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Aliases for LHCGR Gene

Aliases for LHCGR Gene

  • Luteinizing Hormone/Choriogonadotropin Receptor 2 3
  • LCGR 3 4 6
  • LHR 3 4 6
  • Hypergonadotropic Hypogonadism 2 3
  • LH/CG-R 3 4
  • LHRHR 3 4
  • LSH-R 3 4
  • LGR2 3 4
  • Lutropin-Choriogonadotropic Hormone Receptor 3
  • Lutropin/Choriogonadotropin Receptor 3
  • Luteinizing Hormone Receptor 4
  • LH/CGR 3
  • ULG5 3
  • HHG 3

External Ids for LHCGR Gene

Previous Symbols for LHCGR Gene

  • HHG

Summaries for LHCGR Gene

Entrez Gene Summary for LHCGR Gene

  • This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

GeneCards Summary for LHCGR Gene

LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor) is a Protein Coding gene. Diseases associated with LHCGR include leydig cell hypoplasia with pseudohermaphroditism and testotoxicosis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include luteinizing hormone receptor activity and choriogonadotropin hormone binding. An important paralog of this gene is LGR6.

UniProtKB/Swiss-Prot for LHCGR Gene

  • Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase

Gene Wiki entry for LHCGR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHCGR Gene

Genomics for LHCGR Gene

Genomic Location for LHCGR Gene

Start:
48,686,774 bp from pter
End:
48,755,741 bp from pter
Size:
68,968 bases
Orientation:
Minus strand

Genomic View for LHCGR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LHCGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHCGR Gene

Regulatory Elements for LHCGR Gene

Proteins for LHCGR Gene

  • Protein details for LHCGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22888-LSHR_HUMAN
    Recommended name:
    Lutropin-choriogonadotropic hormone receptor
    Protein Accession:
    P22888
    Secondary Accessions:
    • Q14751
    • Q15996
    • Q9UEW9

    Protein attributes for LHCGR Gene

    Size:
    699 amino acids
    Molecular mass:
    78643 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LHCGR Gene

    Alternative splice isoforms for LHCGR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LHCGR Gene

Proteomics data for LHCGR Gene at MOPED

Post-translational modifications for LHCGR Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn99, Asn174, Asn195, Asn291, Asn299, and Asn313

Other Protein References for LHCGR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LHCGR Gene

Domains for LHCGR Gene

Gene Families for LHCGR Gene

HGNC:
  • GTSHR :GPCR / Class A : Gonadotropin and TSH receptors
IUPHAR :

UniProtKB/Swiss-Prot:

LSHR_HUMAN
Domain:
  • Contains 1 LRRNT domain.:
    • P22888
Family:
  • Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.:
    • P22888
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.:
    • P22888
genes like me logo Genes that share domains with LHCGR: view

Function for LHCGR Gene

Molecular function for LHCGR Gene

GENATLAS Biochemistry: luteinizing hormone/choriogonadotropin receptor,G protein coupled receptor superfamily,regulating in males,the devopment and function of Leyding cells with somatic activating mutations leading to Leyding cell and adenomes of the testis
UniProtKB/Swiss-Prot Function: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase

Gene Ontology (GO) - Molecular Function for LHCGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004964 luteinizing hormone receptor activity IBA --
GO:0008528 G-protein coupled peptide receptor activity IBA --
GO:0035472 choriogonadotropin hormone receptor activity ISS --
GO:0038106 choriogonadotropin hormone binding ISS --
genes like me logo Genes that share ontologies with LHCGR: view
genes like me logo Genes that share phenotypes with LHCGR: view

Animal Models for LHCGR Gene

MGI Knock Outs for LHCGR:

miRNA for LHCGR Gene

miRTarBase miRNAs that target LHCGR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LHCGR Gene

Localization for LHCGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHCGR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LHCGR Gene COMPARTMENTS Subcellular localization image for LHCGR gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LHCGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 10617611
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with LHCGR: view

Pathways for LHCGR Gene

genes like me logo Genes that share pathways with LHCGR: view

Gene Ontology (GO) - Biological Process for LHCGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 9626653
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7719343
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007190 activation of adenylate cyclase activity ISS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with LHCGR: view

Compounds for LHCGR Gene

(6) Drugbank Compounds for LHCGR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Buserelin
57982-77-1 target
Cetrorelix
  • Cetrorelixum [INN-Latin]
120287-85-6 target
Choriogonadotropin alfa
  • CG-beta
177073-44-8 target
Goserelin
65807-02-5 target agonist
Lutropin alfa
  • LH-B
152923-57-4 target agonist

(4) IUPHAR Ligand for LHCGR Gene

Ligand Type Action Affinity Pubmed IDs
hCG Agonist Full agonist 11.8
LH Agonist Full agonist 10.9
[125I]LH Agonist Full agonist
[125I]chorionic gonadotropin (human) Agonist Full agonist

(41) Novoseek inferred chemical compound relationships for LHCGR Gene

Compound -log(P) Hits PubMed IDs
fmpp 89.1 6
luteinizing hormone 72.1 3
testosterone 62.6 17
3beta-hydroxysteroid 57 3
progesterone 55.5 23
genes like me logo Genes that share compounds with LHCGR: view

Transcripts for LHCGR Gene

mRNA/cDNA for LHCGR Gene

(10) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LHCGR Gene

Luteinizing hormone/choriogonadotropin receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LHCGR Gene

No ASD Table

Relevant External Links for LHCGR Gene

GeneLoc Exon Structure for
LHCGR
ECgene alternative splicing isoforms for
LHCGR

Expression for LHCGR Gene

mRNA expression in normal human tissues for LHCGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHCGR Gene

This gene is overexpressed in Esophagus - Muscularis (13.1), Nerve - Tibial (8.3), Esophagus - Gastroesophageal Junction (6.7), and Ovary (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LHCGR Gene

SOURCE GeneReport for Unigene cluster for LHCGR Gene Hs.468490

mRNA Expression by UniProt/SwissProt for LHCGR Gene

P22888-LSHR_HUMAN
Tissue specificity: Gonadal and thyroid cells
genes like me logo Genes that share expressions with LHCGR: view

Orthologs for LHCGR Gene

This gene was present in the common ancestor of animals.

