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Aliases for LNPEP Gene

Aliases for LNPEP Gene

  • Leucyl/Cystinyl Aminopeptidase 2 3 5
  • Placental Leucine Aminopeptidase 2 3 4
  • Cystinyl Aminopeptidase 2 3 4
  • Insulin-Regulated Membrane Aminopeptidase 3 4
  • Insulin-Responsive Aminopeptidase 3 4
  • Oxytocinase 3 4
  • EC 3.4.11.3 4 63
  • Otase 3 4
  • P-LAP 3 4
  • IRAP 3 4
  • Insulin-Regulated Aminopeptidase 3
  • Angiotensin IV Receptor 3
  • AT (4) Receptor 3
  • Vasopressinase 3
  • EC 3.4.11 63
  • PLAP 3
  • CAP 3

External Ids for LNPEP Gene

Previous GeneCards Identifiers for LNPEP Gene

  • GC05P095502
  • GC05P096736
  • GC05P096300
  • GC05P096346
  • GC05P096347
  • GC05P096297
  • GC05P096272
  • GC05P091461

Summaries for LNPEP Gene

Entrez Gene Summary for LNPEP Gene

  • This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for LNPEP Gene

LNPEP (Leucyl/Cystinyl Aminopeptidase) is a Protein Coding gene. Diseases associated with LNPEP include Gestational Diabetes Insipidus and Placental Site Trophoblastic Tumor. Among its related pathways are Glucose / Energy Metabolism and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is ENPEP.

UniProtKB/Swiss-Prot for LNPEP Gene

  • Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.

Tocris Summary for LNPEP Gene

Gene Wiki entry for LNPEP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LNPEP Gene

Genomics for LNPEP Gene

Regulatory Elements for LNPEP Gene

Enhancers for LNPEP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LNPEP on UCSC Golden Path with GeneCards custom track

Promoters for LNPEP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LNPEP on UCSC Golden Path with GeneCards custom track

Genomic Location for LNPEP Gene

Chromosome:
5
Start:
96,935,394 bp from pter
End:
97,037,515 bp from pter
Size:
102,122 bases
Orientation:
Plus strand

Genomic View for LNPEP Gene

Genes around LNPEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LNPEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LNPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LNPEP Gene

Proteins for LNPEP Gene

  • Protein details for LNPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIQ6-LCAP_HUMAN
    Recommended name:
    Leucyl-cystinyl aminopeptidase
    Protein Accession:
    Q9UIQ6
    Secondary Accessions:
    • O00769
    • Q15145
    • Q59H76
    • Q9TNQ2
    • Q9TNQ3
    • Q9UIQ7

    Protein attributes for LNPEP Gene

    Size:
    1025 amino acids
    Molecular mass:
    117349 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer. Binds tankyrases 1 and 2.
    SequenceCaution:
    • Sequence=BAA09436.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92120.1; Type=Frameshift; Positions=405; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LNPEP Gene

    Alternative splice isoforms for LNPEP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LNPEP Gene

Proteomics data for LNPEP Gene at MOPED

Post-translational modifications for LNPEP Gene

  • N-glycosylated.
  • The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.
  • Ubiquitination at Lys 75
  • Glycosylation at Asn 145, Asn 184, Asn 215, Asn 256, Asn 266, Asn 368, Asn 374, Asn 448, Asn 525, Asn 578, Asn 598, Asn 664, Asn 682, Asn 760, Asn 834, Asn 850, and Asn 989
  • Modification sites at PhosphoSitePlus

Other Protein References for LNPEP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LNPEP (Leucyl-cystinyl Aminopeptidase/LNPEP)

Domains & Families for LNPEP Gene

Gene Families for LNPEP Gene

Protein Domains for LNPEP Gene

Suggested Antigen Peptide Sequences for LNPEP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIQ6

UniProtKB/Swiss-Prot:

LCAP_HUMAN :
  • Belongs to the peptidase M1 family.
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with LNPEP: view

Function for LNPEP Gene

Molecular function for LNPEP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal amino acid, Cys- -Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.
UniProtKB/Swiss-Prot Function:
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.

Enzyme Numbers (IUBMB) for LNPEP Gene

genes like me logo Genes that share phenotypes with LNPEP: view

Animal Models for LNPEP Gene

MGI Knock Outs for LNPEP:

Animal Model Products

  • Taconic Biosciences Mouse Models for LNPEP

CRISPR Products

miRNA for LNPEP Gene

miRTarBase miRNAs that target LNPEP

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LNPEP Gene

Localization for LNPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LNPEP Gene

Cell membrane; Single-pass type II membrane protein. Note=In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
Leucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted. Note=During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LNPEP Gene COMPARTMENTS Subcellular localization image for LNPEP gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
endoplasmic reticulum 2
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA 19946888
GO:0031905 early endosome lumen TAS --
genes like me logo Genes that share ontologies with LNPEP: view

Pathways & Interactions for LNPEP Gene

genes like me logo Genes that share pathways with LNPEP: view

Pathways by source for LNPEP Gene

Gene Ontology (GO) - Biological Process for LNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0007267 cell-cell signaling TAS 8550619
GO:0030163 protein catabolic process IEA --
GO:0043171 peptide catabolic process IBA --
GO:0060395 SMAD protein signal transduction IEA --
genes like me logo Genes that share ontologies with LNPEP: view

No data available for SIGNOR curated interactions for LNPEP Gene

Drugs & Compounds for LNPEP Gene

(22) Drugs for LNPEP Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
Oxytocin Approved Pharma Full agonist, Agonist Involved in uterine contraction and lactation 376
Vasopressin Approved Pharma Full agonist, Agonist 0
Angiotensin IV Pharma 0

