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Aliases for LBP Gene

Aliases for LBP Gene

  • Lipopolysaccharide Binding Protein 2 3
  • Lipopolysaccharide-Binding Protein 2 3
  • BPI Fold Containing Family D, Member 2 3
  • BPI Fold Containing Family D 2
  • LPS-Binding Protein 3
  • Member 2 2
  • BPIFD2 3

External Ids for LBP Gene

Previous GeneCards Identifiers for LBP Gene

  • GC20P036703
  • GC20P037613
  • GC20P037660
  • GC20P036408
  • GC20P036974
  • GC20P033709

Summaries for LBP Gene

Entrez Gene Summary for LBP Gene

  • The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

GeneCards Summary for LBP Gene

LBP (Lipopolysaccharide Binding Protein) is a Protein Coding gene. Diseases associated with LBP include infective endocarditis and bacteremia. Among its related pathways are IL6-mediated signaling events and Salmonella infection (KEGG). GO annotations related to this gene include receptor binding and lipoteichoic acid binding. An important paralog of this gene is BPI.

UniProtKB/Swiss-Prot for LBP Gene

  • Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.

Gene Wiki entry for LBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LBP Gene

Genomics for LBP Gene

Regulatory Elements for LBP Gene

Genomic Location for LBP Gene

Start:
38,346,356 bp from pter
End:
38,377,023 bp from pter
Size:
30,668 bases
Orientation:
Plus strand

Genomic View for LBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LBP Gene

Proteins for LBP Gene

  • Protein details for LBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18428-LBP_HUMAN
    Recommended name:
    Lipopolysaccharide-binding protein
    Protein Accession:
    P18428
    Secondary Accessions:
    • B2R938
    • O43438
    • Q92672
    • Q9H403
    • Q9UD66

    Protein attributes for LBP Gene

    Size:
    481 amino acids
    Molecular mass:
    53384 Da
    Quaternary structure:
    • When bound to LPS, interacts (via C-terminus) with soluble CD14.

neXtProt entry for LBP Gene

Proteomics data for LBP Gene at MOPED

Post-translational modifications for LBP Gene

  • Glycosylation at Asn300, Asn355, Asn386, and Asn394
  • Modification sites at PhosphoSitePlus

Other Protein References for LBP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

Assay Products

  • Enzo Life Sciences assays for LBP
  • antibodies-online kits for LBP

No data available for DME Specific Peptides for LBP Gene

Domains for LBP Gene

Gene Families for LBP Gene

HGNC:
  • BPIF :BPI fold containing

Suggested Antigen Peptide Sequences for LBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18428

UniProtKB/Swiss-Prot:

LBP_HUMAN :
  • P18428
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with LBP: view

Function for LBP Gene

Molecular function for LBP Gene

GENATLAS Biochemistry: lipopolysaccharide,acute-phase protein specifically binding to the lipid A moiety of liposaceharide (LPS,endotoxin) from the cell wall of Gram- bacteria binding protein,and directing it to the CD14 receptor mainly expressed by phagocytes
UniProtKB/Swiss-Prot Function: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.

Gene Ontology (GO) - Molecular Function for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding ISS 2477488
GO:0005102 receptor binding ISS 2477488
GO:0005515 protein binding IPI 21988832
GO:0008289 lipid binding --
GO:0070891 lipoteichoic acid binding IDA 12594207
genes like me logo Genes that share ontologies with LBP: view
genes like me logo Genes that share phenotypes with LBP: view

Animal Models for LBP Gene

MGI Knock Outs for LBP:

Animal Model Products

CRISPR Products

miRNA for LBP Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LBP Gene

Localization for LBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LBP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LBP Gene COMPARTMENTS Subcellular localization image for LBP gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS 2477488
GO:0009986 cell surface IDA 11528597
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LBP: view

Pathways for LBP Gene

genes like me logo Genes that share pathways with LBP: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat

Gene Ontology (GO) - Biological Process for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002232 leukocyte chemotaxis involved in inflammatory response IEA --
GO:0002281 macrophage activation involved in immune response ISS 2402637
GO:0006953 acute-phase response ISS 2477488
GO:0006968 cellular defense response ISS 2402637
genes like me logo Genes that share ontologies with LBP: view

