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Aliases for ARHGDIB Gene

Aliases for ARHGDIB Gene

  • Rho GDP Dissociation Inhibitor (GDI) Beta 2 3
  • GDID4 3 4 6
  • Rho-GDI Beta 3 4
  • Rho GDI 2 3 4
  • RAP1GN1 3 4
  • Ly-GDI 3 4
  • GDIA2 3 4
  • D4 3 6
  • Rho GDP-Dissociation Inhibitor 2 3
  • RhoGDI2 3
  • LYGDI 3

External Ids for ARHGDIB Gene

Previous Symbols for ARHGDIB Gene

  • RAP1GN1
  • GDIA2
  • GDID4

Summaries for ARHGDIB Gene

Entrez Gene Summary for ARHGDIB Gene

  • Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

GeneCards Summary for ARHGDIB Gene

ARHGDIB (Rho GDP Dissociation Inhibitor (GDI) Beta) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIG.

UniProtKB/Swiss-Prot for ARHGDIB Gene

  • Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them

Gene Wiki entry for ARHGDIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGDIB Gene

Genomics for ARHGDIB Gene

Genomic Location for ARHGDIB Gene

Start:
14,942,016 bp from pter
End:
14,961,728 bp from pter
Size:
19,713 bases
Orientation:
Minus strand

Genomic View for ARHGDIB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGDIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGDIB Gene

Regulatory Elements for ARHGDIB Gene

Proteins for ARHGDIB Gene

  • Protein details for ARHGDIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52566-GDIR2_HUMAN
    Recommended name:
    Rho GDP-dissociation inhibitor 2
    Protein Accession:
    P52566
    Secondary Accessions:
    • B5BU79

    Protein attributes for ARHGDIB Gene

    Size:
    201 amino acids
    Molecular mass:
    22988 Da
    Quaternary structure:
    • Interacts with RHOA.

    Three dimensional structures from OCA and Proteopedia for ARHGDIB Gene

neXtProt entry for ARHGDIB Gene

Proteomics data for ARHGDIB Gene at MOPED

Post-translational modifications for ARHGDIB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys33, Lys50, Lys63, Lys102, Lys124, Lys138, Lys164, and Lys175

Other Protein References for ARHGDIB Gene

No data available for DME Specific Peptides for ARHGDIB Gene

Domains for ARHGDIB Gene

Gene Families for ARHGDIB Gene

HGNC:

Protein Domains for ARHGDIB Gene

Suggested Antigen Peptide Sequences for ARHGDIB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52566

UniProtKB/Swiss-Prot:

GDIR2_HUMAN
Family:
  • Belongs to the Rho GDI family.:
    • P52566
genes like me logo Genes that share domains with ARHGDIB: view

Function for ARHGDIB Gene

Molecular function for ARHGDIB Gene

GENATLAS Biochemistry: Rho GDP-dissociation inhibitor (GDI) beta,aplysia related,preferentially expressed in hematopoietic cells (signal transduction)
UniProtKB/Swiss-Prot Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them

Gene Ontology (GO) - Molecular Function for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP 24554735
GO:0005094 Rho GDP-dissociation inhibitor activity IEA --
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGDIB: view
genes like me logo Genes that share phenotypes with ARHGDIB: view

Animal Models for ARHGDIB Gene

MGI Knock Outs for ARHGDIB:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGDIB Gene

Localization for ARHGDIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGDIB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGDIB Gene COMPARTMENTS Subcellular localization image for ARHGDIB gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton TAS 16130169
GO:0016023 cytoplasmic membrane-bounded vesicle TAS 9113980
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARHGDIB: view

Pathways for ARHGDIB Gene

genes like me logo Genes that share pathways with ARHGDIB: view

Gene Ontology (GO) - Biological Process for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0006955 immune response TAS 8356058
GO:0007162 negative regulation of cell adhesion TAS 9113980
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction TAS 8356058
genes like me logo Genes that share ontologies with ARHGDIB: view

Compounds for ARHGDIB Gene

(2) HMDB Compounds for ARHGDIB Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine triphosphate
  • 5'-GTP
86-01-1

(3) Novoseek inferred chemical compound relationships for ARHGDIB Gene

Compound -log(P) Hits PubMed IDs
gdp 78.1 5
gtp 50.3 1
tyrosine 10.5 2
genes like me logo Genes that share compounds with ARHGDIB: view

