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Aliases for LECT2 Gene

Aliases for LECT2 Gene

  • Leukocyte Cell Derived Chemotaxin 2 2 3 5
  • Leukocyte Cell-Derived Chemotaxin 2 2
  • Leukocyte Cell-Derived Chemotaxin-2 3
  • Chondromodulin-II 3
  • Chm-II 3
  • LECT-2 4
  • HLECT2 4
  • Chm2 3

External Ids for LECT2 Gene

Previous GeneCards Identifiers for LECT2 Gene

  • GC05M135158
  • GC05M135313
  • GC05M135358
  • GC05M135310
  • GC05M130471

Summaries for LECT2 Gene

Entrez Gene Summary for LECT2 Gene

  • This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

GeneCards Summary for LECT2 Gene

LECT2 (Leukocyte Cell Derived Chemotaxin 2) is a Protein Coding gene. Among its related pathways are C-MYB transcription factor network. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for LECT2 Gene

  • Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).

Gene Wiki entry for LECT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LECT2 Gene

Genomics for LECT2 Gene

Regulatory Elements for LECT2 Gene

Enhancers for LECT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G136013 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -62.8 -62824 9.2 PKNOX1 FOXA2 SIN3A FEZF1 FOS REST MAFF STAT3 NR2C1 HNF4A LECT2 SMAD5 SMAD5-AS1 LOC389332 LOC105379189 GC05P136010
GH05G135992 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -40.1 -40122 5.0 FOXA2 ARNT MLX SIN3A NFXL1 RAD21 RARA FOS THAP11 SMARCA5 LECT2 SMAD5 ENSG00000254239 IL9 SMAD5-AS1 TGFBI SLC25A48 GC05P136002
GH05G136051 1.6 Ensembl ENCODE dbSUPER 10.9 -100.9 -100928 9.0 FOXA2 PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 LECT2 ENSG00000254239 IL9 SMAD5 LOC389332 GC05M136082 TGFBI
GH05G136065 1.4 Ensembl ENCODE dbSUPER 11 -111.5 -111470 2.1 ELF3 HNRNPUL1 ZSCAN4 THRB ZNF48 RAD21 YY1 CREM EGR2 CEBPB LECT2 GC05M136082 TGFBI
GH05G136079 1.4 FANTOM5 ENCODE 11 -125.8 -125824 1.7 PKNOX1 ATF1 CREB3L1 ARNT BRCA1 YY1 GTF3C2 GATA2 ZNF143 FOS SMAD5 LECT2 SMAD5-AS1 VTRNA2-1 ENSG00000278815 ENSG00000277859
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LECT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LECT2 Gene

Chromosome:
5
Start:
135,922,279 bp from pter
End:
135,955,034 bp from pter
Size:
32,756 bases
Orientation:
Minus strand

Genomic View for LECT2 Gene

Genes around LECT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LECT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LECT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LECT2 Gene

Proteins for LECT2 Gene

  • Protein details for LECT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14960-LECT2_HUMAN
    Recommended name:
    Leukocyte cell-derived chemotaxin-2
    Protein Accession:
    O14960
    Secondary Accessions:
    • B2RA90
    • O14565
    • Q52M49

    Protein attributes for LECT2 Gene

    Size:
    151 amino acids
    Molecular mass:
    16390 Da
    Quaternary structure:
    • Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for LECT2 Gene

neXtProt entry for LECT2 Gene

Post-translational modifications for LECT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LECT2 Gene

Antibody Products

No data available for DME Specific Peptides for LECT2 Gene

Domains & Families for LECT2 Gene

Protein Domains for LECT2 Gene

Suggested Antigen Peptide Sequences for LECT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14960

UniProtKB/Swiss-Prot:

LECT2_HUMAN :
  • Belongs to the LECT2/MIM-1 family.
Family:
  • Belongs to the LECT2/MIM-1 family.
genes like me logo Genes that share domains with LECT2: view

No data available for Gene Families for LECT2 Gene

Function for LECT2 Gene

Molecular function for LECT2 Gene

GENATLAS Biochemistry:
leukocyte cell-derived chemotaxia 2,16kDa,specifically expressed in liver,identical to chondromodulin II,growth stimulator of bovine chondrocyte
UniProtKB/Swiss-Prot Function:
Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).
UniProtKB/Swiss-Prot Induction:
By phytohemagglutinin (PHA).

