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Aliases for LPP Gene

Aliases for LPP Gene

  • LIM Domain Containing Preferred Translocation Partner In Lipoma 2 3
  • LIM Domain-Containing Preferred Translocation Partner In Lipoma 2 4

External Ids for LPP Gene

Summaries for LPP Gene

Entrez Gene Summary for LPP Gene

  • This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for LPP Gene

LPP (LIM Domain Containing Preferred Translocation Partner In Lipoma) is a Protein Coding gene. Diseases associated with LPP include lipoma and acute t cell leukemia. Among its related pathways are Cytoskeletal Signaling and Stabilization and expansion of the E-cadherin adherens junction. An important paralog of this gene is AJUBA.

UniProtKB/Swiss-Prot for LPP Gene

  • May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.

Gene Wiki entry for LPP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPP Gene

Genomics for LPP Gene

Genomic Location for LPP Gene

Start:
188,153,284 bp from pter
End:
188,890,671 bp from pter
Size:
737,388 bases
Orientation:
Plus strand

Genomic View for LPP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPP Gene

Regulatory Elements for LPP Gene

Proteins for LPP Gene

  • Protein details for LPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93052-LPP_HUMAN
    Recommended name:
    Lipoma-preferred partner
    Protein Accession:
    Q93052
    Secondary Accessions:
    • A1L4L6
    • D3DNV6
    • Q8NFX5

    Protein attributes for LPP Gene

    Size:
    612 amino acids
    Molecular mass:
    65746 Da
    Quaternary structure:
    • Interacts with VASP, with PDZ domains of SCRIB and with ACTN1/alpha-actinin.

neXtProt entry for LPP Gene

Proteomics data for LPP Gene at MOPED

Post-translational modifications for LPP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LPP Gene

Domains for LPP Gene

Protein Domains for LPP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LPP Gene

Graphical View of Domain Structure for InterPro Entry

Q93052

UniProtKB/Swiss-Prot:

LPP_HUMAN
Domain:
  • Contains 3 LIM zinc-binding domains.:
    • Q93052
Family:
  • Belongs to the zyxin/ajuba family.:
    • Q93052
genes like me logo Genes that share domains with LPP: view

No data available for Gene Families for LPP Gene

Function for LPP Gene

Molecular function for LPP Gene

GENATLAS Biochemistry: lipoma preferred fusion partner of HMGIC,LIM protein gene family,group 3
UniProtKB/Swiss-Prot Function: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.

Gene Ontology (GO) - Molecular Function for LPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15649318
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LPP: view
genes like me logo Genes that share phenotypes with LPP: view

miRNA for LPP Gene

miRTarBase miRNAs that target LPP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LPP Gene

Localization for LPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPP Gene

Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPP Gene COMPARTMENTS Subcellular localization image for LPP gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for LPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with LPP: view

Pathways for LPP Gene

genes like me logo Genes that share pathways with LPP: view

Pathways by source for LPP Gene

1 Cell Signaling Technology pathway for LPP Gene

Interacting Proteins for LPP Gene

Gene Ontology (GO) - Biological Process for LPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LPP: view

Compounds for LPP Gene

(2) Novoseek inferred chemical compound relationships for LPP Gene

Compound -log(P) Hits PubMed IDs
leptomycin b 64.1 1
peptidoglycan 56.9 4
genes like me logo Genes that share compounds with LPP: view

Transcripts for LPP Gene

Unigene Clusters for LPP Gene

LIM domain containing preferred translocation partner in lipoma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPP Gene

No ASD Table

Relevant External Links for LPP Gene

GeneLoc Exon Structure for
LPP
ECgene alternative splicing isoforms for
LPP

Expression for LPP Gene

mRNA expression in normal human tissues for LPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPP Gene

This gene is overexpressed in Artery - Tibial (6.6) and Esophagus - Muscularis (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for LPP Gene

SOURCE GeneReport for Unigene cluster for LPP Gene Hs.720220

mRNA Expression by UniProt/SwissProt for LPP Gene

Q93052-LPP_HUMAN
Tissue specificity: Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.
genes like me logo Genes that share expressions with LPP: view

Orthologs for LPP Gene

This gene was present in the common ancestor of animals.

