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Aliases for OR10K1 Gene

Aliases for OR10K1 Gene

  • Olfactory Receptor, Family 10, Subfamily K, Member 1 2 3
  • Olfactory Receptor OR1-6 3 4
  • Olfactory Receptor 10K1 3
  • OR1-6 3

External Ids for OR10K1 Gene

Previous GeneCards Identifiers for OR10K1 Gene

  • GC01U990362
  • GC01P155653
  • GC01P155249
  • GC01P156701

Summaries for OR10K1 Gene

Entrez Gene Summary for OR10K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10K1 Gene

OR10K1 (Olfactory Receptor, Family 10, Subfamily K, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10X1.

UniProtKB/Swiss-Prot for OR10K1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10K1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10K1 Gene

Genomics for OR10K1 Gene

Regulatory Elements for OR10K1 Gene

Genomic Location for OR10K1 Gene

Start:
158,465,562 bp from pter
End:
158,466,503 bp from pter
Size:
942 bases
Orientation:
Plus strand

Genomic View for OR10K1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR10K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10K1 Gene

Proteins for OR10K1 Gene

  • Protein details for OR10K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGX5-O10K1_HUMAN
    Recommended name:
    Olfactory receptor 10K1
    Protein Accession:
    Q8NGX5
    Secondary Accessions:
    • Q6IFS2

    Protein attributes for OR10K1 Gene

    Size:
    313 amino acids
    Molecular mass:
    35079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10K1 Gene

Proteomics data for OR10K1 Gene at MOPED

Post-translational modifications for OR10K1 Gene

  • Glycosylation at Asn5 and Asn265
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10K1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10K1 Gene

Domains for OR10K1 Gene

Gene Families for OR10K1 Gene

HGNC:
  • OR10 :GPCR / Class A : Olfactory receptors

Protein Domains for OR10K1 Gene

Suggested Antigen Peptide Sequences for OR10K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGX5

UniProtKB/Swiss-Prot:

O10K1_HUMAN :
  • Q8NGX5
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10K1: view

Function for OR10K1 Gene

Molecular function for OR10K1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10K1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR10K1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR10K1 Gene

Localization for OR10K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10K1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10K1 Gene COMPARTMENTS Subcellular localization image for OR10K1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10K1: view

Pathways for OR10K1 Gene

genes like me logo Genes that share pathways with OR10K1: view

Pathways by source for OR10K1 Gene

Interacting Proteins for OR10K1 Gene

Gene Ontology (GO) - Biological Process for OR10K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10K1: view

Transcripts for OR10K1 Gene

mRNA/cDNA for OR10K1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR10K1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR10K1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10K1 Gene

No ASD Table

Relevant External Links for OR10K1 Gene

GeneLoc Exon Structure for
OR10K1
ECgene alternative splicing isoforms for
OR10K1

Expression for OR10K1 Gene

mRNA expression in normal human tissues for OR10K1 Gene

SOURCE GeneReport for Unigene cluster for OR10K1 Gene Hs.690410

genes like me logo Genes that share expressions with OR10K1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR10K1 Gene

Orthologs for OR10K1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10K1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC744183 35
  • 98.62 (n)
  • 97.44 (a)
OR10K1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR10K1 35
  • 87.22 (n)
  • 86.58 (a)
OR10K1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC488612 35
  • 84.67 (n)
  • 83.28 (a)
OR10K1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr479 36
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia OR10K1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
Species with no ortholog for OR10K1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10K1 Gene

ENSEMBL:
Gene Tree for OR10K1 (if available)
TreeFam:
Gene Tree for OR10K1 (if available)

Paralogs for OR10K1 Gene

Selected SIMAP similar genes for OR10K1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10K1: view

Variants for OR10K1 Gene

Sequence variations from dbSNP and Humsavar for OR10K1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1002599 -- 158,465,460(-) CAGGT(A/G)GCAGG upstream-variant-2KB
rs1491195 -- 158,463,909(+) ACTAA(C/T)GTTAT upstream-variant-2KB
rs1548355 -- 158,465,115(+) TCATG(G/T)TTGGA upstream-variant-2KB
rs1573519 -- 158,465,488(+) TTCCC(A/G)TACAT upstream-variant-2KB
rs2157688 -- 158,464,205(+) ATTTT(C/G)TATCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10K1 Gene

Variant ID Type Subtype PubMed ID
dgv393n71 CNV Gain 21882294

Relevant External Links for OR10K1 Gene

HapMap Linkage Disequilibrium report
OR10K1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10K1 Gene

Disorders for OR10K1 Gene

Relevant External Links for OR10K1

Genetic Association Database (GAD)
OR10K1
Human Genome Epidemiology (HuGE) Navigator
OR10K1
genes like me logo Genes that share disorders with OR10K1: view

No data available for UniProtKB/Swiss-Prot for OR10K1 Gene

Publications for OR10K1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR10K1 Gene

  • antibodies-online proteins for OR10K1
  • antibodies-online antibodies for OR10K1
  • antibodies-online kits for OR10K1

Sources for OR10K1 Gene

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