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Aliases for LIPE Gene

Aliases for LIPE Gene

  • Lipase, Hormone-Sensitive 2 3
  • EC 4 63
  • LHS 3 6
  • HSL 3 4
  • Hormone-Sensitive Lipase Testicular Isoform 3
  • Hormone-Sensitive Lipase 3
  • AOMS4 3
  • FPLD6 3

External Ids for LIPE Gene

Previous GeneCards Identifiers for LIPE Gene

  • GC19M043552
  • GC19M043297
  • GC19M047581
  • GC19M047597
  • GC19M042906
  • GC19M039335

Summaries for LIPE Gene

Entrez Gene Summary for LIPE Gene

  • The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPE Gene

LIPE (Lipase, Hormone-Sensitive) is a Protein Coding gene. Diseases associated with LIPE include lipodystrophy, familial partial, type 6 and obesity. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase binding and hormone-sensitive lipase activity.

UniProtKB/Swiss-Prot for LIPE Gene

  • In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production

Gene Wiki entry for LIPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPE Gene

Genomics for LIPE Gene

Regulatory Elements for LIPE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LIPE Gene

42,401,507 bp from pter
42,427,426 bp from pter
25,920 bases
Minus strand

Genomic View for LIPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPE Gene

Proteins for LIPE Gene

  • Protein details for LIPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hormone-sensitive lipase
    Protein Accession:
    Secondary Accessions:
    • Q3LRT2
    • Q6NSL7

    Protein attributes for LIPE Gene

    1076 amino acids
    Molecular mass:
    116598 Da
    Quaternary structure:
    • Interacts with PTRF in the adipocyte cytoplasm. Interacts with PLIN5 (By similarity).

    Alternative splice isoforms for LIPE Gene


neXtProt entry for LIPE Gene

Proteomics data for LIPE Gene at MOPED

Post-translational modifications for LIPE Gene

  • Phosphorylation by AMPK may block translocation to lipid droplets.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIPE Gene

Antibody Products

  • R&D Systems Antibodies for LIPE (Hormone-sensitive Lipase/HSL)
  • Cell Signaling Technology (CST) Antibodies for LIPE (HSL)

Domains for LIPE Gene

Gene Families for LIPE Gene


Suggested Antigen Peptide Sequences for LIPE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDXG lipolytic enzyme family.
  • Belongs to the GDXG lipolytic enzyme family.
genes like me logo Genes that share domains with LIPE: view

Function for LIPE Gene

Molecular function for LIPE Gene

GENATLAS Biochemistry:
lipase,hormone sensitive with two isoforms expressed in adipose tissue (HSLadi),testis (HSLtes),associated with obesity and non insulin dependent diabetes
UniProtKB/Swiss-Prot CatalyticActivity:
Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
UniProtKB/Swiss-Prot CatalyticActivity:
Monoacylglycerol + H(2)O = glycerol + a carboxylate
UniProtKB/Swiss-Prot EnzymeRegulation:
Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin
UniProtKB/Swiss-Prot Function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production

Enzyme Numbers (IUBMB) for LIPE Gene

Gene Ontology (GO) - Molecular Function for LIPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity IEA --
GO:0005515 protein binding IPI 17026959
GO:0016298 lipase activity --
GO:0016787 hydrolase activity --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with LIPE: view
genes like me logo Genes that share phenotypes with LIPE: view

Animal Models for LIPE Gene

MGI Knock Outs for LIPE:

Animal Model Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for LIPE Gene

Localization for LIPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPE Gene

Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.

Subcellular locations from

Jensen Localization Image for LIPE Gene COMPARTMENTS Subcellular localization image for LIPE gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LIPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005811 lipid particle ISS --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane --
GO:0005901 caveola IEA --
genes like me logo Genes that share ontologies with LIPE: view

Pathways for LIPE Gene

genes like me logo Genes that share pathways with LIPE: view

PCR Array Products

UniProtKB/Swiss-Prot Q05469-LIPS_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol degradation

Gene Ontology (GO) - Biological Process for LIPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 3420405
GO:0008152 metabolic process --
GO:0008203 cholesterol metabolic process IEA --
GO:0016042 lipid catabolic process ISS --
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with LIPE: view

Drugs for LIPE Gene

(15272) HMDB Compounds for LIPE Gene

Compound Synonyms Cas Number PubMed IDs
  • (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
Arachidic acid
  • Arachate
Arachidonic acid
  • (all-Z)-5,8,11,14-Eicosatetraenoate
Cyclic AMP
  • 3'5'-Cyclic AMP
  • 1-Myristoyl-3-myristoyl-sn-glycerol

(53) Novoseek inferred chemical compound relationships for LIPE Gene

Compound -log(P) Hits PubMed IDs
triacylglycerol 81.6 42
glycerol 75.9 22
fatty acid 74.1 60
monoacylglycerol 71.2 13
lipid 70.8 97
genes like me logo Genes that share compounds with LIPE: view

Transcripts for LIPE Gene

Unigene Clusters for LIPE Gene

Lipase, hormone-sensitive:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIPE Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14
SP1: - - -
SP2: -
SP3: -
SP6: - - - -
SP8: - - - -
SP9: - - -
SP10: -

Relevant External Links for LIPE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPE Gene

mRNA expression in normal human tissues for LIPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPE Gene

This gene is overexpressed in Adipose - Subcutaneous (14.8), Adipose - Visceral (Omentum) (11.2), and Breast - Mammary Tissue (7.7).

Protein differential expression in normal tissues for LIPE Gene

This gene is overexpressed in Adipocyte (47.7) and Nasopharynx (19.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIPE Gene

SOURCE GeneReport for Unigene cluster for LIPE Gene Hs.656980

genes like me logo Genes that share expressions with LIPE: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for LIPE Gene

Orthologs for LIPE Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LIPE 35
  • 86.17 (n)
  • 85.9 (a)
HSL 36
  • 86 (a)
(Canis familiaris)
Mammalia LIPE 35
  • 83.98 (n)
  • 80.21 (a)
HSL 36
  • 80 (a)
(Mus musculus)
Mammalia Lipe 35
  • 81.96 (n)
  • 84.28 (a)
Lipe 16
Lipe 36
  • 81 (a)
(Pan troglodytes)
Mammalia LIPE 35
  • 99.26 (n)
  • 98.98 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Lipe 35
  • 78.08 (n)
  • 74.85 (a)
(Monodelphis domestica)
Mammalia LIPE 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia LIPE 36
  • 48 (a)
(Anolis carolinensis)
Reptilia LIPE 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lipe 35
  • 62.34 (n)
  • 62.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18619 35
(Danio rerio)
Actinopterygii Dr.14982 35
lipeb 35
  • 61.53 (n)
  • 61.72 (a)
lipea 36
  • 53 (a)
lipeb 36
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13588 35
fruit fly
(Drosophila melanogaster)
Insecta CG11055 37
  • 55 (a)
CG11055 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea C46C11.1 37
  • 33 (a)
hosl-1 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
CSA.8706 36
  • 26 (a)
Species with no ortholog for LIPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LIPE Gene

Gene Tree for LIPE (if available)
Gene Tree for LIPE (if available)

Paralogs for LIPE Gene

No data available for Paralogs for LIPE Gene

Variants for LIPE Gene

Sequence variations from dbSNP and Humsavar for LIPE Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_025111 -
VAR_025112 -
VAR_025113 -
VAR_025114 -
VAR_025115 -

Structural Variations from Database of Genomic Variants (DGV) for LIPE Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
nsv520239 CNV Loss 19592680
nsv911782 CNV Loss 21882294
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
nsv911785 CNV Loss 21882294
nsv911788 CNV Gain 21882294
dgv3885n71 CNV Loss 21882294
nsv911791 CNV Gain 21882294
dgv3886n71 CNV Gain 21882294
dgv3887n71 CNV Loss 21882294
dgv3888n71 CNV Gain 21882294
dgv3889n71 CNV Loss 21882294
nsv911804 CNV Loss 21882294
nsv911807 CNV Gain 21882294
nsv911808 CNV Gain 21882294

Relevant External Links for LIPE Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPE Gene

Disorders for LIPE Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for LIPE Gene in MalaCards »

(2) Diseases for LIPE Gene


  • Lipodystrophy, familial partial, 6 (FPLD6) [MIM:615980]: A form of lipodystrophy characterized by abnormal subcutaneous fat distribution. Affected individuals have increased visceral fat, impaired lipolysis, dyslipidemia, hepatic steatosis, systemic insulin resistance, and diabetes. Some patients manifest muscular dystrophy. {ECO:0000269 PubMed:24848981}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for LIPE Gene

(19) Novoseek inferred disease relationships for LIPE Gene

Disease -log(P) Hits PubMed IDs
obesity 69 34
hyperlipidemia familial combined 67.6 4
insulin resistance 58.2 9
insulin sensitivity 52.5 8
hyperinsulinemia 38.7 1

Relevant External Links for LIPE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LIPE: view

No data available for OMIM and Genatlas for LIPE Gene

Publications for LIPE Gene

  1. Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium. (PMID: 8506334) Langin D. … Holm C. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study. (PMID: 11850754) Garenc C. … Bouchard C. (Int. J. Obes. Relat. Metab. Disord. 2002) 3 23 48
  3. Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase. (PMID: 8812477) Holst L.S. … Holm C. (Genomics 1996) 3 4 23
  4. A common hormone-sensitive lipase i6 gene polymorphism is associated with decreased human adipocyte lipolytic function. (PMID: 11574428) Hoffstedt J. … Lavebratt C. (Diabetes 2001) 3 23 48
  5. Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: results from the Ely study. (PMID: 11731226) Talmud P.J. … Wareham N.J. (Biochim. Biophys. Acta 2001) 3 23 48

Products for LIPE Gene

Sources for LIPE Gene

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