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Aliases for LBP Gene

Aliases for LBP Gene

  • Lipopolysaccharide Binding Protein 2 3
  • BPI Fold Containing Family D, Member 2 3
  • Lipopolysaccharide-Binding Protein 2
  • BPI Fold Containing Family D 2
  • LPS-Binding Protein 3
  • Member 2 2
  • BPIFD2 3

External Ids for LBP Gene

Previous GeneCards Identifiers for LBP Gene

  • GC20P036703
  • GC20P037613
  • GC20P037660
  • GC20P036408
  • GC20P036974
  • GC20P033709

Summaries for LBP Gene

Entrez Gene Summary for LBP Gene

  • The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

GeneCards Summary for LBP Gene

LBP (Lipopolysaccharide Binding Protein) is a Protein Coding gene. Diseases associated with LBP include toxic pneumonitis and mesenteric lymphadenitis. Among its related pathways are Immune System and IL6-mediated signaling events. GO annotations related to this gene include receptor binding and lipopolysaccharide binding. An important paralog of this gene is BPI.

UniProtKB/Swiss-Prot for LBP Gene

  • Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

Gene Wiki entry for LBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LBP Gene

Genomics for LBP Gene

Regulatory Elements for LBP Gene

Genomic Location for LBP Gene

Chromosome:
20
Start:
38,346,356 bp from pter
End:
38,377,023 bp from pter
Size:
30,668 bases
Orientation:
Plus strand

Genomic View for LBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LBP Gene

Proteins for LBP Gene

  • Protein details for LBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18428-LBP_HUMAN
    Recommended name:
    Lipopolysaccharide-binding protein
    Protein Accession:
    P18428
    Secondary Accessions:
    • B2R938
    • O43438
    • Q92672
    • Q9H403
    • Q9UD66

    Protein attributes for LBP Gene

    Size:
    481 amino acids
    Molecular mass:
    53384 Da
    Quaternary structure:
    • When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

neXtProt entry for LBP Gene

Proteomics data for LBP Gene at MOPED

Post-translational modifications for LBP Gene

  • Glycosylation at Asn 300, Asn 355, Asn 386, and Asn 394
  • Modification sites at PhosphoSitePlus

Other Protein References for LBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LBP Gene

Domains & Families for LBP Gene

Gene Families for LBP Gene

Suggested Antigen Peptide Sequences for LBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18428

UniProtKB/Swiss-Prot:

LBP_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with LBP: view

Function for LBP Gene

Molecular function for LBP Gene

GENATLAS Biochemistry:
lipopolysaccharide,acute-phase protein specifically binding to the lipid A moiety of liposaceharide (LPS,endotoxin) from the cell wall of Gram- bacteria binding protein,and directing it to the CD14 receptor mainly expressed by phagocytes
UniProtKB/Swiss-Prot Function:
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

Gene Ontology (GO) - Molecular Function for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding ISS 2477488
GO:0005102 receptor binding ISS 2477488
GO:0005515 protein binding IPI 21988832
GO:0008289 lipid binding --
GO:0070891 lipoteichoic acid binding IDA 12594207
genes like me logo Genes that share ontologies with LBP: view
genes like me logo Genes that share phenotypes with LBP: view

Animal Models for LBP Gene

MGI Knock Outs for LBP:

Animal Model Products

miRNA for LBP Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LBP Gene

Localization for LBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LBP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LBP Gene COMPARTMENTS Subcellular localization image for LBP gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS 2477488
GO:0009986 cell surface IDA 11528597
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LBP: view

Pathways & Interactions for LBP Gene

genes like me logo Genes that share pathways with LBP: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002232 leukocyte chemotaxis involved in inflammatory response IEA --
GO:0002281 macrophage activation involved in immune response ISS 2402637
GO:0006953 acute-phase response ISS 2477488
genes like me logo Genes that share ontologies with LBP: view

No data available for SIGNOR curated interactions for LBP Gene

Drugs & Compounds for LBP Gene

(22) Drugs for LBP Gene - From: NovoSeek, HMDB, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menthol Approved Pharma Activator 1748
Dexamethasone Approved, Investigational Pharma Agonist 1806
Diethylcarbamazine Approved Pharma 11
Heparin Approved, Investigational Pharma Antagonist 672,226
Nitric Oxide Approved Pharma 540

(484) Additional Compounds for LBP Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with LBP: view

Transcripts for LBP Gene

mRNA/cDNA for LBP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LBP Gene

Lipopolysaccharide binding protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LBP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LBP Gene

No ASD Table

Relevant External Links for LBP Gene

GeneLoc Exon Structure for
LBP
ECgene alternative splicing isoforms for
LBP

Expression for LBP Gene

mRNA expression in normal human tissues for LBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LBP Gene

This gene is overexpressed in Liver (x49.2).

