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Aliases for LAMP1 Gene

Aliases for LAMP1 Gene

  • Lysosomal-Associated Membrane Protein 1 2 3
  • Lysosome-Associated Membrane Protein 1 3 4
  • CD107 Antigen-Like Family Member A 3 4
  • LAMP-1 3 4
  • CD107a Antigen 4
  • CD107a 3
  • LGP120 3
  • LAMPA 3

External Ids for LAMP1 Gene

Previous GeneCards Identifiers for LAMP1 Gene

  • GC13P112561
  • GC13P108588
  • GC13P113038
  • GC13P111899
  • GC13P112999
  • GC13P113951
  • GC13P094391

Summaries for LAMP1 Gene

Entrez Gene Summary for LAMP1 Gene

  • The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAMP1 Gene

LAMP1 (Lysosomal-Associated Membrane Protein 1) is a Protein Coding gene. Diseases associated with LAMP1 include salla disease and lysosomal acid phosphatase deficiency. Among its related pathways are Cytoskeletal Signaling and Lysosome. GO annotations related to this gene include enzyme binding and protein domain specific binding. An important paralog of this gene is LAMP3.

UniProtKB/Swiss-Prot for LAMP1 Gene

  • Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis

  • Acts as a receptor for Lassa virus protein.

Gene Wiki entry for LAMP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMP1 Gene

Genomics for LAMP1 Gene

Regulatory Elements for LAMP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LAMP1 Gene

Chromosome:
13
Start:
113,297,121 bp from pter
End:
113,323,672 bp from pter
Size:
26,552 bases
Orientation:
Plus strand

Genomic View for LAMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMP1 Gene

Proteins for LAMP1 Gene

  • Protein details for LAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11279-LAMP1_HUMAN
    Recommended name:
    Lysosome-associated membrane glycoprotein 1
    Protein Accession:
    P11279
    Secondary Accessions:
    • B4DWL3
    • Q8WU33
    • Q96I40
    • Q9BRD2
    • Q9NP13

    Protein attributes for LAMP1 Gene

    Size:
    417 amino acids
    Molecular mass:
    44882 Da
    Quaternary structure:
    • (Microbial infection) Interacts with Lassa virus protein glycoprotein.

    Alternative splice isoforms for LAMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAMP1 Gene

Proteomics data for LAMP1 Gene at MOPED

Post-translational modifications for LAMP1 Gene

  • O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.
  • Glycosylation at Asn 37, Asn 45, Asn 62, Asn 76, Asn 84, Asn 103, Asn 107, Asn 121, Asn 130, Asn 165, Asn 181, Ser 197, Thr 199, Thr 200, Ser 207, Ser 209, Ser 211, Asn 223, Asn 228, Asn 241, Asn 249, Asn 261, Asn 293, Asn 322, and Thr 331
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LAMP1 (LAMP-1/CD107a)
  • Cell Signaling Technology (CST) Antibodies for LAMP1 (LAMP1)

No data available for DME Specific Peptides for LAMP1 Gene

Domains & Families for LAMP1 Gene

Gene Families for LAMP1 Gene

Protein Domains for LAMP1 Gene

Suggested Antigen Peptide Sequences for LAMP1 Gene

Graphical View of Domain Structure for InterPro Entry

P11279

UniProtKB/Swiss-Prot:

LAMP1_HUMAN :
  • Belongs to the LAMP family.
Family:
  • Belongs to the LAMP family.
genes like me logo Genes that share domains with LAMP1: view

Function for LAMP1 Gene

Molecular function for LAMP1 Gene

GENATLAS Biochemistry:
lysosomal associated membrane protein 1
UniProtKB/Swiss-Prot Function:
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis
UniProtKB/Swiss-Prot Function:
Acts as a receptor for Lassa virus protein.

Gene Ontology (GO) - Molecular Function for LAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 23394946
GO:0019899 enzyme binding IPI 22641697
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with LAMP1: view
genes like me logo Genes that share phenotypes with LAMP1: view

Animal Models for LAMP1 Gene

MGI Knock Outs for LAMP1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAMP1

Clone Products

  • Addgene plasmids for LAMP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LAMP1 Gene

Localization for LAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMP1 Gene

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAMP1 Gene COMPARTMENTS Subcellular localization image for LAMP1 gene
Compartment Confidence
endosome 5
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21266579
GO:0005764 colocalizes_with lysosome IDA 15613468
GO:0005768 endosome --
GO:0005770 late endosome IDA 15052268
GO:0005771 multivesicular body IEA --
genes like me logo Genes that share ontologies with LAMP1: view

Pathways & Interactions for LAMP1 Gene

genes like me logo Genes that share pathways with LAMP1: view

Pathways by source for LAMP1 Gene

1 Cell Signaling Technology pathway for LAMP1 Gene
1 BioSystems pathway for LAMP1 Gene
3 KEGG pathways for LAMP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0008626 granzyme-mediated apoptotic signaling pathway IMP 23632890
GO:0016032 viral process --
GO:0043323 positive regulation of natural killer cell degranulation IMP 23632890
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP 23632890
genes like me logo Genes that share ontologies with LAMP1: view

