Aliases for LNPEP Gene
Aliases for LNPEP Gene
External Ids for LNPEP Gene
- HGNC: 6656
- Entrez Gene: 4012
- Ensembl: ENSG00000113441
- OMIM: 151300
- UniProtKB: Q9UIQ6
Previous GeneCards Identifiers for LNPEP Gene
- GC05P095502
- GC05P096736
- GC05P096300
- GC05P096346
- GC05P096347
- GC05P096297
- GC05P096272
- GC05P091461
Summaries for LNPEP Gene
-
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for LNPEP Gene
LNPEP (Leucyl And Cystinyl Aminopeptidase) is a Protein Coding gene. Diseases associated with LNPEP include Gestational Diabetes Insipidus and Trophoblastic Neoplasm. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is ERAP1.
UniProtKB/Swiss-Prot for LNPEP Gene
-
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Additional gene information for LNPEP Gene
- Monarch Initiative
- Search for LNPEP at DataMed
- Search for LNPEP at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LNPEP Gene
Genomics for LNPEP Gene
GeneHancer (GH) Regulatory Elements for LNPEP Gene
Promoters and enhancers for LNPEP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LNPEP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for LNPEP Gene
Genomic Locations for LNPEP Gene
- chr5:96,935,394-97,037,515
- (GRCh38/hg38)
- Size:
- 102,122 bases
- Orientation:
- Plus strand
- chr5:96,271,098-96,373,219
- (GRCh37/hg19)
Genomic View for LNPEP Gene
Genes around LNPEP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q15 by Ensembl
- 5q15 by Entrez Gene
- 5q15 by HGNC
LNPEP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LNPEP Gene
Proteins for LNPEP Gene
-
Protein details for LNPEP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UIQ6-LCAP_HUMAN
- Recommended name:
- Leucyl-cystinyl aminopeptidase
- Protein Accession:
- Q9UIQ6
- O00769
- Q15145
- Q59H76
- Q9TNQ2
- Q9TNQ3
- Q9UIQ7
Protein attributes for LNPEP Gene
- Size:
- 1025 amino acids
- Molecular mass:
- 117349 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer. Binds tankyrases 1 and 2.
- SequenceCaution:
-
- Sequence=BAA09436.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92120.1; Type=Frameshift; Positions=405; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for LNPEP Gene
Protein Expression for LNPEP Gene
Selected DME Specific Peptides for LNPEP Gene
- Q9UIQ6:
-
- KLDLVAIPDF
- DEPAFKATF
- WWNDLWLNE
- GAMENWG
- STYLVAF
- GYYIVHY
- WFGNLVT
- HELAHQWFG
- TWTLQKG
- WLNEGFA
- VAIPDFEAGAMENWGL
Post-translational modifications for LNPEP Gene
- N-glycosylated.
- The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.
- Ubiquitination at isoforms=2, 375
- Glycosylation at posLast=145145, isoforms=2, 3184, posLast=215215, posLast=256256, isoforms=2, 3266, posLast=368368, isoforms=2, 3374, isoforms=2, 3448, isoforms=2, 3525, isoforms=2, 3578, isoforms=2, 3598, posLast=664664, posLast=682682, posLast=760760, posLast=834834, isoforms=2, 3850, and posLast=989989
Other Protein References for LNPEP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for LNPEP (Leucyl-cystinyl Aminopeptidase/LNPEP)
-
Custom Antibody ServicesOriGene Antibodies for LNPEP
- Novus Biologicals Antibodies for LNPEP
-
Abcam antibodies for LNPEP
-
Cloud-Clone Corp. Antibodies for LNPEP
- Invitrogen Antibodies for LNPEP
- Search GeneTex for Antibodies for LNPEP
-
Custom Antibody ServicesProSci Antibodies for LNPEP
-
Santa Cruz Biotechnology (SCBT) Antibodies for LNPEP
Protein Products
-
OriGene Purified Proteins for LNPEP
- Search Origene for MassSpec and Protein Over-expression Lysates for LNPEP
- Origene Custom Protein Services for LNPEP
-
Cloud-Clone Corp. Proteins for LNPEP
- Search GeneTex for Proteins for LNPEP
-
Abcam proteins for LNPEP
Assay Products
-
Cloud-Clone Corp. Assay Kits for LNPEP
Domains & Families for LNPEP Gene
Gene Families for LNPEP Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for LNPEP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LNPEP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UIQ6- Family:
-
- Belongs to the peptidase M1 family.
