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Aliases for APOBEC4 Gene

Aliases for APOBEC4 Gene

  • Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide Like 4 2 3 5
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 4 (Putative) 2 3
  • C1orf169 3 4
  • Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 4 4
  • Putative C->U-Editing Enzyme APOBEC-4 3
  • Chromosome 1 Open Reading Frame 169 2
  • EC 3.5.4.- 4

External Ids for APOBEC4 Gene

Previous HGNC Symbols for APOBEC4 Gene

  • C1orf169

Previous GeneCards Identifiers for APOBEC4 Gene

  • GC01M180349
  • GC01M181882
  • GC01M183615
  • GC01M154851

Summaries for APOBEC4 Gene

Entrez Gene Summary for APOBEC4 Gene

  • This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOBEC4 Gene

APOBEC4 (Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide Like 4) is a Protein Coding gene. Among its related pathways are Formation of the Editosome and Gene Expression. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines.

UniProtKB/Swiss-Prot for APOBEC4 Gene

  • Putative C to U editing enzyme whose physiological substrate is not yet known.

Gene Wiki entry for APOBEC4 Gene

Additional gene information for APOBEC4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC4 Gene

Genomics for APOBEC4 Gene

Regulatory Elements for APOBEC4 Gene

Enhancers for APOBEC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H183602 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +46.6 46616 8 HDGF PKNOX1 FOXA2 ATF1 ZNF133 YBX1 YY1 ZNF143 ZNF207 FOS NCF2 ARPC5 LAMC1 RGL1 APOBEC4 SMG7 GC01M183620
GH01H183891 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -238.7 -238728 1 ELF3 PKNOX1 FOXA2 BATF RAD21 RARA RUNX3 CREM MIXL1 THAP11 APOBEC4 NCF2 COLGALT2 ARPC5 GC01M183931 ENSG00000227554
GH01H183895 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -244.1 -244061 3 CTCF SMAD5 CBFB MAX USF2 POLR2A IKZF1 EED NBN NFE2 NCF2 APOBEC4 ARPC5 GC01M183931 ENSG00000227554
GH01H183911 1.5 FANTOM5 ENCODE dbSUPER 11.5 -258.3 -258253 0 TBL1XR1 BMI1 BATF ZNF207 ATF7 ETV6 RUNX3 CREM IKZF2 SMARCA5 COLGALT2 NCF2 APOBEC4 ARPC5 GC01M183931 ENSG00000227554
GH01H183914 1.5 Ensembl ENCODE dbSUPER 11.3 -262.6 -262557 1 ATF1 ARNT ZNF2 YY1 GATA2 ZNF143 ZNF207 ATF7 FOS RUNX3 APOBEC4 GC01M183931 ENSG00000227554
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOBEC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOBEC4 Gene

Chromosome:
1
Start:
183,646,275 bp from pter
End:
183,653,316 bp from pter
Size:
7,042 bases
Orientation:
Minus strand

Genomic View for APOBEC4 Gene

Genes around APOBEC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOBEC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOBEC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBEC4 Gene

Proteins for APOBEC4 Gene

  • Protein details for APOBEC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW27-ABEC4_HUMAN
    Recommended name:
    Putative C->U-editing enzyme APOBEC-4
    Protein Accession:
    Q8WW27
    Secondary Accessions:
    • Q8N7F6

    Protein attributes for APOBEC4 Gene

    Size:
    367 amino acids
    Molecular mass:
    41581 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for APOBEC4 Gene

Post-translational modifications for APOBEC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOBEC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOBEC4 Gene

Domains & Families for APOBEC4 Gene

Gene Families for APOBEC4 Gene

Protein Domains for APOBEC4 Gene

Suggested Antigen Peptide Sequences for APOBEC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WW27

UniProtKB/Swiss-Prot:

ABEC4_HUMAN :
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with APOBEC4: view

Function for APOBEC4 Gene

Molecular function for APOBEC4 Gene

UniProtKB/Swiss-Prot Function:
Putative C to U editing enzyme whose physiological substrate is not yet known.

