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Aliases for CYP4F3 Gene

Aliases for CYP4F3 Gene

  • Cytochrome P450 Family 4 Subfamily F Member 3 2 3 5
  • Cytochrome P450, Subfamily IVF, Polypeptide 3 (Leukotriene B4 Omega Hydroxylase) 2 3
  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 3 2 3
  • 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
  • Leukotriene-B(4) Omega-Hydroxylase 2 3 4
  • Leukotriene-B(4) 20-Monooxygenase 2 3 4
  • Cytochrome P450-LTB-Omega 3 4
  • Cytochrome P450 4F3 3 4
  • 20-HETE Synthase 3 4
  • CYPIVF3 3 4
  • LTB4H 3 4
  • Leukotriene B4 Omega Hydroxylase 3
  • Leukotriene-B4 20-Monooxygenase 3
  • Cytochrome P-450 3
  • EC 1.14.13.199 4
  • EC 1.14.13.30 4
  • EC 1.14.13.- 4
  • CYP4F 3
  • CPF3 3

External Ids for CYP4F3 Gene

Previous HGNC Symbols for CYP4F3 Gene

  • LTB4H

Previous GeneCards Identifiers for CYP4F3 Gene

  • GC19P016130
  • GC19P016013
  • GC19P015482
  • GC19P015612
  • GC19P015751
  • GC19P015320

Summaries for CYP4F3 Gene

Entrez Gene Summary for CYP4F3 Gene

  • This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CYP4F3 Gene

CYP4F3 (Cytochrome P450 Family 4 Subfamily F Member 3) is a Protein Coding gene. Diseases associated with CYP4F3 include trichuriasis and ascariasis. Among its related pathways are Linoleic acid metabolism and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP4F3 Gene

  • Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.

  • Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).

Tocris Summary for CYP4F3 Gene

  • Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), steroid 11-beta hydroxylase (E.C. 1.14.15.4), and LTB4 omega-hydroxylase (E.C. 1.14.13.30).

Gene Wiki entry for CYP4F3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F3 Gene

Genomics for CYP4F3 Gene

Regulatory Elements for CYP4F3 Gene

Enhancers for CYP4F3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP4F3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP4F3 Gene

Chromosome:
19
Start:
15,615,617 bp from pter
End:
15,662,825 bp from pter
Size:
47,209 bases
Orientation:
Plus strand

Genomic View for CYP4F3 Gene

Genes around CYP4F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP4F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP4F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F3 Gene

Proteins for CYP4F3 Gene

  • Protein details for CYP4F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08477-CP4F3_HUMAN
    Recommended name:
    Docosahexaenoic acid omega-hydroxylase CYP4F3
    Protein Accession:
    Q08477
    Secondary Accessions:
    • B7Z8Z3
    • O60634
    • Q5U740

    Protein attributes for CYP4F3 Gene

    Size:
    520 amino acids
    Molecular mass:
    59847 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4F3 Gene

Proteomics data for CYP4F3 Gene at MOPED

Post-translational modifications for CYP4F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYP4F3 Gene

Domains & Families for CYP4F3 Gene

Gene Families for CYP4F3 Gene

Protein Domains for CYP4F3 Gene

Suggested Antigen Peptide Sequences for CYP4F3 Gene

Graphical View of Domain Structure for InterPro Entry

Q08477

UniProtKB/Swiss-Prot:

CP4F3_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F3: view

Function for CYP4F3 Gene

Molecular function for CYP4F3 Gene

GENATLAS Biochemistry:
cytochrome p450,subfamily IVF,polypeptide 3,59.8kDa,expressed in granulocytes,catalyzing the inactivation of leukotrienne beta 4 with two forms resulting from tissue specific splicing and alternative promoters
UniProtKB/Swiss-Prot CatalyticActivity:
Docosahexaenoate + NADPH + O(2) = 22-hydroxydocosahexaenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,8Z,11Z,14Z)-icosatetraenoate + NADPH + O(2) = (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by carbon monoxide (CO).
UniProtKB/Swiss-Prot Function:
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
UniProtKB/Swiss-Prot Function:
Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).

Enzyme Numbers (IUBMB) for CYP4F3 Gene

Gene Ontology (GO) - Molecular Function for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097259 20-aldehyde-leukotriene B4 20-monooxygenase activity TAS --
genes like me logo Genes that share ontologies with CYP4F3: view
genes like me logo Genes that share phenotypes with CYP4F3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CYP4F3

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP4F3 Gene

Localization for CYP4F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F3 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4F3 Gene COMPARTMENTS Subcellular localization image for CYP4F3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
peroxisome 2
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CYP4F3 Gene

Pathways & Interactions for CYP4F3 Gene

genes like me logo Genes that share pathways with CYP4F3: view

Pathways by source for CYP4F3 Gene

2 KEGG pathways for CYP4F3 Gene
1 GeneGo (Thomson Reuters) pathway for CYP4F3 Gene

UniProtKB/Swiss-Prot Q08477-CP4F3_HUMAN

  • Pathway: Lipid metabolism; leukotriene B4 degradation.

