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Aliases for LAMP1 Gene

Aliases for LAMP1 Gene

  • Lysosomal Associated Membrane Protein 1 2 3 5
  • Lysosome-Associated Membrane Protein 1 3 4
  • CD107 Antigen-Like Family Member A 3 4
  • LAMP-1 3 4
  • Lysosome-Associated Membrane Glycoprotein 1 3
  • Lysosomal-Associated Membrane Protein 1 2
  • CD107a Antigen 4
  • CD107a 3
  • LGP120 3
  • LAMPA 3

External Ids for LAMP1 Gene

Previous GeneCards Identifiers for LAMP1 Gene

  • GC13P112561
  • GC13P108588
  • GC13P113038
  • GC13P111899
  • GC13P112999
  • GC13P113951
  • GC13P094391

Summaries for LAMP1 Gene

Entrez Gene Summary for LAMP1 Gene

  • The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAMP1 Gene

LAMP1 (Lysosomal Associated Membrane Protein 1) is a Protein Coding gene. Diseases associated with LAMP1 include Salla Disease and Hermansky-Pudlak Syndrome 2. Among its related pathways are Tuberculosis and Innate Immune System. GO annotations related to this gene include enzyme binding and protein domain specific binding. An important paralog of this gene is LAMP2.

UniProtKB/Swiss-Prot for LAMP1 Gene

  • Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

  • Acts as a receptor for Lassa virus protein.

Gene Wiki entry for LAMP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMP1 Gene

Genomics for LAMP1 Gene

Regulatory Elements for LAMP1 Gene

Enhancers for LAMP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G113272 1.5 FANTOM5 Ensembl ENCODE 17.7 -22.9 -22918 3.3 NFIB RAD21 RARA CHAMP1 RFX5 YY1 FOS ZNF263 SMARCC1 ZNF362 LAMP1 PROZ CUL4A GRTP1 PCID2 DCUN1D2-AS DCUN1D2 LDHBP1 LOC105370377
GH13G113182 1.6 Ensembl ENCODE dbSUPER 10.6 -110.9 -110881 6.5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 PROZ CUL4A PCID2 KARSP2 F10-AS1 F10 GRTP1 F7 LAMP1 ENSG00000269356
GH13G113206 1.4 ENCODE dbSUPER 10.2 -88.3 -88280 5.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 TUBGCP3 PROZ GAS6-AS1 LAMP1 PCID2 CUL4A
GH13G113192 1 ENCODE dbSUPER 10.4 -103.6 -103635 2.0 FOXA2 CEBPG ZIC2 ZNF316 RCOR1 ZNF600 NFE2 MAFK NFE2L2 MAFG PROZ GRTP1-AS1 GRTP1 LAMP1 DCUN1D2-AS DCUN1D2 CUL4A ENSG00000269125
GH13G113327 0.7 ENCODE 11.8 +30.6 30602 1.3 KLF1 KLF17 ZIC2 GLIS2 PRDM10 ZNF600 KLF8 ZHX1 BHLHE40 ZNF843 GRTP1-AS1 GRTP1 LAMP1 F7 DCUN1D2 DCUN1D2-AS GC13P113323 PIR60275 ENSG00000276434
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LAMP1 on UCSC Golden Path with GeneCards custom track

Promoters for LAMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066113 379 2201 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610

Genomic Location for LAMP1 Gene

Chromosome:
13
Start:
113,297,121 bp from pter
End:
113,323,672 bp from pter
Size:
26,552 bases
Orientation:
Plus strand

Genomic View for LAMP1 Gene

Genes around LAMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMP1 Gene

Proteins for LAMP1 Gene

  • Protein details for LAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11279-LAMP1_HUMAN
    Recommended name:
    Lysosome-associated membrane glycoprotein 1
    Protein Accession:
    P11279
    Secondary Accessions:
    • B4DWL3
    • Q8WU33
    • Q96I40
    • Q9BRD2
    • Q9NP13

    Protein attributes for LAMP1 Gene

    Size:
    417 amino acids
    Molecular mass:
    44882 Da
    Quaternary structure:
    • (Microbial infection) Interacts with Lassa virus protein glycoprotein.