Enzyme Numbers (IUBMB) for APOBEC4 Gene

Phenotypes From GWAS Catalog for APOBEC4 Gene

Gene Ontology (GO) - Molecular Function for APOBEC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with APOBEC4: view

Phenotypes for APOBEC4 Gene

genes like me logo Genes that share phenotypes with APOBEC4: view

Animal Model Products

CRISPR Products

miRNA for APOBEC4 Gene

miRTarBase miRNAs that target APOBEC4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for APOBEC4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOBEC4 Gene

Localization for APOBEC4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOBEC4 gene
Compartment Confidence
nucleus 3
peroxisome 2
cytosol 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for APOBEC4 Gene

Pathways & Interactions for APOBEC4 Gene

genes like me logo Genes that share pathways with APOBEC4: view

Pathways by source for APOBEC4 Gene

Interacting Proteins for APOBEC4 Gene

Selected Interacting proteins: Q8WW27-ABEC4_HUMAN for APOBEC4 Gene via IID

Gene Ontology (GO) - Biological Process for APOBEC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with APOBEC4: view

No data available for SIGNOR curated interactions for APOBEC4 Gene

Drugs & Compounds for APOBEC4 Gene

No Compound Related Data Available

Transcripts for APOBEC4 Gene

mRNA/cDNA for APOBEC4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOBEC4 Gene

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for APOBEC4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC4 Gene

No ASD Table

Relevant External Links for APOBEC4 Gene

GeneLoc Exon Structure for
APOBEC4
ECgene alternative splicing isoforms for
APOBEC4

Expression for APOBEC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOBEC4 Gene

mRNA differential expression in normal tissues according to GTEx for APOBEC4 Gene

This gene is overexpressed in Testis (x38.1) and Fallopian Tube (x6.7).

Protein differential expression in normal tissues from HIPED for APOBEC4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOBEC4 Gene



Protein tissue co-expression partners for APOBEC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of APOBEC4 Gene:

APOBEC4

SOURCE GeneReport for Unigene cluster for APOBEC4 Gene:

Hs.97335

mRNA Expression by UniProt/SwissProt for APOBEC4 Gene:

Q8WW27-ABEC4_HUMAN
Tissue specificity: Predominantly expressed in testis.
genes like me logo Genes that share expression patterns with APOBEC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOBEC4 Gene

Orthologs for APOBEC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOBEC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOBEC4 33 34
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia APOBEC4 33 34
  • 86.44 (n)
cow
(Bos Taurus)
Mammalia APOBEC4 33 34
  • 84.18 (n)
rat
(Rattus norvegicus)
Mammalia Apobec4 33
  • 75.05 (n)
mouse
(Mus musculus)
Mammalia Apobec4 33 16 34
  • 74.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia APOBEC4 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves APOBEC4 33 34
  • 57.56 (n)
lizard
(Anolis carolinensis)
Reptilia APOBEC4 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apobec4 33
  • 56.6 (n)
Species where no ortholog for APOBEC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOBEC4 Gene

ENSEMBL:
Gene Tree for APOBEC4 (if available)
TreeFam:
Gene Tree for APOBEC4 (if available)

Paralogs for APOBEC4 Gene

No data available for Paralogs for APOBEC4 Gene

Variants for APOBEC4 Gene

Sequence variations from dbSNP and Humsavar for APOBEC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000075133 -- 183,655,140(+) GAGAT(C/T)ATAAT intron-variant, upstream-variant-2KB
rs1000533964 -- 183,655,061(+) TGTCT(C/T)CCTTT intron-variant, upstream-variant-2KB
rs1000564961 -- 183,651,418(+) TCACC(G/T)TCTGT intron-variant
rs1001511566 -- 183,649,858(+) TCAGA(C/T)TGCAG intron-variant
rs1001634475 -- 183,652,200(+) TGTGT(G/T)TTTAG intron-variant

Variation tolerance for APOBEC4 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.75; 86.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOBEC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOBEC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for APOBEC4 Gene

Disorders for APOBEC4 Gene

Relevant External Links for APOBEC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOBEC4

No disorders were found for APOBEC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC4 Gene

Publications for APOBEC4 Gene

  1. APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis. (PMID: 16082223) Rogozin IB … Koonin EV (Cell cycle (Georgetown, Tex.) 2005) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. APOBEC4 Enhances the Replication of HIV-1. (PMID: 27249646) Marino D … Münk C (PloS one 2016) 3 60

Products for APOBEC4 Gene

Sources for APOBEC4 Gene

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