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Aliases for ARHGAP4 Gene

Aliases for ARHGAP4 Gene

  • Rho GTPase Activating Protein 4 2 3
  • Rho-GAP Hematopoietic Protein C1 2 3 4
  • RGC1 3 4 6
  • Rho-Type GTPase-Activating Protein 4 3 4
  • RhoGAP4 3 4
  • P115 3 4
  • Rho GTPase-Activating Protein 4 3
  • KIAA0131 4
  • SrGAP4 3
  • C1 3

External Ids for ARHGAP4 Gene

Previous GeneCards Identifiers for ARHGAP4 Gene

  • GC0XM147310
  • GC0XM149627
  • GC0XM150758
  • GC0XM151640
  • GC0XM152693
  • GC0XM152826
  • GC0XM153172
  • GC0XM141824

Summaries for ARHGAP4 Gene

Entrez Gene Summary for ARHGAP4 Gene

  • This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for ARHGAP4 Gene

ARHGAP4 (Rho GTPase Activating Protein 4) is a Protein Coding gene. Diseases associated with ARHGAP4 include diabetes insipidus, nephrogenic. Among its related pathways are Signaling by FGFR and RhoGDI Pathway. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP4 Gene

  • Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells

Gene Wiki entry for ARHGAP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP4 Gene

Genomics for ARHGAP4 Gene

Regulatory Elements for ARHGAP4 Gene

Genomic Location for ARHGAP4 Gene

153,907,367 bp from pter
153,934,999 bp from pter
27,633 bases
Minus strand

Genomic View for ARHGAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP4 Gene

Proteins for ARHGAP4 Gene

  • Protein details for ARHGAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 4
    Protein Accession:
    Secondary Accessions:
    • Q14144
    • Q86UY3

    Protein attributes for ARHGAP4 Gene

    946 amino acids
    Molecular mass:
    105026 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARHGAP4 Gene

    Alternative splice isoforms for ARHGAP4 Gene


neXtProt entry for ARHGAP4 Gene

Proteomics data for ARHGAP4 Gene at MOPED

Post-translational modifications for ARHGAP4 Gene

  • Ubiquitination at Lys443
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP4 Gene

Domains for ARHGAP4 Gene

Gene Families for ARHGAP4 Gene

  • ARHGAP :Rho GTPase activating proteins

Suggested Antigen Peptide Sequences for ARHGAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P98171
  • Contains 1 F-BAR domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGAP4: view

Function for ARHGAP4 Gene

Molecular function for ARHGAP4 Gene

GENATLAS Biochemistry: Rho GTPase activating protein 4,155kDa,aplysia related,involved in signal transduction
UniProtKB/Swiss-Prot Function: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells

Gene Ontology (GO) - Molecular Function for ARHGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8570618
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 16417406
GO:0048365 Rac GTPase binding IBA --
genes like me logo Genes that share ontologies with ARHGAP4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGAP4 Gene

Localization for ARHGAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP4 Gene

Cytoplasm. Note=Just below the plasma membrane.

Subcellular locations from

Jensen Localization Image for ARHGAP4 Gene COMPARTMENTS Subcellular localization image for ARHGAP4 gene
Compartment Confidence
cytosol 4
nucleus 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP4: view

Pathways for ARHGAP4 Gene

genes like me logo Genes that share pathways with ARHGAP4: view

Pathways by source for ARHGAP4 Gene

Interacting Proteins for ARHGAP4 Gene

Selected Interacting proteins: P98171-RHG04_HUMAN for ARHGAP4 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for ARHGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization TAS 8570618
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction TAS 8570618
GO:0007399 nervous system development --
genes like me logo Genes that share ontologies with ARHGAP4: view

Compounds for ARHGAP4 Gene

(2) Novoseek inferred chemical compound relationships for ARHGAP4 Gene

Compound -log(P) Hits PubMed IDs
arginine 42.7 3
gtp 42.5 1
genes like me logo Genes that share compounds with ARHGAP4: view

