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Aliases for LRP3 Gene

Aliases for LRP3 Gene

  • Low Density Lipoprotein Receptor-Related Protein 3 2 3
  • 105 KDa Low-Density Lipoprotein Receptor-Related Protein 3 4
  • HLRp105 3 4
  • LRP-3 3 4
  • Low-Density Lipoprotein Receptor-Related Protein 3 3
  • CTD-2540B15.13 3

External Ids for LRP3 Gene

Previous GeneCards Identifiers for LRP3 Gene

  • GC19P034303
  • GC19P034134
  • GC19P038361
  • GC19P038377
  • GC19P033685
  • GC19P030187

Summaries for LRP3 Gene

GeneCards Summary for LRP3 Gene

LRP3 (Low Density Lipoprotein Receptor-Related Protein 3) is a Protein Coding gene. An important paralog of this gene is LRP10.

UniProtKB/Swiss-Prot for LRP3 Gene

  • Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro

Gene Wiki entry for LRP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP3 Gene

Genomics for LRP3 Gene

Regulatory Elements for LRP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRP3 Gene

Start:
33,177,603 bp from pter
End:
33,208,867 bp from pter
Size:
31,265 bases
Orientation:
Plus strand

Genomic View for LRP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP3 Gene

Proteins for LRP3 Gene

  • Protein details for LRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75074-LRP3_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 3
    Protein Accession:
    O75074
    Secondary Accessions:
    • B3KQD6
    • B4DKF2

    Protein attributes for LRP3 Gene

    Size:
    770 amino acids
    Molecular mass:
    82884 Da
    Quaternary structure:
    • Binds GGA1 and GGA2.
    SequenceCaution:
    • Sequence=BAG51998.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG59164.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRP3 Gene

Proteomics data for LRP3 Gene at MOPED

Post-translational modifications for LRP3 Gene

  • Glycosylation at Asn71, Asn199, and Asn359
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRP3 Gene

Domains for LRP3 Gene

Gene Families for LRP3 Gene

HGNC:
  • LDLR :Low density lipoprotein receptors

Suggested Antigen Peptide Sequences for LRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75074

UniProtKB/Swiss-Prot:

LRP3_HUMAN :
  • O75074
Domain:
  • Contains 2 CUB domains.
  • Contains 4 LDL-receptor class A domains.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP3: view

Function for LRP3 Gene

Molecular function for LRP3 Gene

GENATLAS Biochemistry: low density lipoprotein receptor related protein 3,LDLR superfamily
UniProtKB/Swiss-Prot Function: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro

Gene Ontology (GO) - Molecular Function for LRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRP3: view
genes like me logo Genes that share phenotypes with LRP3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LRP3 Gene

Localization for LRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP3 Gene

Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRP3 Gene COMPARTMENTS Subcellular localization image for LRP3 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005905 coated pit IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRP3: view

Pathways for LRP3 Gene

SuperPathways for LRP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS 9693042
genes like me logo Genes that share ontologies with LRP3: view

No data available for Pathways by source for LRP3 Gene

Transcripts for LRP3 Gene

Unigene Clusters for LRP3 Gene

Low density lipoprotein receptor-related protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRP3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3:

Relevant External Links for LRP3 Gene

GeneLoc Exon Structure for
LRP3
ECgene alternative splicing isoforms for
LRP3

Expression for LRP3 Gene

mRNA expression in normal human tissues for LRP3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRP3 Gene

SOURCE GeneReport for Unigene cluster for LRP3 Gene Hs.515340

mRNA Expression by UniProt/SwissProt for LRP3 Gene

O75074-LRP3_HUMAN
Tissue specificity: Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.
genes like me logo Genes that share expressions with LRP3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LRP3 Gene

Orthologs for LRP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRP3 35
  • 99.09 (n)
  • 99.22 (a)
LRP3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRP3 35
  • 88.69 (n)
  • 92.72 (a)
LRP3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRP3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrp3 35
  • 86.09 (n)
  • 92.98 (a)
Lrp3 16
Lrp3 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRP3 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRP3 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrp3 35
  • 86.28 (n)
  • 93.12 (a)
chicken
(Gallus gallus)
Aves LRP3 35
  • 66.57 (n)
  • 71.49 (a)
LRP3 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRP3 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp3 35
  • 66.67 (n)
  • 73.42 (a)
zebrafish
(Danio rerio)
Actinopterygii lrp3 35
  • 69.8 (n)
  • 70.73 (a)
LRP3 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6553 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03E7.4 36
  • 18 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.14 35
Species with no ortholog for LRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LRP3 Gene

ENSEMBL:
Gene Tree for LRP3 (if available)
TreeFam:
Gene Tree for LRP3 (if available)

Paralogs for LRP3 Gene

Paralogs for LRP3 Gene

Selected SIMAP similar genes for LRP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRP3: view

Variants for LRP3 Gene

Sequence variations from dbSNP and Humsavar for LRP3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs875550 -- 33,208,125(+) GGCAC(C/T)GTGGA utr-variant-3-prime
rs929797 -- 33,196,085(-) CACCC(C/T)TCAAG intron-variant
rs929798 -- 33,195,792(-) CGCAC(C/T)GAGGT intron-variant
rs1035445 -- 33,203,252(-) CACAC(A/G)CCTAC intron-variant
rs1035446 -- 33,192,840(-) GATCA(C/T)GGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRP3 Gene

Variant ID Type Subtype PubMed ID
nsv833808 CNV Loss 17160897
nsv911579 CNV Loss 21882294
dgv3839n71 CNV Loss 21882294
dgv3840n71 CNV Loss 21882294
dgv3841n71 CNV Loss 21882294
esv24627 CNV Loss 19812545
dgv3842n71 CNV Loss 21882294

Relevant External Links for LRP3 Gene

HapMap Linkage Disequilibrium report
LRP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP3 Gene

Disorders for LRP3 Gene

No disorders were found for LRP3 Gene.

No data available for UniProtKB/Swiss-Prot for LRP3 Gene

Publications for LRP3 Gene

  1. cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2. (PMID: 9693042) Ishii H. … Yamamoto T.T. (Genomics 1998) 2 3 4 23
  2. Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). (PMID: 7959795) Korenberg J.R. … Argraves W.S. (Genomics 1994) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for LRP3 Gene

Sources for LRP3 Gene

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