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Aliases for LMO1 Gene

Aliases for LMO1 Gene

  • LIM Domain Only 1 (Rhombotin 1) 2 3
  • RBTN1 3 4 6
  • RHOM1 3 4 6
  • T-Cell Translocation Protein 1 3 4
  • Cysteine-Rich Protein TTG-1 3 4
  • LIM Domain Only Protein 1 3 4
  • LMO-1 3 4
  • TTG1 3 4
  • T-Cell Translocation Gene 1 3
  • Rhombotin-1 3

External Ids for LMO1 Gene

Previous Symbols for LMO1 Gene

  • RBTN1

Summaries for LMO1 Gene

Entrez Gene Summary for LMO1 Gene

  • This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]

GeneCards Summary for LMO1 Gene

LMO1 (LIM Domain Only 1 (Rhombotin 1)) is a Protein Coding gene. Diseases associated with LMO1 include exencephaly and cd3epsilon deficiency. An important paralog of this gene is LMO2.

UniProtKB/Swiss-Prot for LMO1 Gene

  • May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.

Gene Wiki entry for LMO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMO1 Gene

Genomics for LMO1 Gene

Genomic Location for LMO1 Gene

Start:
8,224,304 bp from pter
End:
8,268,716 bp from pter
Size:
44,413 bases
Orientation:
Minus strand

Genomic View for LMO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMO1 Gene

Regulatory Elements for LMO1 Gene

Proteins for LMO1 Gene

  • Protein details for LMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25800-RBTN1_HUMAN
    Recommended name:
    Rhombotin-1
    Protein Accession:
    P25800
    Secondary Accessions:
    • E9PSF5
    • Q4VBC5
    • Q8IXR0

    Protein attributes for LMO1 Gene

    Size:
    156 amino acids
    Molecular mass:
    17828 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39512.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for LMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMO1 Gene

Proteomics data for LMO1 Gene at MOPED

Post-translational modifications for LMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LMO1 Gene

No data available for DME Specific Peptides for LMO1 Gene

Domains for LMO1 Gene

Protein Domains for LMO1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RBTN1_HUMAN
Domain:
  • Contains 2 LIM zinc-binding domains.:
    • P25800
genes like me logo Genes that share domains with LMO1: view

No data available for Gene Families for LMO1 Gene

Function for LMO1 Gene

Molecular function for LMO1 Gene

GENATLAS Biochemistry: LIM domain only 1,rhombotin 1,expressed in rhombomeres
UniProtKB/Swiss-Prot Function: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.

Gene Ontology (GO) - Molecular Function for LMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LMO1: view

Phenotypes for LMO1 Gene

MGI mutant phenotypes for LMO1:
inferred from 2 alleles
GenomeRNAi human phenotypes for LMO1:
genes like me logo Genes that share phenotypes with LMO1: view

Animal Models for LMO1 Gene

MGI Knock Outs for LMO1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LMO1 Gene

Localization for LMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMO1 Gene COMPARTMENTS Subcellular localization image for LMO1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for LMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with LMO1: view

Pathways for LMO1 Gene

SuperPathways for LMO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 20855495
genes like me logo Genes that share ontologies with LMO1: view

No data available for Pathways by source for LMO1 Gene

Transcripts for LMO1 Gene

Unigene Clusters for LMO1 Gene

LIM domain only 1 (rhombotin 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LMO1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: -
SP3:

Relevant External Links for LMO1 Gene

GeneLoc Exon Structure for
LMO1
ECgene alternative splicing isoforms for
LMO1

Expression for LMO1 Gene

mRNA expression in normal human tissues for LMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LMO1 Gene

This gene is overexpressed in Muscle - Skeletal (7.6), Skin - Not Sun Exposed (Suprapubic) (6.1), Skin - Sun Exposed (Lower leg) (4.3), and Brain - Hypothalamus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LMO1 Gene

