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Aliases for CYP4F3 Gene

Aliases for CYP4F3 Gene

  • Cytochrome P450, Family 4, Subfamily F, Polypeptide 3 2 3
  • LTB4H 3 4 6
  • Cytochrome P450, Subfamily IVF, Polypeptide 3 (Leukotriene B4 Omega Hydroxylase) 2 3
  • 20-Hydroxyeicosatetraenoic Acid Synthase 3 4
  • Leukotriene-B(4) Omega-Hydroxylase 2 3 4
  • Leukotriene-B(4) 20-Monooxygenase 2 3 4
  • Cytochrome P450-LTB-Omega 3 4
  • Cytochrome P450 4F3 3 4
  • 20-HETE Synthase 3 4
  • CYPIVF3 3 4
  • Docosahexaenoic Acid Omega-Hydroxylase CYP4F3 3
  • Leukotriene B4 Omega Hydroxylase 3
  • Leukotriene-B4 20-Monooxygenase 3
  • Cytochrome P-450 3
  • EC 1.14.13.199 4
  • EC 1.14.13.30 4
  • EC 1.14.13.- 4
  • CYP4F 3
  • CPF3 3

External Ids for CYP4F3 Gene

Previous HGNC Symbols for CYP4F3 Gene

  • LTB4H

Previous GeneCards Identifiers for CYP4F3 Gene

  • GC19P016130
  • GC19P016013
  • GC19P015482
  • GC19P015612
  • GC19P015751
  • GC19P015320

Summaries for CYP4F3 Gene

Entrez Gene Summary for CYP4F3 Gene

  • This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CYP4F3 Gene

CYP4F3 (Cytochrome P450, Family 4, Subfamily F, Polypeptide 3) is a Protein Coding gene. Diseases associated with CYP4F3 include ascariasis and trichuriasis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

UniProtKB/Swiss-Prot for CYP4F3 Gene

  • Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.

  • Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).

Gene Wiki entry for CYP4F3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4F3 Gene

Genomics for CYP4F3 Gene

Regulatory Elements for CYP4F3 Gene

Genomic Location for CYP4F3 Gene

Start:
15,615,617 bp from pter
End:
15,662,825 bp from pter
Size:
47,209 bases
Orientation:
Plus strand

Genomic View for CYP4F3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4F3 Gene

Proteins for CYP4F3 Gene

  • Protein details for CYP4F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08477-CP4F3_HUMAN
    Recommended name:
    Docosahexaenoic acid omega-hydroxylase CYP4F3
    Protein Accession:
    Q08477
    Secondary Accessions:
    • B7Z8Z3
    • O60634
    • Q5U740

    Protein attributes for CYP4F3 Gene

    Size:
    520 amino acids
    Molecular mass:
    59847 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4F3 Gene

Proteomics data for CYP4F3 Gene at MOPED

Post-translational modifications for CYP4F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP4F3 Gene

No data available for DME Specific Peptides for CYP4F3 Gene

Domains for CYP4F3 Gene

Gene Families for CYP4F3 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP4F3 Gene

Suggested Antigen Peptide Sequences for CYP4F3 Gene

Graphical View of Domain Structure for InterPro Entry

Q08477

UniProtKB/Swiss-Prot:

CP4F3_HUMAN :
  • Q08477
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4F3: view

Function for CYP4F3 Gene

Molecular function for CYP4F3 Gene

GENATLAS Biochemistry: cytochrome p450,subfamily IVF,polypeptide 3,59.8kDa,expressed in granulocytes,catalyzing the inactivation of leukotrienne beta 4 with two forms resulting from tissue specific splicing and alternative promoters
UniProtKB/Swiss-Prot CatalyticActivity: Docosahexaenoate + NADPH + O(2) = 22-hydroxydocosahexaenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity: (5Z,8Z,11Z,14Z)-icosatetraenoate + NADPH + O(2) = (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by carbon monoxide (CO)
UniProtKB/Swiss-Prot Function: Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
UniProtKB/Swiss-Prot Function: Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A (PubMed:11461919). Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285).