(9) Additional Compounds for LNPEP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LNPEP: view

Transcripts for LNPEP Gene

Unigene Clusters for LNPEP Gene

Leucyl/cystinyl aminopeptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LNPEP Gene

No ASD Table

Relevant External Links for LNPEP Gene

GeneLoc Exon Structure for
LNPEP
ECgene alternative splicing isoforms for
LNPEP

Expression for LNPEP Gene

mRNA expression in normal human tissues for LNPEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LNPEP Gene

This gene is overexpressed in Lymph node (15.3) and Nasal epithelium (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LNPEP Gene



SOURCE GeneReport for Unigene cluster for LNPEP Gene Hs.527199

mRNA Expression by UniProt/SwissProt for LNPEP Gene

Q9UIQ6-LCAP_HUMAN
Tissue specificity: Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.
genes like me logo Genes that share expression patterns with LNPEP: view

Protein tissue co-expression partners for LNPEP Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for LNPEP Gene

Orthologs for LNPEP Gene

This gene was present in the common ancestor of animals.

Orthologs for LNPEP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LNPEP 35
  • 87.45 (n)
  • 86.24 (a)
LNPEP 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LNPEP 35
  • 90.55 (n)
  • 89.99 (a)
LNPEP 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lnpep 35
  • 87.19 (n)
  • 87.8 (a)
Lnpep 16
Lnpep 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LNPEP 35
  • 99.64 (n)
  • 99.6 (a)
LNPEP 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LNPEP 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LNPEP 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LNPEP 35
  • 70.18 (n)
  • 67.19 (a)
LNPEP 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LNPEP 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lnpep 35
  • 62.59 (n)
  • 58.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69084 35
zebrafish
(Danio rerio)
Actinopterygii lnpep 35
  • 58.87 (n)
  • 55 (a)
wufb73h12 35
lnpep 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00365.1 37
  • 27 (a)
CG11951 37
  • 39 (a)
CG2111 37
  • 26 (a)
CG3502 37
  • 29 (a)
CG5849 37
  • 26 (a)
CG6071 37
  • 22 (a)
CG8773 37
  • 35 (a)
sda 37
  • 30 (a)
CG4467 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea AC3.5 37
  • 22 (a)
R03G8.4 37
  • 29 (a)
R03G8.6 37
  • 29 (a)
T07F10.1 37
  • 26 (a)
T16G12.1 37
  • 26 (a)
Y42A5A.1 37
  • 28 (a)
Y67D8C.9 37
  • 34 (a)
F49B2.6 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for LNPEP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LNPEP Gene

ENSEMBL:
Gene Tree for LNPEP (if available)
TreeFam:
Gene Tree for LNPEP (if available)

Paralogs for LNPEP Gene

Paralogs for LNPEP Gene

(9) SIMAP similar genes for LNPEP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LNPEP: view

Variants for LNPEP Gene

Sequence variations from dbSNP and Humsavar for LNPEP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2303138 - 97,015,006(+) ATACT(A/G)CACCC reference, missense
rs3797799 - 96,979,374(-) GCCTG(A/G)GCTTC reference, missense
rs11746232 - 97,027,755(+) ATACC(A/G)TACAA reference, missense
rs12520455 - 97,003,542(+) TTTTA(A/T)TGAGG reference, missense
rs17087233 - 97,026,631(+) AAGTA(C/G)CCTGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LNPEP Gene

Variant ID Type Subtype PubMed ID
nsv507276 CNV Insertion 20534489
nsv819519 CNV Gain 19587683
esv2730489 CNV Deletion 23290073
esv2730490 CNV Deletion 23290073
esv2740869 CNV Deletion 23290073

Variation tolerance for LNPEP Gene

Residual Variation Intolerance Score: 6.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.22; 88.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LNPEP Gene

Human Gene Mutation Database (HGMD)
LNPEP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LNPEP Gene

Disorders for LNPEP Gene

MalaCards: The human disease database

(12) MalaCards diseases for LNPEP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gestational diabetes insipidus
  • diabetes insipidus gestational
placental site trophoblastic tumor
  • placental-site gestational trophoblastic neoplasm
choriocarcinoma
  • choriocarcinoma, no icd-o subtype
trophoblastic neoplasm
  • trophoblastic neoplasm nos
dysgerminoma of ovary
  • ovarian dysgerminoma
- elite association - COSMIC cancer census association via MalaCards
Search LNPEP in MalaCards View complete list of genes associated with diseases

Relevant External Links for LNPEP

Genetic Association Database (GAD)
LNPEP
Human Genome Epidemiology (HuGE) Navigator
LNPEP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LNPEP
genes like me logo Genes that share disorders with LNPEP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LNPEP Gene

Publications for LNPEP Gene

  1. Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family. (PMID: 8550619) Rogi T. … Tomoda Y. (J. Biol. Chem. 1996) 2 3 4 23 67
  2. Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia. (PMID: 20150869) Landau R. … Cohen M. (Neuro Endocrinol. Lett. 2010) 3 23
  3. Identification of placental leucine aminopeptidase and triton-slowed aminopeptidase N in serum of pregnant women. (PMID: 18996364) Kawai M. … Hara Y. (Clin. Chim. Acta 2009) 3 23
  4. IRAP identifies an endosomal compartment required for MHC class I cross-presentation. (PMID: 19498108) Saveanu L. … van Endert P. (Science 2009) 3 23
  5. Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure. (PMID: 17999179) Tsujimoto M. … Hattori A. (Heart Fail Rev 2008) 3 23

Products for LNPEP Gene

Sources for LNPEP Gene

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