Aliases for LTBR Gene
External Ids for LTBR Gene
Previous HGNC Symbols for LTBR Gene
Previous GeneCards Identifiers for LTBR Gene
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
GeneCards Summary for LTBR Gene
LTBR (Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3)) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include identical protein binding and ubiquitin protein ligase binding. An important paralog of this gene is TNFRSF14.
UniProtKB/Swiss-Prot for LTBR Gene
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.