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Aliases for SPRED3 Gene

Aliases for SPRED3 Gene

  • Sprouty-Related, EVH1 Domain Containing 3 2 3
  • Spred-3 3 4
  • Eve-3 3 4
  • Sprouty-Related, EVH1 Domain-Containing Protein 3 3

External Ids for SPRED3 Gene

Previous GeneCards Identifiers for SPRED3 Gene

  • GC19U900378
  • GC19P043574
  • GC19P038880
  • GC19P035328

Summaries for SPRED3 Gene

Entrez Gene Summary for SPRED3 Gene

  • This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for SPRED3 Gene

SPRED3 (Sprouty-Related, EVH1 Domain Containing 3) is a Protein Coding gene. Diseases associated with SPRED3 include legius syndrome. Among its related pathways are Jak-STAT signaling pathway. An important paralog of this gene is SPRED1.

UniProtKB/Swiss-Prot for SPRED3 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

Gene Wiki entry for SPRED3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRED3 Gene

Genomics for SPRED3 Gene

Regulatory Elements for SPRED3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPRED3 Gene

38,388,421 bp from pter
38,399,884 bp from pter
11,464 bases
Plus strand

Genomic View for SPRED3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRED3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED3 Gene

Proteins for SPRED3 Gene

  • Protein details for SPRED3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q2MJR1

    Protein attributes for SPRED3 Gene

    410 amino acids
    Molecular mass:
    42670 Da
    Quaternary structure:
    • Interacts with Ras.

    Alternative splice isoforms for SPRED3 Gene


neXtProt entry for SPRED3 Gene

Proteomics data for SPRED3 Gene at MOPED

Post-translational modifications for SPRED3 Gene

Other Protein References for SPRED3 Gene

Antibody Products

No data available for DME Specific Peptides for SPRED3 Gene

Domains for SPRED3 Gene

Protein Domains for SPRED3 Gene


Suggested Antigen Peptide Sequences for SPRED3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KBD domain.
  • Contains 1 KBD domain.
  • Contains 1 SPR (sprouty) domain.
  • Contains 1 WH1 domain.
genes like me logo Genes that share domains with SPRED3: view

No data available for Gene Families for SPRED3 Gene

Function for SPRED3 Gene

Molecular function for SPRED3 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRED3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPRED3 Gene

Localization for SPRED3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED3 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for SPRED3 Gene COMPARTMENTS Subcellular localization image for SPRED3 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SPRED3: view

Pathways for SPRED3 Gene

SuperPathways for SPRED3 Gene

Superpath Contained pathways
1 Jak-STAT signaling pathway
genes like me logo Genes that share pathways with SPRED3: view

Pathways by source for SPRED3 Gene

1 KEGG pathway for SPRED3 Gene

Gene Ontology (GO) - Biological Process for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0007275 multicellular organismal development IEA --
GO:0009966 regulation of signal transduction --
genes like me logo Genes that share ontologies with SPRED3: view

Transcripts for SPRED3 Gene

mRNA/cDNA for SPRED3 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRED3 Gene

Sprouty-related, EVH1 domain containing 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRED3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED3 Gene

No ASD Table

Relevant External Links for SPRED3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRED3 Gene

mRNA expression in normal human tissues for SPRED3 Gene

mRNA differential expression in normal tissues according to GTEx for SPRED3 Gene

This gene is overexpressed in Artery - Aorta (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPRED3 Gene

SOURCE GeneReport for Unigene cluster for SPRED3 Gene Hs.196011

mRNA Expression by UniProt/SwissProt for SPRED3 Gene

Tissue specificity: Expression is restricted to liver.
genes like me logo Genes that share expressions with SPRED3: view

Expression partners for SPRED3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for SPRED3 Gene

Orthologs for SPRED3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPRED3 35
  • 91.33 (n)
  • 95.91 (a)
  • 82 (a)
(Canis familiaris)
Mammalia SPRED3 35
  • 92.6 (n)
  • 96.59 (a)
  • 84 (a)
(Mus musculus)
Mammalia Spred3 35
  • 87.14 (n)
  • 95.33 (a)
Spred3 16
Spred3 36
  • 95 (a)
(Pan troglodytes)
Mammalia SPRED3 35
  • 99.59 (n)
  • 99.51 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Spred3 35
  • 83.02 (n)
  • 89.7 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
(Anolis carolinensis)
Reptilia SPRED3 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spred 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10713 36
  • 22 (a)
Species with no ortholog for SPRED3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRED3 Gene

Gene Tree for SPRED3 (if available)
Gene Tree for SPRED3 (if available)

Paralogs for SPRED3 Gene

Paralogs for SPRED3 Gene

(3) SIMAP similar genes for SPRED3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPRED3: view

Variants for SPRED3 Gene

Sequence variations from dbSNP and Humsavar for SPRED3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2368486 -- 38,393,512(+) tttgt(A/T)ttttt intron-variant
rs3745956 -- 38,399,371(+) CAGCC(A/G)CTTGC utr-variant-3-prime, nc-transcript-variant
rs4622632 -- 38,394,153(+) GAACA(A/G)AGGCT intron-variant
rs6508790 -- 38,393,530(+) acggg(A/G)tttca intron-variant
rs6508791 -- 38,393,539(+) cacta(G/T)gttgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRED3 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV Loss 17160897
nsv911658 CNV Loss 21882294
nsv470140 CNV Gain 18288195
nsv911659 CNV Loss 21882294
nsv911660 CNV Gain 21882294
nsv833823 CNV Loss 17160897
dgv3857n71 CNV Loss 21882294

Relevant External Links for SPRED3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED3 Gene

Disorders for SPRED3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SPRED3 Gene in MalaCards »

(1) Disease for SPRED3 Gene

Relevant External Links for SPRED3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPRED3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SPRED3 Gene

Publications for SPRED3 Gene

  1. Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma. (PMID: 14618415) Mizoguchi M. … Louis D.N. (Neurogenetics 2004) 2 3
  2. Eve-3: a liver enriched suppressor of Ras/MAPK signaling. (PMID: 16478641) King J.A.J. … Hovens C.M. (J. Hepatol. 2006) 3 4
  3. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PMID: 16465403) Katoh Y. … Katoh M. (Int. J. Mol. Med. 2006) 3 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. (PMID: 12646235) Kato R. … Yoshimura A. (Biochem. Biophys. Res. Commun. 2003) 3

Products for SPRED3 Gene

Sources for SPRED3 Gene

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