Function for LNPEP Gene
Molecular function for LNPEP Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Release of an N-terminal amino acid, Cys- -Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.
- UniProtKB/Swiss-Prot Function:
- Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Enzyme Numbers (IUBMB) for LNPEP Gene
Phenotypes From GWAS Catalog for LNPEP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004177 | aminopeptidase activity | TAS | 15691326 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | TAS | 9177475 |
| GO:0008270 | zinc ion binding | IBA,TAS | -- |
Phenotypes for LNPEP Gene
- MGI mutant phenotypes for LNPEP:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for LNPEP:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for LNPEP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for LNPEP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LNPEP gene
- Search ViGene Biosciences for LNPEP
CRISPR Products
-
OriGene CRISPR knockouts for LNPEP
- genomics-online: gRNA clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
-
Recommended
- Applied Biological Materials CRISPR for LNPEP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LNPEP
- GenScript: Design CRISPR guide RNA sequences for LNPEP
miRNA for LNPEP Gene
- miRTarBase miRNAs that target LNPEP
-
- hsa-mir-1-3p (MIRT023791)
- hsa-mir-877-5p (MIRT037306)
- hsa-mir-744-5p (MIRT037514)
- hsa-mir-18a-3p (MIRT040837)
- hsa-mir-361-5p (MIRT044081)
- hsa-mir-30e-3p (MIRT044123)
- hsa-mir-4689 (MIRT493282)
- hsa-mir-6858-5p (MIRT493283)
- hsa-mir-3689f (MIRT493284)
- hsa-mir-3689e (MIRT493285)
- hsa-mir-3689b-5p (MIRT493286)
- hsa-mir-3689a-5p (MIRT493287)
- hsa-mir-4451 (MIRT493288)
- hsa-mir-379-5p (MIRT493289)
- hsa-mir-3529-5p (MIRT493290)
- hsa-mir-4650-3p (MIRT493291)
- hsa-mir-4524a-3p (MIRT493292)
- hsa-mir-4302 (MIRT493293)
- hsa-mir-548aw (MIRT511206)
- hsa-mir-5007-3p (MIRT511207)
- hsa-mir-4697-3p (MIRT511208)
- hsa-mir-6131 (MIRT511209)
- hsa-mir-133a-5p (MIRT511210)
- hsa-mir-1468-3p (MIRT511211)
- hsa-mir-548x-5p (MIRT511212)
- hsa-mir-548g-5p (MIRT511213)
- hsa-mir-548f-5p (MIRT511214)
- hsa-mir-4704-3p (MIRT511215)
- hsa-mir-548aj-5p (MIRT511216)
- hsa-mir-512-3p (MIRT511217)
- hsa-mir-148b-3p (MIRT511218)
- hsa-mir-152-3p (MIRT511219)
- hsa-mir-148a-3p (MIRT511220)
- hsa-mir-138-5p (MIRT511221)
- hsa-mir-6783-5p (MIRT522744)
- hsa-mir-6888-5p (MIRT522745)
- hsa-mir-4797-5p (MIRT522746)
- hsa-mir-539-3p (MIRT522747)
- hsa-mir-485-3p (MIRT522748)
- hsa-mir-218-5p (MIRT556442)
- hsa-mir-636 (MIRT556443)
- hsa-mir-4720-3p (MIRT556444)
- hsa-mir-4804-3p (MIRT556445)
- hsa-mir-5692a (MIRT556446)
- hsa-mir-3941 (MIRT608150)
- hsa-mir-603 (MIRT608151)
- hsa-mir-362-3p (MIRT608152)
- hsa-mir-329-3p (MIRT608153)
- hsa-mir-8485 (MIRT608154)
- hsa-mir-6844 (MIRT656699)
- hsa-mir-6868-3p (MIRT656700)
- hsa-mir-6749-3p (MIRT656701)
- hsa-mir-5705 (MIRT656702)
- hsa-mir-3124-3p (MIRT656703)
- hsa-mir-4469 (MIRT656704)
- hsa-mir-1237-3p (MIRT656705)
- hsa-mir-153-5p (MIRT656706)
- hsa-mir-1250-3p (MIRT656707)
- hsa-mir-5196-3p (MIRT656708)
- hsa-mir-6770-5p (MIRT702239)
- hsa-mir-1253 (MIRT702240)
- hsa-mir-3681-3p (MIRT702241)
- hsa-mir-216a-3p (MIRT702242)
- hsa-mir-128-3p (MIRT702243)
- hsa-mir-1197 (MIRT702244)
- hsa-mir-8080 (MIRT702245)
- hsa-mir-3150b-3p (MIRT740313)
- hsa-mir-4784 (MIRT748830)
- hsa-mir-185-5p (MIRT763177)
- hsa-mir-4306 (MIRT768518)
- hsa-mir-4419a (MIRT768742)
- hsa-mir-4510 (MIRT769883)
- hsa-mir-4644 (MIRT770565)
- hsa-mir-6127 (MIRT775802)
- hsa-mir-6129 (MIRT775822)
- hsa-mir-6130 (MIRT775881)
- hsa-mir-6133 (MIRT775914)
- hsa-mir-6758-5p (MIRT778430)
- hsa-mir-6760-5p (MIRT778454)
- hsa-mir-6856-5p (MIRT780492)
- hsa-mir-6873-5p (MIRT780716)
- hsa-mir-539-5p (MIRT787375)
- hsa-mir-5680 (MIRT787732)
- hsa-mir-6731-5p (MIRT788482)
- hsa-mir-8085 (MIRT789856)
miRNA Products