SOURCE GeneReport for Unigene cluster for LMO1 Gene Hs.654426

mRNA Expression by UniProt/SwissProt for LMO1 Gene

P25800-RBTN1_HUMAN
Tissue specificity: Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.
genes like me logo Genes that share expressions with LMO1: view

Orthologs for LMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LMO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMO1 36
  • 100 (n)
  • 100 (a)
LMO1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LMO1 36
  • 94.87 (n)
  • 98.08 (a)
LMO1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LMO1 36
  • 95.73 (n)
  • 100 (a)
LMO1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmo1 36
  • 93.16 (n)
  • 98.72 (a)
Lmo1 16
Lmo1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LMO1 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMO1 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lmo1 36
  • 92.9 (n)
  • 98.71 (a)
chicken
(Gallus gallus)
Aves LMO1 37
  • 97 (a)
OneToOne
LOC100858792 36
  • 84.83 (n)
  • 97.44 (a)
lizard
(Anolis carolinensis)
Reptilia LMO1 37
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32263 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9759 36
zebrafish
(Danio rerio)
Actinopterygii lmo1 36
  • 85.16 (n)
  • 98.06 (a)
lmo1 37
  • 98 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000731 36
  • 73.18 (n)
  • 75.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bx 37
  • 27 (a)
OneToMany
Bx 38
  • 79 (a)
rice
(Oryza sativa)
Liliopsida Os.9021 36
Species with no ortholog for LMO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMO1 Gene

ENSEMBL:
Gene Tree for LMO1 (if available)
TreeFam:
Gene Tree for LMO1 (if available)

Paralogs for LMO1 Gene

Paralogs for LMO1 Gene

Selected SIMAP similar genes for LMO1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LMO1: view

Variants for LMO1 Gene

Sequence variations from dbSNP and Humsavar for LMO1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs110419 -- 8,231,306(+) ATGTG(A/G)TGTTC intron-variant
rs110420 -- 8,231,502(+) ATCCA(C/T)GTGGA intron-variant
rs176083 -- 8,263,434(-) GCCCC(G/T)CCAAA intron-variant
rs204921 -- 8,237,077(-) ATGAG(A/G)GTAAC intron-variant
rs204922 -- 8,235,494(-) tgtca(A/G)tgata intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LMO1 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv896982 CNV Loss 21882294
nsv469936 CNV Loss 18288195
nsv522567 CNV Loss 19592680
nsv527329 CNV Loss 19592680
nsv7663 CNV Insertion 18451855

Relevant External Links for LMO1 Gene

HapMap Linkage Disequilibrium report
LMO1

Disorders for LMO1 Gene

UniProtKB/Swiss-Prot

RBTN1_HUMAN
  • Note=A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

(1) University of Copenhagen DISEASES for LMO1 Gene

(5) Novoseek inferred disease relationships for LMO1 Gene

Disease -log(P) Hits PubMed IDs
t-all 85.3 7
exencephaly 71.6 1
leukemia t-cell 63.7 3
leukemia 50.5 3
acute leukemia 32.9 4

Genatlas disease for LMO1 Gene

acute lymphoblastic leukemia (T ALL),with translocation t(11;14)(p15;q11),and a LMO1/LDB1 interaction,likely involved in tumorigenesis

Relevant External Links for LMO1

Genetic Association Database (GAD)
LMO1
Human Genome Epidemiology (HuGE) Navigator
LMO1
Tumor Gene Database (TGDB):
LMO1
genes like me logo Genes that share disorders with LMO1: view

Publications for LMO1 Gene

  1. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). (PMID: 11528126) Cichutek A. … Zabel B.U. (Cytogenet. Cell Genet. 2001) 3 4 23
  2. T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells. (PMID: 1703797) McGuire E.A. … Korsmeyer S.J. (Blood 1991) 2 3 4
  3. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. (PMID: 2034676) Boehm T. … Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3
  4. Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. (PMID: 2052354) Boehm T. … Rabbitts T.H. (Oncogene 1991) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for LMO1 Gene

Sources for LMO1 Gene

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