Interacting Proteins for CYP4F3 Gene

Gene Ontology (GO) - Biological Process for CYP4F3 Gene

None

No data available for SIGNOR curated interactions for CYP4F3 Gene

Drugs & Compounds for CYP4F3 Gene

(6) Drugs for CYP4F3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metyrapone Approved Pharma 11-beta hydroxylase inhibitor 11
arachidonic acid Experimental Nutra Activator 27
Carbon monoxide Pharma 104
heme Pharma Agonist 0
DMOG Pharma Competitive HIF-PH inhibitor, cell-permeable, Prolyl hydroxylase inhibitor 0

(14) Additional Compounds for CYP4F3 Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Leukotriene B4
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid
71160-24-2
12(S)-Leukotriene B4
  • 2-Epi-LTB4
  • 5(S),12(S)-Dihydroxyeicosatetraenoate
  • 5(S),12(S)-Dihydroxyeicosatetraenoic acid
  • 5S,12S-Dihydroxy-6Z,8E,10E,14Z-eicsatetraenoate
  • 5S,12S-Dihydroxy-6Z,8E,10E,14Z-eicsatetraenoic acid
83709-73-3
12-Keto-tetrahydro-leukotriene B4
  • 12-Keto-10,11,14,15-tetrahydro-LTB4
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoate
  • 5S-Hydroxy-12-keto-6Z,8E-eicosadienoic acid
18-Hydroxyarachidonic acid
  • (18R)-Hydroxyarachidonate
  • (18R)-Hydroxyarachidonic acid
  • 18(R)-Hydroxyeicosatetraenoate
  • 18(R)-Hydroxyeicosatetraenoic acid
  • 18-HETE
133268-58-3
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoate
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid
  • 20-HETE
79551-86-3

(5) Tocris Compounds for CYP4F3 Gene

Compound Action Cas Number
17-ODYA LTB omega-hydroxylase inhibitor 34450-18-5
DMOG Prolyl hydroxylase inhibitor 89464-63-1
Metyrapone 11-beta hydroxylase inhibitor 54-36-4
p-Chlorophenylalanine Tryptophan hydroxylase inhibitor 7424-00-2
Ro 61-8048 Potent kynurenine 3-monooxygenase (KMO) inhibitor 199666-03-0
genes like me logo Genes that share compounds with CYP4F3: view

Transcripts for CYP4F3 Gene

Unigene Clusters for CYP4F3 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: -
SP4: - -

Relevant External Links for CYP4F3 Gene

GeneLoc Exon Structure for
CYP4F3
ECgene alternative splicing isoforms for
CYP4F3

Expression for CYP4F3 Gene

mRNA expression in normal human tissues for CYP4F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4F3 Gene

This gene is overexpressed in Liver (x26.2), Whole Blood (x10.9), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for CYP4F3 Gene

This gene is overexpressed in Liver (32.9) and Gallbladder (32.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP4F3 Gene



SOURCE GeneReport for Unigene cluster for CYP4F3 Gene Hs.106242

mRNA Expression by UniProt/SwissProt for CYP4F3 Gene

Q08477-CP4F3_HUMAN
Tissue specificity: Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract.
genes like me logo Genes that share expression patterns with CYP4F3: view

