Aliases for SPRED3 Gene
External Ids for SPRED3 Gene
Previous GeneCards Identifiers for SPRED3 Gene
This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for SPRED3 Gene
SPRED3 (Sprouty Related EVH1 Domain Containing 3) is a Protein Coding gene. Diseases associated with SPRED3 include Legius Syndrome. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. An important paralog of this gene is SPRED2.
UniProtKB/Swiss-Prot for SPRED3 Gene
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.