- Search ViGene Biosciences for LNPEP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LNPEP
- Browse OriGene Inhibitory RNA Products For LNPEP
- genomics-online: shRNA clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for LNPEP gene
Clone Products
- Sino Biological Human cDNA Clone for LNPEP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for LNPEP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LNPEP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
-
Recommended
- orf clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
-
Recommended
- Applied Biological Materials Clones for LNPEP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LNPEP
-
ViGene Biosciences adenoviral particle packaged cDNA for LNPEP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LNPEP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LNPEP gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LNPEP Gene
Localization for LNPEP Gene
Subcellular locations from UniProtKB/Swiss-Prot for LNPEP Gene
- Cell membrane; Single-pass type II membrane protein. Note=In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
- Leucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted. Note=During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| lysosome | 5 |
| endosome | 5 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005622 | intracellular | IDA | 15691326 |
| GO:0005765 | lysosomal membrane | HDA,IDA | 17897319 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | 9177475 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LNPEP Gene
Pathways & Interactions for LNPEP Gene
Pathways by source for LNPEP Gene
1 Cell Signaling Technology pathway for LNPEP Gene
1 BioSystems pathway for LNPEP Gene
9 Reactome pathways for LNPEP Gene
1 KEGG pathway for LNPEP Gene
Interacting Proteins for LNPEP Gene
Selected Interacting proteins:
ENSP00000231368
Q9UIQ6-LCAP_HUMAN
for LNPEP Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent | TAS | -- |
| GO:0006508 | proteolysis | IEA,TAS | -- |
| GO:0007165 | signal transduction | IBA | -- |
| GO:0007267 | cell-cell signaling | TAS | 8550619 |
No data available for SIGNOR curated interactions for LNPEP Gene
Drugs & Compounds for LNPEP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zinc | Approved, Investigational | Pharma | 2430 | |||
| Oxytocin | Approved, Vet_approved | Pharma | Full agonist, Agonist | Involved in uterine contraction and lactation | 474 | |
| Vasopressin | Approved | Pharma | Full agonist, Agonist | 0 | ||
| bestatin | Pharma | Inhibition, Inhibitor | Aminopeptidase inhibitor | 0 | ||
| Tosedostat (CHR2797) | Pharma | Aminopeptidase inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(2) ApexBio Compounds for LNPEP Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bestatin | Aminopeptidase inhibitor | 58970-76-6 |
| Tosedostat (CHR2797) | Aminopeptidase inhibitor | 238750-77-1 |
Transcripts for LNPEP Gene
mRNA/cDNA for LNPEP Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (123) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for LNPEP Gene
CRISPR Products
-
OriGene CRISPR knockouts for LNPEP
- genomics-online: gRNA clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
-
Recommended
- Applied Biological Materials CRISPR for LNPEP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LNPEP
- GenScript: Design CRISPR guide RNA sequences for LNPEP
miRNA Products
- Search ViGene Biosciences for LNPEP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LNPEP
- Browse OriGene Inhibitory RNA Products For LNPEP
- genomics-online: shRNA clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for LNPEP gene
Clone Products
- Sino Biological Human cDNA Clone for LNPEP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for LNPEP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LNPEP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
-
Recommended
- orf clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