Compounds for LBP Gene

(519) HMDB Compounds for LBP Gene

Compound Synonyms Cas Number PubMed IDs
3-Dehydrosphinganine
  • 1-Hydroxy-2-amino-3-oxo-octadecane
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
244215-65-4

(38) Novoseek inferred chemical compound relationships for LBP Gene

Compound -log(P) Hits PubMed IDs
endotoxin 85.5 108
lipoteichoic acid 68.2 16
polymyxin b 61.2 6
phospholipid 49.4 30
monophosphoryl lipid a 41.9 2
genes like me logo Genes that share compounds with LBP: view

Transcripts for LBP Gene

mRNA/cDNA for LBP Gene

(59) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LBP Gene

Lipopolysaccharide binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LBP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LBP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LBP Gene

No ASD Table

Relevant External Links for LBP Gene

GeneLoc Exon Structure for
LBP
ECgene alternative splicing isoforms for
LBP

Expression for LBP Gene

mRNA expression in normal human tissues for LBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LBP Gene

This gene is overexpressed in Liver (49.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LBP Gene

SOURCE GeneReport for Unigene cluster for LBP Gene Hs.154078

mRNA Expression by UniProt/SwissProt for LBP Gene

P18428-LBP_HUMAN
Tissue specificity: Detected in blood serum (at protein level).
genes like me logo Genes that share expressions with LBP: view

In Situ Assay Products

Orthologs for LBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LBP 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LBP 35
  • 80.68 (n)
  • 75.6 (a)
LBP 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LBP 35
  • 83.99 (n)
  • 80.22 (a)
LBP 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lbp 35
  • 76.66 (n)
  • 69.15 (a)
Lbp 16
Lbp 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LBP 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lbp 35
  • 76.17 (n)
  • 68.9 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for LBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LBP Gene

ENSEMBL:
Gene Tree for LBP (if available)
TreeFam:
Gene Tree for LBP (if available)

Paralogs for LBP Gene

Paralogs for LBP Gene

Selected SIMAP similar genes for LBP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LBP: view

Variants for LBP Gene

Sequence variations from dbSNP and Humsavar for LBP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs745144 -- 38,376,894(+) CTCCC(C/G/T)GACTG utr-variant-3-prime
rs1018470 -- 38,351,693(+) gcaat(G/T)tcctc intron-variant
rs1575056 -- 38,374,276(+) GGGGC(C/T)TGAGG intron-variant
rs1609800 -- 38,350,107(+) AAAAG(A/T)TTACT intron-variant
rs1631643 -- 38,370,399(+) TATTA(A/T)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LBP Gene

Variant ID Type Subtype PubMed ID
esv35121 CNV Gain 17911159
dgv1327e1 CNV Complex 17122850
nsv817893 CNV Gain 17921354
essv13086 CNV CNV 17122850
esv2540422 CNV Insertion 19546169
esv2666106 CNV Deletion 23128226

Relevant External Links for LBP Gene

HapMap Linkage Disequilibrium report
LBP
Human Gene Mutation Database (HGMD)
LBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LBP Gene

Disorders for LBP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (6) Diseases for LBP Gene including...

Search for LBP Gene in MalaCards »

(47) Novoseek inferred disease relationships for LBP Gene

Disease -log(P) Hits PubMed IDs
response acute phase 73.8 22
shock septic 73.5 15
gram-negative bacterial infections 70.7 4
sepsis 68.6 84
systemic inflammatory response syndrome 67.5 10

Relevant External Links for LBP

Genetic Association Database (GAD)
LBP
Human Genome Epidemiology (HuGE) Navigator
LBP
genes like me logo Genes that share disorders with LBP: view

No data available for UniProtKB/Swiss-Prot for LBP Gene

Publications for LBP Gene

  1. Structure and function of lipopolysaccharide binding protein. (PMID: 2402637) Schumann R.R. … Ulevitch R.J. (Science 1990) 3 4 23
  2. Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS- mediated cell activation. (PMID: 7517398) Wilde C.G. … Scott R.W. (J. Biol. Chem. 1994) 3 4 23
  3. The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20. (PMID: 8432532) Gray P.W. … Shows T.B. (Genomics 1993) 2 3 23
  4. The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved. (PMID: 9240454) Hubacek J.A. … Schmitz G. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  5. Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins. (PMID: 9441745) Kirschning C.J. … Schumann R.R. (Genomics 1997) 3 4 23

Products for LBP Gene

Sources for LBP Gene

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