Transcripts for ARHGAP4 Gene

Unigene Clusters for ARHGAP4 Gene

Rho GTPase activating protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP6: - - -
SP9: - - -
SP10: - - - -
SP11: - - - -
SP12: - -
SP16: -

ExUns: 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - -
SP2: - - - -
SP3: - - - - - - -
SP5: - - - -
SP7: - - -
SP8: -

Relevant External Links for ARHGAP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP4 Gene

mRNA expression in normal human tissues for ARHGAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP4 Gene

This gene is overexpressed in Whole Blood (16.4) and Spleen (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARHGAP4 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP4 Gene Hs.701324

mRNA Expression by UniProt/SwissProt for ARHGAP4 Gene

Tissue specificity: Predominantly in hematopoietic cells (spleen, thymus and leukocytes); low levels in placenta, lung and various fetal tissues
genes like me logo Genes that share expressions with ARHGAP4: view

Orthologs for ARHGAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP4 35
  • 99.66 (n)
  • 99.9 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ARHGAP4 35
  • 85.15 (n)
  • 85.82 (a)
  • 85 (a)
(Canis familiaris)
Mammalia ARHGAP4 35
  • 87.92 (n)
  • 88.74 (a)
  • 87 (a)
(Mus musculus)
Mammalia Arhgap4 35
  • 80.7 (n)
  • 81.76 (a)
Arhgap4 16
Arhgap4 36
  • 81 (a)
(Monodelphis domestica)
Mammalia ARHGAP4 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP4 36
  • 66 (a)
(Rattus norvegicus)
Mammalia Arhgap4 35
  • 81.34 (n)
  • 82.86 (a)
(Anolis carolinensis)
Reptilia ARHGAP4 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap4 35
  • 57.7 (n)
  • 52.34 (a)
(Danio rerio)
Actinopterygii arhgap4a 36
  • 40 (a)
arhgap4b 35
  • 56.33 (n)
  • 50.17 (a)
arhgap4b 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea F12F6.5 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for ARHGAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP4 Gene

Gene Tree for ARHGAP4 (if available)
Gene Tree for ARHGAP4 (if available)

Paralogs for ARHGAP4 Gene

genes like me logo Genes that share paralogs with ARHGAP4: view

Variants for ARHGAP4 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs916176 -- 153,922,218(-) CACCT(C/T)CCGGA intron-variant
rs1042856 -- 153,910,967(-) TATCG(G/T)GTGCC reference, missense
rs2070097 -- 153,910,800(-) GCCCA(C/T)GACCT synonymous-codon, reference
rs2070098 -- 153,911,163(-) CTGGT(C/G)GTGGA synonymous-codon, reference
rs2070099 -- 153,909,841(-) GGGAC(G/T)TACTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP4 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
nsv469867 CNV Complex 16826518

Relevant External Links for ARHGAP4 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP4 Gene

Disorders for ARHGAP4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARHGAP4 Gene including...

Search for ARHGAP4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ARHGAP4 Gene

(1) Novoseek inferred disease relationships for ARHGAP4 Gene

Disease -log(P) Hits PubMed IDs
diabetes insipidus nephrogenic 85.9 4

Relevant External Links for ARHGAP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ARHGAP4: view

No data available for UniProtKB/Swiss-Prot for ARHGAP4 Gene

Publications for ARHGAP4 Gene

  1. An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. (PMID: 8570618) Tribioli C. … Pelicci P.-G. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  2. Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus. (PMID: 11754100) Demura M. … Mabuchi H. (Hum. Mutat. 2002) 3 23
  3. Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes. (PMID: 18489790) Fujimoto M. … Noguchi E. (BMC Med. Genet. 2008) 3 23
  4. FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. (PMID: 12736724) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 3 23
  5. Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae. (PMID: 7981673) Tribioli C. … Toniolo D. (Hum. Mol. Genet. 1994) 3 4

Products for ARHGAP4 Gene

  • antibodies-online proteins for ARHGAP4
  • antibodies-online antibodies for ARHGAP4
  • antibodies-online kits for ARHGAP4

Sources for ARHGAP4 Gene

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