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LIPE Gene(Protein Coding)

Lipase E, Hormone Sensitive Type

GCID:
GC19M042401
GIFtS:
69
Genes Participants
UDN Logo

Aliases for LIPE Gene

Aliases for LIPE Gene

  • Lipase E, Hormone Sensitive Type 2 3
  • Lipase, Hormone-Sensitive 2 3 5
  • EC 3.1.1.79 4 63
  • HSL 3 4
  • Hormone-Sensitive Lipase Testicular Isoform 3
  • AOMS4 3
  • FPLD6 3
  • LHS 3

External Ids for LIPE Gene

Previous GeneCards Identifiers for LIPE Gene

  • GC19M043552
  • GC19M043297
  • GC19M047581
  • GC19M047597
  • GC19M042906
  • GC19M039335

Summaries for LIPE Gene

Entrez Gene Summary for LIPE Gene

  • The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPE Gene

LIPE (Lipase E, Hormone Sensitive Type) is a Protein Coding gene. Diseases associated with LIPE include Lipodystrophy, Familial Partial, Type 6 and Lipe-Related Familial Partial Lipodystrophy. Among its related pathways are cAMP signaling pathway and Glucose / Energy Metabolism. GO annotations related to this gene include protein kinase binding and triglyceride lipase activity.

UniProtKB/Swiss-Prot for LIPE Gene

  • In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Gene Wiki entry for LIPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPE Gene

Genomics for LIPE Gene

Products:

  1. Regulatory Element

Regulatory Elements for LIPE Gene

Enhancers for LIPE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LIPE on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LIPE gene promoter:

Genomic Location for LIPE Gene

Chromosome:
19
Start:
42,401,507 bp from pter
End:
42,427,426 bp from pter
Size:
25,920 bases
Orientation:
Minus strand

Genomic View for LIPE Gene

Genes around LIPE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPE Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LIPE Gene

Proteins for LIPE Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LIPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05469-LIPS_HUMAN
    Recommended name:
    Hormone-sensitive lipase
    Protein Accession:
    Q05469
    Secondary Accessions:
    • Q3LRT2
    • Q6NSL7

    Protein attributes for LIPE Gene

    Size:
    1076 amino acids
    Molecular mass:
    116598 Da
    Quaternary structure:
    • Interacts with PTRF in the adipocyte cytoplasm. Interacts with PLIN5 (By similarity).

    Alternative splice isoforms for LIPE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPE Gene

Proteomics data for LIPE Gene at MOPED

Protein Expression for LIPE Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for LIPE Gene

Q05469:

Post-translational modifications for LIPE Gene

  • Phosphorylation by AMPK may block translocation to lipid droplets.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIPE Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LIPE (Hormone-sensitive Lipase/HSL)
  • Cell Signaling Technology (CST) Antibodies for LIPE (HSL)

Domains & Families for LIPE Gene

Gene Families for LIPE Gene

HGNC:

Protein Domains for LIPE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LIPE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05469

UniProtKB/Swiss-Prot:

LIPS_HUMAN :
  • Belongs to the GDXG lipolytic enzyme family.
Family:
  • Belongs to the GDXG lipolytic enzyme family.
genes like me logo Genes that share domains with LIPE: view

Function for LIPE Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for LIPE Gene

GENATLAS Biochemistry:
lipase,hormone sensitive with two isoforms expressed in adipose tissue (HSLadi),testis (HSLtes),associated with obesity and non insulin dependent diabetes
UniProtKB/Swiss-Prot CatalyticActivity:
Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
Monoacylglycerol + H(2)O = glycerol + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.
UniProtKB/Swiss-Prot Function:
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Enzyme Numbers (IUBMB) for LIPE Gene

Gene Ontology (GO) - Molecular Function for LIPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016298 lipase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with LIPE: view

Phenotypes for LIPE Gene

MGI mutant phenotypes for LIPE:
inferred from 5 alleles
GenomeRNAi human phenotypes for LIPE:
genes like me logo Genes that share phenotypes with LIPE: view

Human Phenotype Ontology for LIPE Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LIPE Gene

MGI Knock Outs for LIPE:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for LIPE Gene

Localization for LIPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPE Gene

Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIPE Gene COMPARTMENTS Subcellular localization image for LIPE gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 3
extracellular 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for LIPE Gene

Pathways & Interactions for LIPE Gene

genes like me logo Genes that share pathways with LIPE: view

UniProtKB/Swiss-Prot Q05469-LIPS_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol degradation.

SIGNOR curated interactions for LIPE Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for LIPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016042 lipid catabolic process IEA,ISS --
GO:0019433 triglyceride catabolic process IEA,TAS --
GO:0042758 long-chain fatty acid catabolic process IEA --
genes like me logo Genes that share ontologies with LIPE: view

Drugs & Compounds for LIPE Gene

Products:

  1. Drug

(32) Drugs for LIPE Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Glycerol Experimental Pharma 205
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0

(102) Additional Compounds for LIPE Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Arachidonylglycerol
  • (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
  • (5Z,8Z,11Z,14Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
  • (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoate
  • (all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid
  • 1-Monoacylglyceride
 53847-30-6
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
 506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
genes like me logo Genes that share compounds with LIPE: view

Transcripts for LIPE Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for LIPE Gene

(7) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPE Gene

Lipase, hormone-sensitive:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPE Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:
SP6: - - - -
SP7:
SP8: - - - -
SP9: - - -
SP10: -

Relevant External Links for LIPE Gene

GeneLoc Exon Structure for
LIPE
ECgene alternative splicing isoforms for
LIPE

Expression for LIPE Gene

Products:

  1. Primer

mRNA expression in normal human tissues for LIPE Gene

mRNA expression in normal human tissues for LIPE Gene
mRNA expression by BioGPS for LIPE GenemRNA expression by GTEx for LIPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPE Gene

This gene is overexpressed in Adipose - Subcutaneous (x14.8), Adipose - Visceral (Omentum) (x11.2), and Breast - Mammary Tissue (x7.7).

Protein differential expression in normal tissues from HIPED for LIPE Gene

This gene is overexpressed in Adipocyte (47.7) and Nasopharynx (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIPE Gene



SOURCE GeneReport for Unigene cluster for LIPE Gene Hs.656980

genes like me logo Genes that share expression patterns with LIPE: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LIPE Gene

Orthologs for LIPE Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia LIPE 35
  • 86.17 (n)
  • 85.9 (a)
HSL 36
  • 86 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia LIPE 35
  • 83.98 (n)
  • 80.21 (a)
HSL 36
  • 80 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Lipe 35
  • 81.96 (n)
  • 84.28 (a)
Lipe 16
Lipe 36
  • 81 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia LIPE 35
  • 99.26 (n)
  • 98.98 (a)
LIPE 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Lipe 35
  • 78.08 (n)
  • 74.85 (a)
oppossum
(Monodelphis domestica)
 Mammalia LIPE 36
  • 53 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia LIPE 36
  • 48 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia LIPE 36
  • 65 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia lipe 35
  • 62.34 (n)
  • 62.7 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.18619 35
zebrafish
(Danio rerio)
 Actinopterygii Dr.14982 35
lipeb 35
  • 61.53 (n)
  • 61.72 (a)
lipea 36
  • 53 (a)
 OneToMany
lipeb 36
  • 50 (a)
 OneToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.13588 35
fruit fly
(Drosophila melanogaster)
 Insecta CG11055 37
  • 55 (a)
CG11055 36
  • 28 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea C46C11.1 37
  • 33 (a)
hosl-1 36
  • 24 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 51 (a)
 OneToMany
CSA.8706 36
  • 26 (a)
 OneToMany
Species with no ortholog for LIPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LIPE Gene

ENSEMBL:
Gene Tree for LIPE (if available)
TreeFam:
Gene Tree for LIPE (if available)

Paralogs for LIPE Gene

No data available for Paralogs for LIPE Gene

Variants for LIPE Gene

Sequence variations from dbSNP and Humsavar for LIPE Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_025108 -
VAR_025109 -
VAR_025110 -
VAR_025111 -
VAR_025112 -

Structural Variations from Database of Genomic Variants (DGV) for LIPE Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
nsv520239 CNV Loss 19592680
nsv911782 CNV Loss 21882294
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
nsv911785 CNV Loss 21882294
nsv911788 CNV Gain 21882294
dgv3885n71 CNV Loss 21882294
nsv911791 CNV Gain 21882294
dgv3886n71 CNV Gain 21882294
dgv3887n71 CNV Loss 21882294
dgv3888n71 CNV Gain 21882294
dgv3889n71 CNV Loss 21882294
nsv911804 CNV Loss 21882294
nsv911807 CNV Gain 21882294
nsv911808 CNV Gain 21882294

Variation tolerance for LIPE Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPE Gene

Human Gene Mutation Database (HGMD)
LIPE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPE Gene

Disorders for LIPE Gene

MalaCards: The human disease database

(7) MalaCards diseases for LIPE Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lipodystrophy, familial partial, type 6
  • fpld6
lipe-related familial partial lipodystrophy
  • lipodystrophy, familial partial, type 6
lipodystrophy
obesity
  • obesity, association with
hyperlipidemia, familial combined
  • combined hyperlipidemia, familial
- elite association - COSMIC cancer census association via MalaCards
Search LIPE in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LIPS_HUMAN
  • Lipodystrophy, familial partial, 6 (FPLD6) [MIM:615980]: A form of lipodystrophy characterized by abnormal subcutaneous fat distribution. Affected individuals have increased visceral fat, impaired lipolysis, dyslipidemia, hepatic steatosis, systemic insulin resistance, and diabetes. Some patients manifest muscular dystrophy. {ECO:0000269 PubMed:24848981}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LIPE

Genetic Association Database (GAD)
LIPE
Human Genome Epidemiology (HuGE) Navigator
LIPE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPE
genes like me logo Genes that share disorders with LIPE: view

No data available for Genatlas for LIPE Gene

Publications for LIPE Gene

  1. Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium. (PMID: 8506334) Langin D. … Holm C. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23 67
  2. Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes. (PMID: 19433586) Bezaire V. … Langin D. (J. Biol. Chem. 2009) 3 23
  3. Depot-specific differences in perilipin and hormone-sensitive lipase expression in lean and obese. (PMID: 20017959) Ray H. … Large V. (Lipids Health Dis 2009) 3 23
  4. Blunted beta-adrenoceptor-mediated fat oxidation in overweight subjects: a role for the hormone-sensitive lipase gene. (PMID: 18249203) Jocken J.W. … Saris W.H. (Metab. Clin. Exp. 2008) 3 23
  5. Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation. (PMID: 18398140) Jocken J.W. … Blaak E.E. (Diabetes 2008) 3 23

Products for LIPE Gene

Sources for LIPE Gene