No data available for SIGNOR curated interactions for LAMP1 Gene

Drugs & Compounds for LAMP1 Gene

(7) Drugs for LAMP1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Epinephrine Approved Pharma 768
Iron Approved Pharma 957
Valsartan Approved, Investigational Pharma Antagonist Angiotensin II AT1 receptor antagonist, High affinity, selective AT1 antagonist 260
Formaldehyde Experimental Pharma 65
Sucrose Experimental Pharma 0

(8) Additional Compounds for LAMP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
DMSO
Dopachrome
Ganglioside
Latex
genes like me logo Genes that share compounds with LAMP1: view

Transcripts for LAMP1 Gene

Unigene Clusters for LAMP1 Gene

Lysosomal-associated membrane protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAMP1

Clone Products

  • Addgene plasmids for LAMP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - -
SP2:
SP3:
SP4: - -
SP5: - -
SP6: - - - - -
SP7: -

Relevant External Links for LAMP1 Gene

GeneLoc Exon Structure for
LAMP1
ECgene alternative splicing isoforms for
LAMP1

Expression for LAMP1 Gene

mRNA expression in normal human tissues for LAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LAMP1 Gene

This gene is overexpressed in Nasal epithelium (12.9) and Amniocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAMP1 Gene



SOURCE GeneReport for Unigene cluster for LAMP1 Gene Hs.494419

genes like me logo Genes that share expression patterns with LAMP1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LAMP1 Gene

Orthologs for LAMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LAMP1 35
  • 76.96 (n)
  • 72.55 (a)
LAMP1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LAMP1 35
  • 83.17 (n)
  • 81.8 (a)
LAMP1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lamp1 35
  • 73.89 (n)
  • 67.98 (a)
Lamp1 16
Lamp1 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LAMP1 35
  • 98.8 (n)
  • 98.08 (a)
LAMP1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lamp1 35
  • 72.48 (n)
  • 65.11 (a)
oppossum
(Monodelphis domestica)
Mammalia LAMP1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LAMP1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves LAMP1 35
  • 57.16 (n)
  • 50.39 (a)
LAMP1 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LAMP1 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
LOC563328 35
  • 54.92 (n)
  • 48.7 (a)
lamp1 36
  • 39 (a)
OneToMany
LAMP1 (1 of 2) 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Lamp1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for LAMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAMP1 Gene

ENSEMBL:
Gene Tree for LAMP1 (if available)
TreeFam:
Gene Tree for LAMP1 (if available)

Paralogs for LAMP1 Gene

Paralogs for LAMP1 Gene

(1) SIMAP similar genes for LAMP1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for LAMP1 Gene

genes like me logo Genes that share paralogs with LAMP1: view

Variants for LAMP1 Gene

Sequence variations from dbSNP and Humsavar for LAMP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_046450 -

Structural Variations from Database of Genomic Variants (DGV) for LAMP1 Gene

Variant ID Type Subtype PubMed ID
nsv901039 CNV Loss 21882294
nsv901049 CNV Loss 21882294
dgv1802n71 CNV Loss 21882294
nsv509521 CNV Insertion 20534489
esv2748273 CNV Deletion 23290073

Variation tolerance for LAMP1 Gene

Residual Variation Intolerance Score: 26.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAMP1 Gene

HapMap Linkage Disequilibrium report
LAMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMP1 Gene

Disorders for LAMP1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for LAMP1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
salla disease
  • sialuria
lysosomal acid phosphatase deficiency
  • lysosomal acid phosphatase
progesterone-receptor positive breast cancer
hemophagocytic lymphohistiocytosis
  • hemophagocytic lymphohistiocytosis, familial, 2
gaucher's disease
  • lipoid histiocytosis
- elite association
Search LAMP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LAMP1

Genetic Association Database (GAD)
LAMP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAMP1
genes like me logo Genes that share disorders with LAMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LAMP1 Gene

Publications for LAMP1 Gene

  1. Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis. (PMID: 20212459) Sasaki M. … Nakanuma Y. (Lab. Invest. 2010) 23 67
  2. Rabies DNA vaccine: no impact of MHC class I and class II targeting sequences on immune response and protection against lethal challenge. (PMID: 19356616) Kaur M. … Bhatnagar R. (Vaccine 2009) 23 67
  3. Differential expression of LAMPs and ubiquitin in human thymus. (PMID: 19343823) Sarafian V.S. … Gulubova M.V. (APMIS 2009) 23 67
  4. Relationship between CD107a expression and cytotoxic activity. (PMID: 18835598) Aktas E. … Deniz G. (Cell. Immunol. 2009) 23 67
  5. Glycolipid-dependent sorting of melanosomal from lysosomal membrane proteins by lumenal determinants. (PMID: 18373728) Groux-Degroote S. … Sprong H. (Traffic 2008) 23 67

Products for LAMP1 Gene

Sources for LAMP1 Gene

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