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Aliases for LTC4S Gene

Aliases for LTC4S Gene

  • Leukotriene C4 Synthase 2 3
  • Leukotriene-C(4) Synthase 4
  • LTC4 Synthase 4
  • EC 4

External Ids for LTC4S Gene

Previous GeneCards Identifiers for LTC4S Gene

  • GC05P179333
  • GC05P180165
  • GC05P179285
  • GC05P179330
  • GC05P179153
  • GC05P179220
  • GC05P173947

Summaries for LTC4S Gene

Entrez Gene Summary for LTC4S Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

GeneCards Summary for LTC4S Gene

LTC4S (Leukotriene C4 Synthase) is a Protein Coding gene. Diseases associated with LTC4S include leukotriene c4 synthase deficiency and hypotonia - failure to thrive - microcephaly. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include lipid binding and glutathione transferase activity. An important paralog of this gene is MGST2.

UniProtKB/Swiss-Prot for LTC4S Gene

  • Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4

Gene Wiki entry for LTC4S Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTC4S Gene

Genomics for LTC4S Gene

Regulatory Elements for LTC4S Gene

Transcription factor binding sites by QIAGEN in the LTC4S gene promoter:

Genomic Location for LTC4S Gene

179,793,980 bp from pter
179,796,647 bp from pter
2,668 bases
Plus strand

Genomic View for LTC4S Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LTC4S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTC4S Gene

Proteins for LTC4S Gene

  • Protein details for LTC4S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukotriene C4 synthase
    Protein Accession:
    Secondary Accessions:
    • Q8N6P0
    • Q9UC73
    • Q9UD18

    Protein attributes for LTC4S Gene

    150 amino acids
    Molecular mass:
    16567 Da
    Quaternary structure:
    • Homotrimer. Interacts with ALOX5AP and ALOX5.

    Three dimensional structures from OCA and Proteopedia for LTC4S Gene

neXtProt entry for LTC4S Gene

Proteomics data for LTC4S Gene at MOPED

Post-translational modifications for LTC4S Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LTC4S Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LTC4S Gene

Domains for LTC4S Gene

Gene Families for LTC4S Gene

Suggested Antigen Peptide Sequences for LTC4S Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q16873
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with LTC4S: view

Function for LTC4S Gene

Molecular function for LTC4S Gene

GENATLAS Biochemistry: leukotriene C4 synthase,microsomal,GST superfamily
UniProtKB/Swiss-Prot CatalyticActivity: Leukotriene C(4) = leukotriene A(4) + glutathione
UniProtKB/Swiss-Prot Function: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4

Enzyme Numbers (IUBMB) for LTC4S Gene

Gene Ontology (GO) - Molecular Function for LTC4S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IBA --
GO:0004464 leukotriene-C4 synthase activity IDA 8706658
GO:0004602 glutathione peroxidase activity IBA --
GO:0005515 protein binding IPI 19233132
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with LTC4S: view
genes like me logo Genes that share phenotypes with LTC4S: view

Animal Models for LTC4S Gene

MGI Knock Outs for LTC4S:

miRNA for LTC4S Gene

miRTarBase miRNAs that target LTC4S

No data available for Transcription Factor Targeting and HOMER Transcription for LTC4S Gene

Localization for LTC4S Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTC4S Gene

Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LTC4S Gene COMPARTMENTS Subcellular localization image for LTC4S gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for LTC4S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005640 nuclear outer membrane IEA --
GO:0005783 endoplasmic reticulum IDA 19233132
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LTC4S: view

Pathways for LTC4S Gene

genes like me logo Genes that share pathways with LTC4S: view

Gene Ontology (GO) - Biological Process for LTC4S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006691 leukotriene metabolic process TAS --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019370 leukotriene biosynthetic process IBA --
GO:0019372 lipoxygenase pathway TAS --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with LTC4S: view

Compounds for LTC4S Gene

(3) HMDB Compounds for LTC4S Gene

Compound Synonyms Cas Number PubMed IDs
  • 5-L-Glutamyl-L-cysteinylglycine
Leukotriene A4
  • LTA4
Leukotriene C4
  • (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-Glycine

(1) Drugbank Compounds for LTC4S Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target

(25) Novoseek inferred chemical compound relationships for LTC4S Gene

Compound -log(P) Hits PubMed IDs
ltc4 95.5 177
leukotriene b4 75.6 11
lte4 74.6 1
ltd4 73.5 2
montelukast 69.6 5

(2) PharmGKB related drug/compound annotations for LTC4S Gene

Drug/compound Annotation
aspirin CA
montelukast CA
genes like me logo Genes that share compounds with LTC4S: view

