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Aliases for SPRED3 Gene

Aliases for SPRED3 Gene

  • Sprouty Related EVH1 Domain Containing 3 2 3 5
  • Spred-3 3 4
  • Eve-3 3 4
  • Sprouty-Related, EVH1 Domain-Containing Protein 3 3

External Ids for SPRED3 Gene

Previous GeneCards Identifiers for SPRED3 Gene

  • GC19U900378
  • GC19P043574
  • GC19P038880
  • GC19P035328

Summaries for SPRED3 Gene

Entrez Gene Summary for SPRED3 Gene

  • This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for SPRED3 Gene

SPRED3 (Sprouty Related EVH1 Domain Containing 3) is a Protein Coding gene. Diseases associated with SPRED3 include Legius Syndrome. Among its related pathways are RET signaling and Signaling by PTK6. An important paralog of this gene is SPRED2.

UniProtKB/Swiss-Prot for SPRED3 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

Gene Wiki entry for SPRED3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRED3 Gene

Genomics for SPRED3 Gene

Regulatory Elements for SPRED3 Gene

Enhancers for SPRED3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G038269 1.5 Ensembl ENCODE dbSUPER 10.4 -117.7 -117717 1.7 ARNT SIN3A FEZF1 ZNF2 YY1 FOS ZNF592 SMARCA4 ZSCAN16 GLIS1 C19orf33 CATSPERG ZNF607 ZNF793 LOC100631378 KCNK6 DPF1 YIF1B ENSG00000269688 GGN
GH19G038361 1.1 ENCODE 11 -26.1 -26070 1.6 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B YY1 ZNF416 FOS ZNF263 SP3 C19orf33 CATSPERG ENSG00000267892 SPRED3 GGN FAM98C DPF1 ZNF573 PSMD8 ENSG00000266963
GH19G038272 1.1 ENCODE dbSUPER 10.4 -114.8 -114758 3.0 SOX13 ELF3 DRAP1 SAP130 TAF1 DMAP1 ZNF384 BCL11B YY1 RARA C19orf33 CATSPERG DPF1 YIF1B KCNK6 GGN SPRED3 FAM98C SPINT2 HKR1
GH19G038453 0.9 ENCODE 11.9 +64.7 64735 0.2 HDAC1 TBP PKNOX1 ATF1 CBX3 RB1 CREB3L1 ZNF350 CREM CEBPB ZNF781 MED29 FAM98C GGN SPRED3 ENSG00000267152 ZNF793 CATSPERG PPP1R14A GC19P038435
GH19G038275 0.9 dbSUPER 10.4 -112.2 -112204 0.6 ZNF493 ZFP64 ZEB1 ZNF121 ZNF366 ZNF138 ZNF354C SCRT2 KLF7 ZNF202 ZNF573 ZNF571 ZNF793 ZNF607 C19orf33 ENSG00000267152 ZNF569 ENSG00000267682 ZNF570 ZNF571-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPRED3 on UCSC Golden Path with GeneCards custom track

Promoters for SPRED3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109275 379 2401 HDGF ATF1 AGO1 ZNF2 ZNF48 TCF12 ZNF121 GLIS2 ELK1 ZNF143

Genomic Location for SPRED3 Gene

38,388,421 bp from pter
38,399,884 bp from pter
11,464 bases
Plus strand

Genomic View for SPRED3 Gene

Genes around SPRED3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRED3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRED3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED3 Gene

Proteins for SPRED3 Gene

  • Protein details for SPRED3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q2MJR1

    Protein attributes for SPRED3 Gene

    410 amino acids
    Molecular mass:
    42670 Da
    Quaternary structure:
    • Interacts with Ras.

