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Aliases for LHB Gene

Aliases for LHB Gene

  • Luteinizing Hormone Beta Polypeptide 2 3
  • Luteinizing Hormone Beta Subunit 2 3
  • Lutropin Beta Chain 3 4
  • LSH-Beta 3 4
  • LSH-B 3 4
  • Interstitial Cell Stimulating Hormone, Beta Chain 3
  • Interstitial Cell Stimulating Hormone 2
  • Luteinizing Hormone Subunit Beta 4
  • Beta Chain 2
  • Lutropin 2
  • CGB4 3
  • HH23 3
  • HLHB 3
  • LH-B 4

External Ids for LHB Gene

Previous GeneCards Identifiers for LHB Gene

  • GC19M050177
  • GC19M049887
  • GC19M054195
  • GC19M054211
  • GC19M049519
  • GC19M045895

Summaries for LHB Gene

Entrez Gene Summary for LHB Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

GeneCards Summary for LHB Gene

LHB (Luteinizing Hormone Beta Polypeptide) is a Protein Coding gene. Diseases associated with LHB include hypogonadotropic hypogonadism 23 with or without anosmia and leydig cell hypoplasia due to lhb deficiency. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. GO annotations related to this gene include receptor binding and hormone activity. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot for LHB Gene

  • Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids

Gene Wiki entry for LHB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHB Gene

Genomics for LHB Gene

Regulatory Elements for LHB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LHB Gene

49,015,980 bp from pter
49,017,090 bp from pter
1,111 bases
Minus strand

Genomic View for LHB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHB Gene

Proteins for LHB Gene

  • Protein details for LHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lutropin subunit beta
    Protein Accession:
    Secondary Accessions:
    • Q9UDI0

    Protein attributes for LHB Gene

    141 amino acids
    Molecular mass:
    15345 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin

    Three dimensional structures from OCA and Proteopedia for LHB Gene

neXtProt entry for LHB Gene

Proteomics data for LHB Gene at MOPED

Post-translational modifications for LHB Gene

Other Protein References for LHB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LHB Gene

Domains & Families for LHB Gene

Gene Families for LHB Gene

Suggested Antigen Peptide Sequences for LHB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycoprotein hormones subunit beta family.
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with LHB: view

Function for LHB Gene

Molecular function for LHB Gene

GENATLAS Biochemistry:
luteinizing hormone,beta polypeptide (see CGB@),whith a common genetic variant-leading in the heterozygous or homozygous type to slight but significant alterations in ovarian steroido genesis,delayed progression of puberty in males
UniProtKB/Swiss-Prot Function:
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids

Gene Ontology (GO) - Molecular Function for LHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10484773
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with LHB: view
genes like me logo Genes that share phenotypes with LHB: view

Animal Models for LHB Gene

MGI Knock Outs for LHB:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for LHB Gene

Localization for LHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHB Gene


Subcellular locations from

Jensen Localization Image for LHB Gene COMPARTMENTS Subcellular localization image for LHB gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for LHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LHB: view

Pathways & Interactions for LHB Gene

genes like me logo Genes that share pathways with LHB: view

SIGNOR curated interactions for LHB Gene


Gene Ontology (GO) - Biological Process for LHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006701 progesterone biosynthetic process TAS 14557487
GO:0007165 signal transduction TAS 10484773
GO:0007267 cell-cell signaling TAS 10484773
GO:0008584 male gonad development TAS 6785294
GO:0016486 peptide hormone processing TAS --
genes like me logo Genes that share ontologies with LHB: view

Drugs & Compounds for LHB Gene

(1) Additional Compounds for LHB Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LHB: view

Transcripts for LHB Gene

mRNA/cDNA for LHB Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LHB Gene

Luteinizing hormone beta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LHB Gene

No ASD Table

Relevant External Links for LHB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LHB Gene

mRNA expression in normal human tissues for LHB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHB Gene

This gene is overexpressed in Pituitary (x52.1).

SOURCE GeneReport for Unigene cluster for LHB Gene Hs.154704

mRNA Expression by UniProt/SwissProt for LHB Gene

Tissue specificity: Pituitary gland
genes like me logo Genes that share expression patterns with LHB: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LHB Gene

Orthologs for LHB Gene

This gene was present in the common ancestor of chordates.