Enzyme Numbers (IUBMB) for CYP4F3 Gene

Gene Ontology (GO) - Molecular Function for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS 8486631
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0020037 heme binding IEA --
GO:0050051 leukotriene-B4 20-monooxygenase activity IEA --
genes like me logo Genes that share ontologies with CYP4F3: view

Phenotypes for CYP4F3 Gene

GenomeRNAi human phenotypes for CYP4F3:
genes like me logo Genes that share phenotypes with CYP4F3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4F3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP4F3 Gene

Localization for CYP4F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4F3 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4F3 Gene COMPARTMENTS Subcellular localization image for CYP4F3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
peroxisome 2
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP4F3: view

Pathways for CYP4F3 Gene

genes like me logo Genes that share pathways with CYP4F3: view

Pathways by source for CYP4F3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q08477-CP4F3_HUMAN

  • Pathway: Lipid metabolism; leukotriene B4 degradation

Interacting Proteins for CYP4F3 Gene

Gene Ontology (GO) - Biological Process for CYP4F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006690 icosanoid metabolic process TAS --
GO:0006691 leukotriene metabolic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0036101 leukotriene B4 catabolic process IEA --
genes like me logo Genes that share ontologies with CYP4F3: view

Compounds for CYP4F3 Gene

(28) HMDB Compounds for CYP4F3 Gene

Compound Synonyms Cas Number PubMed IDs
10,11-dihydro-20-dihydroxy-LTB4
  • 10,11-dihydroxy-20-dihydroxy-LTB(,4)
Not Available
10,11-dihydro-20-trihydroxy-leukotriene B4
  • (5S,12R,20)-pentahydroxy-(6Z,8E,14Z)-eicosatrienoic acid anion
Not Available
12(S)-Leukotriene B4
  • 2-epi-LTB4
83709-73-3
12-Keto-tetrahydro-leukotriene B4
  • 12-keto-10,11,14,15-tetrahydro-LTB4
Not Available
12-oxo-20-dihydroxy-leukotriene B4
  • 12-oxo-20,20-dihydroxy-leukotriene B(,4)
Not Available

(3) Novoseek inferred chemical compound relationships for CYP4F3 Gene

Compound -log(P) Hits PubMed IDs
leukotriene b4 86 17
arachidonic acid 66.5 1
clofibrate 64 1
genes like me logo Genes that share compounds with CYP4F3: view

Transcripts for CYP4F3 Gene

Unigene Clusters for CYP4F3 Gene

Cytochrome P450, family 4, subfamily F, polypeptide 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP4F3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CYP4F3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4F3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: -
SP3: -
SP4: - -

Relevant External Links for CYP4F3 Gene

GeneLoc Exon Structure for
CYP4F3
ECgene alternative splicing isoforms for
CYP4F3

Expression for CYP4F3 Gene

mRNA expression in normal human tissues for CYP4F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4F3 Gene

This gene is overexpressed in Liver (26.2), Whole Blood (10.9), and Kidney - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP4F3 Gene

SOURCE GeneReport for Unigene cluster for CYP4F3 Gene Hs.106242

mRNA Expression by UniProt/SwissProt for CYP4F3 Gene

Q08477-CP4F3_HUMAN
Tissue specificity: Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract.
genes like me logo Genes that share expressions with CYP4F3: view

In Situ Assay Products

Orthologs for CYP4F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4F3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP4F3 36
  • 99 (a)
OneToOne
LOC748117 35
  • 98.85 (n)
  • 99.04 (a)
cow
(Bos Taurus)
Mammalia CYP4F3 36
  • 78 (a)
ManyToMany
LOC534967 35
  • 82.02 (n)
  • 78.81 (a)
dog
(Canis familiaris)
Mammalia CYP4F3 36
  • 86 (a)
OneToOne
LOC484867 35
  • 81.33 (n)
  • 77.33 (a)
mouse
(Mus musculus)
Mammalia Cyp4f13 35
  • 77.78 (n)
  • 73.6 (a)
Cyp4f13 16
Cyp4f18 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp4f6 35
  • 78.72 (n)
  • 75.19 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cyp4f3 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp4ae1 37
  • 33 (a)
Cyp4d2 37
  • 38 (a)
Cyp4e3 37
  • 33 (a)
Cyp4d8 37
  • 36 (a)
Cyp4s3 37
  • 37 (a)
Cyp4ac3 37
  • 33 (a)
Cyp4p1 37
  • 35 (a)
Cyp4aa1 37
  • 30 (a)
Cyp4d1 37
  • 36 (a)
Cyp313b1 37
  • 26 (a)
Cyp4d20 37
  • 34 (a)
Cyp313a4 37
  • 26 (a)
Cyp4c3 37
  • 36 (a)
Cyp4e1 37
  • 32 (a)
Cyp311a1 37
  • 31 (a)
Cyp4g1 37
  • 26 (a)
Cyp4p2 37
  • 33 (a)
Cyp4ac1 37
  • 33 (a)
Cyp313a3 37
  • 27 (a)
Cyp4ad1 37
  • 30 (a)
Cyp4d21 37
  • 32 (a)
Cyp4d14 37
  • 37 (a)
Cyp4g15 37
  • 35 (a)
Cyp312a1 37
  • 33 (a)
Cyp4p3 37
  • 35 (a)
Cyp4e2 37
  • 33 (a)
Cyp4ac2 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea F01D5.9 37
  • 36 (a)
Y80D3A.5 37
  • 34 (a)
F28G4.1 37
  • 33 (a)
C26F1.2 37
  • 32 (a)
Y17G9B.3 37
  • 36 (a)
Y5H2B.5 37
  • 36 (a)
B0331.1 37
  • 35 (a)
Y38C9B.1 37
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
CSA.3998 36
  • 40 (a)
ManyToMany
CSA.6060 36
  • 37 (a)
ManyToMany
CSA.8060 36
  • 41 (a)
ManyToMany
Species with no ortholog for CYP4F3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYP4F3 Gene