Protein tissue co-expression partners for CYP4F3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CYP4F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4F3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC534967 35
  • 82.02 (n)
  • 78.81 (a)
CYP4F3 36
  • 78 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC484867 35
  • 81.33 (n)
  • 77.33 (a)
CYP4F3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp4f13 35
  • 77.78 (n)
  • 73.6 (a)
Cyp4f13 16
Cyp4f18 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC748117 35
  • 98.85 (n)
  • 99.04 (a)
CYP4F3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp4f6 35
  • 78.72 (n)
  • 75.19 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp4f3 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp311a1 37
  • 31 (a)
Cyp312a1 37
  • 33 (a)
Cyp313a3 37
  • 27 (a)
Cyp313a4 37
  • 26 (a)
Cyp313b1 37
  • 26 (a)
Cyp4aa1 37
  • 30 (a)
Cyp4ac1 37
  • 33 (a)
Cyp4ac2 37
  • 32 (a)
Cyp4ac3 37
  • 33 (a)
Cyp4ad1 37
  • 30 (a)
Cyp4ae1 37
  • 33 (a)
Cyp4c3 37
  • 36 (a)
Cyp4d1 37
  • 36 (a)
Cyp4d14 37
  • 37 (a)
Cyp4d2 37
  • 38 (a)
Cyp4d20 37
  • 34 (a)
Cyp4d21 37
  • 32 (a)
Cyp4d8 37
  • 36 (a)
Cyp4e1 37
  • 32 (a)
Cyp4e2 37
  • 33 (a)
Cyp4e3 37
  • 33 (a)
Cyp4g1 37
  • 26 (a)
Cyp4g15 37
  • 35 (a)
Cyp4p1 37
  • 35 (a)
Cyp4p2 37
  • 33 (a)
Cyp4p3 37
  • 35 (a)
Cyp4s3 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea B0331.1 37
  • 35 (a)
C26F1.2 37
  • 32 (a)
F01D5.9 37
  • 36 (a)
F28G4.1 37
  • 33 (a)
Y17G9B.3 37
  • 36 (a)
Y38C9B.1 37
  • 34 (a)
Y5H2B.5 37
  • 36 (a)
Y80D3A.5 37
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
CSA.3998 36
  • 40 (a)
ManyToMany
CSA.6060 36
  • 37 (a)
ManyToMany
CSA.8060 36
  • 41 (a)
ManyToMany
Species with no ortholog for CYP4F3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4F3 Gene

ENSEMBL:
Gene Tree for CYP4F3 (if available)
TreeFam:
Gene Tree for CYP4F3 (if available)

Paralogs for CYP4F3 Gene

genes like me logo Genes that share paralogs with CYP4F3: view

Variants for CYP4F3 Gene

Sequence variations from dbSNP and Humsavar for CYP4F3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1805040 - 15,650,071(+) AGATG(A/C)CGTCA reference, missense
rs28371536 - 15,650,073(+) ATGCC(A/G)TCATC reference, missense
rs28371479 - 15,650,077(+) CGTCA(C/T)CCAGG reference, missense
rs34923393 - 15,645,808(+) TGGCA(C/G/T)GCAAT intron-variant, reference, synonymous-codon, missense, utr-variant-5-prime
rs35888783 - 15,645,837(+) CACCT(A/G)CATCA intron-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CYP4F3 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
dgv627e199 CNV Deletion 23128226
esv2718235 CNV Deletion 23290073
nsv911140 CNV Gain 21882294
nsv9670 CNV Loss 18304495
esv2477444 CNV Deletion 19546169
esv1597130 CNV Insertion 17803354
esv2269626 CNV Deletion 18987734
esv2718237 CNV Deletion 23290073
esv2674388 CNV Deletion 23128226
esv22910 CNV Loss 19812545
nsv470128 CNV Gain 18288195
dgv3748n71 CNV Loss 21882294
nsv911143 CNV Loss 21882294
dgv3749n71 CNV Loss 21882294

Variation tolerance for CYP4F3 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP4F3 Gene

HapMap Linkage Disequilibrium report
CYP4F3
Human Gene Mutation Database (HGMD)
CYP4F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F3 Gene

Disorders for CYP4F3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CYP4F3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
trichuriasis
  • infection by trichuris trichura
ascariasis
  • ascariasis - roundworm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP4F3

Genetic Association Database (GAD)
CYP4F3
Human Genome Epidemiology (HuGE) Navigator
CYP4F3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP4F3
genes like me logo Genes that share disorders with CYP4F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP4F3 Gene

Publications for CYP4F3 Gene

  1. Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization. (PMID: 9539102) Kikuta Y. … Kusunose M. (DNA Cell Biol. 1998) 2 3 4 23 67
  2. CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis. (PMID: 18566475) Antoun J. … PlAce-Gautier E. (J. Lipid Res. 2008) 3 23
  3. Expression and physiological function of CYP4F subfamily in human eosinophils. (PMID: 17980168) Kikuta Y. … Ohkawa H. (Biochim. Biophys. Acta 2007) 3 23
  4. Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter. (PMID: 12709424) Christmas P. … Soberman R.J. (J. Biol. Chem. 2003) 3 23
  5. Alternative splicing determines the function of CYP4F3 by switching substrate specificity. (PMID: 11461919) Christmas P. … Soberman R.J. (J. Biol. Chem. 2001) 3 23

Products for CYP4F3 Gene

Sources for CYP4F3 Gene

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