Aliases for LPA Gene
External Ids for LPA Gene
Previous HGNC Symbols for LPA Gene
Previous GeneCards Identifiers for LPA Gene
The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
GeneCards Summary for LPA Gene
LPA (Lipoprotein, Lp(A)) is a Protein Coding gene. Diseases associated with LPA include pontocerebellar hypoplasia type 2d and atherosclerosis. Among its related pathways are amb2 Integrin signaling and Metabolism. GO annotations related to this gene include serine-type endopeptidase activity and endopeptidase inhibitor activity. An important paralog of this gene is PLAT.
UniProtKB/Swiss-Prot for LPA Gene
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.