Transcripts for ARHGDIB Gene

Unigene Clusters for ARHGDIB Gene

Rho GDP dissociation inhibitor (GDI) beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8: -
SP9: - - - - - -
SP10: - - - - -

Relevant External Links for ARHGDIB Gene

GeneLoc Exon Structure for
ARHGDIB
ECgene alternative splicing isoforms for
ARHGDIB

Expression for ARHGDIB Gene

mRNA expression in normal human tissues for ARHGDIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGDIB Gene

This gene is overexpressed in Whole Blood (27.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGDIB Gene

SOURCE GeneReport for Unigene cluster for ARHGDIB Gene Hs.504877

genes like me logo Genes that share expressions with ARHGDIB: view

No data available for mRNA Expression by UniProt/SwissProt for ARHGDIB Gene

Orthologs for ARHGDIB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGDIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGDIB 35
  • 99 (n)
  • 100 (a)
ARHGDIB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGDIB 35
  • 89.17 (n)
  • 93.5 (a)
ARHGDIB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGDIB 35
  • 90.33 (n)
  • 94.5 (a)
ARHGDIB 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgdib 35
  • 83.5 (n)
  • 87 (a)
Arhgdib 16
Arhgdib 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGDIB 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGDIB 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgdib 35
  • 83.67 (n)
  • 84.5 (a)
chicken
(Gallus gallus)
Aves ARHGDIB 35
  • 81.5 (n)
  • 90.5 (a)
ARHGDIB 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGDIB 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia arhgdib-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgdib 35
  • 73.67 (n)
  • 77 (a)
Str.5653 35
zebrafish
(Danio rerio)
Actinopterygii arhgdig 35
  • 71.91 (n)
  • 77.53 (a)
zgc65966 35
fruit fly
(Drosophila melanogaster)
Insecta RhoGDI 36
  • 45 (a)
OneToMany
RhoGDI 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea rhi-1 36
  • 40 (a)
OneToMany
rhi-1 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDI1 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for ARHGDIB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGDIB Gene

ENSEMBL:
Gene Tree for ARHGDIB (if available)
TreeFam:
Gene Tree for ARHGDIB (if available)

Paralogs for ARHGDIB Gene

Paralogs for ARHGDIB Gene

Selected SIMAP similar genes for ARHGDIB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGDIB: view

Variants for ARHGDIB Gene

Sequence variations from dbSNP and Humsavar for ARHGDIB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs921 -- 14,942,228(-) AGCAA(C/T)TAGAG utr-variant-3-prime
rs4703 -- 14,942,624(-) CTGGC(C/G)CGAGG synonymous-codon, reference
rs918124 -- 14,956,637(+) TAATG(C/T)GGACC intron-variant
rs918125 -- 14,959,965(+) ATTAA(A/G)AAAAC intron-variant
rs1051511 -- 14,942,073(-) GAGAC(A/C)CTGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARHGDIB Gene

Variant ID Type Subtype PubMed ID
nsv469120 CNV Gain 19166990
esv268382 CNV Insertion 20981092
esv273504 CNV Insertion 20981092

Relevant External Links for ARHGDIB Gene

HapMap Linkage Disequilibrium report
ARHGDIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGDIB Gene

Disorders for ARHGDIB Gene

(1) University of Copenhagen DISEASES for ARHGDIB Gene

(1) Novoseek inferred disease relationships for ARHGDIB Gene

Disease -log(P) Hits PubMed IDs
cancer 0 2

Relevant External Links for ARHGDIB

Genetic Association Database (GAD)
ARHGDIB
Human Genome Epidemiology (HuGE) Navigator
ARHGDIB
genes like me logo Genes that share disorders with ARHGDIB: view

No data available for UniProtKB/Swiss-Prot for ARHGDIB Gene

Publications for ARHGDIB Gene

  1. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. (PMID: 8356058) Scherle P. … Staudt L.M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. (PMID: 8434008) Lelias J.M. … Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  3. Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation. (PMID: 10664460) Groysman M. … Katzav S. (FEBS Lett. 2000) 3 23
  4. Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways. (PMID: 12386169) Groysman M. … Katzav S. (J. Biol. Chem. 2002) 3 23
  5. Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells. (PMID: 18006811) Schunke D. … Dittmer J. (Cancer Res. 2007) 3 23

Products for ARHGDIB Gene

Sources for ARHGDIB Gene

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