Protein differential expression in normal tissues from HIPED for LBP Gene

This gene is overexpressed in Serum (17.8), Synovial fluid (8.5), and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LBP Gene



SOURCE GeneReport for Unigene cluster for LBP Gene Hs.154078

mRNA Expression by UniProt/SwissProt for LBP Gene

P18428-LBP_HUMAN
Tissue specificity: Detected in blood serum (at protein level).
genes like me logo Genes that share expression patterns with LBP: view

Protein tissue co-expression partners for LBP Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LBP 35
  • 80.68 (n)
  • 75.6 (a)
LBP 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LBP 35
  • 83.99 (n)
  • 80.22 (a)
LBP 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lbp 35
  • 76.66 (n)
  • 69.15 (a)
Lbp 16
Lbp 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lbp 35
  • 76.17 (n)
  • 68.9 (a)
oppossum
(Monodelphis domestica)
Mammalia LBP 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LBP 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for LBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LBP Gene

ENSEMBL:
Gene Tree for LBP (if available)
TreeFam:
Gene Tree for LBP (if available)

Paralogs for LBP Gene

Paralogs for LBP Gene

(1) SIMAP similar genes for LBP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LBP: view

Variants for LBP Gene

Sequence variations from dbSNP and Humsavar for LBP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs745144 -- 38,376,894(+) CTCCC(C/G/T)GACTG utr-variant-3-prime
rs1018470 -- 38,351,693(+) gcaat(G/T)tcctc intron-variant
rs1575056 -- 38,374,276(+) GGGGC(C/T)TGAGG intron-variant
rs1609800 -- 38,350,107(+) AAAAG(A/T)TTACT intron-variant
rs1631643 -- 38,370,399(+) TATTA(A/T)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LBP Gene

Variant ID Type Subtype PubMed ID
esv35121 CNV Gain 17911159
dgv1327e1 CNV Complex 17122850
nsv817893 CNV Gain 17921354
essv13086 CNV CNV 17122850
esv2540422 CNV Insertion 19546169
esv2666106 CNV Deletion 23128226

Variation tolerance for LBP Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.80; 89.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LBP Gene

HapMap Linkage Disequilibrium report
LBP
Human Gene Mutation Database (HGMD)
LBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LBP Gene

Disorders for LBP Gene

MalaCards: The human disease database

(10) MalaCards diseases for LBP Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
toxic pneumonitis
  • acute pulmonary edema due to fumes and vapors
mesenteric lymphadenitis
  • mesenteric adenitis
infective endocarditis
  • endocarditis, infective
mastitis
  • inflammatory breast disease
appendicitis
  • acute appendicitis
- elite association
Search LBP in MalaCards View complete list of genes associated with diseases

Relevant External Links for LBP

Genetic Association Database (GAD)
LBP
Human Genome Epidemiology (HuGE) Navigator
LBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LBP
genes like me logo Genes that share disorders with LBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LBP Gene

Publications for LBP Gene

  1. High-mobility group box-1 protein, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in children with community acquired infections and bacteraemia: a prospective study. (PMID: 20158885) Pavare J. … Gardovska D. (BMC Infect. Dis. 2010) 23 67
  2. Proteomic evidence of bacterial peptide translocation in afebrile patients with cirrhosis and ascites. (PMID: 20087563) CaA+o R. … FrancAcs R. (J. Mol. Med. 2010) 23 67
  3. Lipopolysaccharide-binding protein and soluble CD14 in the vitreous fluid of patients with proliferative diabetic retinopathy. (PMID: 20175275) HernA!ndez C. … SimA^ R. (Retina (Philadelphia, Pa.) 2010) 23 67
  4. Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohn's disease and murine colitis. (PMID: 19924809) Pasternak B.A. … Denson L.A. (Inflamm. Bowel Dis. 2010) 23 67
  5. The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. (PMID: 20226507) Mueller G.A. … Pedersen L.C. (J. Allergy Clin. Immunol. 2010) 23 67

Products for LBP Gene

Sources for LBP Gene

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