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Aliases for LBP Gene

Aliases for LBP Gene

  • Lipopolysaccharide Binding Protein 2 3 5
  • BPI Fold Containing Family D, Member 2 2 3
  • Lipopolysaccharide-Binding Protein 2 3
  • LPS-Binding Protein 3
  • BPIFD2 3

External Ids for LBP Gene

Previous GeneCards Identifiers for LBP Gene

  • GC20P036703
  • GC20P037613
  • GC20P037660
  • GC20P036408
  • GC20P036974
  • GC20P033709

Summaries for LBP Gene

Entrez Gene Summary for LBP Gene

  • The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

GeneCards Summary for LBP Gene

LBP (Lipopolysaccharide Binding Protein) is a Protein Coding gene. Diseases associated with LBP include Toxic Pneumonitis and Infective Endocarditis. Among its related pathways are Bacterial infections in CF airways and Tuberculosis. GO annotations related to this gene include receptor binding and lipopolysaccharide binding. An important paralog of this gene is BPI.

UniProtKB/Swiss-Prot for LBP Gene

  • Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

Gene Wiki entry for LBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LBP Gene

Genomics for LBP Gene

Regulatory Elements for LBP Gene

Enhancers for LBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G038245 1.4 FANTOM5 ENCODE dbSUPER 6.9 -99.3 -99292 2.5 TBP PKNOX1 ZSCAN4 ARID4B DMAP1 ZNF48 ZNF121 EGR2 ZNF623 KAT8 KIAA1755 TGM2 LBP BPI ENSG00000277829
GH20G038341 1.2 Ensembl ENCODE 7.6 -3.4 -3393 2.7 PKNOX1 FOXA2 ATF1 ARID4B DMAP1 ZNF48 TCF12 SLC30A9 GATA2 SP5 BPI ENSG00000224635 SNORA71A SNORA71B LBP GC20P038342 GC20P038343 PIR48740
GH20G038230 0.7 dbSUPER 11.9 -114.6 -114606 1.7 CTCF ESRRA ZMYM3 CEBPB CEBPG ZBTB48 ADNP PRDM10 MLLT1 ZNF652 LBP ENSG00000206249 KIAA1755 ENSG00000277829 TGM2
GH20G037362 0.5 dbSUPER 4.5 -983.2 -983164 1.7 CTCF SMC3 PRDM10 RAD21 EGR2 GHRH LBP GC20M037240 RPL7AP14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LBP on UCSC Golden Path with GeneCards custom track

Genomic Location for LBP Gene

Chromosome:
20
Start:
38,346,356 bp from pter
End:
38,377,023 bp from pter
Size:
30,668 bases
Orientation:
Plus strand

Genomic View for LBP Gene

Genes around LBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LBP Gene

Proteins for LBP Gene

  • Protein details for LBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18428-LBP_HUMAN
    Recommended name:
    Lipopolysaccharide-binding protein
    Protein Accession:
    P18428
    Secondary Accessions:
    • B2R938
    • O43438
    • Q92672
    • Q9H403
    • Q9UD66

    Protein attributes for LBP Gene

    Size:
    481 amino acids
    Molecular mass:
    53384 Da
    Quaternary structure:
    • When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

neXtProt entry for LBP Gene

Post-translational modifications for LBP Gene

  • Glycosylation at posLast=300300, posLast=355355, posLast=386386, and posLast=394394
  • Modification sites at PhosphoSitePlus

Other Protein References for LBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for LBP
  • Santa Cruz Biotechnology (SCBT) Antibodies for LBP

No data available for DME Specific Peptides for LBP Gene

Domains & Families for LBP Gene

Gene Families for LBP Gene

Suggested Antigen Peptide Sequences for LBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18428

UniProtKB/Swiss-Prot:

LBP_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with LBP: view

Function for LBP Gene

Molecular function for LBP Gene

GENATLAS Biochemistry:
lipopolysaccharide,acute-phase protein specifically binding to the lipid A moiety of liposaceharide (LPS,endotoxin) from the cell wall of Gram- bacteria binding protein,and directing it to the CD14 receptor mainly expressed by phagocytes
UniProtKB/Swiss-Prot Function:
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

Gene Ontology (GO) - Molecular Function for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding ISS 2477488
GO:0005102 receptor binding ISS 2477488
GO:0005515 protein binding IPI 15294986
GO:0008289 lipid binding IEA --
GO:0070891 lipoteichoic acid binding IDA 12594207
genes like me logo Genes that share ontologies with LBP: view
genes like me logo Genes that share phenotypes with LBP: view

Animal Models for LBP Gene

MGI Knock Outs for LBP:
  • Lbp tm1Jack
  • Lbp tm1Buru
  • Lbp tm1b(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for LBP

CRISPR Products

miRNA for LBP Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LBP Gene

Localization for LBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LBP Gene

Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000250 UniProtKB:P17213}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LBP gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS 2477488
GO:0009986 cell surface IDA 11528597
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LBP: view

Pathways & Interactions for LBP Gene

genes like me logo Genes that share pathways with LBP: view

Gene Ontology (GO) - Biological Process for LBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002232 leukocyte chemotaxis involved in inflammatory response IEA --
GO:0002281 macrophage activation involved in immune response IMP,ISS 2402637
GO:0002376 immune system process IEA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with LBP: view