    Alternative splice isoforms for SPRED3 Gene


neXtProt entry for SPRED3 Gene

Post-translational modifications for SPRED3 Gene

Other Protein References for SPRED3 Gene

No data available for DME Specific Peptides for SPRED3 Gene

Domains & Families for SPRED3 Gene

Protein Domains for SPRED3 Gene

Suggested Antigen Peptide Sequences for SPRED3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPRED3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPRED3 Gene

Function for SPRED3 Gene

Molecular function for SPRED3 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
genes like me logo Genes that share phenotypes with SPRED3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRED3 Gene

Localization for SPRED3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED3 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRED3 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SPRED3: view

Pathways & Interactions for SPRED3 Gene

SuperPathways for SPRED3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by PTK6
genes like me logo Genes that share pathways with SPRED3: view

Pathways by source for SPRED3 Gene

Gene Ontology (GO) - Biological Process for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SPRED3: view

No data available for SIGNOR curated interactions for SPRED3 Gene

Drugs & Compounds for SPRED3 Gene

No Compound Related Data Available

Transcripts for SPRED3 Gene

mRNA/cDNA for SPRED3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRED3 Gene

Sprouty-related, EVH1 domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED3 Gene

No ASD Table

Relevant External Links for SPRED3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRED3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRED3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRED3 Gene

This gene is overexpressed in Artery - Aorta (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPRED3 Gene

Protein tissue co-expression partners for SPRED3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPRED3 Gene:


SOURCE GeneReport for Unigene cluster for SPRED3 Gene:


mRNA Expression by UniProt/SwissProt for SPRED3 Gene:

Tissue specificity: Expression is restricted to liver.

Evidence on tissue expression from TISSUES for SPRED3 Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with SPRED3: view

Primer Products

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRED3 Gene

Orthologs for SPRED3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRED3 34 35
  • 99.59 (n)
(Canis familiaris)
Mammalia SPRED3 34 35
  • 92.6 (n)
(Bos Taurus)
Mammalia SPRED3 34 35
  • 91.33 (n)
(Mus musculus)
Mammalia Spred3 34 16 35
  • 87.14 (n)
(Rattus norvegicus)
Mammalia Spred3 34
  • 83.02 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 30 (a)
(Anolis carolinensis)
Reptilia SPRED3 35
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spred 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10713 35
  • 22 (a)
Species where no ortholog for SPRED3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRED3 Gene

Gene Tree for SPRED3 (if available)
Gene Tree for SPRED3 (if available)

Paralogs for SPRED3 Gene

Paralogs for SPRED3 Gene

(3) SIMAP similar genes for SPRED3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPRED3: view

Variants for SPRED3 Gene

Sequence variations from dbSNP and Humsavar for SPRED3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000495198 -- 38,388,820(+) CCGAG(G/T)GGGGC upstream-variant-2KB
rs1000565679 -- 38,393,345(+) TTATC(-/TTTT)TTTTT intron-variant
rs1000674996 -- 38,388,072(+) CCCTC(A/C)CCTTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001012869 -- 38,394,889(+) ATTCC(A/T)GGGGA intron-variant
rs1001576983 -- 38,390,190(+) TGGAC(A/G)TGAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SPRED3 Gene

Variant ID Type Subtype PubMed ID
nsv1064275 CNV loss 25217958
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for SPRED3 Gene

Gene Damage Index Score: 2.68; 46.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRED3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED3 Gene

Disorders for SPRED3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPRED3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
legius syndrome
  • neurofibromatosis type 1-like syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPRED3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPRED3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRED3 Gene

Publications for SPRED3 Gene

  1. Eve-3: a liver enriched suppressor of Ras/MAPK signaling. (PMID: 16478641) King J.A.J. … Hovens C.M. (J. Hepatol. 2006) 3 4 64
  2. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PMID: 16465403) Katoh Y. … Katoh M. (Int. J. Mol. Med. 2006) 3 22 64
  3. Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma. (PMID: 14618415) Mizoguchi M. … Louis D.N. (Neurogenetics 2004) 2 3 64
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64
  5. SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. (PMID: 19443465) Spurlock G. … Upadhyaya M. (J. Med. Genet. 2009) 46 64

Products for SPRED3 Gene

Sources for SPRED3 Gene

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