Gene Ontology (GO) - Molecular Function for LECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27334921
GO:0042802 identical protein binding IPI 23352894
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LECT2: view
genes like me logo Genes that share phenotypes with LECT2: view

Animal Models for LECT2 Gene

MGI Knock Outs for LECT2:

Animal Model Products

CRISPR Products

miRNA for LECT2 Gene

miRTarBase miRNAs that target LECT2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LECT2 Gene

Localization for LECT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LECT2 Gene

Cytoplasm. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LECT2 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for LECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 9266841
GO:0005737 cytoplasm TAS,IEA --
genes like me logo Genes that share ontologies with LECT2: view

Pathways & Interactions for LECT2 Gene

genes like me logo Genes that share pathways with LECT2: view

Pathways by source for LECT2 Gene

1 BioSystems pathway for LECT2 Gene

Gene Ontology (GO) - Biological Process for LECT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 9545637
GO:0006935 chemotaxis IEA,TAS --
genes like me logo Genes that share ontologies with LECT2: view

No data available for SIGNOR curated interactions for LECT2 Gene

Drugs & Compounds for LECT2 Gene

(5) Drugs for LECT2 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 6394
Immunoglobulins Pharma 6394
Liver Extracts Pharma 4067

(1) Additional Compounds for LECT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LECT2: view

Transcripts for LECT2 Gene

mRNA/cDNA for LECT2 Gene

Unigene Clusters for LECT2 Gene

Leukocyte cell-derived chemotaxin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LECT2 Gene

No ASD Table

Relevant External Links for LECT2 Gene

GeneLoc Exon Structure for
LECT2
ECgene alternative splicing isoforms for
LECT2

Expression for LECT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LECT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LECT2 Gene

This gene is overexpressed in Liver (x46.8).

NURSA nuclear receptor signaling pathways regulating expression of LECT2 Gene:

LECT2

SOURCE GeneReport for Unigene cluster for LECT2 Gene:

Hs.512580

mRNA Expression by UniProt/SwissProt for LECT2 Gene:

O14960-LECT2_HUMAN
Tissue specificity: Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.

Evidence on tissue expression from TISSUES for LECT2 Gene

  • Liver(4.7)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with LECT2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LECT2 Gene

Orthologs for LECT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LECT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LECT2 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia LECT2 34 35
  • 85.87 (n)
cow
(Bos Taurus)
Mammalia LECT2 34 35
  • 85.43 (n)
mouse
(Mus musculus)
Mammalia Lect2 34 16 35
  • 83.22 (n)
rat
(Rattus norvegicus)
Mammalia Lect2 34
  • 81.9 (n)
oppossum
(Monodelphis domestica)
Mammalia LECT2 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LECT2 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves LECT2 34 35
  • 59.6 (n)
zebrafish
(Danio rerio)
Actinopterygii lect2l 34 35
  • 58.85 (n)
BX005069.2 35
  • 53 (a)
OneToMany
BX005069.4 35
  • 42 (a)
OneToMany
LECT2 (4 of 4) 35
  • 36 (a)
OneToMany
Species where no ortholog for LECT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LECT2 Gene

ENSEMBL:
Gene Tree for LECT2 (if available)
TreeFam:
Gene Tree for LECT2 (if available)

Paralogs for LECT2 Gene

No data available for Paralogs for LECT2 Gene

Variants for LECT2 Gene

Sequence variations from dbSNP and Humsavar for LECT2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000208019 -- 135,953,801(+) CAACA(G/T)GGAAG intron-variant
rs1000845122 -- 135,951,721(+) CTTTG(-/A)AAAAC intron-variant
rs1001107852 -- 135,948,319(+) GAAAC(A/G)TAGAT intron-variant
rs1001319621 -- 135,951,094(+) ACTCT(A/G)TATTC intron-variant
rs1001478138 -- 135,956,846(+) CCTTT(C/G)AAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LECT2 Gene

Variant ID Type Subtype PubMed ID
esv2759380 CNV loss 17122850
esv3606871 CNV loss 21293372
nsv471050 CNV loss 18288195
nsv599796 CNV loss 21841781

Variation tolerance for LECT2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LECT2 Gene

Human Gene Mutation Database (HGMD)
LECT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LECT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LECT2 Gene

Disorders for LECT2 Gene

Relevant External Links for LECT2

Genetic Association Database (GAD)
LECT2
Human Genome Epidemiology (HuGE) Navigator
LECT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LECT2

No disorders were found for LECT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LECT2 Gene

Publications for LECT2 Gene

  1. Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene. (PMID: 9545637) Yamagoe S. … Suzuki K. (Genomics 1998) 2 3 4 22 64
  2. Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver. (PMID: 9524238) Yamagoe S. … Suzuki K. (Biochim. Biophys. Acta 1998) 3 4 22 64
  3. Systemic expression of a newly recognized protein, LECT2, in the human body. (PMID: 9832057) Nagai H. … Suzuki K. (Pathol. Int. 1998) 3 4 22 64
  4. Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2. (PMID: 8877413) Yamagoe S. … Suzuki K. (Immunol. Lett. 1996) 3 4 22 64
  5. Crystal structure of human leukocyte cell-derived chemotaxin 2 (LECT2) reveals a mechanistic basis of functional evolution in a mammalian protein with an M23 metalloendopeptidase fold. (PMID: 27334921) Zheng H. … Tanokura M. (J. Biol. Chem. 2016) 3 4 64

Products for LECT2 Gene

Sources for LECT2 Gene

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