ENSEMBL:
Gene Tree for CYP4F3 (if available)
TreeFam:
Gene Tree for CYP4F3 (if available)

Paralogs for CYP4F3 Gene

Selected SIMAP similar genes for CYP4F3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYP4F3: view

Variants for CYP4F3 Gene

Sequence variations from dbSNP and Humsavar for CYP4F3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs718258 -- 15,655,609(+) ATCCC(A/G)ATGCC intron-variant
rs759998 -- 15,644,632(+) ATTTC(C/T)GTGAT intron-variant
rs1053037 -- 15,649,243(+) AGTCT(A/G)CAGAA synonymous-codon, reference
rs1063802 -- 15,661,104(+) ctaaa(A/G)tacaa downstream-variant-500B
rs1140855 -- 15,659,890(+) ggttt(C/T)ctcct utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CYP4F3 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
dgv627e199 CNV Deletion 23128226
esv2718235 CNV Deletion 23290073
nsv911140 CNV Gain 21882294
nsv9670 CNV Loss 18304495
esv2477444 CNV Deletion 19546169
esv1597130 CNV Insertion 17803354
esv2269626 CNV Deletion 18987734
esv2718237 CNV Deletion 23290073
esv2674388 CNV Deletion 23128226
esv22910 CNV Loss 19812545
nsv470128 CNV Gain 18288195
dgv3748n71 CNV Loss 21882294
nsv911143 CNV Loss 21882294
dgv3749n71 CNV Loss 21882294

Relevant External Links for CYP4F3 Gene

HapMap Linkage Disequilibrium report
CYP4F3
Human Gene Mutation Database (HGMD)
CYP4F3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4F3 Gene

Disorders for CYP4F3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CYP4F3 Gene including...

Search for CYP4F3 Gene in MalaCards »

(1) Novoseek inferred disease relationships for CYP4F3 Gene

Disease -log(P) Hits PubMed IDs
inflammation 19 5

Relevant External Links for CYP4F3

Genetic Association Database (GAD)
CYP4F3
Human Genome Epidemiology (HuGE) Navigator
CYP4F3
genes like me logo Genes that share disorders with CYP4F3: view

No data available for UniProtKB/Swiss-Prot for CYP4F3 Gene

Publications for CYP4F3 Gene

  1. Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization. (PMID: 9539102) Kikuta Y. … Kusunose M. (DNA Cell Biol. 1998) 2 3 4 23
  2. Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase. (PMID: 10409674) Christmas P. … Soberman R.J. (J. Biol. Chem. 1999) 3 4 23
  3. Alternative splicing determines the function of CYP4F3 by switching substrate specificity. (PMID: 11461919) Christmas P. … Soberman R.J. (J. Biol. Chem. 2001) 3 4 23
  4. A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega- hydroxylase. (PMID: 8486631) Kikuta Y. … Kusunose M. (J. Biol. Chem. 1993) 2 3 4
  5. CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis. (PMID: 18566475) Antoun J. … PlAce-Gautier E. (J. Lipid Res. 2008) 3 23

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