Transcripts for LTC4S Gene

mRNA/cDNA for LTC4S Gene

Unigene Clusters for LTC4S Gene

Leukotriene C4 synthase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LTC4S Gene

No ASD Table

Relevant External Links for LTC4S Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LTC4S Gene

mRNA expression in normal human tissues for LTC4S Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LTC4S Gene

SOURCE GeneReport for Unigene cluster for LTC4S Gene Hs.706741

mRNA Expression by UniProt/SwissProt for LTC4S Gene

Tissue specificity: Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.
genes like me logo Genes that share expressions with LTC4S: view

No data available for mRNA differential expression in normal tissues for LTC4S Gene

Orthologs for LTC4S Gene

This gene was present in the common ancestor of chordates.

Orthologs for LTC4S Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LTC4S 35
  • 99.56 (n)
  • 99.33 (a)
LTC4S 36
  • 99 (a)
(Bos Taurus)
Mammalia LTC4S 35
  • 92.03 (n)
  • 96.38 (a)
LTC4S 36
  • 93 (a)
(Canis familiaris)
Mammalia LTC4S 35
  • 89.43 (n)
  • 91.03 (a)
LTC4S 36
  • 88 (a)
(Mus musculus)
Mammalia Ltc4s 35
  • 89.19 (n)
  • 93.69 (a)
Ltc4s 16
Ltc4s 36
  • 88 (a)
(Monodelphis domestica)
Mammalia LTC4S 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Ltc4s 35
  • 88.89 (n)
  • 90.09 (a)
(Gallus gallus)
Aves LOC770619 35
  • 72.37 (n)
  • 70.27 (a)
LTC4S 36
  • 64 (a)
(Anolis carolinensis)
Reptilia LTC4S 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mgst2 35
  • 66.36 (n)
  • 69.72 (a)
(Danio rerio)
Actinopterygii ltc4s 36
  • 54 (a)
Species with no ortholog for LTC4S:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LTC4S Gene

Gene Tree for LTC4S (if available)
Gene Tree for LTC4S (if available)

Paralogs for LTC4S Gene

Paralogs for LTC4S Gene

Selected SIMAP similar genes for LTC4S Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LTC4S: view

Variants for LTC4S Gene

Sequence variations from dbSNP and Humsavar for LTC4S Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs272431 -- 179,794,788(+) CGGGA(G/T)GTCTG intron-variant
rs523487 -- 179,794,148(+) GCTGG(G/T)TCCTA intron-variant
rs524308 -- 179,794,222(+) GGGCA(C/G)AGGTG intron-variant
rs524372 -- 179,794,205(+) CCCTA(G/T)GCCCA intron-variant
rs730012 -- 179,793,637(+) GGGAC(A/C)GGGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LTC4S Gene

Variant ID Type Subtype PubMed ID
nsv883270 CNV Loss 21882294
nsv483062 CNV Loss 15286789
nsv469579 CNV Loss 16826518
dgv6400n71 CNV Loss 21882294
nsv518964 CNV Loss 19592680
nsv883275 CNV Loss 21882294
nsv823361 CNV Loss 20364138
nsv883278 CNV Loss 21882294
dgv6401n71 CNV Loss 21882294
dgv6402n71 CNV Loss 21882294
dgv6403n71 CNV Loss 21882294

Relevant External Links for LTC4S Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LTC4S Gene

Disorders for LTC4S Gene

(1) OMIM Diseases for LTC4S Gene (246530)


  • Note=LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

(1) University of Copenhagen DISEASES for LTC4S Gene

(17) Novoseek inferred disease relationships for LTC4S Gene

Disease -log(P) Hits PubMed IDs
asthma 71.2 37
leukemia basophilic 60.7 3
monocytic leukemia 51.8 1
idiopathic urticaria 44.6 1
urticaria 36.8 5

Relevant External Links for LTC4S

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LTC4S: view

Publications for LTC4S Gene

  1. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. (PMID: 8052639) Lam B.K. … Austen K.F. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. (PMID: 17632546) Martinez Molina D. … Nordlund P. (Nature 2007) 3 4 23 25
  3. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. (PMID: 17632548) Ago H. … Miyano M. (Nature 2007) 3 4 23 25
  4. Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody. (PMID: 7599836) Penrose J.F. … Austen K.F. (Am. J. Respir. Crit. Care Med. 1995) 3 4 23
  5. Molecular cloning and expression of human leukotriene-C4 synthase. (PMID: 7937884) Welsch D.J. … Isakson P.C. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23

Products for LTC4S Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate LTC4S
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for LTC4S
    • Block miRNA regulation of LTC4S using miScript Target Protectors

    Sources for LTC4S Gene

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