Aliases for LHCGR Gene
External Ids for LHCGR Gene
Previous HGNC Symbols for LHCGR Gene
Previous GeneCards Identifiers for LHCGR Gene
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]
GeneCards Summary for LHCGR Gene
LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor) is a Protein Coding gene. Diseases associated with LHCGR include Precocious Puberty, Male and Leydig Cell Hypoplasia With Pseudohermaphroditism. Among its related pathways are Arf6 signaling events and DAG and IP3 signaling. GO annotations related to this gene include G-protein coupled receptor activity and luteinizing hormone receptor activity. An important paralog of this gene is TSHR.
UniProtKB/Swiss-Prot for LHCGR Gene
Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).