Orthologs for LHCGR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LHCGR 36
  • 99.48 (n)
  • 99.43 (a)
LHCGR 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LHCGR 36
  • 89.11 (n)
  • 89.11 (a)
LHCGR 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LHCGR 36
  • 90.2 (n)
  • 88.79 (a)
LHCGR 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lhcgr 36
  • 84.64 (n)
  • 85.8 (a)
Lhcgr 16
Lhcgr 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LHCGR 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LHCGR 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lhcgr 36
  • 84.89 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves LHCGR 36
  • 72.45 (n)
  • 74.65 (a)
LHCGR 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia lhcgr-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia lhcgr 36
  • 66.94 (n)
  • 68.71 (a)
zebrafish
(Danio rerio)
Actinopterygii lhcgr 36
  • 58.6 (n)
  • 55.97 (a)
lhcgr 37
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRFSH 36
  • 49.4 (n)
  • 41.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lgr1 36
  • 50.91 (n)
  • 43.16 (a)
Lgr1 37
  • 32 (a)
OneToMany
rk 38
  • 33 (a)
Fsh 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea fshr-1 36
  • 46.42 (n)
  • 32.64 (a)
fshr-1 37
  • 20 (a)
OneToMany
C50H2.1 38
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
Species with no ortholog for LHCGR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHCGR Gene

ENSEMBL:
Gene Tree for LHCGR (if available)
TreeFam:
Gene Tree for LHCGR (if available)

Paralogs for LHCGR Gene

Paralogs for LHCGR Gene

Selected SIMAP similar genes for LHCGR Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with LHCGR: view

Variants for LHCGR Gene

Sequence variations from dbSNP and Humsavar for LHCGR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_003550 -
VAR_003551 -
VAR_003552 Luteinizing hormone resistance (LHR)
VAR_003553 Familial male precocious puberty (FMPP)
VAR_003554 Familial male precocious puberty (FMPP)

Structural Variations from Database of Genomic Variants (DGV) for LHCGR Gene

Variant ID Type Subtype PubMed ID
nsv833992 CNV Gain 17160897
nsv817851 CNV Gain 17921354

Relevant External Links for LHCGR Gene

HapMap Linkage Disequilibrium report
LHCGR
Human Gene Mutation Database (HGMD)
LHCGR

Disorders for LHCGR Gene

(2) OMIM Diseases for LHCGR Gene (152790)

UniProtKB/Swiss-Prot

LSHR_HUMAN
  • Familial male precocious puberty (FMPP) [MIM:176410]: In FMPP the receptor is constitutively activated. {ECO:0000269 PubMed:11134146, ECO:0000269 PubMed:11391350, ECO:0000269 PubMed:7629248, ECO:0000269 PubMed:7692306, ECO:0000269 PubMed:7714085, ECO:0000269 PubMed:7757065, ECO:0000269 PubMed:8281137, ECO:0000269 PubMed:8829636, ECO:0000269 PubMed:8929952, ECO:0000269 PubMed:9467560, ECO:0000269 PubMed:9661624}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Luteinizing hormone resistance (LHR) [MIM:238320]: An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. {ECO:0000269 PubMed:12050206, ECO:0000269 PubMed:15372531, ECO:0000269 PubMed:15472221, ECO:0000269 PubMed:19551906, ECO:0000269 PubMed:7719343, ECO:0000269 PubMed:8559204, ECO:0000269 PubMed:9215288, ECO:0000269 PubMed:9514160, ECO:0000269 PubMed:9626144, ECO:0000269 PubMed:9626653}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for LHCGR Gene

(30) Novoseek inferred disease relationships for LHCGR Gene

Disease -log(P) Hits PubMed IDs
precocious puberty, male-limited 94.2 18
puberty precocious 81.8 30
pseudohermaphroditism male 80.1 10
leydig cell tumor 71.2 6
ovarian dysgenesis 65 1

Relevant External Links for LHCGR

Genetic Association Database (GAD)
LHCGR
Human Genome Epidemiology (HuGE) Navigator
LHCGR
genes like me logo Genes that share disorders with LHCGR: view

Publications for LHCGR Gene

  1. Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset. (PMID: 12679452) Powell B.L. … Berns E.M.J.J. (J. Clin. Endocrinol. Metab. 2003) 3 4 23 49
  2. Evidence that palmitoylation of carboxyl terminus cysteine residues of the human luteinizing hormone receptor regulates postendocytic processing. (PMID: 15539429) Munshi U.M. … Menon K.M. (Mol. Endocrinol. 2005) 3 4 23
  3. A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters. (PMID: 9626144) Stavrou S.S. … Imperato-Mcginley J. (J. Clin. Endocrinol. Metab. 1998) 3 4 23
  4. A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: correlation between receptor activity and phenotype. (PMID: 9626653) Martens J.W. … Themmen A.P. (Mol. Endocrinol. 1998) 3 4 23
  5. Polymorphisms in the coding exons of the human luteinizing hormone receptor gene. (PMID: 10215412) Wu S.-M. … Chan W.-Y. (Hum. Mutat. 1998) 3 4 23

Products for LHCGR Gene

Sources for LHCGR Gene

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