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Aliases for APOBEC4 Gene

Aliases for APOBEC4 Gene

  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 4 (Putative) 2 3
  • Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 4 3 4
  • C1orf169 3 4
  • Chromosome 1 Open Reading Frame 169 2
  • EC 3.5.4.- 4

External Ids for APOBEC4 Gene

Previous HGNC Symbols for APOBEC4 Gene

  • C1orf169

Previous GeneCards Identifiers for APOBEC4 Gene

  • GC01M180349
  • GC01M181882
  • GC01M183615
  • GC01M154851

Summaries for APOBEC4 Gene

Entrez Gene Summary for APOBEC4 Gene

  • This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOBEC4 Gene

APOBEC4 (Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 4 (Putative)) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines.

UniProtKB/Swiss-Prot for APOBEC4 Gene

  • Putative C to U editing enzyme whose physiological substrate is not yet known.

Gene Wiki entry for APOBEC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC4 Gene

Genomics for APOBEC4 Gene

Regulatory Elements for APOBEC4 Gene

Genomic Location for APOBEC4 Gene

Chromosome:
1
Start:
183,646,275 bp from pter
End:
183,653,316 bp from pter
Size:
7,042 bases
Orientation:
Minus strand

Genomic View for APOBEC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOBEC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBEC4 Gene

Proteins for APOBEC4 Gene

  • Protein details for APOBEC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW27-ABEC4_HUMAN
    Recommended name:
    Putative C->U-editing enzyme APOBEC-4
    Protein Accession:
    Q8WW27
    Secondary Accessions:
    • Q8N7F6

    Protein attributes for APOBEC4 Gene

    Size:
    367 amino acids
    Molecular mass:
    41581 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for APOBEC4 Gene

Proteomics data for APOBEC4 Gene at MOPED

Post-translational modifications for APOBEC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOBEC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for APOBEC4 Gene

Domains & Families for APOBEC4 Gene

Protein Domains for APOBEC4 Gene

Suggested Antigen Peptide Sequences for APOBEC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WW27

UniProtKB/Swiss-Prot:

ABEC4_HUMAN :
  • Contains 1 CMP/dCMP-type deaminase domain.
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with APOBEC4: view

Function for APOBEC4 Gene

Molecular function for APOBEC4 Gene

UniProtKB/Swiss-Prot Function:
Putative C to U editing enzyme whose physiological substrate is not yet known.

Enzyme Numbers (IUBMB) for APOBEC4 Gene

Gene Ontology (GO) - Molecular Function for APOBEC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA --
genes like me logo Genes that share ontologies with APOBEC4: view

Phenotypes for APOBEC4 Gene

GenomeRNAi human phenotypes for APOBEC4:
genes like me logo Genes that share phenotypes with APOBEC4: view

Animal Model Products

CRISPR Products

miRNA for APOBEC4 Gene

miRTarBase miRNAs that target APOBEC4

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for APOBEC4 Gene

Localization for APOBEC4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for APOBEC4 Gene

Pathways & Interactions for APOBEC4 Gene

SuperPathways for APOBEC4 Gene

No Data Available

Interacting Proteins for APOBEC4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310622%0d%0a9606.ENSP00000368552%0d%0a
Selected Interacting proteins: ENSP00000310622 for APOBEC4 Gene via STRING

Symbol External ID(s) Details
SIRT5

Gene Ontology (GO) - Biological Process for APOBEC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with APOBEC4: view

No data available for Pathways by source and SIGNOR curated interactions for APOBEC4 Gene

Drugs & Compounds for APOBEC4 Gene

No Compound Related Data Available

Transcripts for APOBEC4 Gene

mRNA/cDNA for APOBEC4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOBEC4 Gene

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOBEC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC4 Gene

No ASD Table

Relevant External Links for APOBEC4 Gene

GeneLoc Exon Structure for
APOBEC4
ECgene alternative splicing isoforms for
APOBEC4

Expression for APOBEC4 Gene

mRNA expression in normal human tissues for APOBEC4 Gene

mRNA differential expression in normal tissues according to GTEx for APOBEC4 Gene

This gene is overexpressed in Testis (x38.1) and Fallopian Tube (x6.7).

Protein differential expression in normal tissues from HIPED for APOBEC4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOBEC4 Gene



SOURCE GeneReport for Unigene cluster for APOBEC4 Gene Hs.97335

mRNA Expression by UniProt/SwissProt for APOBEC4 Gene

Q8WW27-ABEC4_HUMAN
Tissue specificity: Predominantly expressed in testis.
genes like me logo Genes that share expression patterns with APOBEC4: view

Protein tissue co-expression partners for APOBEC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for APOBEC4 Gene

Orthologs for APOBEC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOBEC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOBEC4 35
  • 84.18 (n)
  • 80.23 (a)
APOBEC4 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOBEC4 35
  • 86.44 (n)
  • 82.17 (a)
APOBEC4 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apobec4 35
  • 74.76 (n)
  • 64 (a)
Apobec4 16
Apobec4 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APOBEC4 35
  • 99.18 (n)
  • 98.37 (a)
APOBEC4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apobec4 35
  • 75.05 (n)
  • 64.29 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia APOBEC4 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves APOBEC4 35
  • 57.56 (n)
  • 50.31 (a)
APOBEC4 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APOBEC4 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apobec4 35
  • 56.6 (n)
  • 47.58 (a)
Species with no ortholog for APOBEC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOBEC4 Gene

ENSEMBL:
Gene Tree for APOBEC4 (if available)
TreeFam:
Gene Tree for APOBEC4 (if available)

Paralogs for APOBEC4 Gene

No data available for Paralogs for APOBEC4 Gene

Variants for APOBEC4 Gene

Sequence variations from dbSNP and Humsavar for APOBEC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_026639 -
VAR_026640 -
VAR_026641 -
VAR_026642 -
VAR_026643 -

Structural Variations from Database of Genomic Variants (DGV) for APOBEC4 Gene

Variant ID Type Subtype PubMed ID
nsv872582 CNV Loss 21882294

Variation tolerance for APOBEC4 Gene

Residual Variation Intolerance Score: 87.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.75; 86.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOBEC4 Gene

HapMap Linkage Disequilibrium report
APOBEC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC4 Gene

Disorders for APOBEC4 Gene

Relevant External Links for APOBEC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOBEC4
genes like me logo Genes that share disorders with APOBEC4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC4 Gene

Publications for APOBEC4 Gene

  1. APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis. (PMID: 16082223) Rogozin I.B. … Koonin E.V. (Cell Cycle 2005) 2 67
  2. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PMID: 23273568) Yang W. … Lau Y.L. (Am. J. Hum. Genet. 2013) 67
  3. APOBEC deaminases-mutases with defensive roles for immunity. (PMID: 19911124) Prochnow C. … Chen X.S. (Sci. China, C, Life Sci. 2009) 67
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for APOBEC4 Gene

Sources for APOBEC4 Gene

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