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Aliases for LAMC1 Gene

Aliases for LAMC1 Gene

  • Laminin, Gamma 1 (Formerly LAMB2) 2 3
  • LAMB2 3 4 6
  • Laminin-10 Subunit Gamma 3 4
  • Laminin-11 Subunit Gamma 3 4
  • Laminin-2 Subunit Gamma 3 4
  • Laminin-3 Subunit Gamma 3 4
  • Laminin-4 Subunit Gamma 3 4
  • Laminin-6 Subunit Gamma 3 4
  • Laminin-7 Subunit Gamma 3 4
  • Laminin-8 Subunit Gamma 3 4
  • Laminin-9 Subunit Gamma 3 4
  • S-Laminin Subunit Gamma 3 4
  • Laminin B2 Chain 3 4
  • S-LAM Gamma 3 4
  • Laminin Subunit Gamma-1 3
  • Laminin-1 Subunit Gamma 4

External Ids for LAMC1 Gene

Previous HGNC Symbols for LAMC1 Gene

  • LAMB2

Previous GeneCards Identifiers for LAMC1 Gene

  • GC01P180518
  • GC01P178420
  • GC01P179512
  • GC01P180231
  • GC01P179724
  • GC01P181259
  • GC01P154228

Summaries for LAMC1 Gene

Entrez Gene Summary for LAMC1 Gene

  • Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]

GeneCards Summary for LAMC1 Gene

LAMC1 (Laminin, Gamma 1 (Formerly LAMB2)) is a Protein Coding gene. Diseases associated with LAMC1 include diffuse mesangial sclerosis and junctional epidermolysis bullosa inversa. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include extracellular matrix structural constituent and glycosphingolipid binding. An important paralog of this gene is LAMC2.

UniProtKB/Swiss-Prot for LAMC1 Gene

  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

Gene Wiki entry for LAMC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAMC1 Gene

Genomics for LAMC1 Gene

Regulatory Elements for LAMC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LAMC1 Gene

183,023,460 bp from pter
183,145,592 bp from pter
122,133 bases
Plus strand

Genomic View for LAMC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAMC1 Gene

Proteins for LAMC1 Gene

  • Protein details for LAMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Laminin subunit gamma-1
    Protein Accession:
    Secondary Accessions:
    • Q5VYE7

    Protein attributes for LAMC1 Gene

    1609 amino acids
    Molecular mass:
    177603 Da
    Quaternary structure:
    • Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521)

neXtProt entry for LAMC1 Gene

Proteomics data for LAMC1 Gene at MOPED

Post-translational modifications for LAMC1 Gene

  • Glycosylation at Asn60, Asn134, Asn576, Asn650, Asn1022, Asn1107, Asn1161, Asn1175, Asn1205, Asn1223, Asn1241, Asn1380, Asn1395, Asn1439, and Thr1603
  • Modification sites at PhosphoSitePlus

Other Protein References for LAMC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LAMC1 (Laminin gamma 1)

No data available for DME Specific Peptides for LAMC1 Gene

Domains for LAMC1 Gene

Gene Families for LAMC1 Gene

Suggested Antigen Peptide Sequences for LAMC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure
  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure
  • Domains VI and IV are globular
  • Contains 11 laminin EGF-like domains.
  • Contains 1 laminin IV type A domain.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with LAMC1: view

Function for LAMC1 Gene

Molecular function for LAMC1 Gene

GENATLAS Biochemistry:
laminin,gamma 1 polypeptide,component of cutaneous basement membrane zone
UniProtKB/Swiss-Prot Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

Gene Ontology (GO) - Molecular Function for LAMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IMP 15159456
GO:0005515 protein binding --
GO:0043208 glycosphingolipid binding IEA --
genes like me logo Genes that share ontologies with LAMC1: view
genes like me logo Genes that share phenotypes with LAMC1: view

Animal Models for LAMC1 Gene

MGI Knock Outs for LAMC1:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAMC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LAMC1 Gene

Localization for LAMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAMC1 Gene

Secreted, extracellular space, extracellular matrix, basement membrane.

Subcellular locations from

Jensen Localization Image for LAMC1 Gene COMPARTMENTS Subcellular localization image for LAMC1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LAMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix --
GO:0005604 basement membrane IDA 14557481
GO:0005605 basal lamina --
GO:0005606 laminin-1 complex TAS 14557481
genes like me logo Genes that share ontologies with LAMC1: view

Pathways for LAMC1 Gene

genes like me logo Genes that share pathways with LAMC1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LAMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly IDA 15159456
GO:0007155 cell adhesion IDA 15159456
GO:0007411 axon guidance TAS --
GO:0007492 endoderm development TAS 9885251
GO:0016477 cell migration IMP 15561105
genes like me logo Genes that share ontologies with LAMC1: view

