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Aliases for LTBR Gene

Aliases for LTBR Gene

  • Lymphotoxin Beta Receptor 2 3 5
  • Tumor Necrosis Factor Receptor 2-Related Protein 3 4
  • Tumor Necrosis Factor Receptor Type III 3 4
  • Tumor Necrosis Factor C Receptor 3 4
  • D12S370 3 4
  • TNFRSF3 3 4
  • TNFCR 3 4
  • TNFR3 3 4
  • Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3) 3
  • Lymphotoxin-Beta Receptor 4
  • Lymphotoxin B Receptor 3
  • TNFR Superfamily 2
  • LT-BETA-R 3
  • TNF-R-III 3
  • Member 3 2
  • TNFR2-RP 3
  • TNF-RIII 4
  • TNFR-III 4
  • TNFR-RP 3
  • CD18 3

External Ids for LTBR Gene

Previous HGNC Symbols for LTBR Gene

  • D12S370

Previous GeneCards Identifiers for LTBR Gene

  • GC12P006348
  • GC12P006467
  • GC12P006363
  • GC12P006347
  • GC12P006484

Summaries for LTBR Gene

Entrez Gene Summary for LTBR Gene

  • This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

GeneCards Summary for LTBR Gene

LTBR (Lymphotoxin Beta Receptor) is a Protein Coding gene. Among its related pathways are HTLV-I infection and TNF Signaling (sino). GO annotations related to this gene include identical protein binding and ubiquitin protein ligase binding. An important paralog of this gene is TNFRSF14.

UniProtKB/Swiss-Prot for LTBR Gene

  • Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

Gene Wiki entry for LTBR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LTBR Gene

Genomics for LTBR Gene

Regulatory Elements for LTBR Gene

Enhancers for LTBR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LTBR on UCSC Golden Path with GeneCards custom track

Genomic Location for LTBR Gene

6,375,045 bp from pter
6,391,571 bp from pter
16,527 bases
Plus strand

Genomic View for LTBR Gene

Genes around LTBR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LTBR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LTBR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LTBR Gene

Proteins for LTBR Gene

  • Protein details for LTBR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 3
    Protein Accession:
    Secondary Accessions:
    • B7Z1D2
    • D3DUR2
    • F5GXE7

    Protein attributes for LTBR Gene

    435 amino acids
    Molecular mass:
    46709 Da
    Quaternary structure:
    • Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein.

    Three dimensional structures from OCA and Proteopedia for LTBR Gene

    Alternative splice isoforms for LTBR Gene


neXtProt entry for LTBR Gene

Proteomics data for LTBR Gene at MOPED

Post-translational modifications for LTBR Gene

  • Glycosylation at Asn 40 and Asn 177
  • Modification sites at PhosphoSitePlus

Other Protein References for LTBR Gene

Antibody Products

  • R&D Systems Antibodies for LTBR (Lymphotoxin beta R/TNFRSF3)
  • Abcam antibodies for LTBR

No data available for DME Specific Peptides for LTBR Gene

Domains & Families for LTBR Gene

Protein Domains for LTBR Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 TNFR-Cys repeats.
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with LTBR: view

Function for LTBR Gene

Molecular function for LTBR Gene

GENATLAS Biochemistry:
lymphotoxin B receptor,(tumor necrosis factor receptor TNFR superfamily,member 3),expressed at the surface of most cell types,including cells of epithelial and myeloid lineages but not on T and B cells,involved in lymphoid organ development and apoptosis through interaction with TRAF3
UniProtKB/Swiss-Prot Function:
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

Gene Ontology (GO) - Molecular Function for LTBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 11279055
genes like me logo Genes that share ontologies with LTBR: view
genes like me logo Genes that share phenotypes with LTBR: view

Animal Models for LTBR Gene

MGI Knock Outs for LTBR:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LTBR Gene

Localization for LTBR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LTBR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LTBR Gene COMPARTMENTS Subcellular localization image for LTBR gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
golgi apparatus 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for LTBR Gene

Pathways & Interactions for LTBR Gene

genes like me logo Genes that share pathways with LTBR: view

SIGNOR curated interactions for LTBR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LTBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 8171323
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with LTBR: view

Drugs & Compounds for LTBR Gene

(3) Drugs for LTBR Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LIGHT Pharma 0

(3) Additional Compounds for LTBR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LTBR: view

Transcripts for LTBR Gene

mRNA/cDNA for LTBR Gene

Unigene Clusters for LTBR Gene

Lymphotoxin beta receptor (TNFR superfamily, member 3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LTBR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - - - -
SP5: -
SP6: -
SP8: - -

Relevant External Links for LTBR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LTBR Gene

mRNA expression in normal human tissues for LTBR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LTBR Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LTBR Gene

SOURCE GeneReport for Unigene cluster for LTBR Gene Hs.1116

genes like me logo Genes that share expression patterns with LTBR: view

Protein tissue co-expression partners for LTBR Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LTBR Gene

Orthologs for LTBR Gene

This gene was present in the common ancestor of mammals.

Orthologs for LTBR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LTBR 35
  • 78.18 (n)
  • 71.46 (a)
  • 70 (a)
(Canis familiaris)
Mammalia LTBR 35
  • 80.69 (n)
  • 73.8 (a)
  • 72 (a)
(Mus musculus)
Mammalia Ltbr 35
  • 76.28 (n)
  • 70.17 (a)
Ltbr 16
Ltbr 36
  • 69 (a)
(Pan troglodytes)
Mammalia LTBR 35
  • 98.85 (n)
  • 98.16 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Ltbr 35
  • 76.1 (n)
  • 69.27 (a)
(Monodelphis domestica)
Mammalia LTBR 36
  • 56 (a)
Species with no ortholog for LTBR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LTBR Gene

Gene Tree for LTBR (if available)
Gene Tree for LTBR (if available)

Paralogs for LTBR Gene

genes like me logo Genes that share paralogs with LTBR: view

Variants for LTBR Gene

Sequence variations from dbSNP and Humsavar for LTBR Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs35681405 - 6,390,130(-) AGCTA(C/G/T)AGGAT reference, missense
rs12354 -- 6,390,939(+) CTGAC(A/G/T)GAGTC utr-variant-3-prime
rs7137702 -- 6,388,093(+) GCACA(C/T)ACAAG intron-variant
rs10849448 -- 6,384,185(+) CCGCC(A/G)TGGGA intron-variant, utr-variant-5-prime
rs10849449 -- 6,389,496(+) TCTGA(A/G)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LTBR Gene

Variant ID Type Subtype PubMed ID
esv34325 CNV Gain 17911159
dgv453e1 CNV Complex 17122850

Variation tolerance for LTBR Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LTBR Gene

Disorders for LTBR Gene

Relevant External Links for LTBR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LTBR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LTBR Gene

Publications for LTBR Gene

  1. A lymphotoxin-beta-specific receptor. (PMID: 8171323) Crowe P.D. … Smith C.A. (Science 1994) 2 3 4 23 67
  2. TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. (PMID: 20185819) Bista P. … Lukashev M.E. (J. Biol. Chem. 2010) 3 23
  3. Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor. (PMID: 20348096) Sanjo H. … Ware C.F. (J. Biol. Chem. 2010) 3 23
  4. Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells. (PMID: 18292573) Madge L.A. … May M.J. (J. Immunol. 2008) 3 23
  5. The lymphotoxin-beta receptor is an upstream activator of NF-kappaB-mediated transcription in melanoma cells. (PMID: 18347013) Dhawan P. … Richmond A. (J. Biol. Chem. 2008) 3 23

Products for LTBR Gene

Sources for LTBR Gene