    Alternative splice isoforms for LAMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAMP1 Gene

Post-translational modifications for LAMP1 Gene

  • O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.
  • Glycosylation at posLast=3737, posLast=4545, posLast=6262, isoforms=276, posLast=8484, isoforms=2103, posLast=107107, isoforms=2121, posLast=130130, isoforms=165, posLast=181181, isoforms=2197, isoforms=2199, isoforms=2200, posLast=207207, isoforms=2209, posLast=211211, isoforms=2223, isoforms=2228, posLast=241241, isoforms=2249, posLast=261261, isoforms=2293, posLast=322322, and isoforms=2331
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LAMP1 (LAMP-1/CD107a)
  • Cell Signaling Technology (CST) Antibodies for LAMP1 (LAMP1)
  • Cloud-Clone Corp. Antibodies for LAMP1

No data available for DME Specific Peptides for LAMP1 Gene

Domains & Families for LAMP1 Gene

Gene Families for LAMP1 Gene

Suggested Antigen Peptide Sequences for LAMP1 Gene

Graphical View of Domain Structure for InterPro Entry

P11279

UniProtKB/Swiss-Prot:

LAMP1_HUMAN :
  • Belongs to the LAMP family.
Family:
  • Belongs to the LAMP family.
genes like me logo Genes that share domains with LAMP1: view

Function for LAMP1 Gene

Molecular function for LAMP1 Gene

GENATLAS Biochemistry:
lysosomal associated membrane protein 1
UniProtKB/Swiss-Prot Function:
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
UniProtKB/Swiss-Prot Function:
Acts as a receptor for Lassa virus protein.

Gene Ontology (GO) - Molecular Function for LAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 23394946
GO:0019899 enzyme binding IPI 22641697
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with LAMP1: view
genes like me logo Genes that share phenotypes with LAMP1: view

Animal Models for LAMP1 Gene

MGI Knock Outs for LAMP1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LAMP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LAMP1 Gene

Localization for LAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMP1 Gene

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250 UniProtKB:P05300, ECO:0000269 PubMed:16176980, ECO:0000269 PubMed:17897319}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LAMP1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
endosome 5
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21266579
GO:0005764 colocalizes_with lysosome IDA,TAS 15613468
GO:0005765 lysosomal membrane ISS --
GO:0005768 endosome IEA --
GO:0005770 late endosome IDA 15052268
genes like me logo Genes that share ontologies with LAMP1: view

Pathways & Interactions for LAMP1 Gene

genes like me logo Genes that share pathways with LAMP1: view

Pathways by source for LAMP1 Gene

1 Cell Signaling Technology pathway for LAMP1 Gene
1 BioSystems pathway for LAMP1 Gene
3 Reactome pathways for LAMP1 Gene

Gene Ontology (GO) - Biological Process for LAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008626 granzyme-mediated apoptotic signaling pathway IMP 23632890
GO:0016032 viral process IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0043323 positive regulation of natural killer cell degranulation IMP 23632890
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP 23632890
genes like me logo Genes that share ontologies with LAMP1: view

No data available for SIGNOR curated interactions for LAMP1 Gene

Drugs & Compounds for LAMP1 Gene

(7) Drugs for LAMP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for LAMP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LAMP1: view

Transcripts for LAMP1 Gene

Unigene Clusters for LAMP1 Gene

Lysosomal-associated membrane protein 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LAMP1

Alternative Splicing Database (ASD) splice patterns (SP) for LAMP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - -
SP2:
SP3:
SP4: - -
SP5: - -
SP6: - - - - -
SP7: -

Relevant External Links for LAMP1 Gene

GeneLoc Exon Structure for
LAMP1
ECgene alternative splicing isoforms for
LAMP1

Expression for LAMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LAMP1 Gene

This gene is overexpressed in Nasal epithelium (12.9) and Amniocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LAMP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of LAMP1 Gene:

LAMP1

SOURCE GeneReport for Unigene cluster for LAMP1 Gene:

Hs.494419

Evidence on tissue expression from TISSUES for LAMP1 Gene

  • Nervous system(4.9)
  • Pancreas(4.7)
  • Liver(4.6)
  • Bone marrow(4.4)
  • Lung(3.8)
  • Intestine(3.6)
  • Skin(3.6)
  • Spleen(3.4)
  • Kidney(3.3)
  • Blood(3.2)
  • Lymph node(3)
  • Heart(2.8)
  • Stomach(2.8)
  • Muscle(2.4)
  • Eye(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with LAMP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LAMP1 Gene

Orthologs for LAMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAMP1 34 35
  • 98.8 (n)
dog
(Canis familiaris)
Mammalia LAMP1 34 35
  • 83.17 (n)
cow
(Bos Taurus)
Mammalia LAMP1 34 35
  • 76.96 (n)
mouse
(Mus musculus)
Mammalia Lamp1 34 16 35
  • 73.89 (n)
rat
(Rattus norvegicus)
Mammalia Lamp1 34
  • 72.48 (n)
oppossum
(Monodelphis domestica)
Mammalia LAMP1 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMP1 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves LAMP1 34 35
  • 57.16 (n)
lizard
(Anolis carolinensis)
Reptilia LAMP1 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC563328 34
  • 54.92 (n)
LAMP1 (1 of 2) 35
  • 41 (a)
OneToMany
lamp1 35
  • 39 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Lamp1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
Species where no ortholog for LAMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMP1 Gene

ENSEMBL:
Gene Tree for LAMP1 (if available)
TreeFam:
Gene Tree for LAMP1 (if available)

Paralogs for LAMP1 Gene

Paralogs for LAMP1 Gene

(1) SIMAP similar genes for LAMP1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for LAMP1 Gene

genes like me logo Genes that share paralogs with LAMP1: view

Variants for LAMP1 Gene

Sequence variations from dbSNP and Humsavar for LAMP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000001261 -- 113,315,738(+) AGGAA(A/G)TGAAG intron-variant
rs1000293289 -- 113,313,444(+) AACAC(C/G)CATGT intron-variant
rs1000373041 -- 113,297,366(+) CAGCG(C/T)CCGGC utr-variant-5-prime
rs1000552257 -- 113,299,550(+) GAGCC(A/C)CCGTA intron-variant
rs1000570531 -- 113,308,321(+) TCCAA(C/G)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAMP1 Gene

Variant ID Type Subtype PubMed ID
esv2748273 CNV deletion 23290073
esv3633598 CNV loss 21293372
nsv1048814 CNV gain 25217958
nsv509521 CNV insertion 20534489
nsv563316 CNV loss 21841781
nsv563317 CNV loss 21841781
nsv563318 CNV loss 21841781
nsv951927 CNV deletion 24416366

Variation tolerance for LAMP1 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LAMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMP1 Gene

Disorders for LAMP1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for LAMP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
salla disease
  • sialuria, finnish type
hermansky-pudlak syndrome 2
  • platelet storage pool deficiency
lysosomal acid phosphatase deficiency
  • acid phosphatase deficiency
tuberculosis
  • kochs disease
hemophagocytic lymphohistiocytosis
  • haemophagocytic syndrome
- elite association - COSMIC cancer census association via MalaCards
Search LAMP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LAMP1

Genetic Association Database (GAD)
LAMP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMP1
genes like me logo Genes that share disorders with LAMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAMP1 Gene

Publications for LAMP1 Gene

  1. The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp- 2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes. (PMID: 8517882) Sawada R. … Fukuda M. (J. Biol. Chem. 1993) 3 4 22 64
  2. The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones. (PMID: 2243102) Carlsson S.R. … Fukuda M. (J. Biol. Chem. 1990) 3 4 22 64
  3. Virus entry. Lassa virus entry requires a trigger-induced receptor switch. (PMID: 24970085) Jae L.T. … Brummelkamp T.R. (Science 2014) 3 4 64
  4. Relationship between CD107a expression and cytotoxic activity. (PMID: 18835598) Aktas E. … Deniz G. (Cell. Immunol. 2009) 3 22 64
  5. Differential expression of LAMPs and ubiquitin in human thymus. (PMID: 19343823) Sarafian V.S. … Gulubova M.V. (APMIS 2009) 3 22 64

Products for LAMP1 Gene

  • Addgene plasmids for LAMP1

Sources for LAMP1 Gene

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