No data available for SIGNOR curated interactions for LBP Gene

Drugs & Compounds for LBP Gene

(25) Drugs for LBP Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menthol Approved Pharma Partial agonist, Activator 2606
Sphingosine Experimental Pharma 0
Eleuthero Nutra 10
Goji Nutra 12
Lycium Nutra 12

(482) Additional Compounds for LBP Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Dehydrosphinganine
  • (2S)-2-amino-1-hydroxyoctadecan-3-one
  • 1-Hydroxy-2-amino-3-oxo-octadecane
  • 2-Amino-1-hydroxy-3-Octadecanone
  • 3-Dehydro-D-sphinganine
  • 3-Dehydrosphinganine
16105-69-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
genes like me logo Genes that share compounds with LBP: view

Transcripts for LBP Gene

mRNA/cDNA for LBP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LBP Gene

Lipopolysaccharide binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LBP Gene

No ASD Table

Relevant External Links for LBP Gene

GeneLoc Exon Structure for
LBP
ECgene alternative splicing isoforms for
LBP

Expression for LBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LBP Gene

This gene is overexpressed in Liver (x49.2).

Protein differential expression in normal tissues from HIPED for LBP Gene

This gene is overexpressed in Serum (17.8), Synovial fluid (8.5), and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LBP Gene



Protein tissue co-expression partners for LBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LBP Gene:

LBP

SOURCE GeneReport for Unigene cluster for LBP Gene:

Hs.154078

mRNA Expression by UniProt/SwissProt for LBP Gene:

P18428-LBP_HUMAN
Tissue specificity: Detected in blood serum (at protein level).

Evidence on tissue expression from TISSUES for LBP Gene

  • Liver(4.7)
  • Blood(2.7)
  • Intestine(2.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with LBP: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LBP Gene

Orthologs for LBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LBP 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LBP 34 35
  • 83.99 (n)
cow
(Bos Taurus)
Mammalia LBP 34 35
  • 80.68 (n)
mouse
(Mus musculus)
Mammalia Lbp 34 16 35
  • 76.66 (n)
rat
(Rattus norvegicus)
Mammalia Lbp 34
  • 76.17 (n)
oppossum
(Monodelphis domestica)
Mammalia LBP 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for LBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LBP Gene

ENSEMBL:
Gene Tree for LBP (if available)
TreeFam:
Gene Tree for LBP (if available)

Paralogs for LBP Gene

Paralogs for LBP Gene

(1) SIMAP similar genes for LBP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LBP: view

Variants for LBP Gene

Sequence variations from dbSNP and Humsavar for LBP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2232613 Uncertain significance 38,369,011(+) CTACC(C/T)CAACA reference, missense
rs1000008739 -- 38,374,621(+) AAAAA(-/AAAG)AAAGA intron-variant
rs1000124144 -- 38,362,977(+) CATGA(A/G)GTCCA intron-variant
rs1000255860 -- 38,351,784(+) GGGAG(A/G)CTGAG intron-variant
rs1000286293 -- 38,365,884(+) CTCAA(A/T)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LBP Gene

Variant ID Type Subtype PubMed ID
esv2666106 CNV deletion 23128226
esv2758794 CNV gain 17122850
esv3429648 CNV duplication 20981092
esv35121 CNV gain 17911159
esv3645775 CNV loss 21293372
nsv1058457 CNV loss 25217958
nsv1063495 CNV gain 25217958
nsv817893 CNV gain 17921354

Variation tolerance for LBP Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.80; 89.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LBP Gene

Human Gene Mutation Database (HGMD)
LBP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LBP Gene

Disorders for LBP Gene

MalaCards: The human disease database

(10) MalaCards diseases for LBP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
toxic pneumonitis
  • acute chemical fume pulmonary edema
infective endocarditis
  • endocarditis, infective
mesenteric lymphadenitis
  • mesenteric adenitis
mastitis
  • breast inflammation
alcoholic hepatitis
  • acute alcoholic hepatitis
- elite association - COSMIC cancer census association via MalaCards
Search LBP in MalaCards View complete list of genes associated with diseases

Relevant External Links for LBP

Genetic Association Database (GAD)
LBP
Human Genome Epidemiology (HuGE) Navigator
LBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LBP
genes like me logo Genes that share disorders with LBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LBP Gene

Publications for LBP Gene

  1. Lipopolysaccharide-binding protein (LBP) gene polymorphisms: rapid genotyping by real-time PCR and association with infective endocarditis. (PMID: 19560454) Vollmer T. … Dreier J. (Clin. Biochem. 2009) 3 22 46 64
  2. A common haplotype of the LBP gene predisposes to severe sepsis. (PMID: 19707138) Flores C. … Villar J. (Crit. Care Med. 2009) 3 22 46 64
  3. Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation. (PMID: 18056482) Chien J.W. … Clark J.G. (Blood 2008) 3 22 46 64
  4. Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. (PMID: 12521224) Hubacek J.A. … Poledne R. (Clin. Chem. Lab. Med. 2002) 3 22 46 64
  5. Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. (PMID: 11373419) Hubacek J.A. … Schmitz G. (Crit. Care Med. 2001) 3 22 46 64

Products for LBP Gene

Sources for LBP Gene

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