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Aliases for LPA Gene

Aliases for LPA Gene

  • Lipoprotein, Lp(A) 2 3
  • Apo(A) 3 4
  • Lp(A) 3 4
  • Antiangiogenic AK38 Protein 3
  • Apolipoprotein(A) 3
  • EC 3.4.21.7 64
  • EC 3.4.21.- 4
  • EC 3.4.21 64
  • AK38 3
  • APOA 3
  • LP 3

External Ids for LPA Gene

Previous Symbols for LPA Gene

  • LP

Summaries for LPA Gene

Entrez Gene Summary for LPA Gene

  • The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

GeneCards Summary for LPA Gene

LPA (Lipoprotein, Lp(A)) is a Protein Coding gene. Diseases associated with LPA include atherosclerosis and hyperlipoproteinemia type iii. Among its related pathways are amb2 Integrin signaling and Metabolism. GO annotations related to this gene include serine-type endopeptidase activity and endopeptidase inhibitor activity. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot for LPA Gene

  • Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.

Gene Wiki entry for LPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPA Gene

Genomics for LPA Gene

Genomic Location for LPA Gene

Start:
160,531,483 bp from pter
End:
160,666,375 bp from pter
Size:
134,893 bases
Orientation:
Minus strand

Genomic View for LPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPA Gene

Regulatory Elements for LPA Gene

Proteins for LPA Gene

  • Protein details for LPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08519-APOA_HUMAN
    Recommended name:
    Apolipoprotein(a)
    Protein Accession:
    P08519
    Secondary Accessions:
    • Q5VTD7
    • Q9UD88

    Protein attributes for LPA Gene

    Size:
    4548 amino acids
    Molecular mass:
    501319 Da
    Quaternary structure:
    • Disulfide-linked to apo-B100. Binds to fibronectin and decorin
    Miscellaneous:
    • Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding

    Three dimensional structures from OCA and Proteopedia for LPA Gene

neXtProt entry for LPA Gene

Proteomics data for LPA Gene at MOPED

Post-translational modifications for LPA Gene

  • N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn61, Asn101, Asn215, Asn329, Asn443, Asn557, Asn671, Asn785, Asn899, Asn1013, Asn1127, Asn1241, Asn1355, Asn1469, Asn1583, Asn1697, Asn1811, Asn1925, Asn2039, Asn2153, Asn2267, Asn2381, Asn2495, Asn2609, Asn2723, Asn2837, Asn2951, Asn3065, Asn3179, Asn3293, Asn3407, Asn3521, Asn3635, Asn3749, Asn3855, Asn3889, Asn3969, Asn4083, and Asn4197

Other Protein References for LPA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for LPA Gene

UniProtKB/Swiss-Prot:

APOA_HUMAN
Domain:
  • Contains 38 kringle domains.:
    • P08519
  • Contains 1 peptidase S1 domain.:
    • P08519
Family:
  • Belongs to the peptidase S1 family. Plasminogen subfamily.:
    • P08519
genes like me logo Genes that share domains with LPA: view

No data available for Gene Families for LPA Gene

Function for LPA Gene

Molecular function for LPA Gene

GENATLAS Biochemistry: lipoprotein,Lp(a),tightly linked (50k6) and highly homologous to PLG,susceptibility gene for IDDM8
UniProtKB/Swiss-Prot Function: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.

Enzyme Numbers (IUBMB) for LPA Gene

Gene Ontology (GO) - Molecular Function for LPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IPI 2531657
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IDA 2531657
GO:0004866 endopeptidase inhibitor activity TAS 8047165
GO:0005515 protein binding IPI 2531657
genes like me logo Genes that share ontologies with LPA: view
genes like me logo Genes that share phenotypes with LPA: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LPA Gene

Localization for LPA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPA Gene COMPARTMENTS Subcellular localization image for LPA gene
Compartment Confidence
extracellular 4
nucleus 2
peroxisome 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0019897 extrinsic component of plasma membrane IEA --
GO:0034358 plasma lipoprotein particle IDA 2531657
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with LPA: view

Pathways for LPA Gene

genes like me logo Genes that share pathways with LPA: view

Gene Ontology (GO) - Biological Process for LPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006629 lipid metabolic process NAS 8047165
GO:0006869 lipid transport IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0008015 blood circulation TAS 8047165
genes like me logo Genes that share ontologies with LPA: view

Compounds for LPA Gene

(1) Drugbank Compounds for LPA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aminocaproic Acid
  • 6-aminohexanoic acid
60-32-2 target other

(68) Novoseek inferred chemical compound relationships for LPA Gene

Compound -log(P) Hits PubMed IDs
cholesterol 83.8 119
lipid 75.3 111
fibrinogen 59 34
cholesterol ester 54.1 3
homocysteine 48.1 20
genes like me logo Genes that share compounds with LPA: view

Transcripts for LPA Gene

mRNA/cDNA for LPA Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LPA Gene

Lipoprotein, Lp(a):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPA Gene

No ASD Table

Relevant External Links for LPA Gene

GeneLoc Exon Structure for
LPA
ECgene alternative splicing isoforms for
LPA

Expression for LPA Gene

mRNA expression in normal human tissues for LPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPA Gene

This gene is overexpressed in Liver (47.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LPA Gene

SOURCE GeneReport for Unigene cluster for LPA Gene Hs.520120

genes like me logo Genes that share expressions with LPA: view

Orthologs for LPA Gene

This gene was present in the common ancestor of animals.