-
Recommended
- Applied Biological Materials Clones for LNPEP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LNPEP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Adipose (Muscoskeletal System)
This gene is overexpressed in Lymph node (15.3) and Nasal epithelium (9.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LNPEP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of LNPEP Gene:
LNPEPSOURCE GeneReport for Unigene cluster for LNPEP Gene:
Hs.527199mRNA Expression by UniProt/SwissProt for LNPEP Gene:
Q9UIQ6-LCAP_HUMAN
Tissue specificity:
Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.
Evidence on tissue expression from TISSUES for LNPEP Gene
- Nervous system(4.4)
- Liver(4.2)
- Muscle(2.5)
- Blood(2.2)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for LNPEP
- genomics-online: primer clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
-
Recommended
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LNPEP Gene
Orthologs for LNPEP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LNPEP 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | LNPEP 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | LNPEP 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Lnpep 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | LNPEP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | LNPEP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LNPEP 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | LNPEP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lnpep 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC69084 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lnpep 33 34 |
|
||
| wufb73h12 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG11951 35 |
|
|
|
| CG8773 35 |
|
|
|||
| sda 35 |
|
|
|||
| CG3502 35 |
|
|
|||
| BG:DS00365.1 35 |
|
|
|||
| CG2111 35 |
|
|
|||
| CG5849 35 |
|
|
|||
| CG6071 35 |
|
|
|||
| CG4467 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | Y67D8C.9 35 |
|
|
|
| R03G8.4 35 |
|
|
|||
| R03G8.6 35 |
|
|
|||
| Y42A5A.1 35 |
|
|
|||
| F49B2.6 34 |
|
OneToMany | |||
| T07F10.1 35 |
|
|
|||
| T16G12.1 35 |
|
|
|||
| AC3.5 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for LNPEP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for LNPEP Gene
Variants for LNPEP Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000017993 | -- | 97,002,696(+) | A/G | intron_variant | |
| rs1000060592 | -- | 97,022,865(+) | C/T | intron_variant | |
| rs1000100819 | -- | 96,969,429(+) | C/G | intron_variant | |
| rs1000157881 | -- | 96,974,558(+) | A/G | intron_variant | |
| rs1000182073 | -- | 97,004,417(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2730489 | CNV | deletion | 23290073 |
| esv2730490 | CNV | deletion | 23290073 |
| esv2740869 | CNV | deletion | 23290073 |
| esv3605871 | CNV | loss | 21293372 |
| esv3890674 | CNV | gain | 25118596 |
| nsv1021263 | CNV | loss | 25217958 |
| nsv1028741 | CNV | gain | 25217958 |
| nsv1123970 | CNV | deletion | 24896259 |
| nsv1131903 | CNV | deletion | 24896259 |
| nsv507276 | OTHER | sequence alteration | 20534489 |
| nsv598962 | CNV | gain | 21841781 |
| nsv598963 | CNV | gain | 21841781 |
| nsv819519 | CNV | gain | 19587683 |
| nsv980700 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
6.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.22;
88.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LNPEP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LNPEP Gene
Disorders for LNPEP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gestational diabetes insipidus |
|
|
| trophoblastic neoplasm |
|
|
| placental site trophoblastic tumor |
|
|
| choriocarcinoma |
|
|
| dysgerminoma of ovary |
|
|
Search LNPEP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LNPEP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for LNPEP Gene
Publications for LNPEP Gene
- Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family. (PMID: 8550619) Rogi T … Tomoda Y (The Journal of biological chemistry 1996) 2 3 4 22 58
- Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides. (PMID: 11389728) Matsumoto H … Tsujimoto M (European journal of biochemistry 2001) 3 4 22 58
- Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. (PMID: 11707427) Albiston AL … Chai SY (The Journal of biological chemistry 2001) 3 4 22 58
- Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21. (PMID: 10759854) Rasmussen TE … Kristensen T (European journal of biochemistry 2000) 3 4 22 58
- The complete amino acid sequence of human placental oxytocinase. (PMID: 9177475) Laustsen PG … Kristensen T (Biochimica et biophysica acta 1997) 3 4 22 58
Products for LNPEP Gene
- R&D Systems Antibodies for LNPEP (Leucyl-cystinyl Aminopeptidase/LNPEP)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for LNPEP
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for LNPEP
- Search Origene for MassSpec and Protein Over-expression Lysates for LNPEP
- Origene Custom Protein Services for LNPEP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for LNPEP
- Browse OriGene Inhibitory RNA Products For LNPEP
- OriGene qPCR primer pairs for LNPEP
- OriGene CRISPR knockouts for LNPEP
- OriGene ORF clones in human for LNPEP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For LNPEP
- GenScript: Next-day shipping of latest version cDNA ORF clones for LNPEP in any vector
- GenScript Custom Purified and Recombinant Proteins Services for LNPEP
- GenScript Custom Assay Services for LNPEP
- GenScript Custom overexpressing Cell Line Services for LNPEP
- GenScript: Design CRISPR guide RNA sequences for LNPEP
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for LNPEP
- Sino Biological Human cDNA Clone for LNPEP
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for LNPEP
- Novus Biologicals proteins and lysates for LNPEP
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for LNPEP
- Abcam proteins for LNPEP
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for LNPEP
- Cloud-Clone Corp. Proteins for LNPEP
- Cloud-Clone Corp. Assay Kits for LNPEP
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for LNPEP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for LNPEP
- Cyagen custom Knockout/knockin (KOKI) mouse models for LNPEP
- VectorBuilder custom plasmid, inducible vectors for LNPEP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LNPEP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 43 available LNPEP Antibodies ranked by validation data
- Compare Top LNPEP Antibodies
- antibodies-online: Search results for 24 available LNPEP Elisa Kits ranked by validation data
- Compare Top LNPEP Elisa Kits
- antibodies-online: Search results for 9 available LNPEP Proteins ranked by validation data
- Compare Top LNPEP Proteins
- Search GeneTex for Antibodies for LNPEP
- Search GeneTex for Proteins for LNPEP
- ViGene Biosciences adenoviral particle packaged cDNA for LNPEP gene
- ViGene Biosciences lentiviral particle packaged cDNA for LNPEP gene
- ViGene Biosciences ready-to-package AAV shRNAs for LNPEP gene
- Search ViGene Biosciences for LNPEP
- Santa Cruz Biotechnology (SCBT) Antibodies for LNPEP
- Search Santa Cruz Biotechnology (SCBT) for LNPEP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LNPEP
- Custom Antibody ServicesProSci Antibodies for LNPEP
- Search for LNPEP Proteins at ProSci
- Horizon Cell Lines for LNPEP
- genomics-online: cdna clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
- Recommended
- orf clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
- Recommended
- genomics-online: primer clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 106 available LNPEP gene related products
- Overview of 106 available LNPEP gene related products
- Recommended
Sources for LNPEP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew