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Aliases for RHOH Gene

Aliases for RHOH Gene

  • Ras Homolog Family Member H 2 3
  • ARHH 3 4 6
  • TTF 3 4 6
  • Ras Homolog Gene Family, Member H 2 3
  • GTP-Binding Protein TTF 3 4
  • Rho-Related GTP-Binding Protein RhoH 3
  • Translocation Three Four Protein 4
  • TTF, Translocation Three Four 3

External Ids for RHOH Gene

Previous HGNC Symbols for RHOH Gene

  • ARHH

Previous GeneCards Identifiers for RHOH Gene

  • GC04P040096
  • GC04P040021
  • GC04P039875
  • GC04P040198
  • GC04P039521

Summaries for RHOH Gene

Entrez Gene Summary for RHOH Gene

  • The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

GeneCards Summary for RHOH Gene

RHOH (Ras Homolog Family Member H) is a Protein Coding gene. Diseases associated with RHOH include t-cell immunodeficiency with epidermodysplasia verruciformis and nodal marginal zone b-cell lymphoma. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase inhibitor activity. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RHOH Gene

  • Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.

Gene Wiki entry for RHOH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOH Gene

Genomics for RHOH Gene

Regulatory Elements for RHOH Gene

Genomic Location for RHOH Gene

Start:
40,191,011 bp from pter
End:
40,246,967 bp from pter
Size:
55,957 bases
Orientation:
Plus strand

Genomic View for RHOH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOH Gene

Proteins for RHOH Gene

  • Protein details for RHOH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15669-RHOH_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoH
    Protein Accession:
    Q15669
    Secondary Accessions:

    Protein attributes for RHOH Gene

    Size:
    191 amino acids
    Molecular mass:
    21331 Da
    Quaternary structure:
    • Interacts with ZAP70 (via SH2 domains) and the interaction is enhanced by its phosphorylation by LCK. Interacts with SYK and the interaction is enhanced by its phosphorylation by FYN (By similarity). Interacts with GDI1 and GDI2. Interacts with PAK7/PAK5 (By similarity).

neXtProt entry for RHOH Gene

Proteomics data for RHOH Gene at MOPED

Post-translational modifications for RHOH Gene

  • Phosphorylated on tyrosine by LCK. Phosphorylated by FYN. Phosphorylation enhances the interactions with ZAP70 and SYK and is critical for its function in thymocyte development (By similarity).
  • Ubiquitination at Lys17, Lys138, and Lys146
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RHOH Gene

Domains for RHOH Gene

Suggested Antigen Peptide Sequences for RHOH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15669

UniProtKB/Swiss-Prot:

RHOH_HUMAN :
  • Q15669
Domain:
  • The region involved in interaction with ZAP70 is a non-canonical immunoreceptor tyrosine-based activation motif (ITAM).
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOH: view

No data available for Gene Families for RHOH Gene

Function for RHOH Gene

Molecular function for RHOH Gene

UniProtKB/Swiss-Prot Function: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.
UniProtKB/Swiss-Prot Induction: By CSF2/GM-CSF. Down-regulated by phorbol myristate acetate (PMA).

Gene Ontology (GO) - Molecular Function for RHOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity NAS 11809807
GO:0005515 protein binding IPI 11809807
GO:0005525 GTP binding IDA 11809807
GO:0017048 Rho GTPase binding NAS 11809807
GO:0019210 kinase inhibitor activity IDA 11809807
genes like me logo Genes that share ontologies with RHOH: view
genes like me logo Genes that share phenotypes with RHOH: view

Animal Models for RHOH Gene

MGI Knock Outs for RHOH:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RHOH Gene

Localization for RHOH Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOH Gene

Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Colocalizes together with ZAP70 in the immunological synapse. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOH Gene COMPARTMENTS Subcellular localization image for RHOH gene
Compartment Confidence
plasma membrane 5
cytosol 4
mitochondrion 4
extracellular 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 11809807
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOH: view

Pathways for RHOH Gene

genes like me logo Genes that share pathways with RHOH: view

Pathways by source for RHOH Gene

Gene Ontology (GO) - Biological Process for RHOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006355 regulation of transcription, DNA-templated NAS 11809807
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RHOH: view

Compounds for RHOH Gene

(7) Novoseek inferred chemical compound relationships for RHOH Gene

Compound -log(P) Hits PubMed IDs
geranylgeranyl pyrophosphate 64.9 1
gtp 54.3 9
gdp 51.2 1
toxin a 49 1
mevalonate 47.2 1
genes like me logo Genes that share compounds with RHOH: view