Orthologs for LPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPA 36
  • 97.27 (n)
  • 95.1 (a)
LPA 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 42 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 51 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii plg 37
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tequila 37
  • 6 (a)
OneToMany
CG13744 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea svh-1 37
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4525 37
  • 18 (a)
ManyToMany
Species with no ortholog for LPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LPA Gene

ENSEMBL:
Gene Tree for LPA (if available)
TreeFam:
Gene Tree for LPA (if available)

Paralogs for LPA Gene

Paralogs for LPA Gene

Pseudogenes.org Pseudogenes for LPA Gene

genes like me logo Genes that share paralogs with LPA: view

Variants for LPA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for LPA Gene

P08519-APOA_HUMAN
The reference genome sequence encodes a variant that contains 16 Kringle domains and that lack residues 533 to 3040. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 38 copies of the kringle-type repeats

Sequence variations from dbSNP and Humsavar for LPA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs783148 -- 160,666,837(+) TTTAA(A/T)GGAGA upstream-variant-2KB
rs783149 -- 160,667,886(+) CAGCT(A/C)AGCTC upstream-variant-2KB
rs934266 -- 160,664,175(-) TATTT(C/T)TGAAA reference, synonymous-codon
rs1321195 -- 160,663,124(-) CGTAC(C/T)ACTTC intron-variant
rs1321196 -- 160,660,810(-) AAATG(A/G)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPA Gene

Variant ID Type Subtype PubMed ID
dgv2024e1 CNV Complex 17122850
esv35098 CNV Gain 17911159
nsv818463 CNV Gain 17921354
dgv7013n71 CNV Gain 21882294
essv6642 CNV CNV 17122850
esv6519 CNV Loss 19470904
esv5050 CNV Duplication 18987735
esv2733055 CNV Deletion 23290073
nsv525990 CNV Loss 19592680
dgv2025e1 CNV Complex 17122850
nsv428155 CNV Gain 18775914
nsv886814 CNV Gain 21882294
nsv830852 CNV Loss 17160897
nsv5567 CNV Loss 18451855
esv2663797 CNV Deletion 23128226
esv2750777 CNV Loss 17666407
nsv290 CNV Insertion 15895083
nsv5568 CNV Insertion 18451855
nsv823905 CNV Gain 20364138
nsv509160 CNV Insertion 20534489
nsv515029 CNV Complex 21397061
nsv471501 CNV Duplication 19718026
esv28656 CNV Gain+Loss 19812545
nsv7986 CNV Gain 18304495
dgv127n17 CNV Loss 16327808
esv33502 CNV Loss 17666407
esv2530911 CNV Deletion 19546169
nsv5569 CNV Insertion 18451855
nsv348956 CNV Loss 16902084
nsv5570 CNV Insertion 18451855
esv2733056 CNV Deletion 23290073

Relevant External Links for LPA Gene

HapMap Linkage Disequilibrium report
LPA
Human Gene Mutation Database (HGMD)
LPA

Disorders for LPA Gene

(71) Novoseek inferred disease relationships for LPA Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 72.6 50
dyslipoproteinemia 71.1 2
hyperlipoproteinemia type iii 69.7 3
coronary heart disease 65.6 16
hypertriglyceridemia 64.4 3

Genatlas disease for LPA Gene

coronary atherosclerosis,premature,with high Lpa

Relevant External Links for LPA

Genetic Association Database (GAD)
LPA
Human Genome Epidemiology (HuGE) Navigator
LPA
genes like me logo Genes that share disorders with LPA: view

No data available for UniProtKB/Swiss-Prot for LPA Gene

Publications for LPA Gene

  1. Lp(a) and apoE polymorphisms in young South African Indians with myocardial infarction. (PMID: 15258620) Ranjith N. … Naidoo D.P. (Cardiovasc J S Afr 2004) 3 23 49
  2. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. (PMID: 19880117) Arai K. … Tsimikas S. (Atherosclerosis 2010) 3 23 49
  3. Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation. (PMID: 19636317) BrandstAotter A. … Kronenberg F. (Int J Obes (Lond) 2009) 3 23 49
  4. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. (PMID: 3670400) McLean J.W. … Lawn R.M. (Nature 1987) 2 3 4
  5. A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a). (PMID: 7918682) Scanu A.M. … Hinman J. (Biochim. Biophys. Acta 1994) 3 4

Products for LPA Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Atherosclerosis in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate LPA
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for LPA
    • Block miRNA regulation of LPA using miScript Target Protectors

    Sources for LPA Gene

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