (GO) - Molecular Function for LTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 10445845
GO:0004713 protein tyrosine kinase activity TAS 7685902
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with LTK: view
genes like me logo Genes that share phenotypes with LTK: view

miRNA for LTK Gene

miRTarBase miRNAs that target LTK

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for LTK Gene

Localization for LTK Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTK Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LTK Gene COMPARTMENTS Subcellular localization image for LTK gene
Compartment Confidence
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 7685902
GO:0005887 integral component of plasma membrane TAS 7685902
GO:0016020 membrane IDA 10445845
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with LTK: view

Pathways for LTK Gene

SuperPathways for LTK Gene

No Data Available

Gene Ontology (GO) - Biological Process for LTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 9223670
GO:0007165 signal transduction TAS 7685902
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0008283 cell proliferation IDA 10445845
GO:0010666 positive regulation of cardiac muscle cell apoptotic process IDA 10445845
genes like me logo Genes that share ontologies with LTK: view

No data available for Pathways by source for LTK Gene

Compounds for LTK Gene

(1) Novoseek inferred chemical compound relationships for LTK Gene

Compound -log(P) Hits PubMed IDs
tyrosine 62.4 27
genes like me logo Genes that share compounds with LTK: view

Transcripts for LTK Gene

Unigene Clusters for LTK Gene

Leukocyte receptor tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LTK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2: - - -
SP3: - - - -
SP4:
SP5:

Relevant External Links for LTK Gene

GeneLoc Exon Structure for
LTK
ECgene alternative splicing isoforms for
LTK

Expression for LTK Gene

mRNA expression in normal human tissues for LTK Gene

mRNA differential expression in normal tissues according to GTEx for LTK Gene

This gene is overexpressed in Lung (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LTK Gene

SOURCE GeneReport for Unigene cluster for LTK Gene Hs.434481

mRNA Expression by UniProt/SwissProt for LTK Gene

P29376-LTK_HUMAN
Tissue specificity: Expressed in non-hematopoietic cell lines and T- and B-cell lines.
genes like me logo Genes that share expressions with LTK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LTK Gene

Orthologs for LTK Gene

This gene was present in the common ancestor of animals.

Orthologs for LTK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LTK 35
  • 99.46 (n)
  • 99.42 (a)
LTK 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ltk 35
  • 82.25 (n)
  • 79.53 (a)
Ltk 16
Ltk 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LTK 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ltk 35
  • 83.52 (n)
  • 82.01 (a)
chicken
(Gallus gallus)
Aves LTK 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LTK 36
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ltk 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Alk 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scd-2 36
  • 16 (a)
OneToMany
scd-2 37
  • 36 (a)
Species with no ortholog for LTK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LTK Gene

ENSEMBL:
Gene Tree for LTK (if available)
TreeFam:
Gene Tree for LTK (if available)

Paralogs for LTK Gene

Paralogs for LTK Gene

genes like me logo Genes that share paralogs with LTK: view

Variants for LTK Gene

Sequence variations from dbSNP and Humsavar for LTK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs170296 -- 41,504,703(+) GAGGT(G/T)GCTGG intron-variant
rs316618 -- 41,504,300(+) CCTCC(A/T)GACCC intron-variant
rs316619 -- 41,506,416(+) TCTCC(C/T)GCCTC intron-variant
rs316620 -- 41,506,564(+) CCTCC(C/G)AAAGT intron-variant
rs316621 -- 41,506,598(+) ATATT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LTK Gene

Variant ID Type Subtype PubMed ID
nsv524476 CNV Loss 19592680
dgv2362n71 CNV Loss 21882294
nsv471241 CNV Loss 18288195
esv33378 CNV Gain 17666407

Relevant External Links for LTK Gene

HapMap Linkage Disequilibrium report
LTK
Human Gene Mutation Database (HGMD)
LTK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTK Gene

Disorders for LTK Gene

UniProtKB/Swiss-Prot

LTK_HUMAN
  • Note=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B-cells and, therefore, to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system.

(4) Novoseek inferred disease relationships for LTK Gene

Disease -log(P) Hits PubMed IDs
lymphoma 28.1 1
breast carcinoma 23.5 2
metastasis 0 1
tumors 0 2

Relevant External Links for LTK

Genetic Association Database (GAD)
LTK
Human Genome Epidemiology (HuGE) Navigator
LTK
Tumor Gene Database (TGDB):
LTK
genes like me logo Genes that share disorders with LTK: view

Publications for LTK Gene

  1. Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. (PMID: 7685902) Toyoshima H. … Hirai H. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  2. Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. (PMID: 8084603) Kozutsumi H. … Hirai H. (Oncogene 1994) 3 4 23
  3. Identification and chromosomal mapping of new human tyrosine kinase genes. (PMID: 2156206) Krolewski J.J. … Dalla-Favera R. (Oncogene 1990) 3 4 23
  4. The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase. (PMID: 9223670) Ueno H. … Hirai H. (Oncogene 1997) 3 4 23
  5. Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. (PMID: 14695357) Li N. … Hirose S. (Hum. Mol. Genet. 2004) 3 4 23

Products for LTK Gene

Sources for LTK Gene

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