Transcripts for RHOH Gene

Unigene Clusters for RHOH Gene

Ras homolog family member H:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RHOH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOH Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - - -

ExUns: 10d · 10e · 10f · 10g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for RHOH Gene

GeneLoc Exon Structure for
RHOH
ECgene alternative splicing isoforms for
RHOH

Expression for RHOH Gene

mRNA expression in normal human tissues for RHOH Gene

mRNA differential expression in normal tissues according to GTEx for RHOH Gene

This gene is overexpressed in Whole Blood (10.3) and Spleen (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOH Gene

SOURCE GeneReport for Unigene cluster for RHOH Gene Hs.654594

mRNA Expression by UniProt/SwissProt for RHOH Gene

Q15669-RHOH_HUMAN
Tissue specificity: Expressed only in hematopoietic cells. Present at very high levels in the thymus, less abundant in the spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of T-helper cells than in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as cystic fibrosis, ulcerative colitis and appendicitis.
genes like me logo Genes that share expressions with RHOH: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RHOH Gene

Orthologs for RHOH Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOH 35
  • 99.48 (n)
  • 99.48 (a)
RHOH 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOH 35
  • 89.35 (n)
  • 96.34 (a)
RHOH 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOH 35
  • 91.45 (n)
  • 96.86 (a)
RHOH 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhoh 35
  • 90.58 (n)
  • 96.86 (a)
Rhoh 16
Rhoh 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOH 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOH 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhoh 35
  • 89.01 (n)
  • 96.34 (a)
chicken
(Gallus gallus)
Aves RHOH 35
  • 79.41 (n)
  • 84.29 (a)
RHOH 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOH 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhoh 35
  • 72.11 (n)
  • 77.37 (a)
zebrafish
(Danio rerio)
Actinopterygii rhoh 35
  • 67.91 (n)
  • 76.6 (a)
rhoh 36
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea crp-1 36
  • 32 (a)
OneToOne
Species with no ortholog for RHOH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOH Gene

ENSEMBL:
Gene Tree for RHOH (if available)
TreeFam:
Gene Tree for RHOH (if available)

Paralogs for RHOH Gene

Paralogs for RHOH Gene

genes like me logo Genes that share paralogs with RHOH: view

Variants for RHOH Gene

Sequence variations from dbSNP and Humsavar for RHOH Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1053504 -- 40,197,222(+) TTTTC(A/G)CCTGC utr-variant-5-prime, intron-variant
rs1053509 -- 40,244,370(+) CGAAA(A/C)CATAA utr-variant-3-prime
rs1053510 -- 40,244,508(+) AAATG(A/C)CCATA utr-variant-3-prime
rs1317160 -- 40,193,793(-) CCTGT(C/G)CCTTT intron-variant, utr-variant-5-prime
rs1317219 -- 40,193,193(+) TTGCA(A/G)TGGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RHOH Gene

Variant ID Type Subtype PubMed ID
nsv513655 OTHER Inversion 21212237
nsv513656 OTHER Inversion 21212237

Relevant External Links for RHOH Gene

HapMap Linkage Disequilibrium report
RHOH
Human Gene Mutation Database (HGMD)
RHOH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOH Gene

Disorders for RHOH Gene

UniProtKB/Swiss-Prot

RHOH_HUMAN
  • Note=A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation t(3;4)(q27;p11) with BCL6.

(1) Novoseek inferred disease relationships for RHOH Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for RHOH

Genetic Association Database (GAD)
RHOH
Human Genome Epidemiology (HuGE) Navigator
RHOH
genes like me logo Genes that share disorders with RHOH: view

Publications for RHOH Gene

  1. TTF, a gene encoding a novel small G protein, fuses to the lymphoma- associated LAZ3 gene by t(3;4) chromosomal translocation. (PMID: 7784061) Dallery E. … Kerckaert J.-P. (Oncogene 1995) 2 3 4 23
  2. Hypermutation of multiple proto-oncogenes in B-cell diffuse large- cell lymphomas. (PMID: 11460166) Pasqualucci L. … Dalla-Favera R. (Nature 2001) 3 23
  3. Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization. (PMID: 9226377) Dallery-Prudhomme E. … Galiegue-Zouitina S. (Genomics 1997) 3 23
  4. Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation. (PMID: 15563831) Lahousse S. … GaliA"gue-Zouitina S. (Gene 2004) 3 23
  5. Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma. (PMID: 10803463) Preudhomme C. … GaliA"gue-Zouitina S. (Oncogene 2000) 3 23

Products for RHOH Gene

  • Addgene plasmids for RHOH

Sources for RHOH Gene

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