Compounds for LAMC1 Gene

(2) Novoseek inferred chemical compound relationships for LAMC1 Gene

Compound -log(P) Hits PubMed IDs
kalinin 74.4 1
heparin 0 1
genes like me logo Genes that share compounds with LAMC1: view

Transcripts for LAMC1 Gene

Unigene Clusters for LAMC1 Gene

Laminin, gamma 1 (formerly LAMB2):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAMC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAMC1 Gene

No ASD Table

Relevant External Links for LAMC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAMC1 Gene

mRNA expression in normal human tissues for LAMC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for LAMC1 Gene

This gene is overexpressed in Urinary Bladder (13.4), Gallbladder (10.9), and Adipocyte (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAMC1 Gene

SOURCE GeneReport for Unigene cluster for LAMC1 Gene Hs.609663

mRNA Expression by UniProt/SwissProt for LAMC1 Gene

Tissue specificity: Found in the basement membranes (major component)
genes like me logo Genes that share expressions with LAMC1: view

Expression partners for LAMC1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LAMC1 Gene

Orthologs for LAMC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LAMC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LAMC1 35
  • 90.49 (n)
  • 94.59 (a)
LAMC1 36
  • 95 (a)
(Canis familiaris)
Mammalia LAMC1 35
  • 91.35 (n)
  • 95.23 (a)
LAMC1 36
  • 95 (a)
(Mus musculus)
Mammalia Lamc1 35
  • 86.99 (n)
  • 92.84 (a)
Lamc1 16
Lamc1 36
  • 93 (a)
(Pan troglodytes)
Mammalia LAMC1 35
  • 99.34 (n)
  • 99.32 (a)
LAMC1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lamc1 35
  • 86.39 (n)
  • 92.35 (a)
(Monodelphis domestica)
Mammalia LAMC1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia LAMC1 36
  • 89 (a)
(Gallus gallus)
Aves LAMC1 35
  • 76.24 (n)
  • 82.64 (a)
LAMC1 36
  • 81 (a)
(Anolis carolinensis)
Reptilia LAMC1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lamc1 35
  • 70.93 (n)
  • 75.51 (a)
Str.17820 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1922 35
(Danio rerio)
Actinopterygii lamc1 35
  • 68.76 (n)
  • 69.55 (a)
lamc1 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta LanB2 37
  • 40 (a)
LanB2 35
  • 51.03 (n)
  • 42.57 (a)
LanB2 36
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta LANB2 35
  • 50.42 (n)
  • 42.83 (a)
(Caenorhabditis elegans)
Secernentea C54D1.5 37
  • 40 (a)
lam-2 35
  • 49.71 (n)
  • 41.61 (a)
lam-2 36
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5158 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for LAMC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LAMC1 Gene

Gene Tree for LAMC1 (if available)
Gene Tree for LAMC1 (if available)

Paralogs for LAMC1 Gene

Paralogs for LAMC1 Gene

(4) SIMAP similar genes for LAMC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LAMC1: view

Variants for LAMC1 Gene

Sequence variations from dbSNP and Humsavar for LAMC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2593 -- 183,142,906(-) GACAG(A/T)GATGG utr-variant-3-prime
rs3359 -- 183,142,906(+) TCCAT(C/G)ACTGT utr-variant-3-prime
rs7473 -- 183,145,499(+) TCTCC(A/G)GGGTG utr-variant-3-prime
rs20557 -- 183,124,740(+) CCCAA(A/C/G/T)GCAGT missense, synonymous-codon, reference
rs20558 - 183,125,412(+) CAATC(C/T)GTATG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for LAMC1 Gene

Variant ID Type Subtype PubMed ID
nsv819917 CNV Loss 19587683

Relevant External Links for LAMC1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAMC1 Gene

Disorders for LAMC1 Gene

(4) Novoseek inferred disease relationships for LAMC1 Gene

Disease -log(P) Hits PubMed IDs
epidermolysis bullosa junctional 61.9 2
glioma 3 1
tumors 0 1
melanoma 0 1

Relevant External Links for LAMC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LAMC1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for LAMC1 Gene

Publications for LAMC1 Gene

  1. Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene. (PMID: 1985895) Kallunki T. … Tryggvason K. (J. Biol. Chem. 1991) 3 4 23
  2. Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1. (PMID: 15370542) Hayashi M. … Allikmets R. (Ophthalmic Genet. 2004) 3 23 48
  3. Differences in human laminin B2 sequences. (PMID: 1806043) Santos C.L.S. … Brentani R. (DNA Seq. 1991) 3 4 23
  4. Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment of the gene to chromosome region 1q25-->q31. (PMID: 3234037) Fukushima Y. … Shows T.B. (Cytogenet. Cell Genet. 1988) 2 3 4
  5. Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse? (PMID: 20223449) Chen C. … Matthews C.A. (Am. J. Obstet. Gynecol. 2010) 3 23 48

Products for LAMC1 Gene

Sources for LAMC1 Gene

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