External Ids for LIMK2 Gene
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for LIMK2 Gene
LIMK2 (LIM Domain Kinase 2) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and L1CAM interactions. GO annotations related to this gene include protein heterodimerization activity and protein serine/threonine kinase activity. An important paralog of this gene is LIMK1.
UniProtKB/Swiss-Prot for LIMK2 Gene
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.