Orthologs for LPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPP 35
  • 99.51 (n)
  • 99.84 (a)
LPP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPP 35
  • 89.54 (n)
  • 93.14 (a)
LPP 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPP 35
  • 88.94 (n)
  • 92.97 (a)
LPP 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpp 35
  • 85.73 (n)
  • 89.54 (a)
Lpp 16
Lpp 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPP 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPP 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpp 35
  • 84.05 (n)
  • 86.84 (a)
chicken
(Gallus gallus)
Aves LPP 35
  • 74.23 (n)
  • 80.67 (a)
LPP 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPP 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpp 35
  • 74.82 (n)
  • 81.84 (a)
zebrafish
(Danio rerio)
Actinopterygii lpp 35
  • 68.91 (n)
  • 72.76 (a)
lpp 36
  • 67 (a)
OneToOne
zgc56152 35
fruit fly
(Drosophila melanogaster)
Insecta Zyx 36
  • 30 (a)
OneToMany
Zyx102EF 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea zyx-1 37
  • 52 (a)
Species with no ortholog for LPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LPP Gene

ENSEMBL:
Gene Tree for LPP (if available)
TreeFam:
Gene Tree for LPP (if available)

Paralogs for LPP Gene

Paralogs for LPP Gene

genes like me logo Genes that share paralogs with LPP: view

Variants for LPP Gene

Sequence variations from dbSNP and Humsavar for LPP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs869631 -- 188,395,343(-) tactc(A/G/T)ggagg intron-variant
rs1464510 -- 188,394,766(-) AGGCT(A/G/T)TTTCA intron-variant
rs1515432 -- 188,540,817(-) CATCA(A/C/T)GGGCC intron-variant
rs1679195 -- 188,162,659(+) ATCCC(C/G/T)GAGCC intron-variant
rs3796287 -- 188,535,125(-) AAATG(A/C/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPP Gene

Variant ID Type Subtype PubMed ID
esv2751987 CNV Gain 17911159
esv34193 CNV Loss 18971310
esv1535519 CNV Insertion 17803354
nsv461046 CNV Loss 19166990
nsv4161 CNV Insertion 18451855
nsv819096 CNV Loss 19587683
esv33400 CNV Gain 17666407
nsv461047 CNV Loss 19166990
esv2664419 CNV Deletion 23128226
nsv822370 CNV Loss 20364138
esv2669680 CNV Deletion 23128226
esv270890 CNV Insertion 20981092
esv274075 CNV Insertion 20981092
esv2471009 CNV Deletion 19546169
esv2506913 CNV Deletion 19546169
esv2313176 CNV Deletion 18987734
esv2726356 CNV Deletion 23290073
nsv236225 CNV Loss 16902084
esv7339 CNV Loss 19470904
esv1727014 CNV Deletion 17803354
nsv878087 CNV Loss 21882294
nsv4162 CNV Insertion 18451855
esv2726357 CNV Deletion 23290073
esv2541501 CNV Deletion 19546169
nsv513100 CNV Loss 21212237
dgv900e199 CNV Deletion 23128226

Relevant External Links for LPP Gene

HapMap Linkage Disequilibrium report
LPP
Human Gene Mutation Database (HGMD)
LPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPP Gene

Disorders for LPP Gene

(1) OMIM Diseases for LPP Gene (600700)

UniProtKB/Swiss-Prot

LPP_HUMAN
  • Note=A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.
  • Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.
  • Note=A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.
  • Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia.

(3) Novoseek inferred disease relationships for LPP Gene

Disease -log(P) Hits PubMed IDs
lipoma 50.5 4
tumors 5.49 1
cancer 0 1

Relevant External Links for LPP

Genetic Association Database (GAD)
LPP
Human Genome Epidemiology (HuGE) Navigator
LPP
genes like me logo Genes that share disorders with LPP: view

Publications for LPP Gene

  1. The focal adhesion and nuclear targeting capacity of the LIM- containing lipoma-preferred partner (LPP) protein. (PMID: 12441356) Petit M.M. … Van de Ven W.J.M. (J. Biol. Chem. 2003) 3 4 23
  2. Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. (PMID: 9772904) Petit M.M. … Van de Ven W.J.M. (Cancer Genet. Cytogenet. 1998) 3 4 23
  3. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. (PMID: 10637295) Petit M.M. … Friederich E. (Mol. Biol. Cell 2000) 3 4 23
  4. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. (PMID: 8812423) Petit M.M.R. … Van de Ven W.J.M. (Genomics 1996) 2 3 4
  5. An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15). (PMID: 11066083) Rogalla P. … Bullerdiek J. (Genes Chromosomes Cancer 2000) 3 4

Products for LPP Gene

Sources for LPP Gene

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