Orthologs for LHB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LHB 35
  • 82.98 (n)
  • 70.92 (a)
LHB 36
  • 70 (a)
(Canis familiaris)
Mammalia LHB 35
  • 82.27 (n)
  • 74.47 (a)
LHB 36
  • 74 (a)
(Mus musculus)
Mammalia Lhb 35
  • 78.96 (n)
  • 71.63 (a)
Lhb 16
Lhb 36
  • 71 (a)
(Pan troglodytes)
Mammalia LHB 35
  • 98.11 (n)
  • 99.29 (a)
LHB 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lhb 35
  • 79.91 (n)
  • 71.63 (a)
(Monodelphis domestica)
Mammalia LHB 36
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490615 35
  • 51.82 (n)
  • 37.5 (a)
(Danio rerio)
Actinopterygii lhb 35
  • 54.95 (n)
  • 46.85 (a)
lhb 36
  • 38 (a)
Species with no ortholog for LHB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LHB Gene

Gene Tree for LHB (if available)
Gene Tree for LHB (if available)

Paralogs for LHB Gene

Paralogs for LHB Gene

(8) SIMAP similar genes for LHB Gene using alignment to 3 proteins: Pseudogenes for LHB Gene

genes like me logo Genes that share paralogs with LHB: view

Variants for LHB Gene

Sequence variations from dbSNP and Humsavar for LHB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs6521 -- 49,016,616(-) GCTGT(C/G)GAGAA reference, synonymous-codon
rs1056914 -- 49,016,598(-) TGCCC(A/C)GTGTG reference, synonymous-codon
rs1800447 Benign, - 49,016,648(-) GGCCA(C/T)GGTGC missense, reference
rs1960072 -- 49,017,245(-) GGGGC(A/G)CTCTG upstream-variant-2KB
rs2387588 -- 49,016,536(+) GCCCC(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LHB Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
esv22462 CNV Gain 19812545
nsv471416 CNV Duplication 19718026

Variation tolerance for LHB Gene

Residual Variation Intolerance Score: 87.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LHB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHB Gene

Disorders for LHB Gene

MalaCards: The human disease database

(11) MalaCards diseases for LHB Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 23 with or without anosmia
  • fertile eunuch syndrome
leydig cell hypoplasia due to lhb deficiency
  • 46,xy dsd due to lhb deficiency
gonococcal synovitis
  • gonococcal synovitis /or tenosynovitis
calcific tendinitis
drug-induced mental disorder
- elite association
Search LHB in MalaCards View complete list of genes associated with diseases


  • Hypogonadotropic hypogonadism 23 without anosmia (HH23) [MIM:228300]: A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea. {ECO:0000269 PubMed:1727547}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for LHB Gene

fertile eunuchoidism,hypogonadotropic hypogonadism,male infantilism,male infertility in heterozygotes but normal sexual development and fertility in female heterozygotes

Relevant External Links for LHB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LHB: view

Publications for LHB Gene

  1. Production of recombinant orange-spotted grouper (Epinephelus coioides) luteinizing hormone in insect cells by the baculovirus expression system and its biological effect. (PMID: 17021348) Cui M. … Haoran L. (Biol. Reprod. 2007) 23 67
  2. Sex steroids are involved in the regulation of gonadotropin-releasing hormone and dopamine D2 receptors in female tilapia pituitary. (PMID: 16807382) Levavi-Sivan B. … Fireman E. (Biol. Reprod. 2006) 23 67
  3. Structural characterisation of human recombinant glycohormones follitropin, lutropin and choriogonadotropin expressed in Chinese hamster ovary cells. (PMID: 9022688) Amoresano A. … Pucci P. (Eur. J. Biochem. 1996) 23 67
  4. The lutropin beta-subunit N-terminus facilitates subunit combination by offsetting the inhibitory effects of residues needed for LH activity. (PMID: 7589781) Slaughter S. … Moyle W.R. (Mol. Cell. Endocrinol. 1995) 23 67
  5. Structural analysis of N-linked oligosaccharides of equine chorionic gonadotropin and lutropin beta-subunits. (PMID: 7524670) Matsui T. … Ward D.N. (Biochemistry 1994) 23 67

Products for LHB Gene

Sources for LHB Gene

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