Aliases for LSS Gene
External Ids for LSS Gene
Previous GeneCards Identifiers for LSS Gene
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
GeneCards Summary for LSS Gene
LSS (Lanosterol Synthase (2,3-Oxidosqualene-Lanosterol Cyclase)) is a Protein Coding gene. Diseases associated with LSS include laurin-sandrow syndrome and polydactyly, preaxial type ii. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include lanosterol synthase activity.
UniProtKB/Swiss-Prot for LSS Gene
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.